Erectile dysfunction (ED), historically referred to as impotence, is a common condition that affects millions of men worldwide, including about 30 million in the US. Despite its prevalence, the 2021 National Survey of Sexual Wellbeing revealed that only 7.7% of men reported being medically diagnosed with ED.
Many individuals turn to medications like Cialis (tadalafil) or Viagra (sildenafil) but often struggle to determine if they’ve chosen the right one. Some are disappointed by the duration of the effects, while others are concerned about potential side effects. This uncertainty can make an already challenging situation even more stressful.
In this article, we’ll break down the differences between Cialis and Viagra to help you make an informed choice. We’ll explore how effective they are, how long their effects last, and the side effects you might encounter.
Effectiveness of Viagra vs Cialis
Studies have shown that Cialis and Viagra are both effective and safe for treating erectile dysfunction (ED). However, Cialis may have additional advantages.
A systematic review and meta-analysis comparing Cialis vs Viagra revealed that both medications provided similar improvements in erectile function and satisfaction based on the International Index of Erectile Function (IIEF) scores. However, Cialis showed an advantage in psychological outcomes. Patients using Cialis reported benefits in areas like:
-
- sexual confidence
- relationship satisfaction
- overall satisfaction
Another research focused on men who had never used ED medications before, comparing 20 mg Cialis vs 100 mg Viagra. Both medications improved the following:
-
- erectile function
- penetration success
- successful intercourse
Cialis also showed effectiveness in managing benign prostatic hyperplasia (BPH) symptoms. In a placebo-controlled trial, men taking Cialis experienced significant relief from urinary symptoms. Their IPSS scores, which measure the severity of urinary symptoms, improved by an average of 5.6 points compared to 3.6 points in the placebo group. These benefits appeared quickly, with noticeable changes within a week.
How Long Does it Take for Viagra or Cialis to Work?

Viagra works quickly, often faster than Cialis. It helped some men achieve a penetrative erection in 12 minutes, with most seeing results within 30 minutes. Another trial found that around 51% of participants were able to have successful intercourse within 20 minutes, with the average time being 36 minutes.
Cialis, on the other hand, can start working within 16-30 minutes when taken on-demand at a 20 mg dose. The 10 mg dose is also effective within 30 minutes but is slightly less powerful. When taken daily for the treatment of ED, the 5 mg dose starts working by day 2, while the 2.5 mg dose takes about 3 days to show noticeable effects.
How Long Does Viagra or Cialis Last?
The effects of Cialis last longer than those of Viagra–typically up to 36 hours. Viagra, on the other hand, remains effective for up to 4 hours. However, some studies suggest that Viagra’s effects can last much longer than previously thought.
A paper published in the Journal of Sexual Medicine demonstrated that Viagra remains effective for up to 12 hours. It can help achieve an erection when sexually stimulated during that time. However, the duration of each erection becomes shorter as time passes after taking the medication.
-
- Within 1 hour: Erections last the longest, typically around 26-33 minutes, as the medication is at its peak effectiveness.
- After 8 hours: Erections shorten to approximately 11-23 minutes.
- After 12 hours: The effects are weaker, with erections lasting around 8-16 minutes.
These findings align with a European study, where 97% of patients achieved erections leading to successful intercourse at 1 hour post-dose, and 74% were successful at 12 hours post-dose.
Potential Side Effects

Cialis and Viagra share similar side effects, including:
-
- Headache
- Indigestion
- Back pain
- Muscle pain or muscle soreness
- Nasal congestion
- Flushing or redness of the skin
- Pain in limb
- Abnormal vision
- Nausea
- Dizziness
- Rash
However, a comparative study found that Cialis is more likely to cause muscle and back pain, while Viagra is more associated with flushing.
Both medications can also cause serious side effects, such as:
-
- Priapism: A prolonged, painful erection lasting more than 6 hours. If left untreated, it can cause permanent damage to the penis.
-
- Sudden Vision Loss: This could indicate a rare condition called NAION, which may lead to partial or permanent vision loss.
-
- Hearing Loss: Sudden hearing loss, sometimes accompanied by ringing in the ears (tinnitus) or dizziness.
-
- Allergic Reactions: Severe reactions can include rash, itching, swelling (especially of the face or throat), dizziness, or difficulty breathing.
While these severe side effects are uncommon, it’s important to stop taking the medication and seek medical help immediately if any of them occur.
Mechanism of Action
Cialis (tadalafil) and Viagra (sildenafil) both belong to a group of drugs called PDE5 inhibitors. They work by blocking an enzyme called phosphodiesterase type 5 (PDE5). This enzyme is responsible for breaking down a substance called cyclic guanosine monophosphate (cGMP), which is important in relaxing the smooth muscles in the walls of blood vessels.
By inhibiting PDE5, Cialis and Viagra allow cGMP to accumulate, leading to the relaxation of blood vessels in the penis. This relaxation increases blood flow, making it easier to achieve and maintain an erection during sexual stimulation.
Note that Cialis and Viagra only work when there is sexual arousal. They do not cause an automatic erection but enhance the body’s natural response to sexual stimulation.
Comparing Dosage
Both drugs are limited to once-daily dosing, but Cialis provides more detailed dosing options and versatility compared to Viagra. Here’s how:
| Feature | Cialis | Viagra |
|---|---|---|
| Starting dose for ED |
10 mg (when taken as needed before sexual activity) 2.5 mg (when taken daily, without regard to the timing of sexual activity) |
50 mg (when taken as needed before sexual activity) |
| Adjustments based on efficacy or tolerability | As Needed: Increased to 20 mg or decreased to 5 mg Daily Use: Increased to 5 mg | Increased to 100 mg or decreased to 25 mg |
| Maximum dose | As Needed: 20 mg Daily Use: 5 mg | 100 mg |
| Timing | As Needed: Taken before having sex Daily: Taken at the same time each day | Taken 30 minutes to 4 hours before sexual activity |
| Additional uses | Dose for BPH or combined ED/BPH: 5 mg, taken at the same time every day. | Not approved for BPH |
Price and Discounts
At Pharma Giant, Cialis starts at $99 for 4 tablets, while the generic equivalent (tadalafil) is more budget-friendly, starting at $65. Viagra, on the other hand, is more affordable upfront, with prices starting at $57 for the brand-name version and $49 for the generic equivalent (sildenafil).
Customers can save an additional 10% on their first order with coupon code FIRST10.
Keep in mind that these prices can vary depending on the pharmacy, location, and insurance coverage. Buying larger quantities often lowers the cost per tablet, making it more economical.
Studies and Reviews
A study comparing how men with ED responded to 50 mg Viagra vs 20mg Cialis revealed that Cialis was the preferred option for the majority. Among the 190 men who completed the study, 66.3% chose Cialis, while 33.7% favored Viagra. This preference for Cialis remained consistent regardless of age, the duration of ED, or prior experience with Viagra.
In another study, the findings were similar–69.1% of participants preferred Cialis, while 30.9% chose Viagra. Many of those who preferred Cialis cited its longer-lasting effects as the main reason, as it allowed them to achieve erections even hours after taking the medication.
A more recent study further confirmed that most patients who tried both medications ultimately leaned toward Cialis. The preference was especially strong among younger, healthier individuals with early-stage ED.
Discussions on Reddit also highlight real-world experiences with these medications. One 35-year-old male shared his positive experience with Viagra and raised questions about Cialis’ extended effectiveness and whether side effects, like headaches, could last as long as its effects. Other users chimed in with personal insights, comparing the two options.
Users often prefer Cialis for its long-lasting effects and flexibility, while Viagra is favored for its quick and intense results. One user described how Viagra produces a fast, automatic response but often comes with more pronounced side effects like headaches.
On the other hand, Cialis provides a smoother experience with fewer harsh side effects, though it requires genuine arousal to be effective. These insights reflect the general consensus that both medications have unique advantages, making the choice dependent on individual needs and preferences.
Related Articles
Which is Better?
Cialis and Viagra are both effective options for treating ED. They improve erectile function, penetration success, and overall satisfaction. However, many people prefer Cialis because of its longer-lasting effects and added versatility. It can also be taken daily and is approved for treating symptoms of BPH.
Viagra, on the other hand, is a great choice if you want something that works quickly and for shorter periods. Both drugs are safe, but their side effects vary slightly. Cialis is more likely to cause back and muscle pain, while Viagra may cause more flushing.
When deciding between the two, consider your lifestyle and what works best for you. It’s also important to talk to a healthcare provider to find the right option.
Frequently Asked Questions
Sources
Mark, K. P., Arenella, K., Girard, A., Herbenick, D., Fu, J., & Coleman, E. (2024). Erectile dysfunction prevalence in the United States: report from the 2021 National Survey of Sexual Wellbeing. The Journal of Sexual Medicine, 21(4), 296–303. https://doi.org/10.1093/jsxmed/qdae008
Porst, H., Kim, E. D., Casabé, A. R., Mirone, V., Secrest, R. J., Xu, L., Sundin, D. P., & Viktrup, L. (2011). Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of an international randomized, Double-Blind, Placebo-Controlled trial. European Urology, 60(5), 1105–1113. https://doi.org/10.1016/j.eururo.2011.08.005
Gong, B., Ma, M., Xie, W., Yang, X., Huang, Y., Sun, T., Luo, Y., & Huang, J. (2017). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International Urology and Nephrology, 49(10), 1731–1740. https://doi.org/10.1007/s11255-017-1644-5
Wang, X., Bai, W., Li, H., Dai, Y., He, X., Huang, Y., Liu, J., Sorsaburu, S., Ji, C., & Jin, J. (2014). An open-label, multicenter, randomized, crossover study comparing sildenafil citrate and tadalafil for treating erectile dysfunction in Chinese men naïve to phosphodiesterase 5 inhibitor therapy. Asian Journal of Andrology, 17(1), 61. https://doi.org/10.4103/1008-682x.143244
Coward, R., & Carson, C. (2008b). Tadalafil in the treatment of erectile dysfunction. Therapeutics and Clinical Risk Management, Volume 4, 1315–1329. https://doi.org/10.2147/tcrm.s3336
Moncada, I., Jara, J., Subirá, D., Castaño, I., & Hernández, C. (2004). Efficacy of Sildenafil Citrate at 12 Hours after Dosing: Re-exploring the Therapeutic Window. European Urology, 46(3), 357–361. https://doi.org/10.1016/j.eururo.2004.04.025
Eardley, I., Ellis, P., Boolell, M., & Wulff, M. (2002). Onset and duration of action of sildenafil for the treatment of erectile dysfunction. British Journal of Clinical Pharmacology, 53(s1). https://doi.org/10.1046/j.0306-5251.2001.00034.x
Padma-Nathan, H., Stecher, V., Sweeney, M., Orazem, J., Tseng, L., & Deriesthal, H. (2003). Minimal time to successful intercourse after sildenafil citrate: results of a randomized, double-blind, placebo-controlled trial. Urology, 62(3), 400–403. https://doi.org/10.1016/s0090-4295(03)00567-3
Gingell, C., Sultana, S. R., Wulff, M. B., & Gepi-Attee, S. (2004). Duration of Action of Sildenafil Citrate in Men with Erectile Dysfunction. The Journal of Sexual Medicine, 1(2), 179–184. https://doi.org/10.1111/j.1743-6109.2004.04026.x
Rosen, R. C., Padma-Nathan, H., Shabsigh, R., Saikali, K., Watkins, V., & Pullman, W. (2004). Determining the Earliest Time within 30 Minutes to Erectogenic Effect after Tadalafil 10 and 20 mg: A Multicenter, Randomized, Double?Blind, Placebo?Controlled, At?Home Study. The Journal of Sexual Medicine, 1(2), 193–200. https://doi.org/10.1111/j.1743-6109.2004.04028.x
Seftel, A., Goldfischer, E., Kim, E. D., Dula, E., Zeigler, H., & Burns, P. (2010). Onset of efficacy of Tadalafil once daily in men with erectile dysfunction: a randomized, Double-Blind, Placebo controlled trial. The Journal of Urology, 185(1), 243–248. https://doi.org/10.1016/j.juro.2010.09.035
Govier, F., Potempa, A., Kaufman, J., Denne, J., Kovalenko, P., & Ahuja, S. (2003). A multicenter, randomized, double-blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction. Clinical Therapeutics, 25(11), 2709–2723. https://doi.org/10.1016/s0149-2918(03)80328-4
Von Büren, M., Rodler, S., Wiesenhütter, I., Schröder, F., Buchner, A., Stief, C., Gratzke, C., Wülfing, C., & Von Büren, J. (2021). Digital Real-world Data Suggest Patient Preference for Tadalafil over Sildenafil in Patients with Erectile Dysfunction. European Urology Focus, 8(3), 794–802. https://doi.org/10.1016/j.euf.2021.04.019
Eli Lilly and Company. (2023). HIGHLIGHTS OF PRESCRIBING INFORMATION OF CIALIS. Retrieved from https://pi.lilly.com/us/cialis-pi.pdf
PFIZER LABORATORIES DIV PFIZER INC. (2017). HIGHLIGHTS OF PRESCRIBING INFORMATION OF VIAGRA. Retrieved from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=0b0be196-0c62-461c-94f4-9a35339b4501&type=display
Doggrell, S. A. (2005). Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction. Expert Opinion on Pharmacotherapy, 6(1), 75–84. https://doi.org/10.1517/14656566.6.1.75




