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What is Afrezza?

Afrezza (insulin human) is a type of insulin that helps lower high blood sugar in adults with diabetes. Unlike regular insulin, which you inject, Afrezza is a powder you breathe in through your mouth using an inhaler.

This type of insulin works very quickly, so people usually use it at the beginning of a meal to control blood sugar levels after eating. Afrezza medication is only for adults and should not be used by children under 18 years old.

If you have type 1 diabetes, you must use Afrezza with a long-acting insulin to keep your blood sugar steady all day.

Afrezza is not meant to treat diabetic ketoacidosis, which is a serious condition that can happen when your body does not have enough insulin. It is also not safe for people who smoke or who have recently quit smoking, because smoking can affect how the medication works in the lungs.

Some people should not use Afrezza. These include people with lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Afrezza can make breathing worse for these people.

You should also not use Afrezza if allergic to human insulin or any of the medication’s ingredients. Another reason not to use Afrezza is if you are having an episode of low blood sugar at the time.

Before starting Afrezza medication, talk to your healthcare provider. Let them know if you have any lung conditions, have ever had lung cancer, or use any other inhaled medications.

It is also important to tell your doctor if you are pregnant or breastfeeding, because Afrezza may affect your baby. Your doctor will help you understand the risks and benefits and how to manage low blood sugar while using Afrezza.

How Does Afrezza Work?

Afrezza works by helping your body lower blood sugar levels after you eat. When you have a meal, the food turns into sugar in your stomach, and that sugar enters your blood.

Usually, your body makes insulin to move that sugar from your blood into your cells, where it is used for energy. But if you have diabetes, your body might not make enough insulin or may not use it properly, causing blood sugar to rise.

Afrezza is a fast-acting insulin that you breathe in through your mouth. Because it is inhaled, it reaches your bloodstream very quickly, usually in less than one minute.

Afrezza medication helps your cells take in the blood sugar from your blood, bringing your blood sugar levels down and giving your body the energy it needs.

It works in about 12 minutes and works best around 35 to 45 minutes after use. This makes Afrezza a helpful option for controlling blood sugar spikes after meals.

Afrezza Dosage Information and Usage

Afrezza is a fast-acting insulin in powder form that is inhaled through a special inhaler.

It is used at the beginning of each meal to help manage blood sugar levels in adults with type 1 or 2 diabetes.

The Afrezza dose varies based on individual needs, such as prior insulin use, meal size, and blood sugar levels. It is important to use Afrezza exactly as prescribed and only with the Afrezza inhaler.

Dosage Form and Strengths of Afrezza

Afrezza is available in cartridge form for oral inhalation. Each cartridge contains a specific dose of insulin powder.

  • 4-unit cartridge
  • 8-unit cartridge
  • 12-unit cartridge

These cartridges can be combined to reach the required Afrezza dose before meals.

How to Take Afrezza?

Afrezza must be taken at the start of each meal. Follow these steps to use it correctly:

  1. Check the inhaler and insert the correct cartridge.
  2. Keep the inhaler upright with the white mouthpiece on top.
  3. Exhale fully away from the inhaler.
  4. Place the mouthpiece in your mouth and seal your lips around it.
  5. Tilt the inhaler slightly downward and inhale deeply.
  6. Remove the inhaler and hold your breath for as long as comfortable.
  7. Exhale and breathe normally.
  8. If your prescribed dose requires more than one cartridge, use an additional cartridge to complete the dosage.

Recommended Afrezza Dose by Population or Condition

Afrezza Dose for Type 1 Diabetes

For people with type 1 diabetes who have never taken insulin before, the typical starting dose of Afrezza is four units taken by inhalation at the beginning of each meal.

For those already using mealtime insulin, the Afrezza dose is based on the amount of rapid-acting insulin they usually use with meals. For example, if you usually take up to 4 units of mealtime insulin, you will likely use a 4-unit Afrezza cartridge.

If you take 5 to 8 units, you will use the 8-unit cartridge; for 9 to 12 units, a 12-unit dose is appropriate. Higher insulin needs may require combining cartridges, such as using a 4-unit and an 8-unit cartridge for a 12-unit dose or two 12-unit cartridges for 24 units.

Your doctor may adjust the dosage based on your blood sugar readings, the amount of carbohydrates in your meals, and your physical activity level.

Afrezza Dose for Type 2 Diabetes

For those with type 2 diabetes who have never used insulin, the starting Afrezza dose is also four units at the beginning of each meal. If you switch from another mealtime insulin, the dosage will match your usual insulin requirements.

As in type 1 diabetes, higher doses may require cartridge combinations.

For example, if you take 17 to 20 units of rapid-acting insulin at meals, you might use an 8-unit and a 12-unit cartridge to get a 20-unit dose.

Your doctor will help you adjust your dose depending on your blood sugar goals, meals, and physical activity level. People switching from pre-mixed insulin regimens need a tailored plan separating basal and mealtime doses.

Dose Adjustments in Special Situations

Your Afrezza dose may need to be adjusted in certain situations. Your insulin needs may change if you become more active, eat different kinds or amounts of food, become ill, or develop liver or kidney problems. It is essential to monitor your blood sugar more frequently during these times.

If your blood sugar remains too high even with increased Afrezza doses, your doctor may consider changing your treatment plan.

Certain medications can interact with Afrezza and affect your blood sugar levels, so your dose may need to be changed when starting or stopping other drugs.

Afrezza Side Effects

While Afrezza works well for many, it can also cause side effects. Some of the most common Afrezza side effects include cough, sore throat, and low blood sugar (hypoglycemia).

On the other hand, some people may experience severe side effects like breathing problems, allergic reactions, or diabetic ketoacidosis.

Knowing the mild and severe Afrezza side effects can help you take action quickly and stay safe during treatment.

Common Side Effects

  • Cough
  • Sore throat
  • Headache
  • Diarrhea
  • Tiredness or lack of energy
  • Nausea
  • Swelling in the airways (bronchitis)
  • Low blood sugar (hypoglycemia)

These Afrezza side effects are usually mild and may go away quickly. If they continue or get worse, talk to your doctor.

Severe Side Effects

  • Trouble breathing or wheezing
  • A cough that does not go away
  • Chest tightness or shortness of breath
  • Severe low blood sugar (can cause confusion or fainting)
  • Very low potassium levels (can cause irregular heartbeats or muscle cramps)
  • Diabetic ketoacidosis (can cause nausea, vomiting, or fruity breath)
  • Allergic reaction (swelling of the face, lips, tongue, or throat)
  • Acute bronchospasm, especially in people with asthma or COPD

Call your doctor immediately if you notice any of these severe Afrezza side effects. In an emergency, call 911 or your local emergency number.

Warnings and Precautions for Afrezza

It is important to know the safety risks of Afrezza before you start using it.

  • Do not use Afrezza if you have asthma or a long-term lung problem like COPD. It can cause a serious problem called bronchospasm, making breathing very hard.
  • Your doctor may check your lungs before you start Afrezza. This helps make sure it is safe for you to use.
  • Afrezza may lower your blood sugar too much. Low blood sugar can cause sweating, shakiness, confusion, blurry vision, or even seizures.
  • When using Afrezza, you should check your blood sugar often. This helps catch low or high blood sugar early and keeps you safe.
  • Changing the type or brand of insulin may affect your blood sugar. Always talk to your doctor before making any changes.
  • Afrezza may affect your breathing over time. It can slowly reduce the efficiency of your lungs, even if you do not feel any breathing problems.
  • Your doctor should test your lung function before starting Afrezza, again at 6 months, and once every year after that. If your breathing gets worse, your doctor may stop Afrezza.
  • Afrezza may increase the risk of lung cancer. Some people in studies developed lung cancer after using Afrezza, although it is not clear if the medication was the cause.
  • You should not use Afrezza if you have lung cancer or have had it in the past. Talk with your doctor about other ways to manage your blood sugar.
  • People with heart failure should be careful when using Afrezza. It can make heart failure worse and cause symptoms like swelling, shortness of breath, and feeling tired.
  • People with type 1 diabetes need to use Afrezza with another insulin that works slowly. Afrezza alone is not enough and may cause a serious condition called diabetic ketoacidosis.
  • Some people may have a severe allergic reaction to Afrezza. Signs include rash, swelling, or trouble breathing. If this happens, stop using Afrezza and get help right away.
  • If you are pregnant or planning to become pregnant, talk to your doctor. It is not known if Afrezza is safe for pregnant women or their babies.
  • If you are breastfeeding or plan to breastfeed, ask your doctor if Afrezza is right for you. Animal studies show it may pass into breast milk, but we do not know if it affects human babies.
  • Do not use more Afrezza than your doctor tells you. Using too much can lead to very low blood sugar, which may cause serious problems like fainting, seizures, or coma.

Afrezza Drug Interactions

Afrezza can interact with many medications. These interactions might change how Afrezza works or increase the chance of side effects. Always tell your doctor about all your drugs, vitamins, and supplements before starting Afrezza.

  • metformin
  • glipizide
  • liraglutide
  • semaglutide
  • dulaglutide
  • pramlintide
  • rosiglitazone
  • pioglitazone
  • sulfamethoxazole and trimethoprim
  • sulfadiazine
  • pentamidine
  • lisinopril
  • enalapril
  • benazepril
  • metoprolol
  • nadolol
  • atenolol
  • clonidine
  • hydrochlorothiazide
  • furosemide
  • prednisone
  • methylprednisolone

Afrezza Alternatives

If Afrezza does not work well for you or causes side effects your doctor may suggest a different insulin. Everyone reacts differently to medications and finding the right one can help you manage your blood sugar better.

Talk with your doctor about which option may be the best for you.

Affordable Afrezza Available in Pharma Giant

Many people living with diabetes worry about how to afford their insulin. If you are concerned about Afrezza cost, you are not alone.

Pharma Giant understands how stressful it can be to manage your health while watching your budget. We work with trusted Canadian pharmacies to ensure you get access to safe, effective medication at the lowest possible Afrezza price.

You should not have to choose between your health and your wallet.

At Pharma Giant, you can order Afrezza online without the high prices you see in the United States. Our prices are listed, with no hidden fees, and you can even buy a 3-month supply to save more.

We handle each order carefully and ship your insulin in temperature-controlled packaging to protect its quality. If you are looking for an affordable Afrezza cost and a simple way to refill your prescription, Pharma Giant is here to help.

How to Order Afrezza Online?

  1. Search for Afrezza, choose the correct strength, and click Buy to add it to your cart. You can keep shopping and add more items if needed.
  2. When your cart is ready, click Continue Checkout and enter your name, address, and payment details. Use code PGSAVE10 to get 10% off your first order.
  3. After placing your order, you can send your prescription by uploading it to the website, emailing it to info@pharmagiant.com, or faxing it to 1-888-562-8159.

Frequently Asked Questions

Afrezza controls blood sugar levels in adults with type 1 or 2 diabetes.
The FDA approved Afrezza on June 27, 2014.
As your doctor prescribes, Afrezza is inhaled through the mouth using the supplied inhaler before each meal.
No, Afrezza is not regular insulin. It is an ultra-rapid-acting mealtime insulin taken by inhalation.
Store Afrezza in the refrigerator. Unopened strips can stay at room temperature for up to 10 days. After opening, use the cartridges within 3 days.
Yes, Afrezza can cause low blood sugar (hypoglycemia), which is one of its most common side effects.
Afrezza starts working quickly and reaches its peak effect in about 35 to 45 minutes.
Lung cancer occurred in a few more people taking Afrezza compared to other diabetes treatments, but a clear link has not been proven.
Afrezza is not approved for use in children under 18 years of age.
Afrezza starts working in about 12 minutes and lasts for 1.5 to 3 hours, depending on your dose.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Price Match Guarantee

Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online pharmacy with a verifiable address.
  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone prior to completing your order.

Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.