Weight loss medications are currently a hot topic in America, with drugs like Ozempic and Wegovy making frequent appearances in health news. However, a significant claim happened in November 2023 when a comprehensive study highlighted one particular weight loss drug – Mounjaro (tirzepatide).

The study, led by Truveta Research and still awaiting peer review, revealed that individuals taking Mounjaro were notably more successful in achieving weight loss milestones of 5%, 10%, and 15% of their body weight. Additionally, they experienced more significant reductions in body weight after three months, six months, and a year compared to those using Ozempic.

This study analyzed real-world data from over 18,000 adults in the US who were either obese or overweight and had initiated treatment with either Ozempic or Mounjaro between May 2022 and September 2023.

As the demand for Mounjaro and similar weight loss medications continues to surge in the US, many are curious to know which option is the most effective. In this article, we’ll look into expert insights and real-life experiences of individuals who have undergone this treatment to understand the extent of their weight loss success.

Key Findings

  • Mounjaro consistently demonstrated efficacy in reducing body weight across different doses and durations of treatment, as evidenced by findings from the SURPASS program’s phase 3 clinical trials.
  • Real-life experiences from individuals who have undergone Mounjaro treatment showcased impressive weight loss results and significant improvements in overall health.
  • Celebrities such as Whoopi Goldberg and Lauren Manzo have openly shared their successful weight loss journeys with Mounjaro.

Research on Mounjaro for Weight Loss

Mounjaro’s FDA approval was based on the results of phase 3 of the SURPASS program. Although not primarily intended for weight loss, the studies assessed its effect on body weight as a secondary endpoint.

The SURPASS phase 3 global clinical development program for tirzepatide, marketed as Mounjaro, started in late 2018 and included five global registration trials lasting 40 to 104 weeks. These trials evaluated Mounjaro’s efficacy and safety at doses of 5 mg, 10 mg, and 15 mg.

Key findings from the trials include:

  • SURPASS-1: A 40-week study comparing Mounjaro to placebo in adults whose type 2 diabetes is not adequately managed through diet and exercise alone. From a baseline weight of 189 lbs, the average weight loss by week 40 was 14 lbs with the 5 mg dose, 15 lbs with the 10 mg dose, and 17 lbs with the 15 mg dose, in contrast to 2 lbs for the placebo group.
  • SURPASS-2: Also a 40-week study comparing Mounjaro to injectable semaglutide in adults with type 2 diabetes inadequately controlled with metformin alone. Mounjaro showed superior weight loss results. From an initial weight of 207 lb., participants experienced weight decreases averaging 17 lb (5 mg), 21 lb (10 mg), and 25 lb (15 mg) with Mounjaro versus 13 lb with semaglutide.
  • SURPASS-3: A 52-week study comparing Mounjaro to insulin degludec in adults with type 2 diabetes treated with metformin with or without an SGLT-2 inhibitor. Starting at 208 lb, Mounjaro reduced participants’ weight by a mean of 15 lb (5 mg), 21 lb (10 mg), and 25 lb (15 mg), while insulin degludec increased the participant’s weight by 4 lb.
  • SURPASS-4: A 104-week study comparing Mounjaro to insulin glargine in adults with type 2 diabetes inadequately controlled with oral antihyperglycemic medications and increased cardiovascular risk. Mounjaro demonstrated significant weight reductions by a mean of 14 lb (5 mg), 20 lb (10 mg), and 23 lb (15 mg) from an initial weight of 199 lb. In contrast, those treated with insulin glargine saw an increase of 4 lb.
  • SURPASS-5: A 40-week study comparing Mounjaro to placebo in adults with inadequately controlled type 2 diabetes already treated with insulin glargine, with or without metformin. Participants treated with Mounjaro experienced significant mean weight reductions of 12 lb (5 mg), 17 lb (10 mg), and 19 lb (15 mg) from a baseline weight of 210 lb, while those on placebo saw an increase of 4 lb.

Across these trials, Mounjaro consistently showed efficacy in reducing A1C levels and promoting weight loss, making it a promising treatment option for individuals with type 2 diabetes mellitus (T2DM) and obesity.

A more recent meta-analysis examined tirzepatide’s effectiveness and safety for weight loss in patients with T2DM and obesity. Results showed a notable decrease in body weight in the tirzepatide group compared to placebo (9.81 kg), GLP-1 receptor agonists (GLP-1 RAs) (1.05 kg), and insulin (1.93 kg).

Sub-analysis indicated significant weight reduction across all three tirzepatide doses (5 mg, 10 mg, and 15 mg) compared to placebo, GLP-1 RAs, and insulin. However, careful monitoring of gastrointestinal reactions is necessary.

Real-Life Experiences with Mounjaro for Weight Loss

Personal Testimonials on Mounjaro

Here are inspiring stories from individuals who have seen remarkable health improvements with Mounjaro:

Heather Winterstein

Heather Winterstein shared on ABC News that she initially encountered nausea when she began the medication. Her doctor prescribed Zofran to manage the symptoms, allowing her to continue with Mounjaro for nearly nine months.

Despite the initial challenges, she achieved a remarkable weight loss of 73 lbs. More importantly, she no longer requires medication for high blood pressure, showcasing significant improvements in her health since starting the treatment.

Tiffany Groves

Tiffany opened up to Good Morning America about her decade-long battle with polycystic ovary syndrome (PCOS), a hormone disorder affecting many women. After learning about Mounjaro on social media in 2022, she opted to use it off-label for her PCOS symptoms.

Shortly after starting the treatment, Groves saw significant changes and lost 43 lbs. In addition to that, she experienced regular menstrual cycles for the first time.

Reflecting on her journey, Groves expressed disbelief at how she had previously normalized constant food cravings and now finds herself content with smaller portions.

Branneisha Cooper

Branneisha Cooper, aged 26, shared her story with Good Morning America, talking about her fight with PCOS since high school. After her diagnosis, she started taking Mounjaro in 2022. Since then, she has lost more than 40 lbs, noticed less swelling, and now has regular periods.

Cooper thanked her doctor for suggesting Mounjaro, saying it made her feel much better and relieved a lot of stress. She said the medicine changed how she sees PCOS, making her realize it’s a lasting problem, not her fault.

Tara Rothenhoefer

Tara Rothenhoefer signed up in 2020 to participate in a clinical trial for tirzepatide, the generic name for Mounjaro. Over the course of the 18-month trial, Rothenhoefer saw significant progress, losing an impressive 132 lbs. After the trial, she continued her weight loss journey with a prescription for the medication.

Celebrities Who Took Mounjaro

Celebrities often serve as influential figures in society. Recently, many have openly shared their weight loss struggles, and some have turned to pharmaceutical interventions like Mounjaro.

Let’s look into the experiences of a few celebrities who took this weight-loss drug:

Whoopi Goldberg

Whoopi Goldberg, the renowned American actor, comedian, author, and television personality, opened up about her weight loss journey on The View, joined by Oprah Winfrey, her former co-star from The Color Purple.

Goldberg revealed that she turned to Mounjaro for weight loss after filming Till. At the time, she weighed close to 300 lbs and was recovering from a serious health scare.

Boy George

In his book “Karma,” Boy George talks openly about losing weight with Mounjaro. He admits it’s tough to stay slim with everyone watching. Before going on the show, “I’m a Celebrity…Get Me Out of Here!” in 2022, he tried a diabetes drug called Ozempic to get in shape but later switched to Mounjaro.

Boy George mentioned that he has always struggled with his weight, loving food but finding it hard to control his appetite. Thanks to Mounjaro, though, he finally feels like he’s in control and happier with himself. And he’s not alone—many others are using Mounjaro and feeling the same way.

Sunny Hostin

Sunny Hostin, an American lawyer, journalist, author, and television host, recently shared her struggles with weight gain during the COVID-19 pandemic. She revealed that she gained 40 lbs during this period and turned to the prescription weight-loss medication Mounjaro to address it.

Hostin highlighted the positive impact on her health, noting a significant decrease in her cholesterol levels from 200 to 140 after using the medication.

Charles Barkley

Former NBA star Charles Barkley has lost 62 pounds on his weight loss journey. During an appearance on The Pat McAfee Show, Barkley shared his transformation, revealing that he started at 352 lbs and is now down to 290 lbs at the age of 60.

He shared that he used Mounjaro alongside regular exercise and a healthier diet, as his doctor advised. Barkley credits the drug for kickstarting his weight loss efforts.

Dolores Catania

Dolores Catania, a 52-year-old star of The Real Housewives of New Jersey, shed 20 lbs with the help of Mounjaro. Expressing her goal to reach the low 130s in weight, she disclosed to The US Sun that she’s currently at 137 lbs, down from her starting weight of 157 lbs.

Lauren Manzo

After being diagnosed as “morbidly obese” by a doctor, the former Real Housewives of New Jersey alum turned to Mounjaro for weight loss. Speaking on a podcast episode, Lauren revealed that she lost 30 lbs from Mounjaro.

Having struggled with weight since her twenties, she expressed gratitude for the medication. She stated it surpassed other weight-loss methods and even helped her mental well-being, making her “so much better” and free from potential eating disorder struggles.


Mounjaro brings hope and real results for those battling type 2 diabetes and obesity. With evidence from clinical trials and personal experiences, Mounjaro proves its effectiveness and potential to change how people manage their weight. Even celebrities have shared their positive experiences, highlighting its impact.

As the demand for effective diabetes and weight loss solutions increases, Mounjaro presents a promising avenue for healthier living. With ongoing advancements, it is positioned to redefine approaches to managing diabetes and weight loss, helping individuals take charge of their health for a brighter future.

Frequently Asked Questions

Is Mounjaro FDA-approved for weight loss?

No. Mounjaro has been approved by the US Food and Drug Administration (FDA) as an adjunct treatment for adults with type 2 diabetes to improve glycemic control. However, it has not been approved specifically for weight loss.

Doctors may prescribe Mounjaro off-label for obesity. Off-label usage refers to instances where a physician prescribes a medication for a condition or dosage that hasn’t been approved by the FDA but is deemed appropriate.

How does Mounjaro work for weight loss?

Mounjaro (tirzepatide) works by activating receptors for glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones regulate blood sugar levels and contribute to the sensation of fullness after eating.

By mimicking GLP-1 and GIP, Mounjaro helps individuals feel full sooner and stay satisfied for longer periods, thus aiding in weight loss. Moreover, it slows digestion, helps control portions, and reduces hunger. Mounjaro also targets brain regions like the hypothalamus that regulate appetite and eating behaviors, further enhancing its efficacy in weight management.

What are the side effects of Mounjaro?

Individuals may experience gastrointestinal side effects, which can include nausea, vomiting, diarrhea, constipation, indigestion, reduced appetite, and stomach pain. These side effects are typically mild to moderate and often occur during the initial dose-escalation phase.

Although rare, serious side effects may include pancreatitis (inflammation of the pancreas), hypoglycemia (low blood sugar), severe allergic reactions, kidney failure (especially in those with pre-existing kidney issues), persistent stomach problems, changes in vision, and gallbladder issues. These serious side effects necessitate immediate medical attention and monitoring.

How much is Mounjaro’s monthly cost?

Without insurance coverage, Mounjaro’s monthly expense ranges from $1,000 to $1,200, depending on the pharmacy. If you have a prescription, you can get Mounjaro from Pharma Giant for as low as $130. With a prescription, Americans can save up to 90% off top-brand medications. Their diabetes meds are recommended by doctors for safe and reliable treatment. You can even save more with bulk orders. Use code FIRST10 for 10% off your first purchase and enjoy fast shipping from Canada to anywhere in the US for all your medication needs.

How much weight can you lose on Mounjaro in a month?

The results and onset of action of Mounjaro may vary among individuals, particularly when used alongside lifestyle changes such as diet and exercise. However, based on clinical trials, individuals experienced weight reductions averaging 14 lb (5 mg), 15 lb (10 mg), and 17 lb (15 mg) over approximately ten months. In another trial, participants achieved weight loss averaging 17 lb (5 mg), 21 lb (10 mg), and 25 lb (15 mg) over the same duration.

How quickly does mounjaro work for weight loss?

Mounjaro can impact your appetite right from the start. Typically, weight loss begins within the initial four weeks, with substantial results seen over a 72-week period.

Who is eligible to receive Mounjaro for weight management?

Mounjaro is available through a doctor’s prescription, provided only if deemed medically suitable. Eligibility for a prescription may include individuals who:

  • Have type 2 diabetes and desire weight loss
  • Are classified as obese, with a body mass index (BMI) exceeding 30
  • Are overweight, with a BMI over 27, and have other weight-related health issue like high blood pressure, high cholesterol, or sleep apnea.

Who should avoid taking Mounjaro?

Mounjaro is not suitable for the following:

  • Individuals with a personal or family history of medullary thyroid carcinoma (MTC)
  • Those with multiple endocrine neoplasia syndrome type 2 (MEN2)
  • Individuals allergic to any ingredients of Mounjaro
  • Pregnant or breastfeeding individuals

Can I get Mounjaro without diabetes?

Yes, you can obtain Mounjaro even if you don’t have diabetes. It can be prescribed off-label for weight loss purposes. This medication is generally recommended for individuals with a BMI exceeding 30 or for those with a BMI over 27 who have at least one weight-related condition like high blood pressure, heart disease, or obstructive sleep apnea.

Doctors usually consider prescribing a GLP-1 agonist for weight loss only after other weight loss methods, including dietary changes, exercise, and lifestyle adjustments, have been attempted without success. You can also consider Zepbound, which has the same active ingredient as Mounjaro and is FDA-approved specifically as a weight loss medication.

How to get insurance approval for Mounjaro?

You may find coverage for type 2 diabetes treatment to obtain insurance approval for Mounjaro. However, since Mounjaro lacks FDA approval for weight loss, your insurance is unlikely to cover it for this purpose, even if it’s prescribed “off-label.”


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