What is Adcirca?
Adcirca, also called tadalafil, is a prescription medication used to treat pulmonary arterial hypertension (PAH).
This is a type of high blood pressure in the lungs that makes it harder for the heart to pump blood and deliver oxygen to the body.
Adcirca works by relaxing the blood vessels in the lungs, allowing blood to flow more easily and lowering the pressure in these arteries.
It is FDA-approved to improve exercise ability and stamina in both men and women with PAH.
A more affordable Adcirca generic version is also available with the same active ingredient and benefits.
Indications and Benefits of Adcirca
- Adcirca enhances exercise capacity by facilitating the lungs’ ability to deliver more oxygen to the body during physical activity.
- Adcirca reduces shortness of breath and tiredness, making daily activities easier to manage.
- Adcirca relaxes the muscles around the blood vessels in the lungs, allowing blood to flow more freely.
- Adcirca lowers blood pressure in the lungs, which reduces the strain on the heart.
- Adcirca increases stamina and endurance over time for people with PAH.
- Adcirca supports better oxygen delivery to the body, which can improve overall energy levels.
- Adcirca helps reduce chest discomfort and dizziness caused by PAH.
- Adcirca can slow the worsening of PAH symptoms when used as directed by a healthcare provider.
How It Works
Adcirca contains tadalafil, which works by blocking an enzyme called phosphodiesterase type 5 (PDE5). This enzyme normally breaks down a natural chemical in the body called cyclic guanosine monophosphate (cGMP).
cGMP helps relax the muscles around the blood vessels in the lungs so they can open wider.
People with pulmonary arterial hypertension (PAH) often have lower levels of cGMP because their blood vessels do not release enough nitric oxide. This substance signals the body to make more cGMP.
By stopping PDE5 from breaking down cGMP, Adcirca increases the levels of cGMP. This allows the blood vessels in the lungs to relax and widen, improving blood flow, lowering blood pressure in the lungs, and making it easier to exercise.
Dosage
The recommended Adcirca dosing for pulmonary arterial hypertension (PAH) is usually 40 mg taken once daily.
This equals two 20 mg tablets taken at the same time each day, with or without food. The dose should not be split into smaller amounts throughout the day.
Doctors may adjust your dose based on your kidney or liver function, other health conditions, or if you are taking certain medications.
Follow the dosage instructions given by your doctor to reduce the risk of side effects and ensure the best results.
What Dosage Strengths Does Adcirca Come In?
- 20 mg tablets
Dosage Chart
| Condition / Situation | Strength | Recommended Dose | Special Notes |
| Pulmonary Arterial Hypertension (PAH) | 20 mg tablets | 40 mg once daily (2 tablets together) | Do not split or divide dose |
| Mild to Moderate Kidney Impairment | 20 mg tablets | Start at 20 mg once daily, may increase to 40 mg if tolerated | Dose adjustments needed based on kidney function |
| Severe Kidney Impairment or on Dialysis | 20 mg tablets | Not recommended | Higher risk of tadalafil build-up in the body |
| Mild to Moderate Liver Impairment | 20 mg tablets | Start at 20 mg once daily | Limited data in these patients |
| Severe Liver Impairment | 20 mg tablets | Not recommended | Safety not established |
| Taking Ritonavir (already on ritonavir for at least 1 week) | 20 mg tablets | Start at 20 mg once daily, may increase to 40 mg if tolerated | Ritonavir increases tadalafil levels |
| Starting Ritonavir while on Adcirca | 20 mg tablets | Stop Adcirca at least 24 hours before starting ritonavir, resume at 20 mg after 1 week | Increase to 40 mg if tolerated |
Usage Guide
Adcirca is taken to treat pulmonary arterial hypertension (PAH) by helping blood flow more easily through the lungs. Ask your doctor about your Adcirca dosing and how long to take it. Do not change your dose or stop using it without medical advice.
How do you take Adcirca?
- Take Adcirca exactly as your healthcare provider instructs you.
- Take both 20 mg tablets at the same time once a day. This equals the recommended 40 mg daily dose for PAH.
- Swallow the tablets one at a time without splitting or crushing them.
- Take Adcirca at the same time every day to keep a steady amount in your body.
- You can take Adcirca with or without food.
- If you take too much Adcirca, call your healthcare provider or go to the emergency room right away.
- Avoid drinking more than four alcoholic drinks in a short time while taking Adcirca, as this can lower your blood pressure and make you dizzy or faint.
Side Effects
When taking Adcirca for pulmonary arterial hypertension (PAH), you may experience side effects. These can be mild or severe. Always speak to your healthcare provider if you notice any changes in your health.
Common Adcirca Side Effects
- Headache
- Muscle pain
- Flushing or feeling hot in the face
- Nausea
- Pain in the arms, legs, or back
- Upset stomach
- Stuffy or congested nose
Severe Adcirca Side Effects
- Sudden decrease or loss of vision in one or both eyes
- Sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness
- Erection in men lasting more than 4 hours
- Chest pain
- Severe dizziness or fainting
Missed Dose
If you forget to take your Adcirca dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take extra Adcirca to make up for the missed dose, as this can increase the risk of side effects.
Overdose
Taking more Adcirca than prescribed can increase the risk of serious Adcirca side effects such as severe headache, dizziness, low blood pressure, vision changes, or prolonged erection in men.
Doses higher than 40 mg have not been studied for pulmonary arterial hypertension and may cause harmful effects. If you think you have taken too much Adcirca, seek immediate medical help or go to the emergency room.
Warnings
Adcirca can cause serious side effects in certain people. Before using Adcirca, it is important to understand the possible risks and discuss them with your healthcare provider. These warnings help ensure safe use and minimize the risk of adverse effects.
- Adcirca can lower blood pressure temporarily. People with heart problems or very low blood pressure should use caution because this pressure drop can cause dizziness or fainting.
- People with a rare lung condition called pulmonary veno-occlusive disease should avoid Adcirca because it can exacerbate symptoms and may lead to fluid buildup in the lungs.
- Adcirca has been linked to rare cases of sudden vision loss due to a condition called non-arteritic anterior ischemic optic neuropathy. This is more likely in people over age 50 or those with health problems such as diabetes, high blood pressure, or heart disease.
- People with inherited eye diseases such as retinitis pigmentosa should not use Adcirca because the effects on these conditions are unknown.
- Sudden hearing loss has been reported in some people taking Adcirca. This can happen with or without ringing in the ears or dizziness.
- Adcirca should not be taken together with other PDE5 inhibitors used for erectile dysfunction because the safety of this combination is not known.
- Rarely, Adcirca can cause an erection in men that lasts longer than four hours. This is a medical emergency and can cause permanent damage if not treated quickly. Men with blood disorders or certain physical conditions affecting the penis are at higher risk.
Boxed Warning and Precautions for Adcirca
| Adcirca must be used with care because it can cause sudden drops in blood pressure, rare vision or hearing problems, and serious prolonged erections in men. It should not be combined with other PDE5 inhibitors or used in people with certain lung or eye conditions. Always follow the dose instructions from your healthcare provider to lower the risk of serious side effects. |
Contraindications
Adcirca should not be used in people who are taking any type of organic nitrate medication because this combination can cause a dangerous drop in blood pressure. It should also not be taken with guanylate cyclase stimulators such as riociguat because of the risk of severe low blood pressure.
People who have had a serious allergic reaction to tadalafil or any ingredients in Adcirca should not take this medication. Allergic reactions may include rare but serious skin conditions, such as Stevens-Johnson syndrome or severe skin peeling.
Interactions
Adcirca can interact with certain medications, supplements, and substances. These interactions can affect how Adcirca works or increase the risk of side effects. Always tell your healthcare provider about all medications you are taking before starting Adcirca.
- Nitrates
- Alpha blockers
- Antihypertensive medications
- Alcohol
- Ritonavir
- Ketoconazole
- Itraconazole
- Rifampin
Storage Information
Store Adcirca at room temperature, away from moisture and direct sunlight. Keep it in its original container and make sure the lid is tightly closed. Do not store it in the bathroom or in places with high humidity. Keep it out of reach of children and pets.
Alternatives
Adcirca is not the only treatment option for pulmonary arterial hypertension. Other treatments can work in similar ways or target the condition differently.
These alternatives may be used if Adcirca is not suitable or if a healthcare provider recommends a different treatment.
Cost & Coupons
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Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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