ABRILADA is a TNF blocker biosimilar to Humira, effectively treating autoimmune conditions like rheumatoid arthritis and psoriatic arthritis. It reduces inflammation and pain, improving quality of life for those with chronic autoimmune diseases.

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ABRILADA is a cutting-edge biologic medication that has been developed to provide relief and treatment for a range of chronic inflammatory conditions. As a biosimilar to the well-known drug adalimumab, ABRILADA offers a similar therapeutic action but often at a more accessible price point, making it a significant addition to the arsenal of treatments for autoimmune diseases. Its primary role is to reduce inflammation and halt disease progression in conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and other serious autoimmune disorders. The introduction of ABRILADA represents a crucial step forward in making biologic treatments more available to patients who need long-term, effective management of their conditions.

What is ABRILADA?

ABRILADA, containing the active ingredient adalimumab, is a biosimilar medication used in the treatment of various autoimmune diseases. It belongs to a class of drugs known as tumor necrosis factor (TNF) blockers. Adalimumab in ABRILADA works by inhibiting TNF, a substance in the body that causes inflammation and can lead to autoimmune diseases. By blocking the action of TNF, ABRILADA helps reduce inflammation, alleviate symptoms, and slow the progression of the disease. This mechanism of action makes it effective in treating a range of inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, among others. Its role in managing these conditions is vital, as it helps improve the quality of life for patients suffering from chronic inflammation and pain.

How is ABRILADA Used?

ABRILADA is administered through a pre-filled syringe, designed for subcutaneous injection, meaning it is injected under the skin. Before using ABRILADA, patients should receive proper training from a healthcare professional on how to self-administer the injection. This includes selecting an appropriate injection site, such as the abdomen or thigh, and rotating these sites to avoid skin reactions. The syringe should be used only once and then disposed of in a sharps container.

ABRILADA is commonly prescribed for a variety of inflammatory conditions, primarily autoimmune diseases. These include moderate to severe rheumatoid arthritis, where it helps reduce joint pain and swelling; psoriatic arthritis, where it can prevent joint damage; ankylosing spondylitis, to reduce spinal inflammation; and certain skin conditions like plaque psoriasis. It is also used in gastrointestinal disorders such as Crohn’s disease and ulcerative colitis, helping to reduce symptoms and achieve and maintain remission in these conditions. The use of ABRILADA can significantly improve the quality of life for patients suffering from these chronic conditions by providing effective and sustained relief from symptoms.

Side Effects

Common Side Effects

  • Injection Site Reactions: Redness, bruising, itching, or swelling at the injection site.
  • Respiratory Issues: Cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
  • Headaches: Occurrence of headaches.
  • Skin Reactions: Rash.

These common side effects are usually mild and may diminish as the body adjusts to the medication. However, if they persist or worsen, it’s advisable to consult a healthcare provider.

Serious Side Effects

  • Infections: Increased risk of serious infections leading to hospitalization or death, including tuberculosis (TB), bacterial sepsis, and invasive fungal infections like histoplasmosis.
  • Cancer: Increased risk of lymphoma and other malignancies, especially in children and adolescents.
  • Autoimmune Reactions: Symptoms of lupus-like syndrome, such as joint pain, chest pain, and skin color changes.
  • Liver Problems: Symptoms include body aches, tiredness, stomach pain, and jaundice.
  • Heart Problems: Worsening of heart failure symptoms.
  • Nervous System Issues: Numbness, tingling, dizziness, and vision problems.

Patients should seek immediate medical attention if they experience any of these serious side effects. It’s crucial to discuss the risks and benefits of ABRILADA with a healthcare provider before starting treatment.

Warnings & Precautions

Before starting ABRILADA, patients should be screened for tuberculosis and monitored for signs of infection. Those with a history of recurrent infections or conditions like heart failure and liver disease should use ABRILADA with caution. It’s also important to consider the potential for increased cancer risk, particularly in children and adolescents.

Patients should inform their healthcare provider of all medications they are taking, as ABRILADA can interact with other drugs, potentially altering its effectiveness or increasing the risk of adverse effects. Regular monitoring and follow-up appointments are essential to assess the effectiveness of the treatment and to monitor for any adverse reactions.

Overdose

In clinical trials, doses of ABRILADA up to 10 mg/kg have been administered without evidence of dose-limiting toxicities. However, in the case of an overdose, it is crucial to monitor the patient for any signs or symptoms of adverse reactions. Immediate steps should include providing appropriate symptomatic treatment. If an overdose is suspected, medical attention should be sought promptly. It’s important to follow the prescribed dosage and administration guidelines to minimize the risk of overdose.

ABRILADA is a medication primarily used to treat various autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, and plaque psoriasis. It works by reducing inflammation and pain associated with these conditions, improving physical function and quality of life for patients.

ABRILADA belongs to a class of drugs known as TNF (tumor necrosis factor) blockers. It works by inhibiting the activity of TNF, a substance in the body that causes inflammation. By blocking TNF, ABRILADA helps to reduce the inflammatory response that contributes to the symptoms of autoimmune diseases.

Common side effects include injection site reactions (redness, itching, swelling), respiratory issues like stuffy nose and sore throat, headaches, and skin rashes. These side effects are generally mild and often resolve with continued treatment.

Serious side effects include increased risk of infections, potential development of certain types of cancer, autoimmune reactions like lupus-like syndrome, liver problems, heart issues, and nervous system problems. Immediate medical attention is required if these symptoms occur.

Store ABRILADA syringes in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. They can be kept at room temperature for a limited period if necessary, but should not be put back in the refrigerator once removed.

The effects of ABRILADA during pregnancy are not fully known. It should only be used if clearly needed and after discussing the potential risks and benefits with a healthcare provider.

It’s unclear if ABRILADA passes into breast milk. The decision to breastfeed while using ABRILADA should be made after considering the potential risks and benefits with a healthcare provider.

ABRILADA is administered as a subcutaneous injection using a pre-filled syringe or pen. Patients should be trained by a healthcare professional on the correct technique for self-administration.

If a dose is missed, it should be taken as soon as remembered. However, if it’s close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double doses.

Avoid receiving live vaccines while using ABRILADA, as it may weaken the immune response to the vaccine. Also, be cautious around people who are sick or have infections, as ABRILADA can increase the risk of infections.

ABRILADA can interact with other immunosuppressants, potentially increasing the risk of infections. It’s important to inform healthcare providers of all medications being taken to assess for potential interactions.

ABRILADA, as a biosimilar to Humira, offers similar efficacy and safety profiles to other TNF blockers. The choice between these medications often depends on individual patient factors and physician preference.

ABRILADA is approved for use in children for certain conditions, such as juvenile idiopathic arthritis. However, children should be current on all vaccinations before starting treatment.

Before starting ABRILADA, patients should be screened for tuberculosis and other infections. It’s also important to discuss any history of chronic infections, cancer, or heart failure with a healthcare provider.

ABRILADA has been used in long-term treatment for various autoimmune conditions. Ongoing monitoring for side effects and effectiveness is crucial. The long-term safety profile is generally considered favorable, but risks such as increased infection and potential cancer development should be regularly reviewed with a healthcare provider.