ABRILADA is a cutting-edge biologic medication that has been developed to provide relief and treatment for a range of chronic inflammatory conditions. As a biosimilar to the well-known drug adalimumab, ABRILADA offers a similar therapeutic action but often at a more accessible price point, making it a significant addition to the arsenal of treatments for autoimmune diseases. Its primary role is to reduce inflammation and halt disease progression in conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and other serious autoimmune disorders. The introduction of ABRILADA represents a crucial step forward in making biologic treatments more available to patients who need long-term, effective management of their conditions.
What is ABRILADA?
ABRILADA, containing the active ingredient adalimumab, is a biosimilar medication used in the treatment of various autoimmune diseases. It belongs to a class of drugs known as tumor necrosis factor (TNF) blockers. Adalimumab in ABRILADA works by inhibiting TNF, a substance in the body that causes inflammation and can lead to autoimmune diseases. By blocking the action of TNF, ABRILADA helps reduce inflammation, alleviate symptoms, and slow the progression of the disease. This mechanism of action makes it effective in treating a range of inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, among others. Its role in managing these conditions is vital, as it helps improve the quality of life for patients suffering from chronic inflammation and pain.
How is ABRILADA Used?
ABRILADA is administered through a pre-filled syringe, designed for subcutaneous injection, meaning it is injected under the skin. Before using ABRILADA, patients should receive proper training from a healthcare professional on how to self-administer the injection. This includes selecting an appropriate injection site, such as the abdomen or thigh, and rotating these sites to avoid skin reactions. The syringe should be used only once and then disposed of in a sharps container.
ABRILADA is commonly prescribed for a variety of inflammatory conditions, primarily autoimmune diseases. These include moderate to severe rheumatoid arthritis, where it helps reduce joint pain and swelling; psoriatic arthritis, where it can prevent joint damage; ankylosing spondylitis, to reduce spinal inflammation; and certain skin conditions like plaque psoriasis. It is also used in gastrointestinal disorders such as Crohn’s disease and ulcerative colitis, helping to reduce symptoms and achieve and maintain remission in these conditions. The use of ABRILADA can significantly improve the quality of life for patients suffering from these chronic conditions by providing effective and sustained relief from symptoms.
Common Side Effects
- Injection Site Reactions: Redness, bruising, itching, or swelling at the injection site.
- Respiratory Issues: Cold symptoms such as stuffy nose, sinus pain, sneezing, sore throat.
- Headaches: Occurrence of headaches.
- Skin Reactions: Rash.
These common side effects are usually mild and may diminish as the body adjusts to the medication. However, if they persist or worsen, it’s advisable to consult a healthcare provider.
Serious Side Effects
- Infections: Increased risk of serious infections leading to hospitalization or death, including tuberculosis (TB), bacterial sepsis, and invasive fungal infections like histoplasmosis.
- Cancer: Increased risk of lymphoma and other malignancies, especially in children and adolescents.
- Autoimmune Reactions: Symptoms of lupus-like syndrome, such as joint pain, chest pain, and skin color changes.
- Liver Problems: Symptoms include body aches, tiredness, stomach pain, and jaundice.
- Heart Problems: Worsening of heart failure symptoms.
- Nervous System Issues: Numbness, tingling, dizziness, and vision problems.
Patients should seek immediate medical attention if they experience any of these serious side effects. It’s crucial to discuss the risks and benefits of ABRILADA with a healthcare provider before starting treatment.
Warnings & Precautions
Before starting ABRILADA, patients should be screened for tuberculosis and monitored for signs of infection. Those with a history of recurrent infections or conditions like heart failure and liver disease should use ABRILADA with caution. It’s also important to consider the potential for increased cancer risk, particularly in children and adolescents.
Patients should inform their healthcare provider of all medications they are taking, as ABRILADA can interact with other drugs, potentially altering its effectiveness or increasing the risk of adverse effects. Regular monitoring and follow-up appointments are essential to assess the effectiveness of the treatment and to monitor for any adverse reactions.
In clinical trials, doses of ABRILADA up to 10 mg/kg have been administered without evidence of dose-limiting toxicities. However, in the case of an overdose, it is crucial to monitor the patient for any signs or symptoms of adverse reactions. Immediate steps should include providing appropriate symptomatic treatment. If an overdose is suspected, medical attention should be sought promptly. It’s important to follow the prescribed dosage and administration guidelines to minimize the risk of overdose.