- What is Adtralza?
- Indications and Benefits of Adtralza
- Adtralza Drug Information
- How It Works
- Adtralza Dosage
- Usage Guide
- Side Effects
- Missed Dose
- Overdose
- Storage Information
- Warnings
- Contraindications
- Interactions
- Alternatives
- Buy Adtralza Online From Canada: Cost & Coupons
- Frequently Asked Questions
- Disclaimer
- Price Match Guarantee
What is Adtralza?
Adtralza (tralokinumab) is FDA-approved to treat moderate-to-severe atopic dermatitis, also called eczema, in adults and children 12 years and older.
Atopic dermatitis is a long-lasting skin condition that can cause dry, itchy, red, and inflamed skin. Adtralza works by blocking a protein in the body that can trigger skin inflammation and itching.
Doctors usually prescribe Adtralza to patients whose eczema is not well controlled with prescription creams or ointments, or when topical treatments are not suitable. It may be used alone or together with topical corticosteroids.
Many patients also search for ways to buy Adtralza in Canada to help manage long-term treatment costs while maintaining access to their prescribed therapy.
Indications and Benefits of Adtralza
Adtralza is used to help control moderate-to-severe eczema in patients who need more than topical treatments alone.
FDA-Approved Indications
- Adtralza is FDA-approved for the treatment of moderate-to-severe atopic dermatitis, also known as eczema, in adults and adolescents 12 years of age and older.
- It is prescribed for patients whose eczema is not adequately controlled with prescription creams or ointments.
- Adtralza may also be used when topical therapies are not recommended or suitable for the patient.
- The treatment can be used with or without topical corticosteroids.
Key Clinical Benefits
- Adtralza helps reduce common eczema symptoms such as itching, redness, dryness, scaling, and skin inflammation.
- Clinical studies showed that many patients experienced clearer or almost clear skin after 16 weeks of treatment.
- In clinical trials, more patients treated with Adtralza achieved at least a 75% improvement in eczema severity compared to placebo.
- Some patients reported noticeable itch relief within the first few weeks of treatment.
- Adtralza may also help improve sleep quality and overall daily comfort by reducing eczema flare-ups.
Off-Label Uses
- Adtralza is mainly prescribed for atopic dermatitis, and there are currently no widely accepted off-label uses routinely recommended for tralokinumab.
Adtralza Drug Information
| Category | Details |
| Brand Name | Adtralza. In the United States, tralokinumab is marketed as Adbry. |
| Generic Name | Tralokinumab. In the U.S. label, it is listed as tralokinumab-ldrm. |
| Medication Class | Interleukin-13 antagonist. This means it blocks IL-13, a body protein that can drive skin inflammation in eczema. |
| Primary Use | It is used to treat moderate-to-severe atopic dermatitis, also called eczema, in adults and children 12 years and older when prescription skin treatments do not work well enough or are not suitable. |
| Additional Uses / Off-Label | No common off-label uses are listed in the FDA prescribing information. |
| Available Form | Injection in a single-dose prefilled syringe or single-dose autoinjector/prefilled pen. |
| Method of Administration | It is injected under the skin. This is called a subcutaneous injection. |
| Available Dosage Strengths | Prefilled syringe: 150 mg/mL. Autoinjector/prefilled pen: 300 mg/2 mL. |
| Dosing Frequency | Adults usually start with 600 mg, followed by 300 mg every other week. Some adults under 100 kg who achieve clear or almost clear skin after 16 weeks may use 300 mg every 4 weeks. Patients 12 years and older usually start with 300 mg, followed by 150 mg every other week. |
| Storage Instructions | Store in the refrigerator at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light. Do not freeze, shake, or expose to heat. It may be kept at room temperature up to 86°F (30°C) for up to 14 days. |
| Pregnancy & Breastfeeding | It is not known if tralokinumab can harm an unborn baby. It is also not known if it passes into breast milk or affects a breastfed baby. Patients should discuss pregnancy or breastfeeding plans before use. |
| Major Drug Interactions | The FDA label does not list 5 specific drug-drug interactions. Key treatment considerations include live vaccines, age-appropriate vaccines before starting treatment, parasitic worm infections, topical corticosteroids, and topical calcineurin inhibitors for limited areas such as the face, neck, skin folds, or genital areas. |
| Manufacturer | LEO Pharma Inc. / LEO Pharma A/S. |
How It Works
Adtralza works by targeting a protein in the body called interleukin-13, also known as IL-13. This protein plays a major role in causing inflammation linked to atopic dermatitis, or eczema.
People with moderate-to-severe eczema often have higher levels of IL-13, which can lead to redness, itching, dry skin, and irritation. Adtralza blocks the action of IL-13 to help calm the immune response that triggers these skin symptoms.
By reducing inflammation under the skin, Adtralza can help improve skin appearance and reduce itching over time.
Some patients notice itch relief within the first few weeks of treatment, while clearer skin and larger improvements may take several weeks to a few months with regular use.
Since eczema is a long-term condition, Adtralza is designed to provide ongoing symptom control when used consistently as prescribed.
Adtralza Dosage
Adtralza is available as a pre-filled syringe containing 150 mg of tralokinumab in 1 mL solution and as a pre-filled pen containing 300 mg in 2 mL solution.
The syringes and pens are designed for single use only and do not require mixing before injection.
Available Dosage Strengths and Forms
- Pre-filled syringe: 150 mg/1 mL
- Pre-filled pen: 300 mg/2 mL
- Both forms are supplied as single-use injections for subcutaneous use
Dosage Chart
| Condition | Starting Dose | Maintenance Dose | Maximum Dose |
| Moderate-to-severe atopic dermatitis (eczema) in adults and adolescents 12 years and older | 600 mg given as four 150 mg injections or two 300 mg injections | 300 mg every other week, given as two 150 mg injections or one 300 mg injection | 600 mg initial dose |
| Patients who achieve clear or almost clear skin after 16 weeks | 600 mg initial dose | Some patients may continue with 300 mg every 4 weeks at the prescriber’s discretion | 600 mg initial dose |
Usage Guide
Follow your healthcare provider’s instructions carefully when using Adtralza. This treatment is given as an injection under the skin and may be self-injected after proper training.
Step-by-Step Instructions
- Remove Adtralza from the refrigerator and allow it to reach room temperature before use. Do not heat it using hot water, sunlight, or a microwave.
- Wash your hands thoroughly before handling the syringe or prefilled pen.
- Check the solution before use. It should appear slightly yellow. Do not use it if it looks cloudy, frozen, or damaged.
- Choose an injection site on the thigh or abdomen, avoiding the area within 2 inches of the belly button. If another person is giving the injection, the upper arm may also be used.
- Clean the injection area with an alcohol swab and let it dry.
- Inject Adtralza under the skin exactly as instructed by your healthcare provider. Do not inject into the muscle.
- Rotate injection sites with each dose and avoid skin that is bruised, scarred, damaged, or tender.
- Dispose of used syringes or pens in a sharps container.
Timing and Dosing
Adtralza can be used at any time of day. Since it is an injection, it is not affected by food or water intake. The starting dose is usually 600 mg, followed by 300 mg every other week. Some patients may later switch to every 4 weeks if advised by their healthcare provider.
Important Things to Avoid
- Do not shake the syringe or pen.
- Do not freeze Adtralza.
- Do not inject into irritated or injured skin.
- Do not skip doses or stop treatment without medical advice.
- Avoid live vaccines while using Adtralza unless approved by your healthcare provider.
How to Know Adtralza Is Working?
Many patients notice less itching, redness, dryness, and skin irritation after several weeks of treatment. Skin flare-ups may happen less often, and sleep and daily comfort may improve over time. Your healthcare provider will regularly monitor your progress to make sure the treatment is helping.
Side Effects
| Common Side Effects (with frequency %) | Serious Side Effects |
| Upper respiratory tract infections, such as the common cold or sore throat (reported in clinical studies). | Serious allergic reactions may occur and require immediate medical attention. Symptoms may include trouble breathing, swelling of the face, lips, mouth, or tongue, severe rash, hives, dizziness, or fainting. |
| Injection site reactions, including redness, itching, pain, tenderness, or swelling where the injection was given. | Severe hypersensitivity reactions can happen rarely and may include low blood pressure, severe itching, or widespread skin rash. Stop using Adtralza and seek emergency help right away. |
| Eye problems such as redness, itching, swelling, eye inflammation, or irritation were commonly reported during treatment. | Worsening eye symptoms, such as eye pain or vision changes, should be evaluated by a healthcare provider as soon as possible. |
Missed Dose
If you miss a dose of Adtralza, inject the missed dose as soon as possible. After taking the missed dose, continue your regular dosing schedule at the usual planned time.
If it is almost time for your next scheduled injection, contact your healthcare provider for guidance on when to take the next dose.
Do not give yourself two doses at the same time to make up for a missed dose. Using Adtralza consistently as prescribed can help maintain better control of eczema symptoms.
Overdose
There is no specific antidote or reversal treatment for an Adtralza overdose. Although high doses were generally well tolerated in clinical studies, taking more than the prescribed amount may increase the risk of side effects such as injection site reactions, allergic reactions, or worsening eye problems.
If you think you or someone else has used too much Adtralza, contact Poison Control immediately at 1-800-222-1222 or go to the nearest emergency room right away, even if there are no symptoms. Bring the medication packaging or prescription information with you if possible.
Storage Information
Store Adtralza in the refrigerator between 36°F and 46°F (2°C to 8°C) in its original carton to protect it from light. Do not expose the prefilled syringe or prefilled pen to direct sunlight, heat, or excessive humidity, and do not shake it.
If needed, Adtralza may be stored at room temperature up to 86°F (30°C) for up to 14 days, as long as it remains within the expiration date.
Once it reaches room temperature, do not place it back in the refrigerator. Do not freeze Adtralza.
If the product has been frozen, damaged, dropped, expired, or left at room temperature longer than 14 days, it should be discarded safely according to local disposal guidelines.
Warnings
Important Warnings and Precautions
- Serious allergic reactions, including hypersensitivity and rare cases of anaphylaxis, have been reported with Adtralza. Stop treatment immediately and seek emergency medical care if symptoms such as trouble breathing, swelling of the face or throat, severe rash, dizziness, or fainting occur.
- Eye problems, including conjunctivitis and eye inflammation, may occur more often in patients using Adtralza. Report new or worsening eye redness, itching, swelling, pain, or vision changes to your healthcare provider promptly.
- Patients with parasitic worm infections should be treated before starting Adtralza. If a worm infection develops and does not improve with treatment, Adtralza may need to be stopped until the infection resolves.
- Live vaccines should be avoided during treatment with Adtralza.
- Do not use Adtralza if you are allergic to tralokinumab or any of its ingredients.
Patient Groups Requiring Extra Caution
- Pregnant patients should use Adtralza cautiously because there is limited information about safety during pregnancy.
- Breastfeeding patients should discuss the risks and benefits with their healthcare provider because it is unknown if Adtralza passes into breast milk.
- Adtralza is not approved for children under 12 years old.
- Studies in adults 65 years and older did not show major differences in safety or effectiveness compared with younger adults.
Monitoring Requirements
- Regular follow-up appointments are recommended to monitor eczema symptoms and treatment response.
- Patients should be monitored for allergic reactions, eye problems, and signs of infection during treatment.
- No routine laboratory monitoring is specifically required in the FDA prescribing information.
Contraindications
- Adtralza should not be used in patients who are allergic to tralokinumab or any of the ingredients in the product. Using the treatment in these patients may cause serious allergic reactions, including swelling, rash, breathing problems, or anaphylaxis.
- Patients who previously experienced a severe hypersensitivity reaction after using Adtralza should not use it again unless specifically directed by a healthcare provider.
- Adtralza should not be used in anyone with a known allergy to any component of the prefilled syringe or prefilled pen formulation.
Patients who are unsure about possible allergies or previous reactions should speak with their healthcare provider before starting treatment.
Interactions
| Drug / Substance | What Happens | What to Do |
| Live vaccines | Live vaccines may increase the risk of infection while using Adtralza because the treatment affects part of the immune system. | Avoid live vaccines during treatment unless approved by your healthcare provider. |
| Non-live vaccines | Non-live vaccines, such as tetanus or meningococcal vaccines, did not show harmful interactions in studies. | These vaccines can usually be given while using Adtralza. |
| Topical corticosteroids | Adtralza may be used together with steroid creams or ointments for eczema treatment. | Use both treatments exactly as prescribed by your healthcare provider. |
| Topical calcineurin inhibitors | These skin treatments may be used alongside Adtralza, especially on sensitive skin areas. | Follow the application instructions provided by your healthcare provider. |
| Midazolam | Clinical studies showed a decrease in midazolam levels after Adtralza treatment. | Your healthcare provider may monitor treatment response if both are used together. |
| Warfarin | No major interaction was seen in clinical studies. | Continue routine monitoring as directed by your healthcare provider. |
| Omeprazole and metoprolol | Studies did not show clinically meaningful interactions with Adtralza. | Usually, no dose adjustment is needed. |
| Herbal supplements and vitamins | Interactions with supplements or herbal products have not been fully studied. | Tell your healthcare provider about all supplements and natural products you use. |
Alternatives
| Drug Name | Generic Name | Drug Class | Key Difference from Adtralza | Best For |
| Dupixent | Dupilumab | IL-4 and IL-13 inhibitor biologic | Targets both IL-4 and IL-13 pathways instead of IL-13 alone. | Patients with eczema who may also have asthma, nasal polyps, or related inflammatory conditions. |
| Ebglyss | Lebrikizumab | IL-13 inhibitor biologic | Works on the IL-13 pathway similarly to Adtralza but uses a different antibody formulation. | Adults and adolescents with moderate-to-severe atopic dermatitis need biologic treatment. |
| Adbry | Tralokinumab-ldrm | IL-13 inhibitor biologic | Adbry is the U.S. brand name for tralokinumab, the same active ingredient used in Adtralza. | Patients are looking for the U.S.-marketed version of tralokinumab treatment. |
| Rinvoq | Upadacitinib | Janus kinase (JAK) inhibitor | Taken orally instead of injection and works through a different immune pathway. | Patients who prefer an oral treatment option for moderate-to-severe eczema. |
| Cibinqo | Abrocitinib | Janus kinase (JAK) inhibitor | An oral tablet that works differently from biologic injections like Adtralza. | Adults with moderate-to-severe atopic dermatitis who may prefer non-injectable treatment. |
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Pharma Giant’s Guarantee
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Patients can also choose larger supply quantities when appropriate to help reduce ongoing treatment costs while maintaining consistent access to therapy.
Frequently Asked Questions
Buying Adtralza from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
Adverse Reactions
Food & Drug Interactions
Storage & Travel
Drug Comparison
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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