Humira is a common medication for autoimmune diseases like rheumatoid arthritis, psoriasis, and Crohn’s disease. But if it doesn’t work well for you or you can’t handle the side effects, there are other alternatives for Humira.

These include Trexall (methotrexate), Remicade (infliximab), Orencia (abatacept), Rituxan (rituximab), and Xeljanz (tofacitinib).

Each Humira alternative works differently and maybe a better fit depending on your health situation and how you react to treatments.

Key Findings

  • Different alternatives to Humira, such as Methotrexate, Remicade (infliximab), Orencia (abatacept), Rituxan (rituximab), and Xeljanz (tofacitinib), are available for treating conditions like arthritis and Crohn’s disease.
  • Each alternative works differently and may have varying side effects, including common ones like nausea, headache, and fatigue.
  • Patients should consult their doctors to find the best treatment option for them, considering factors like effectiveness, ease of use, and potential risks.
  • Research suggests that these alternatives are generally safe and effective for long-term use, but some biosimilar alternatives may require regular monitoring and testing for side effects.
  • Cost can be a significant factor in choosing an alternative to Humira, and some options may be more affordable for patients.
  • The availability of biosimilar alternatives to Humira provides more choices for patients and may contribute to increased access to treatment.
  • Patients need to communicate openly with their healthcare providers about their preferences, concerns, and experiences with different treatment options to optimize their care.

What is Humira?

Humira (adalimumab) is a medication that helps with swelling and inflammation in conditions like arthritis and Crohn’s disease. It’s given as a shot under the skin and can be used at home.

Research has shown it is generally safe for long-term use, even though it might slightly increase the risk of infections and lymphoma.

There are other options to Humira, like Remicade and Simponi, which work in similar ways. These alternatives have different strengths and ways to take them. By talking to their doctors, patients can choose the best treatment for them.

How Does Humira Work?

Humira is a kind of medicine that falls into TNF blockers. It works by latching onto a protein in the body called TNF-alpha. This protein is known for causing inflammation, which can harm healthy cells.

Humira prevents TNF-alpha from causing inflammation, which is helpful for people with conditions like rheumatoid arthritis, Crohn’s disease, and psoriasis.

Essentially, Humira acts as a sort of “off switch” for inflammation, helping to ease symptoms and improve the overall health of those with inflammatory conditions.

Overview of Humira vs. Alternatives to Humira

AlternativeTypical doseSide EffectsImportant Considerations
Humira
  • Pen: 40 mg, 80 mg
  • Prefilled Syringe: 10 mg, 20 mg, 40 mg
  • Single-Dose Institutional Use Vial: 40 mg
  • Serious infections
  • Skin rash
  • Injection site reaction
  • Headache
Avoid Humira if patients have:

  • Chronic infections
  • Active infections
  • Exposure to tuberculosis
  • History of opportunistic infections
  • Lived/traveled in areas with endemic tuberculosis or mycoses
  • Underlying conditions increase infection risk.
Methotrexate7.5 to 10 milligrams (mg) once a week. The dose may gradually increase by 2.5 mg per week if needed.
  • Nausea
  • Vomiting
  • Loss of appetite
  • Stomach pain
  • Diarrhea
  • Increased risk of infection
  • Fatigue
  • Headache
Methotrexate is not safe to use during pregnancy for non-cancer conditions and for those who have had severe allergic reactions to it in the past.
Remicade (infliximab)
  • Initial IV infusion: 3-5 mg per kilogram of body weight given at weeks 0, 2, and 6.
  • Maintenance dose frequency varies depending on the condition but typically every 6 to 8 weeks.
  • Serious infections
  • Abdominal pain
  • Nausea
  • Anemia
  • Liver dysfunction
  • Headache
  • Infusion-related reactions
Before starting Remicade, inform your doctor if you suspect you have an infection or are undergoing treatment for one, have signs of infection like fever or cough, have open cuts or frequent infections, diabetes, or immune system problems.
Orencia (abatacept)
  • Intravenous: 250 mg powder in one vial
  • Subcutaneous:
    • Injection: 50 mg/0.4 mL, 87.5 mg/0.7 mL, 125 mg/mL in a prefilled syringe
    • 125 mg/mL in single-dose autoinjectors
  • Headache
  • Nausea
  • Bronchitis
  • Upper respiratory tract infection
  • Sinus infection
  • Skin rash
Avoid combining Orencia with TNF antagonists due to the higher infection risk. Rare hypersensitivity reactions, such as anaphylaxis, have been noted, requiring immediate Orencia discontinuation and proper treatment.
Rituxan (rituximab)Comes in 100 mg/10 mL and 500 mg/50 mL single-dose vials
  • Infusion reactions
  • Infections
  • Heart problems
  • Severe skin and mouth reactions
  • Hepatitis B virus reactivation
  • Progressive multifocal leukoencephalopathy
  • Tumor lysis syndrome
Before starting Rituxan, inform your doctor about any infections, heart issues, or hepatitis B history. Watch for infusion reactions during treatment, and be aware of the risk of severe skin reactions and tumor lysis syndrome.
Xeljanz (tofacitinib)
  • Xeljanz comes in immediate-release tablets, extended-release tablets, and oral solution.
  • Immediate-release tablets: 5mg and 10mg.
  • Extended-release tablets: 11mg and 22mg.
  • Oral solution: 1mg/ml liquid.
  • Skin rashes (including shingles)
  • Increased blood pressure
  • Fever
  • Abnormal blood tests
  • Headache
  • Nausea, vomiting, diarrhea
  • Cold symptoms (stuffy nose, sneezing, sore throat)
Xeljanz assists children aged two and older with specific forms of arthritis if they haven’t responded positively to other treatments.

Five Good Alternatives to Humira

Differences in managing inflammation, the way treatment is given, how often it’s needed, and the side effects can make some options better than others.

Here are some of the alternatives for Humira:

1. Methotrexate

What is Methotrexate?

Methotrexate is an alternative for Humira often recommended as the first line of treatment for rheumatoid arthritis. If a person doesn’t respond well to methotrexate after taking it for three to four months, doctors may consider trying a different medication. Methotrexate helps decrease damage to tissues by reducing toxic compounds that can harm them.

Methotrexate Form and Dosage

Methotrexate usually comes in tablet form, with each tablet containing 2.5 mg of the medication. It’s typically taken once a week. For some people, splitting the weekly dose into two or three smaller doses, taken 12 hours apart, may help reduce side effects like nausea and vomiting.

Methotrexate Side Effects

Here are the common side effects of Methotrexate:

  • Mouth sores
  • Low white blood cell count
  • Nausea and upset stomach

Here are some severe allergic reaction symptoms:

  • Skin rash, itching, and hives
  • Swelling of the face, lips, tongue, or throat
  • Dizziness
  • Trouble breathing or wheezing
  • Fast heart rate
  • Feeling faint
  • Stomach-area pain
  • Vomiting or diarrhea

Who Should Avoid Taking Methotrexate?

Methotrexate is not recommended for individuals with kidney problems. Pregnant women should avoid using methotrexate, as it can harm the fetus. Females of reproductive age need to use effective contraception while taking methotrexate and for at least six months after stopping treatment.

Methotrexate Cost

You can find Methotrexate at a much lower cost compared to other drugs like Humira. With GoodRx, the average retail price is about $20.06. 

Additionally, at PharmaGiant, you can get it for just $39.60 for 100 tablets (2.5mg).

Remicade2. Remicade (infliximab)

What is Remicade?

Remicade is an alternative to Humira, belonging to a class of medications called monoclonal antibodies. It’s used to treat inflammatory conditions like rheumatoid arthritis, Crohn’s disease, and psoriasis by targeting a protein in the body called tumor necrosis factor-alpha (TNF-alpha) involved in inflammation.

At the American University of Beirut Medical Centre (AUBMC), Remicade has been used for around two decades to treat various rheumatic diseases.

In a study, out of 198 patients who received Remicade, most had rheumatoid arthritis. While some experienced mild adverse events, like hypersensitivity reactions, a few withdrew due to infections, including tuberculosis reactivation.

Remicade Form and Dosage

Remicade is administered as an intravenous infusion, typically in a healthcare setting such as a hospital or infusion center.

The medication comes in a single-dose vial containing 100 mg of infliximab as a lyophilized powder. Before administration, the powder needs to be reconstituted and diluted according to the healthcare provider’s instructions.

Remicade Side Effects

Common side effects of Remicade include:

  • Infusion reactions, such as fever, chills, and skin reactions
  • Nausea and upset stomach
  • Fatigue
  • Headache
  • Upper respiratory tract infections
  • Sinusitis
  • Urinary tract infections

It’s important to note that while these side effects are common, not everyone experiences them, and some individuals may experience different or more severe side effects. Additionally, missing doses of Remicade can increase the risk of infusion reactions and other adverse effects.

Who Should Avoid Taking Remicade?

You should avoid Remicade if you have heart failure or if you’ve had an allergic reaction to Remicade or any of its ingredients. If you experience symptoms such as fever, extreme tiredness, cough, flu-like symptoms, or warm, red, or painful skin, contact your healthcare provider.

It’s essential to discuss any concerns or questions about Remicade with your doctor to ensure it’s the right treatment option for you.

Remicade Cost

Remicade, as listed on Drugs.com, typically costs around $1,239 for one 100 mg powder for injection. This price may vary depending on the pharmacy.

Orencia3. Orencia (abatacept)

What is Orencia?

Orencia is a medication used to alleviate symptoms of conditions like rheumatoid arthritis, juvenile arthritis, and psoriatic arthritis, which cause inflammation and pain in organs and connective tissues.

Unlike Humira, Orencia functions by modulating T-cell costimulation, which helps inhibit T-cell activation in the immune system, thereby addressing these conditions.

A study on pregnancy and rheumatoid arthritis treatment suggests that certain medications, including Orencia, may be relatively safe options for managing RA during pregnancy, but it’s crucial to consult healthcare providers before altering medication routines to understand the benefits and risks thoroughly.

Orencia Form and Dosage

  • For intravenous infusion: 250 mg lyophilized powder in a single-dose vial.
  • For subcutaneous use:
    • Injection: 50 mg/0.4 mL, 87.5 mg/0.7 mL, 125 mg/mL solution in single-dose prefilled syringe.
    • Injection: 125 mg/mL solution in a single-dose prefilled ClickJect™ autoinjectors.

Orencia Side Effects

  • Headache
  • Upper respiratory tract infection
  • Sore throat
  • Nausea
    For kids and teens:
  • Diarrhea
  • Cough
  • Fever
  • Abdominal pain

Who Should Avoid Taking Orencia?

You should avoid Orencia if you have a known allergy to abatacept or any of its ingredients. Additionally, it is not recommended to add Orencia to a treatment regimen already including a TNF inhibitor like Humira, as this could increase the risk of serious infections.

Orencia Cost

According to Drugs.Com, the cost for Orencia intravenous powder for injection of the same dosage is approximately $1,513 for one powder for injection, contingent upon the pharmacy visited.

Rituxan4. Rituxan (rituximab)

What is Rituxan?

Rituxan (rituximab) is a medication that targets and removes B cells from the body, which can worsen rheumatoid arthritis. It’s given through an IV infusion, where it’s slowly dripped into a vein.

However, it’s not suitable for those with severe infections, and doctors always check for hepatitis B before starting treatment.

Besides its approved use, Rituxan is also used off-label for conditions like autoimmune hemolytic anemia, multiple sclerosis, and lupus, among others, as shown in a cross-sectional study conducted in the US.

Rituxan Form and Dosage

For intravenous infusion:

  • 100 mg/10 mL (10 mg/mL) in a single-dose vial
  • 500 mg/50 mL (10 mg/mL) in a single-dose vial

Rituxan Side Effects

Common side effects include:

  • Infections (may include fever, chills)
  • Body aches
  • Tiredness
  • Nausea

In adults with GPA or MPA:

  • Low white and red blood cells
  • Swelling
  • Diarrhea
  • Muscle spasms

In children with B-cell NHL or B-AL who receive Rituxan with chemotherapy:

  • Decreased white blood cells with fever
  • Mouth sores
  • Inflammation of the upper intestine
  • Serious infection throughout the body and organs (sepsis)
  • Changes in liver function blood tests
  • Low level of potassium in the blood

Other side effects include:

  • Aching joints during or within hours of receiving an infusion
  • More frequent upper respiratory tract infection

Who Should Avoid Taking Rituxan?

Rituxan should not be used in individuals with severe active infections. It may also not be suitable for those with a history of certain heart problems, kidney issues, or serious stomach and bowel problems. If someone experiences severe, serious, or life-threatening side effects, their healthcare provider will stop treatment with Rituxan.

Cost of Rituxan

As indicated in the Drugs.Com, Rituxan intravenous solution (10 mg/mL) is about $999 for 10 milliliters. Please note that some prices vary depending on your insurance and pharmacy company.

Xeljanz5. Xeljanz (tofacitinib)

What is Xeljanz?

Xeljanz is a medication that helps reduce inflammation in the body, especially in joints, by blocking certain enzymes.

You can take Xeljanz by mouth twice a day, which is easier for many people. While taking Xeljanz, it’s important to regularly check things like your cholesterol, liver, and kidney function, and the levels of certain types of blood cells to make sure everything is okay.

The way Xeljanz works is by stopping enzymes called Janus kinases (JAKs), which are involved in diseases where the immune system attacks the body.

By targeting specific JAKs, Xeljanz helps reduce inflammation. However, there are some things to be careful about: don’t take strong immunosuppressant medicines or certain other treatments with Xeljanz, and try not to get live vaccines while you’re taking it.

Xeljanz Form and Dosage

  • Xeljanz tablets: 5 mg, 10 mg tofacitinib
  • Xeljanz XR tablets: 11 mg, 22 mg tofacitinib
  • Xeljanz oral solution : 1 mg/mL tofacitinib

Xeljanz Side Effects

Serious side effects may include:

  • All-cause mortality (including sudden cardiovascular death)
  • Thrombosis (blood clots)

Other side effects:

  • Upper respiratory tract infection
  • Headaches
  • Diarrhea
  • Skin rash
  • Nausea
  • Vomiting
  • Reduced white blood cells
  • Risks of other cancers

Who Should Avoid Taking Xeljanz?

Xeljanz may not be suitable for individuals who are experiencing severe infections, liver problems, or kidney issues.

Moreover, individuals over 50 years of age with cardiovascular risk factors should be cautious, as higher doses of Xeljanz have shown an increased risk of serious side effects such as sudden cardiovascular death and thrombosis. Regular monitoring and dose adjustments may be necessary based on test results.

Cost of Xeljanz

The cost of Xeljanz XR, an extended-release oral tablet with a strength of 11 mg, is approximately $6,100 for a 30-tablet supply at different pharmacies. These prices are typically for individuals paying in cash and may not be compatible with insurance coverage. Additionally, PharmaGiant offers Xeljanz at competitive prices.

They provide 60 tablets of 5 mg strength for $2483.21 and 60 tablets of 10 mg strength for $2667.66.

What Other Drugs Are Similar to Humira?

Several drugs are similar to Humira and are used in the management of inflammatory conditions. These include:

Did you know…

Looking for affordable Humira alternatives? Check out PharmaGiant. With competitive pricing and convenient delivery, we offer cost-effective options for rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and more. Visit our website or contact us for more info.

Cost Comparison: US Price vs. PharmaGiant

MedicationUS PricePharmaGiantPrice Difference 
Methotrexate$86.94 for 100 tablets (2.5mg)

$137 for 100 tablets (10mg)

$39.60 for 100 tablets (2.5mg)

$96.95 for 100 tablets (10mg)

$47.34 for 100 tablet (2.5mg)

$40.05 for 100 tablet (10mg)

Remicade (infliximab)$7085 for 1 vial (100mg)$1,555.40 for 1 vial (100mg)$5,529.6 for 1 vial (100mg)
Orencia (abatacept)$5,545 for 4 syringes (125mg/mL) 1 carton

$1,430 for 1 vial ( 250mg)

$1,799.95 for 4 pre-filled syringes (125mg/mL)

$788.04 for 1 vial (250mg) x 15 ml

$ 3,745.05 for 4 pre-filled syringes

$641.96 for 1 vial (250mg)

Rituxan (rituximab)$4,956.07 for 50 milliliters (500 mg/ 50mL)$3,798.10 for 50 ml (500mg/50ml)$1,157.9 for 50ml (500mg/50ml)
Xeljanz (tofacitinib)$5635 for 60 tablet (5mg)$2,483.21 for 60 tablets (5mg)$3,151.79 for 60 tablet (5mg)
Xeljanz XR$5904 for 1 bottle of 60 tablets (10mg)

$5634 for 30 tablet (11mg)

$2,667.66 for 60 tablets (10mg)

$2,279.95 for 30 tablets (11mg)

$3,236.34 for 60 tablet (10mg)

$3,354.05 for 30 tablet (11mg)

Humira Alternatives: Approved Biosimilars

Elderly patient injecting syringe into stomach | Humira Alternative

Biosimilars offer a promising alternative to Humira, providing similar efficacy and safety profiles at potentially lower costs.

These biosimilars have been approved by the FDA since 2016 and offer various forms, doses, and concentrations, making them adaptable to individual patient needs.

Here are the following biosimilar alternatives for Humira:

Amgevita (known as Amjevita in the US)

Amgevita is a medication known as a Tumor Necrosis Factor (TNF)-blocker. It’s like Humira but was approved by the FDA in 2016 as its first biosimilar.

People use Amgevita to ease symptoms of conditions like

  • Rheumatoid arthritis
  • Juvenile arthritis
  • Psoriatic arthritis
  • Ankylosing spondylitis
  • Hidradenitis suppurativa
  • Crohn’s disease
  • Ulcerative colitis
  • Chronic plaque psoriasis
  • Certain eye inflammations

It’s available for both adults and children over 2 years old. Before starting Amgevita, consult your doctor about its benefits and risks. Amgevita, a TNF blocker, can weaken the immune system, increasing susceptibility to infections.

Serious infections, including tuberculosis, have occurred, and the risk of certain cancers may rise, particularly lymphoma and skin cancers.

Cyltezo

Cyltezo, first approved by the FDA in 2017 and granted interchangeability designation in 2021, is a medication known as a Tumor Necrosis Factor (TNF) blocker.

While it targets TNF to reduce inflammation, it can also lead to serious side effects such as infections, allergic reactions, nervous system problems, and liver issues. It’s crucial to talk to your doctor about the possible benefits and risks, especially if you have any current infections or symptoms of these conditions.

HyrimozHyrimoz

Hyrimoz treats chronic inflammatory conditions like arthritis and Crohn’s disease. Made by Sandoz Inc., it’s similar in safety and effectiveness but may cost less.

Prescribed for rheumatoid arthritis, psoriatic arthritis, and more, it can be used alone or with methotrexate.

Common side effects include headaches and injection site reactions, while serious ones like abdominal pain or breathing difficulties are rare. Long-term use may increase the risk of cancer, especially in children and teens.

Hyrimoz prices range from $742.24 to $1484.50 depending on the dosage.

Hadlima

Hadlima, a biosimilar to Humira, provides accessible treatment for autoimmune conditions. Approved by the FDA in 2019 and developed by Samsung Bioepis Co., Ltd., it offers patients an alternative therapy option.

Administered via subcutaneous injection, its dosage varies based on the condition treated and individual response.

Hadlima is available in pre-filled syringes and autoinjector pens, offering convenience for self-administration. With different concentrations to suit patient needs, Hadlima ensures flexibility in dosing. Prices for Hadlima range from $1484.50 for a supply of 2 syringes to $1484.50 for 2 autoinjectors.

Hulio Injection PenHulio

Hulio, a biosimilar to Humira, is a valuable treatment option for various inflammatory conditions such as arthritis and psoriasis. With its prefilled syringe and pen forms, Hulio simplifies the treatment process, making it easier for both adults and children to administer.

Administered via subcutaneous injection, Hulio requires careful adherence to proper techniques and storage guidelines.

Patients or caregivers need to be trained in the correct injection methods, ensuring effective delivery of the medication. It’s essential to rotate injection sites and inspect the solution for any abnormalities before administration.

Hulio comes in prefilled syringe and pen forms, with prices ranging from $2331.45 for a 50mg/0.5mL autoinjector to other concentrations and quantities.

Buy Idacio from CanadaIdacio

Idacio is a special medicine that helps with autoimmune diseases by blocking a protein called tumor necrosis factor (TNF). This protein can make the body’s immune system too active, causing inflammation.

It’s administered with a small needle, either in the thigh or the belly, and comes in pre-filled pens or syringes, which makes it easy for people to use by themselves.

Using Idacio can help improve conditions like rheumatoid arthritis, psoriatic arthritis, and Crohn’s disease. But like all medicines, it can have side effects. Some common ones are infections and reactions where the needle goes in, but there can also be serious risks like getting tuberculosis or having an allergic reaction.

Idacio prices are available for $1484.50 for a pack of 2 pens, making it a helpful option for people dealing with autoimmune issues.

AbriladaAbrilada

Abrilada, an FDA-approved biosimilar to Humira since 2019, offers relief for various autoimmune conditions. Its approval was based on a thorough review showing its similarity to the original medication.

Notably, Abrilada’s prefilled syringes offer convenience, and it’s safe for those with latex allergies. Plus, it can be stored at room temperature for up to 30 days if needed, and patients can administer it at home under their provider’s guidance, simplifying treatment.

Yusimry

Yusimry, a biosimilar of Humira, is a medication used to ease pain, swelling, and skin issues in long-lasting autoimmune disorders. Available as a prefilled pen or syringe, it’s a close match to the original Humira.

However, Yusimry can weaken your immune system, making you more prone to infections, including severe ones. Before and during treatment, watch out for signs like fever or cough, as they could indicate an infection.

Your doctor will also check for tuberculosis before starting Yusimry and monitor you closely for any signs. Additionally, there’s a slight increase in the risk of cancer for both children and adults using TNF-blockers like Yusimry.

Simlandi

Simlandi (adalimumab-ryvk) is a biosimilar of Humira, prescribed to ease pain, inflammation, and skin issues in various autoimmune conditions like plaque psoriasis, Crohn’s disease, and rheumatoid arthritis. It’s also used for hidradenitis suppurativa and uveitis in certain cases.

Common side effects may include headache, cold symptoms, rash, or redness at the injection site.

However, serious reactions can occur. Seek immediate medical help if you experience signs of an allergic reaction, such as hives or difficulty breathing. Contact your doctor promptly if you notice symptoms like fever, swollen glands, joint pain, or new psoriasis.

Also, be vigilant for signs of more severe conditions like sepsis, liver problems, nerve issues, or tuberculosis. Older adults using Simlandi may have a higher risk of infections or cancer.

Buy Yuflyma from CanadaYuflyma

Yuflyma, also known as adalimumab-aaty, is a vital treatment for autoimmune disorders, blocking TNF (Tumor Necrosis Factor) to reduce inflammation in conditions like rheumatoid arthritis and psoriasis. Available in pre-filled syringes and auto-injectors, Yuflyma offers convenience in administration, with dosages typically given every other week.

While common side effects like mild injection site reactions, upper respiratory infections, headaches, nausea, or rash may occur, serious reactions such as severe infections, allergic responses, or neurological symptoms are possible.

Long-term use may also pose risks like increased susceptibility to infections or certain cancers.

Natural Remedies that can Assist Treatment

Complementary methods for managing conditions treated by Humira should be viewed as supplementary to the medications mentioned.

Here are some natural options that may help:

  • Probiotics and prebiotics: Help manage Crohn’s disease and ulcerative colitis by promoting gut health.
  • Aloe vera: Known for its soothing properties, it may alleviate symptoms of inflammatory bowel diseases.
  • Micronutrient supplements: Deficiencies in iron, B12, vitamin D, and others are common in these conditions.
  • Anti-inflammatory supplements: Fish oil, cayenne pepper, and turmeric may help reduce inflammation.
  • Healthy lifestyle: Important to boost immunity and minimize infection risk when on immunosuppressants.

Takeaways

In conclusion, exploring different options for Humira can give patients more choices for managing their conditions effectively.

By looking at various treatments, individuals can find one that fits their needs and preferences. From biologics to targeted patients, the wide range of alternatives gives hope to those looking for options or facing challenges with Humira.

Talking to healthcare providers and discussing the available choices is crucial for making informed treatment decisions.

Ultimately, finding the best alternative to Humira is a journey that needs patience, effort, and teamwork between patients and healthcare pros to achieve the best results and improve quality of life.

Frequently Asked Questions about Humira

What other drugs are similar to Humira?

Alternatives for Humira include Methotrexate, Remicade (infliximab), Orencia (abatacept), Rituxan (rituximab), and Xeljanz (tofacitinib).

These medications are used to treat various autoimmune conditions like rheumatoid arthritis, psoriatic arthritis, and Crohn’s disease.

Each alternative works differently in the body but shares the goal of reducing inflammation and managing symptoms. It’s important to discuss with your healthcare provider to determine which alternative is the best fit based on your condition, medical history, and treatment goals.

Which is better methotrexate or Humira?

Deciding between methotrexate and Humira depends on factors like the specific condition, medical history, and treatment response. Methotrexate is a common first-line treatment for rheumatoid arthritis and autoimmune conditions.

In contrast, Humira is a biologic TNF inhibitor used when methotrexate isn’t enough or well-tolerated. Talk to a healthcare provider to choose the right treatment plan.

Who should not use Humira?

If you have any kind of infection, it’s important not to start taking Humira unless your doctor says it’s okay. Your doctor might want to treat the infection before you start Humira.

Also, if you have heart failure, Humira may not be suitable for you. Make sure to tell your doctor about all your health conditions, including any infections, before starting Humira treatment.

Is there a generic alternative for Humira?

Cyltezo is now the only adalimumab biosimilar considered interchangeable, allowing pharmacists to recommend this as an alternative to Humira without a doctor’s permission. It’s approved for use in adults with conditions like severe rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, and chronic plaque psoriasis.

Acting FDA Commissioner Janet Woodcock, M.D., stated that creating the biosimilar and interchangeable approval process aims to give patients more treatment options for serious health issues.

What happens if you stop taking Humira?

If you stop taking Humira, your symptoms might come back or get worse. This could include pain, inflammation, and other symptoms of your condition. It’s important to talk to your doctor before stopping Humira to understand the potential risks and to discuss any alternatives or adjustments to your treatment plan.

What drugs are in the same class as Humira?

Drugs in the same class as Humira belong to a group called TNF blockers or TNF inhibitors. Some other drugs in this class include Remicade (infliximab), Enbrel (etanercept), Simponi (golimumab), and Cimzia (certolizumab pegol).

Which arthritis drug is considered the safest for rheumatoid arthritis?

Methotrexate is often recognized as one of the safest options, despite some possible drawbacks. Its main side effects typically involve gastrointestinal symptoms like nausea and vomiting.

How often is Humira taken?

On the first day, you’ll take 160 mg either all at once or split over two days. Then, on Day 15, you’ll take 80 mg. After that, starting on day 29, you’ll take a maintenance dose of 40 mg every other week. This smaller dose helps to keep the level of Humira steady in your body.

Is there a cheaper alternative to Humira?

Yes, there are cheaper alternatives to Humira available in the form of biosimilar medications. Biosimilars are drugs that are highly similar to the original biological drug (in this case, Humira) but are usually more affordable.

These biosimilars have been approved by regulatory authorities such as the FDA and have demonstrated comparable safety and effectiveness to the original drug.

By opting for these cheaper Humira alternatives, patients may be able to access the same treatment benefits at a lower cost, potentially making treatment more accessible and affordable for those in need.

Can you stop taking Humira once you start?

Generally, you should not stop taking Humira without consulting your doctor. It’s essential to follow your doctor’s instructions regarding your medication regimen. Suddenly stopping Humira without medical guidance can lead to a worsening of your condition or potential adverse effects. Always consult your healthcare provider before making any changes to your treatment plan.

Why is Humira referred to as a biologic?

Humira contains adalimumab, an active drug classified as a biologic medication. Biologics are drugs produced from living cells. Adalimumab falls under the category of tumor necrosis factor (TNF) blockers, which work similarly to each other.

Sources

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Drugs.com. (n.d.). Humira Alternatives Compared – Drugs.com. https://www.drugs.com/compare/humira

Schiff, M. H., Burmester, G. R., Kent, J. D., Pangan, A. L., Kupper, H., Fitzpatrick, S. B., & Donovan, C. (2006). Safety analyses of adalimumab (HUMIRA) in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis. Annals of the rheumatic diseases, 65(7), 889–894.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1798196/

Ellis, C. R. (2023). Adalimumab. StatPearls [Internet].
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FDA Approves Cyltezo, the First Interchangeable Biosimilar to Humira. (2021). U.S. Food And Drug Administration.
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