What is Abrilada?
Abrilada, containing the active ingredient adalimumab, is a biosimilar medication used in the treatment of various autoimmune diseases. It belongs to a class of drugs known as tumor necrosis factor (TNF) blockers.
Adalimumab in Abrilada works by inhibiting TNF, a substance in the body that causes inflammation and can lead to autoimmune diseases.
By blocking the action of TNF, Abrilada helps reduce inflammation, alleviate symptoms, and slow the progression of the disease. This mechanism of action makes it effective in treating a range of inflammatory conditions, including rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, among others.
Its role in managing these conditions is vital, as it helps improve the quality of life for patients suffering from chronic inflammation and pain.
Indications and Benefits of Abrilada
Abrilada is commonly prescribed for a variety of inflammatory conditions, primarily autoimmune diseases. These include:
- Moderate to severe rheumatoid arthritis – helps reduce joint pain and swelling
- Psoriatic arthritis – prevents joint damage
- Ankylosing spondylitis – reduces spinal inflammation
- Plaque psoriasis – treats certain skin conditions
- Crohn’s disease and ulcerative colitis – reduces symptoms and helps achieve and maintain remission
The use of Abrilada can significantly improve the quality of life by providing effective and sustained relief from symptoms.
What Are the Benefits of Abrilada?
- Reduces inflammation
- Alleviates symptoms
- Slows disease progression
- Improves quality of life in autoimmune and inflammatory conditions
How It Works
Adalimumab in Abrilada works by inhibiting TNF (tumor necrosis factor), a substance that causes inflammation. By binding to TNF, Abrilada inhibits its interaction with TNF receptors on cell surfaces, reducing inflammatory pathways that lead to tissue damage in autoimmune diseases.
Dosage
Abrilada is a biosimilar to adalimumab and is used to manage autoimmune conditions.
Abrilada is administered by subcutaneous (under the skin) injection into the thigh or abdomen. Always rotate injection sites to reduce skin irritation. Do not inject into areas with active skin disease or scars.
What Dosage Strengths Does Abrilada Come In?
- Prefilled Pen (Abrilada Pen)
- 40 mg/0.8 mL in a single-dose pen
- Prefilled Syringe
- 40 mg/0.8 mL in a single-dose syringe
- 20 mg/0.4 mL in a single-dose syringe
- 10 mg/0.2 mL in a single-dose syringe
- Single-Dose Institutional Use Vial:
- 40 mg/0.8 mL for healthcare setting use only
Dosage Chart
| Condition | Age / Weight | Recommended Abrilada Dose | Frequency |
| Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis | Adults | 40 mg | Every other week |
| Rheumatoid Arthritis (without MTX) | Adults | 40 mg | Weekly or 80 mg every other week |
| Polyarticular Juvenile Idiopathic Arthritis | 10–15 kg (22–33 lbs) | 10 mg | Every other week |
| 15–30 kg (33–66 lbs) | 20 mg | Every other week | |
| 30 kg (66 lbs) and up | 40 mg | Every other week | |
| Crohn’s Disease | Adults | 160 mg (Day 1), 80 mg (Day 15), 40 mg | Start Day 29, every other week |
| Crohn’s Disease (Pediatric) | 17–40 kg (37–88 lbs) | 80 mg (Day 1), 40 mg (Day 15), 20 mg | Start Day 29, every other week |
| 40 kg (88 lbs) and up | 160 mg (Day 1), 80 mg (Day 15), 40 mg | Start Day 29, every other week | |
| Ulcerative Colitis | Adults | 160 mg (Day 1), 80 mg (Day 15), 40 mg | Start Day 29, every other week |
| Plaque Psoriasis / Adult Uveitis | Adults | 80 mg (initial), 40 mg | Start 1 week later, every other week |
| Hidradenitis Suppurativa | Adults | 160 mg (Day 1), 80 mg (Day 15), 40 mg or 80 mg | Start Day 29, weekly or every other week |
Usage Guide
Abrilada injection instructions
Abrilada is administered through a pre-filled syringe, designed for subcutaneous injection (under the skin). Before using, patients should:
- Receive proper training from a healthcare professional
- Select an appropriate injection site (abdomen or thigh)
- Rotate injection sites to avoid skin reactions
- Use each syringe once and dispose of it in a sharps container
- Not shake Abrilada pens or syringes. Let the medication warm to room temperature for 15-30 minutes before injection
Side Effects
Common Side Effects
- Injection Site Reactions: redness, bruising, itching, or swelling
- Respiratory Issues: cold symptoms, stuffy nose, sinus pain, sneezing, sore throat
- Headaches
- Skin Reactions: rash
These are usually mild and may diminish as the body adjusts. If they persist or worsen, consult a healthcare provider.
Serious Side Effects
- Infections: risk of TB, sepsis, fungal infections
- Cancer: increased risk of lymphoma and malignancies in children/adolescents
- Autoimmune Reactions: lupus-like symptoms (joint pain, chest pain, skin changes)
- Liver Problems: body aches, tiredness, stomach pain, jaundice
- Heart Problems: worsening of heart failure
- Nervous System Issues: numbness, tingling, dizziness, vision problems
Seek immediate medical attention if any serious side effects occur.
Missed Dose
If you miss a dose of Abrilada, take it as soon as you remember. After that, go back to your regular dosing schedule.
Do not take two doses at the same time. If you use the single-dose vial, a healthcare provider must give the injection in a clinic or hospital.
Use only one dose per vial and throw away any leftover medication.
Overdose
In clinical trials, doses of Abrilada up to 10 mg/kg have been administered without dose-limiting toxicities.
In case of overdose:
- Monitor for adverse symptoms
- Provide symptomatic treatment
- Seek medical attention promptly
Follow the prescribed dosage to minimize risk.
Warnings
- Patients must be screened for TB before starting
- Use with caution in those with recurrent infections, heart failure, and liver disease
- Potential increased cancer risk, especially in children
- Notify your doctor of all medications, as interactions are possible
- Regular monitoring is required throughout treatment
Boxed Warning and Precautions for Abrilada
- Increased risk of serious infections (e.g., TB, sepsis, fungal infections)
- Risk of malignancies, including lymphoma, particularly in pediatric patients
Contraindications
There are no known specific contraindications for using Abrilada. However, it is always best to talk to your doctor before starting this medication. Your doctor can check if it is safe for you based on your health condition and medical history.
Interactions
Tell your doctor about all products you use, including over-the-counter drugs, vitamins, or herbal products.
Abrilada can interact with other drugs and may increase the chance of side effects or reduce how well it works.
Check with your doctor before starting or stopping any drug while using Abrilada.
Common drug interactions include:
- methotrexate
- anakinra
- abatacept
- rituximab
- infliximab
- etanercept
- certolizumab pegol
- golimumab
- azathioprine
- 6-mercaptopurine
- warfarin
- cyclosporine
- theophylline
- live vaccines
Storage Information
Store Abrilada the right way to keep it safe and effective. Keep the pen in the refrigerator between 36 to 46 degrees Fahrenheit or 2 to 8 degrees Celsius. Do not freeze it. If it gets frozen, do not use it, even if it thaws later.
Keep Abrilada in its original carton to protect it from light.
You can also store Abrilada at room temperature, up to 86 degrees Fahrenheit or 30 degrees Celsius, for up to 30 days.
Alternatives
If Abrilada is not suitable or effective for you, other options may be available. These alternatives can help treat similar conditions, such as rheumatoid arthritis, Crohn’s disease, psoriasis, and more.
Ask your doctor before switching treatments. They can help you choose the right option based on your condition, health history, and treatment goals.
Here are some common alternatives to Abrilada:
Cost & Discounts
Your health is a priority, and purchasing essential medication shouldn’t be prohibitively expensive. At Pharma Giant, we offer affordable and accessible healthcare solutions.
In the United States, the cost of Abrilada can reach as high as $3,656 for those without insurance coverage. However, through Pharma Giant, you can access more affordable options:
| Strength | Form | Quantity | Pharma Giant Cost |
|---|---|---|---|
| 40MG/0.8ML | Pens | 2 pens | $1,399.99 |
| Pens | 4 pens | $2,760.00 | |
| Pens | 6 pens | $4,110.00 | |
| 20MG/0.4ML | Pre-Filled Syringes | 2 syringes | $739.99 |
| Pre-Filled Syringes | 4 syringes | $1,460.00 | |
| Pre-Filled Syringes | 6 syringes | $2,160.00 |
Abrilada Discounts and Coupons from Pharma Giant
Take control of your healthcare costs with Pharma Giant’s exclusive discount. Apply the code PGSAVE10 at checkout to receive a 10% discount on your Abrilada purchase. This special offer is designed to help you save on essential medications without compromising on quality or affordability.
Pharma Giant provides express shipping (3–5 business days) across the US. All packages are securely packed for safe transit.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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