Patients may opt for alternatives to Ozempic pens for various reasons. Some may experience unwanted side effects, leading them to explore other treatment options. Clinical trials have shown higher discontinuation rates due to such adverse reactions with Ozempic (3.1% to 3.8%) compared to placebo (0.4%).

Moreover, the high cost of Ozempic, especially if not covered by insurance, may lead patients to seek more affordable options. Effectiveness is also a concern. While Ozempic works for many, some find it inadequate for managing diabetes.

Furthermore, people with specific medical conditions or contraindications may need alternative treatments. Fortunately, several drugs offer viable alternatives to Ozempic. This article will discuss their efficacy, side effects, and costs to provide insights into their suitability as an alternative.

Key Findings

  • Metformin, a biguanide drug, offers a cheaper alternative to Ozempic and is widely accepted as the first-line treatment for type 2 diabetes.
  • GLP-1 agonists, including Byetta, Bydureon, Trulicity, Victoza, and Adlyxin, mimic the action of GLP-1 hormone similar to that of Ozempic.
  • DPP-4 inhibitors, such as Januvia, Zituvio, Onglyza, Tradjenta, and Nesina, inhibit the breakdown of GLP-1 and GIP hormones, providing a cheaper alternative to Ozempic in managing type 2 diabetes.
  • For weight management, alternatives to Ozempic include FDA-approved drugs like Wegovy, Saxenda, and Zepbound, as well as more affordable options like Qsymia, Contrave, phentermine, and orlistat.
  • Natural alternatives and supplements such as berberine, psyllium husk fiber, magnesium, aloe vera, cinnamon, and over-the-counter options like Alli offer additional choices for weight loss.

Ozempic Alternatives for Diabetics

Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist medication that helps lower blood sugar levels in people with type 2 diabetes. Several alternatives to Ozempic work in similar ways or target different aspects of diabetes management.

Some alternatives include:

1. Metformin

Metformin is the only medication currently available in the biguanide drug class. It was approved by the US Food and Drug Administration (FDA) in 1994 for treating type 2 diabetes.

Metformin comes in both immediate-release and extended-release versions and is frequently combined with other antidiabetic drugs. It has been extensively studied and widely accepted as the first-line treatment for T2DM in individuals aged ten and above.

Unlike Ozempic, which stimulates insulin release from the pancreas, metformin operates by reducing glucose production in the liver, lowering intestinal glucose absorption, and improving insulin sensitivity.

Generic metformin provides a cheap alternative to Ozempic. Average out-of-pocket expenses start at $4.40, and branded versions begin at $34. Popular brand names of metformin include Glucophage, Glumetza, and Riomet.

The most common side effects of Metformin are gastrointestinal issues, including bloating, gas, diarrhea, belly pain, constipation, and decreased appetite. However, metformin carries a risk of lactic acidosis and vitamin B12 deficiency.

2. Other GLP-1 Agonists and Dual GLP-1/GIP Agonists

GLP-1 receptor agonists, which are in the same drug class as Ozempic, work by mimicking the action of the hormone GLP-1. This mechanism helps regulate insulin secretion, suppresses glucagon secretion, and slows gastric emptying.

The following are the GLP-1 agonist medications available in the US. The majority are injectable medications, except for Rybelsus (semaglutide), which is taken orally once a day.

  • Byetta (exenatide) – twice daily injection
  • Bydureon (exenatide extended-release) – once weekly injection
  • Trulicity (dulaglutide) – once weekly injection
  • Victoza (liraglutide) – once daily injection
  • Adlyxin (lixisenatide) – once daily injection

Gastric Inhibitory Polypeptide (GIP) analogs can enhance insulin secretion, primarily in response to meal ingestion. Mounjaro (tirzepatide), a once-weekly injection, activates both the GLP-1 and GIP receptors, offering dual action.

Many people experience nausea and vomiting as the primary side effects of these drugs, particularly during the initial stages or when the dosage is escalated. In terms of pricing, most of these medications are comparable to the cost of Ozempic. However, Victoza and Adlyxin are slightly cheaper.

3. DPP-4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) inhibitors, referred to as gliptins, are oral medications for treating type 2 diabetes mellitus in adults. They function differently from Ozempic or other GLP-1 agonists.

Instead of mimicking GLP-1 and GIP hormones, they inhibit the breakdown of these naturally occurring hormones in the body. These hormones help lower blood glucose levels but are rapidly broken down. By interfering with this breakdown process, DPP-4 inhibitors allow these hormones to remain active longer in the body, reducing blood glucose levels only when they are high.

All DPP-4 inhibitors are taken orally once daily. FDA-approved brand names in this class include:

  • Januvia (sitagliptin)
  • Zituvio (sitagliptin)
  • Onglyza (saxagliptin)
  • Tradjenta (linagliptin)
  • Nesina (alogliptin)

DPP-4 inhibitors are generally well-tolerated, with common side effects like upper respiratory tract infections, headaches, and nasopharyngitis.

As for the cost, these drugs provide a cheaper alternative to Ozempic for managing type 2 diabetes, with prices almost half as much.

4. SGLT-2 Inhibitors

The majority of filtered glucose in the kidneys is reabsorbed back into the bloodstream to prevent its loss in urine. This reabsorption primarily occurs through specialized proteins called sodium-glucose co-transporters (SGLTs), particularly SGLT-2.

However, in individuals with diabetes, where blood glucose levels are already elevated, the excretion of excess glucose in urine can be beneficial.

SGLT-2 inhibitors work by inhibiting the activity of SGLT-2 proteins. By blocking SGLT-2, these inhibitors reduce the reabsorption of glucose in the kidneys, causing more glucose to be excreted in the urine.

All approved SGLT-2 inhibitors are administered orally once daily. These include:

Since they elevate glucose levels in urine, the primary side effects often involve genital yeast infections, urinary tract infections, and increased urination. The cost of these medications ranges from $60 to $500, making them cheaper than Ozempic.

5. Combination Drugs

These medications contain a combination of two or more active ingredients. They offer several benefits, including improved efficacy, simplified dosing regimens, and potentially reduced side effects compared to taking multiple separate medications.

Here are combination drugs that can serve as alternatives to Ozempic:

  • Xultophy: Combination of insulin degludec and liraglutide (a GLP-1 RA). Xultophy received its FDA approval in 2016 and is administered once daily through a subcutaneous injection.
  • Soliqua: Similar to Xultophy, Soliqua is a combination of insulin glargine and lixisenatide (a GLP-1 RA). It is also given once daily via subcutaneous injection and provides both basal insulin and GLP-1 agonist effects to improve glycemic control.
  • Glyxambi: This medication contains empagliflozin (an SGLT-2 inhibitor) and linagliptin (a DPP-4 inhibitor). It is recommended alongside diet and exercise to reduce blood glucose levels in adults diagnosed with type 2 diabetes.
  • Steglujan: This drug combines ertugliflozin (an SGLT-2 inhibitor) and sitagliptin (a DPP-4 inhibitor). It’s prescribed for adults with type 2 diabetes to enhance blood sugar control in conjunction with dietary adjustments and exercise.

Additionally, metformin is commonly combined with other medications to enhance its efficacy in managing type 2 diabetes. When combined with a DPP-4 inhibitor, several medications are available, including:

  • Janumet (sitagliptin/metformin)
  • Jentadueto (linagliptin/metformin)
  • Kombiglyze XR (saxagliptin/metformin XR)

Available brands combining metformin and SGLT2 inhibitors include:

  • Synjardy (empagliflozin/metformin)
  • Invokamet (canagliflozin/metformin)
  • Xigduo XR (dapagliflozin/metformin XR)

The costs of these medications differ significantly. Janumet is the most expensive, whereas Kombiglyze XR is the most affordable choice.

Ozempic Alternatives for Weight Loss

Alternatives to Ozempic for Weight Loss

Ozempic is known to reduce appetite, resulting in weight loss for numerous diabetes patients using the medication. However, it’s important to recognize that Ozempic does not possess FDA clearance for weight management.

In some cases, healthcare providers prescribe it off-label under certain circumstances. However, for those seeking medications specifically indicated for weight loss, here are some substitutes for Ozempic:

1. Wegovy (semaglutide)

Wegovy has FDA approval for long-term weight management in two groups:

  • Adults who are categorized as obese or overweight, and exhibit at least one condition related to weight.
  • People in the pediatric age group, 12 years and above, with a BMI at or exceeding the 95th percentile for their age and gender.

It belongs to the same class of medications as Ozempic. However, Wegovy is administered at a higher dose of up to 2.4 mg once weekly.

In STEP 3 trials, participants were randomly assigned to receive either Wegovy or a placebo alongside behavioral therapy. By week 68, those on Wegovy lost an average of 37.04 lbs, while the placebo group lost 13.67 lbs.

As with any medication, Wegovy can cause side effects. Common side effects include discomfort in the abdomen, vomiting, nausea, diarrhea, constipation, and headaches. These side effects are similar to those reported with Ozempic. However, due to its higher dosage, Wegovy may lead to a higher incidence of gastrointestinal side effects than Ozempic.

Wegovy’s price could be a factor for those considering this treatment option. The list price of Wegovy is $1349.02 per package, which is more expensive than Ozempic. However, the potential for significant weight loss and improvement in weight-related health conditions may justify the cost for many individuals.

2. Saxenda (liraglutide)

Saxenda is another FDA-approved drug with a similar indication to Wegovy. However, it contains a different active ingredient called liraglutide. Despite this difference, Saxenda belongs to the same drug class as Wegovy and Ozempic, known as GLP-1 agonists.

The first major phase 3 trial of liraglutide, which lasted 20 weeks, involved obese participants in Europe and compared liraglutide with a placebo and orlistat. Liraglutide in all doses resulted in significantly greater weight loss than placebo (approximately 6.2 lbs), with reductions ranging from approximately 10.6 lbs to 15.8 lbs.

Moreover, participants on 2.4 mg and 3.0 mg of liraglutide had notably higher weight loss than those on orlistat (approximately 9.0 lbs), with reductions of approximately 13.9 lbs and 15.8 lbs.

Saxenda shares similar side effects with other GLP-1 receptor agonists, including nausea, diarrhea, constipation, vomiting, and abdominal pain. As for the cost, Saxenda shares the same list price as Wegovy, which is $1349.02.

3. Zepbound (Tirzepatide)

Zepbound is a relatively new medication for weight management. It gained FDA approval in 2023 and is indicated for adults who have obesity or are overweight with weight-related medical conditions. Zepbound is not yet approved for people under age 18.

During a 17-month clinical trial, individuals were on a reduced-calorie diet, increased physical activity, and Zepbound. Average weight loss ranged from 34 to 48 lbs for non-diabetic adults and from 28 to 33 lbs for adults with diabetes, compared to 7 lbs for placebo.

Due to its dual GLP-1 and GIP agonist action, Zepbound may induce more side effects than Wegovy and Saxenda. Reported side effects during clinical trials, occurring in more than 5% of people treated with Zepbound, include:

  • nausea
  • diarrhea
  • vomiting
  • constipation
  • abdominal pain
  • dyspepsia
  • injection site reactions
  • fatigue
  • hypersensitivity reactions
  • eructation
  • hair loss
  • gastroesophageal reflux disease

One advantage of Zepbound is that it’s cheaper than other alternatives. Its list price is $1059.87, which is approximately 20% lower than Wegovy and Saxenda.

Cheaper Ozempic Alternative Medications for Weight Loss

Alt text: A pharmacist handing over medicine while receiving payment.

Pharmacist exchanging money with patient for medication

Since popular weight loss alternatives like Wegovy come at a higher price tag, here are more affordable alternatives to Ozempic for weight loss:

1. Phentermine/Topiramate ER (Qsymia)

Qsymia is a brand-name medication that gained FDA approval in 2012 and obtained an additional indication in 2022. It now shares similar indications with the popular weight loss drugs Wegovy and Saxenda, but at a significantly lower cost, averaging $250.32, according to GoodRx.

Qsymia works through a combination of two medications, phentermine and topiramate. Phentermine is an appetite suppressant, while topiramate helps reduce appetite and increase feelings of fullness.

Together, these drugs work synergistically to help control appetite, leading to weight loss. In studies, around 70% of adults lost at least 5% of their body weight after a year, with nearly half losing 10% or more.

Common side effects of Qsymia include dry mouth, constipation, insomnia, and tingling sensations in the hands and feet.

2. Naltrexone/Bupropion ER (Contrave)

Contrave is another FDA-approved medication for weight management in adults, similar to Qysmia. However, it’s not approved for use in children under 18. The active ingredients in Contrave, bupropion, helps reduce appetite and increase energy expenditure, while naltrexone helps reduce food cravings.

In three separate clinical trials, individuals with obesity who took Contrave for one year, alongside diet and exercise, experienced weight loss two to four times greater compared to those relying solely on diet and exercise.

Common side effects of Contrave include gastrointestinal issues, headache, insomnia, and dry mouth. In terms of cost, despite being more expensive than Qsymia, Contrave remains a more affordable option than Ozempic. The retail price for a month’s supply of Contrave ranges from $500 to $600.

3. Phentermine (Adipex-P, Lomaira)

In 1959, the FDA approved the short-term use of phentermine in weight management. Unlike Qsymia and Contrave, phentermine’s use is limited to 12 weeks. This restriction was imposed due to the absence of long-term safety studies at the time of approval, coupled with concerns surrounding potential cardiovascular risks.

However, emerging research indicates that the use of phentermine may extend beyond the initial 12-week period without an increased risk of adverse cardiovascular events.

Phentermine is available in brand-name and generic formulations for individuals aged 17 and older. Typical side effects associated with phentermine use include dry mouth, insomnia, headache, diarrhea, and dizziness.

Despite its limitations, phentermine remains one of the most frequently prescribed medications for weight loss due to its relatively low cost. Adipex-P is typically priced around $100 for a 30-day supply, while the generic version of phentermine is available for approximately $30. Another brand, Lomaira, provides an even more economical option, costing around $28.

4. Orlistat (Xenical)

Orlistat, marketed as Xenical, is a brand-name prescription medication for weight loss intended for adults. However, due to its potential side effects, it is not as widely used as other weight-loss medications.

Orlistat operates by inhibiting the action of lipase enzymes in the intestines, thereby reducing the absorption of dietary fat. This impaired absorption causes steatorrhea, which is a condition marked by the excessive presence of fat in the stool, leading to stools that are oily, bulky, and foul-smelling. Other side effects include fecal spotting, diarrhea, abdominal pain, and anal fissures.

In studies, orlistat significantly reduced weight, waist circumference, cholesterol, and low-density lipoprotein (LDL) level, often referred to as “bad” cholesterol.

The cost of orlistat may be a consideration. While it’s less expensive than Ozempic, it still amounts to a significant sum. A 30-day supply of generic orlistat (120 mg) ranges from $600 to $800, while the branded version, Xenical, ranges from $700 to $850.

Natural Ozempic Alternatives for Weight Loss

A woman enjoying a healthy juice for weight loss.

While there isn’t a direct natural alternative to Ozempic with the same mechanism of action, there are supplements that may support weight loss. However, their efficacy varies, and they should be used with caution as these are not reviewed and approved by the FDA.

1. Berberine

Berberine has become increasingly popular as a dietary supplement, often referred to as ‘nature’s Ozempic’ in online discussions. This bioactive compound belongs to the group of natural alkaloids, which are nitrogen-containing compounds found in various plants like goldenseal, barberry, and Oregon grape.

Researchers suggest that berberine might inhibit the growth of fat molecules in the body and regulate metabolism, potentially aiding weight loss. A review conducted in 2022 analyzed studies on berberine’s impact on body weight and its effect on body mass index (BMI).

The studies revealed significant reductions in both weight and BMI among individuals using berberine. However, these effects were more pronounced in those taking doses exceeding 1000 mg daily for over eight weeks. Yet, the review highlighted inconsistencies among studies and noted a high risk of bias in many.

Similar to weight loss medications, berberine supplementation also has side effects. These include nausea, abdominal discomfort, bloating, constipation, or diarrhea, as reported in research studies.

By cost comparison, berberine is widely available online, and its price usually ranges from $10 to $56.

2. Psyllium Husk Fiber

Psyllium husk fiber, sourced from the seeds of the Plantago ovata plant, is a natural supplement that is rich in soluble fiber. It’s commonly used to support digestive health and ease constipation.

When mixed with water, psyllium forms a thick, gel-like substance that is resistant to digestion in the small intestine. This characteristic contributes to its ability to regulate cholesterol, triglycerides, blood sugar levels, and aid in weight management.

Research indicates numerous health benefits of psyllium, including its role in managing blood sugar and promoting weight loss, earning it the nickname “poor man’s Ozempic.” In a study involving participants diagnosed with type 2 diabetes and constipation, consuming 10 g of psyllium twice daily improved constipation, body weight, blood sugar, and cholesterol levels.

Furthermore, psyllium may delay stomach emptying and increase satiety after meals. Another study showed that consuming up to 10.2 g of psyllium before breakfast and lunch resulted in notable decreases in hunger, desire to eat, and increased feelings of fullness between meals.

Psyllium supplements generally have few serious side effects, while uncommon, allergic reactions like rashes or breathing difficulties may occur.

Psyllium husk fiber is available in various forms, such as whole husks, powder, capsules, and ready-to-mix drinks. It is also affordable, typically costing between $10 and $53, depending on the formulation.

3. Magnesium

Magnesium is an essential mineral vital for various bodily functions. It has a crucial function in controlling blood pressure and supporting immune function and metabolism.

While further research is needed to confirm its direct impact on weight loss, magnesium shows promise in improving several risk factors associated with overweight and obesity. One study suggests that magnesium deficiency could potentially heighten the risk of obesity and diabetes by impairing insulin sensitivity.

There are different types of magnesium supplements available, and prices typically start at $15. These include magnesium aspartate, citrate, chloride, and lactate. Moreover, numerous foods are rich in magnesium, such as leafy greens, nuts, seeds, whole grains, legumes, avocados, bananas, dark chocolate, fatty fish, tofu, and dairy products.

Side effects from magnesium supplements are rare. They may include stomach upset, nausea, abdominal cramping, and diarrhea. However, consuming excessively high levels of magnesium (over 5,000 mg per day) can lead to severe health issues like low blood pressure and cardiac arrest.

4. Aloe Vera

Aloe vera, renowned for its therapeutic attributes, is popularly used topically for burns and skin health. Recently, it’s been included in juices, supplements, and diet drinks targeting weight loss.

Studies suggest aloe vera aids weight loss in two ways. Animal research indicates it influences fat and sugar metabolism, potentially preventing belly fat accumulation. However, further research is needed to confirm if it provides comparable health benefits in humans.

Another way is to enhance blood sugar control. In one study, aloe vera supplements significantly reduced blood sugar levels in individuals with prediabetes. Another study found that an aloe vera gel complex taken over eight weeks reduced body weight and fat while enhancing insulin utilization.

Common side effects of aloe vera include digestive issues like diarrhea and stomach cramps. Aloe vera supplements start at $90, but aloe vera gel can also be consumed directly by adding it to smoothies or shakes.

5. Cinnamon

Cinnamon, commonly added to toasts and desserts, has a rich history of medicinal use and is renowned for its health benefits. A comprehensive review of randomized controlled trials examined cinnamon’s impact on body weight, BMI, waist circumference, and fat mass in adults.

Among 679 records and 12 trials that enrolled 786 subjects, cinnamon supplementation showed significant effects on obesity measures, suggesting its potential as a weight-reducing supplement in obesity management.

While excessive consumption of cinnamon isn’t advisable, incorporating it into fruits, bread, desserts, and other foods may enhance a person’s diet healthily.

Over-the-Counter (OTC) Alternatives to Ozempic for Weight Loss

While no OTC drugs offer the same mechanisms of action as Ozempic, one popular OTC weight loss pill claims to promote weight loss by reducing the absorption of dietary fat.

This pill contains a lower-dose version (60 mg) of orlistat, known as Alli, which is available without a prescription. Studies have shown that the 60 mg dose of orlistat has about 85% of the efficacy of the prescription 120 mg dose. Most individuals using the 60 mg version in clinical trials lost between 5 to 10 lbs over six months.

When combined with a low-fat, low-calorie diet, Alli can aid adults in losing weight. Since Alli shares the same active ingredient as Xenical, it comes with similar side effects and safety considerations.

Bottom Line

While Ozempic remains a valuable option for the management of blood glucose levels in individuals diagnosed with type 2 diabetes, it’s important to know there are many other options out there for managing diabetes and losing weight.

These include different medicines, natural remedies, and over-the-counter supplements. Some of these options are cheaper than Ozempic and can be easily found at stores. However, it’s essential to approach these alternatives with careful consideration of their efficacy, safety, and compatibility with individual health needs.

In the end, combining medical guidance, lifestyle modifications, and the right treatments can help you stay healthy and reach your goals.

Frequently Asked Questions

Where can I get Ozempic for weight loss?

If you’re considering Ozempic for weight loss, it’s wise to consult a healthcare professional. They’ll assess your health status, discuss the potential benefits and risks of using Ozempic off-label, and determine if it’s suitable for you. If they recommend it, they can provide a prescription.

With a prescription, people in the US can purchase Ozempic from Canadian mail-order pharmacy platforms such as Pharma Giant. They offer significant savings, with Ozempic prices starting at $429.96. Plus, enjoy 10% off on your first order using code FIRST10. Additional discounts are available for bulk purchases. Pharma Giant ensures fast delivery within 3-5 business days.

What drug is similar to Ozempic?

Several medications share similarities with Ozempic when it comes to blood sugar management due to their classification as GLP-1 agonists. Trulicity, Victoza, and Rybelsus fall within this category and are commonly prescribed for individuals with type 2 diabetes to enhance glycemic control.

Regarding weight loss, medications such as Wegovy and Saxenda offer comparable options. These drugs belong to the same class of GLP-1 agonists and are specifically indicated for weight loss.

Who can take Ozempic for weight loss?

Generally, Ozempic for weight loss may be suitable for individuals who have type 2 diabetes and are looking to improve both glycemic control and manage their weight. Experts commonly suggest considering Wegovy as an alternative option.

How often is Ozempic injected?

Ozempic is administered subcutaneously once a week.

What is better than Ozempic?

Studies have demonstrated that Mounjaro surpasses Ozempic in both blood sugar management and weight reduction.

Can you use Ozempic for weight loss without diabetes?

Using Ozempic specifically for weight loss without a diagnosis of type 2 diabetes is considered off-label use. If you’re considering a medication specifically for weight loss and do not have diabetes, a more suitable option may be Wegovy. Wegovy contains the same active ingredient as Ozempic but is specifically formulated and FDA-approved for weight loss.

What is the lowest dose of Ozempic?

The lowest dose of Ozempic available is 0.25 mg, which is typically the starting dose.

What are the potential side effects of Ozempic for weight loss in non-diabetic individuals?

The potential side effects are similar to those observed in individuals with type 2 diabetes. These may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, constipation, and abdominal pain.

What is the best alternative to Ozempic?

Determining the “best” Ozempic alternative depends on individual health needs, treatment goals, and preferences. Several medications share similarities with Ozempic in terms of their mechanism of action and efficacy in managing type 2 diabetes and promoting weight loss. Some common alternatives to Ozempic include other GLP-1 receptor agonists such as Trulicity, Victoza, and Rybelsus.

Which is better for weight loss, Ozempic or Saxenda?

Although direct comparisons between Ozempic and Saxenda are lacking, insights from trials comparing their active ingredients provide valuable information. In one such trial, semaglutide showed greater efficacy for weight loss than liraglutide. For instance, in the SCALE trial, semaglutide resulted in a weight loss of 12.4%, while liraglutide led to a weight loss of 5.4% in the STEP 1 trial. Additionally, the cost required to achieve a 1% reduction in body weight was lower with semaglutide ($1,845) compared to liraglutide ($3,256).

Is Berberine similar to Ozempic?

No, despite being nicknamed “nature’s Ozempic,” Berberine and Ozempic are not considered similar. They operate through different mechanisms, and their effectiveness and safety profiles vary.

Is Jardiance similar to Ozempic?

Ozempic (semaglutide) and Jardiance (empagliflozin) are both prescribed for Type 2 diabetes management. While Ozempic requires a once-weekly injection, Jardiance is taken daily as a pill. They operate through distinct mechanisms, offering varied benefits, applications, and potential side effects. Notably, Ozempic is associated with greater weight loss and more significant reductions in hemoglobin A1C compared to Jardiance.

Is Wegovy similar to Ozempic?

Wegovy and Ozempic share the same active ingredient, semaglutide. However, they are formulated and indicated for different purposes.

Is Trulicity similar to Ozempic?

Yes, Trulicity is similar to Ozempic in that they both belong to the same class of medications, and they are both prescribed for the management of type 2 diabetes. However, there are differences between them in terms of their dosing strength and specific clinical characteristics.


Shmerling, R. H., MD. (2024, Apr). Is metformin a wonder drug? Harvard Health.

Backman, I. (2022, Feb). Metformin: How a widely used diabetes medication actually works. Yale School of Medicine.

Corcoran, C., & Jacobs, T. (2023, Aug). Metformin. PubMed.

Collins, L. C., & Costello, R. (2023, Jan). Glucagon-Like peptide-1 receptor agonists. PubMed.

Kasina, S. V. S. K., & Baradhi, K. M. (2023, May). Dipeptidyl Peptidase IV (DPP IV) Inhibitors. PubMed.

Nair, A. S., Bagchi, D., Lehmann, T., & Nair, S. (2018). Renal Sodium-Glucose transporter-2 inhibitors as antidiabetic agents. In Elsevier eBooks (pp. 207–214).

Padda, I., Mahtani A., & Parmar, M. (2023, Jun). Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors. PubMed.

McDermid, E. (2021, Feb). STEP 3: Semaglutide boosts weight loss during intensive behavioral therapy. Medicine Matters.

Mehta et al. (2016, Dec 19). Liraglutide for weight management: a critical review of the evidence. NCBI.

Yanovski, S. Z., & Yanovski, J. A. (2014, Jan). Long-term drug treatment for obesity. JAMA, 311(1), 74.

Lewis, K. H., et. al. (2019). Safety and Effectiveness of Longer?Term Phentermine Use: Clinical Outcomes from an Electronic Health Record Cohort. Obesity, 27(4), 591–602.

Jain, S., Ramanand, et. al. (2011). Evaluation of efficacy and safety of orlistat in obese patients. Indian Journal of Endocrinology and Metabolism, 15(2), 99.

Bansal, A. B., & Al Khalili, Y. (2022, Dec). Orlistat. In StatPearls. StatPearls Publishing.

GoodRx Prices.

Firouzi, S., Malekahmadi, et. al. (2018, Nov). Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action. Diabetes, Metabolic Syndrome and Obesity, Volume 11, 699–705.

NCCIH. (2023, Nov). Berberine and Weight Loss: What You Need To Know. Retrieved from

Soltanian, N., Janghorbani, M., & Adibi, P. (2018, Oct). Effects of psyllium vs. placebo on constipation, weight, glycemia, and lipids: A randomized trial in patients with type 2 diabetes and chronic constipation. Complementary Therapies in Medicine, 40, 1–7.

Brum, J. M., Gibb, R., Peters, J. C., & Mattes, R. D. (2016, Oct). Satiety effects of psyllium in healthy volunteers. Appetite, 105, 27–36.

Solati, M., Kazemi, L., Shahabi Majd, N., Keshavarz, M., Pouladian, N., & Soltani, N. (2019, Feb). Oral herbal supplement containing magnesium sulfate improve metabolic control and insulin resistance in non-diabetic overweight patients: A randomized double blind clinical trial. Medical journal of the Islamic Republic of Iran, 33, 2.

Choi, H. C., Kim, S. J., Son, K. Y., Oh, B. J., & Cho, B. L. (2013, Jun). Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial. Nutrition (Burbank, Los Angeles County, Calif.), 29(9), 1110–1114.

Alinejad-Mofrad, S., Foadoddini, M., Saadatjoo, S. A., & Shayesteh, M. (2015, Apr). Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. Journal of diabetes and metabolic disorders, 14, 22.

Radha, M. H., & Laxmipriya, N. P. (2014, Dec). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of traditional and complementary medicine, 5(1), 21–26.

Mousavi, S. M., et. al. (2020, Jan). Cinnamon supplementation positively affects obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Clinical nutrition (Edinburgh, Scotland), 39(1), 123–133.

Anderson, J. W. (2007, Aug). Orlistat for the management of overweight individuals and obesity: a review of potential for the 60-mg, over-the-counter dosage. Expert Opinion on Pharmacotherapy, 8(11), 1733–1742.

Azuri, J., Hammerman, A., Aboalhasan, E., Sluckis, B., & Arbel, R. (2023, May). Liraglutide versus semaglutide for weight reduction—a cost needed to treat analysis. Obesity, 31(6), 1510–1513.