What is Akynzeo?
Akynzeo is a prescription medicine used with dexamethasone to prevent nausea and vomiting caused by cancer chemotherapy.
It is effective for both immediate and delayed nausea and vomiting.
Akynzeo combines two medicines: palonosetron and netupitant. Palonosetron stops nausea and vomiting right after chemotherapy, while netupitant works for both short-term and delayed nausea and vomiting.
Akynzeo is used by adults undergoing initial or repeat courses of chemotherapy, including highly emetogenic treatments.
It helps patients feel better during cancer treatment by managing one of the most common side effects of chemotherapy.
How Does Akynzeo Work?
Akynzeo works by blocking the signals that cause nausea and vomiting during cancer chemotherapy.
It combines two medicines: netupitant and palonosetron. Netupitant blocks NK-1 receptors, which stop delayed nausea and vomiting.
Palonosetron blocks 5-HT3 receptors, which stop nausea and vomiting after chemotherapy.
By targeting both immediate and delayed nausea, Akynzeo helps patients feel better during and after cancer treatment.
Akynzeo Dose Information and Usage
Akynzeo Akynzeo dose depends on the type of chemotherapy. It is usually taken with dexamethasone.
Akynzeo comes in capsules or injections.
The capsule is taken by mouth about one hour before chemotherapy, while the injection is given through an IV about 30 minutes before treatment.
Dosage Form and Strengths of Akynzeo
Akynzeo is available in two forms:
- Akynzeo Capsule: 300 mg netupitant/0.5 mg palonosetron in a hard gelatin capsule with a white body and caramel cap.
- Akynzeo for Injection: 235 mg fosnetupitant/0.25 mg palonosetron as a mixed powder before use.
How to Use Akynzeo?
Take one Akynzeo capsule by mouth about one hour before chemotherapy. You can take it with or without food.
If you are receiving Akynzeo for injection, it will be given through an IV about 30 minutes before chemotherapy.
Follow your doctor’s instructions closely to get the best results from Akynzeo.
Side Effects of Akynzeo
Akynzeo can cause side effects. Common side effects include headache, fatigue, and constipation. Some people may also experience upset stomachs or skin redness.
In rare cases, Akynzeo side effects can be severe, such as allergic reactions or serotonin syndrome.
It is important to be aware of these potential side effects before using Akynzeo and to seek medical help if severe symptoms occur.
Common Side Effects
- Headache
- Fatigue
- Weakness
- Upset stomach
- Constipation
- Skin redness
Severe Side Effects
- Allergic reactions (hives, swollen face, trouble breathing, chest pain)
- Serotonin syndrome (agitation, hallucinations, dizziness, fast heartbeat, sweating, low body temperature, shaking, unsteady movements, muscle twitching, seizures)
Warnings and Precautions for Akynzeo
Akynzeo is used to prevent nausea and vomiting caused by chemotherapy.
However, knowing specific warnings and precautions before using this medication is important.
Knowing these risks helps ensure the safe and effective use of Akynzeo.
- Hypersensitivity: Severe allergic reactions, including anaphylaxis, have been reported. If symptoms such as hives, swelling, or trouble breathing occur, seek medical help.
- Serotonin Syndrome: This serious condition can happen when Akynzeo is used with other serotonergic drugs. Symptoms may include agitation, hallucinations, fast heartbeat, sweating, tremors, and seizures. Discontinue use and seek emergency care if symptoms develop.
- Drug Interactions: Akynzeo may interact with certain medications, such as antidepressants and pain relievers. Inform your doctor about all the medicines you are taking.
- Use in Specific Populations: Pregnant or breastfeeding women should consult their healthcare provider before using Akynzeo.
Akynzeo Drug Interactions With Other Medications
Akynzeo can interact with other medications, affecting its effectiveness or increasing the risk of side effects. To use Akynzeo safely, it is essential to be aware of these drug interactions.
Some of these interactions relate to its impact on CYP3A4, an enzyme that metabolizes many drugs.
- CYP3A4 Substrates: Akynzeo inhibits CYP3A4, increasing the levels of drugs metabolized by this enzyme. Avoid using CYP3A4 substrates for one week or adjust their dose.
- Dexamethasone: Akynzeo increases dexamethasone levels, so a reduced dose of dexamethasone is recommended.
- Midazolam and Benzodiazepines: Akynzeo raises the levels of midazolam and other CYP3A4-metabolized benzodiazepines (e.g., alprazolam, triazolam). Monitor for enhanced sedative effects.
- Chemotherapeutic Agents: Increases the levels of chemotherapy drugs metabolized by CYP3A4 (e.g., docetaxel, paclitaxel). Monitor for adverse reactions.
- Oral Contraceptives: No significant impact on oral contraceptives containing levonorgestrel and ethinyl estradiol.
- Warfarin: Monitor INR levels as Akynzeo may affect blood-thinning effects.
- CYP3A4 Inducers: Avoid using strong CYP3A4 inducers (e.g., rifampin) as they decrease Akynzeo’s effectiveness.
- CYP3A4 Inhibitors: Strong CYP3A4 inhibitors (e.g., ketoconazole) increase Akynzeo levels, but no dose adjustment is needed.
- Serotonergic Drugs: Combining Akynzeo with SSRIs or SNRIs can cause serotonin syndrome. Stop Akynzeo and seek medical help if symptoms occur.
Alternative Medications to Akynzeo
If Akynzeo is not suitable or effective for you, there are other medications available to help prevent nausea and vomiting caused by chemotherapy.
Here are some alternative options:
- Emend (aprepitant)
- Marinol (dronabinol)
- Ativan (lorazepam)
- Reglan (metoclopramide)
- Cesamet (nabilone)
Affordable Akynzeo is Now Available from Pharma Giant
Getting the medications you need should not be expensive or complicated.
Pharma Giant now offers Akynzeo at affordable prices, making it easier for patients to manage chemotherapy-induced nausea and vomiting.
Pharma Giant provides significant cost savings by partnering with licensed Canadian pharmacies without compromising quality or safety.
Enjoy the convenience of fast delivery right to your door, with transparent pricing and no hidden fees. Save money and get the relief you need today with Akynzeo from Pharma Giant.
How to Order Akynzeo Online?
- Search for Akynzeo using the search icon at the top of the website. Select the correct medication and strength, then click “Buy” to add it to your cart. If you need to add more items, click “Continue shopping” and repeat the process.
- Once your cart is ready, click “Continue Checkout.” Enter your contact, payment, and address details. Create an account with your email and password if you are a new customer. Use the coupon code PGSAVE10 to save 10% on your first order. If you are a returning customer, log in with your email and password. Click “Submit” to complete your order, and a confirmation email will be sent to you.
- You can upload your prescription using the website’s RX document uploader tool, email a clear photo or scanned copy to info@pharmagiant.com, or fax it to 1-888-562-8159. Your order will be processed without additional documentation if no prescription is needed.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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