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AMGEVITA is a medication whose active ingredient is adalimumab, a monoclonal antibody that has been engineered to specifically target and neutralize tumor necrosis factor-alpha (TNF-alpha), a protein that plays a central role in the inflammatory processes of the body. Classified pharmacologically as a TNF blocker, or anti-TNF drug, AMGEVITA belongs to a class of biologic medicines known as biological response modifiers.

Adalimumab, the active component of AMGEVITA, is a recombinant human IgG1 monoclonal antibody. It is produced through recombinant DNA technology in a mammalian cell expression system. The antibody binds specifically to TNF-alpha, thereby inhibiting its interaction with the p55 and p75 cell surface TNF receptors. TNF-alpha is a cytokine that is a key regulator of the inflammatory response in many autoimmune diseases. By binding to this cytokine, adalimumab reduces the inflammatory response, which is responsible for the symptoms and tissue damage associated with autoimmune diseases.

The mechanism of action of AMGEVITA is rooted in its ability to mimic the immune system’s natural response to inflammation. In normal physiological conditions, TNF-alpha is involved in the defense against infections and in the healing process of tissues. However, in autoimmune diseases, excessive production of TNF-alpha contributes to a pathological inflammatory response. By neutralizing TNF-alpha, AMGEVITA helps to restore balance to the immune system, thereby reducing inflammation and its associated symptoms.

AMGEVITA’s effectiveness has been demonstrated in various clinical trials across its approved indications. In rheumatoid arthritis, for example, it has been shown to reduce signs and symptoms, induce major clinical response, inhibit the progression of structural damage, and improve physical function. In conditions like plaque psoriasis, it reduces the extent and severity of the skin lesions. Similarly, in Crohn’s disease and ulcerative colitis, it has been effective in reducing the signs and symptoms and inducing and maintaining clinical remission in patients who have had an inadequate response to conventional therapies.

In summary, AMGEVITA, with adalimumab as its active ingredient, represents a targeted approach to treating autoimmune diseases. Its mechanism of action, centered around the inhibition of TNF-alpha, addresses the underlying pathophysiology of these conditions, offering relief from symptoms and a chance at improved quality of life for patients suffering from chronic inflammatory conditions.

How is AMGEVITA Used?

AMGEVITA, a biosimilar to Humira, is used in the treatment of various autoimmune and inflammatory conditions. Its administration and dosage vary depending on the specific condition being treated, the severity of the disease, and the patient’s response to therapy.


AMGEVITA is administered via subcutaneous injection, typically into the thigh or abdomen. Patients are often trained to self-administer the medication, although it can also be given by a healthcare professional. The pre-filled syringe or pen makes the injection process more manageable for patients administering the medication at home. It’s crucial to rotate the injection sites to prevent skin issues. Before administration, patients should allow the medication to reach room temperature, which can make the injection more comfortable.

Dosage Variations by Condition

  • Rheumatoid Arthritis: For adults with rheumatoid arthritis, the standard dosage is usually 40 mg of AMGEVITA every other week. It can be used alone or in combination with methotrexate.
  • Psoriatic Arthritis and Ankylosing Spondylitis: The recommended dose for both conditions is 40 mg every other week.
  • Crohn’s Disease and Ulcerative Colitis: Treatment typically starts with an initial higher dose (known as a loading dose) of 160 mg, followed by 80 mg after two weeks, and then 40 mg every other week.
  • Plaque Psoriasis: The initial dose is 80 mg, followed by 40 mg every other week starting one week after the first dose.
  • Hidradenitis Suppurativa: The dosing begins with 160 mg initially, followed by 80 mg after two weeks, and then 40 mg weekly or 80 mg every other week.
  • Uveitis: The dosage and frequency depend on the severity and the specific type of uveitis being treated.

It’s important to note that dosages may be adjusted based on individual patient needs and responses. Regular monitoring and consultation with a healthcare provider are essential to ensure the effectiveness and safety of the treatment.


Proper storage of AMGEVITA is crucial to maintain its efficacy and safety. The medication should be stored in a refrigerator at a temperature between 2°C to 8°C (36°F to 46°F). It must not be frozen, as freezing can damage the integrity of the medication. The pre-filled syringes or pens should be kept in their original carton to protect them from light.

Before administration, AMGEVITA can be allowed to reach room temperature, which usually takes about 15 to 30 minutes. This makes the injection more comfortable. However, it should not be heated in any way, such as using a microwave or hot water. Once removed from the refrigerator, if not used within the specified time (usually within 14 days), it should be discarded.

Patients should also be aware of the medication’s expiration date and ensure that it is not used beyond this date. Disposal of expired or unused medication should be done in accordance with local regulations to ensure environmental safety.

Side Effects

The use of AMGEVITA, like any medication, can be associated with a range of side effects. These effects can vary in severity and frequency, and not every patient will experience them. It’s important for patients to be aware of these potential side effects so they can monitor their health and communicate any concerns to their healthcare provider. Understanding these side effects also helps in making informed decisions about the use of AMGEVITA in managing their condition.

Common Side Effects

The most commonly reported side effects of AMGEVITA are usually mild to moderate and can often be managed with medical guidance. These include:

  • Injection Site Reactions: Redness, itching, pain, or swelling at the injection site is common but usually mild and temporary.
  • Upper Respiratory Infections: Symptoms like a runny nose, sore throat, or sinus infections may occur.
  • Headaches: Some patients may experience headaches, which are generally manageable.
  • Rash: Skin rashes, though not severe, can occur in some individuals.
  • Nausea: Feelings of nausea or stomach discomfort are possible but typically not severe.

Patients should inform their healthcare provider if these common side effects become bothersome or persist.

Serious Side Effects

While less common, there are serious side effects associated with AMGEVITA that require immediate medical attention:

  • Serious Infections: Including tuberculosis and bacterial, fungal, or viral infections. Symptoms like fever, fatigue, cough, or flu-like symptoms should be reported immediately.
  • Allergic Reactions: Signs include hives, difficulty breathing, and swelling of the face, lips, or throat.
  • Nervous System Problems: Symptoms such as numbness, tingling, vision changes, or weakness in the limbs.
  • Heart Failure: New or worsening symptoms like shortness of breath, swelling in the ankles or feet, and sudden weight gain.
  • Liver Problems: Indicated by yellowing of the skin or eyes, dark urine, and abdominal pain.

Patients experiencing these symptoms should seek urgent medical care.

Warnings & Precautions

Before starting treatment with AMGEVITA, it is crucial to consider several warnings and precautions to ensure the safe and effective use of the medication.

  • Infection History: Patients with a history of recurrent infections or those currently battling an infection may be at increased risk when using AMGEVITA. The medication can lower the body’s ability to fight infections, making it crucial to resolve any current infections before starting treatment.
  • Tuberculosis (TB) Screening: Due to the risk of reactivating latent TB, patients should be screened for TB prior to initiating AMGEVITA therapy.
  • Hepatitis B: Patients who are carriers of the hepatitis B virus should be monitored for signs of active infection throughout treatment, as AMGEVITA can cause reactivation of hepatitis B.
  • Cancer History: Caution is advised for patients with a history of malignancies or when considering the use of AMGEVITA in patients with a known malignancy.
  • Heart Failure: Patients with heart failure should be closely monitored while on AMGEVITA, as the medication can worsen the condition.
  • Neurological Disorders: There is a risk of new onset or exacerbation of demyelinating disorders, such as multiple sclerosis; patients should be monitored for neurological symptoms.
  • Allergic Reactions: Patients with known allergies to any component of AMGEVITA should not use the medication.
  • Pregnancy and Breastfeeding: The effects of AMGEVITA on pregnant women or nursing infants are not fully known. Women should discuss the potential risks and benefits with their healthcare provider.
  • Vaccinations: Live vaccines should be avoided during treatment with AMGEVITA.

Patients should always discuss their full medical history with their healthcare provider and regularly consult them during treatment to ensure any potential issues are addressed promptly. Regular monitoring and adherence to medical advice are key to safely benefiting from AMGEVITA’s therapeutic effects.

Drug Interactions

AMGEVITA, like many medications, can interact with other drugs, potentially affecting its efficacy or increasing the risk of adverse effects. Understanding these interactions is crucial for safe medication management.

  • Immunosuppressants: Concurrent use with other immunosuppressive drugs, such as methotrexate, corticosteroids, or cyclosporine, may enhance the immunosuppressive effects, increasing the risk of infections.
  • Biologic Agents: Combining AMGEVITA with other biologic agents, especially other TNF blockers, can increase the risk of serious infections and should generally be avoided.
  • Live Vaccines: Patients on AMGEVITA should avoid live vaccines, as the drug can impair the immune response to the vaccine, potentially leading to an active infection.
  • Over-the-Counter Medications: Non-steroidal anti-inflammatory drugs (NSAIDs) and over-the-counter pain relievers should be used cautiously, as they can increase the risk of gastrointestinal issues.
  • Herbal Supplements: Certain supplements known to affect the immune system, such as echinacea, should be used with caution, as they may alter the effectiveness of AMGEVITA.

Patients should always inform their healthcare provider about all medications, including over-the-counter drugs and supplements, to avoid potential drug interactions.


An overdose of AMGEVITA can lead to exacerbated side effects and potentially severe health complications. Recognizing the symptoms and knowing the immediate steps to take is crucial.

  • Symptoms of Overdose: These may include increased severity of common side effects such as severe injection site reactions, extreme fatigue, and heightened susceptibility to infections. In some cases, symptoms may mimic an allergic reaction or exacerbate existing conditions.
  • Immediate Steps: If an overdose is suspected, it is essential to seek immediate medical attention. Contacting a healthcare provider or going to the nearest emergency room is crucial. Providing medical personnel with information about the dosage and timing of the overdose can aid in prompt and effective treatment.

Alternative Medications

For the conditions treated by AMGEVITA, several alternative medications are available, offering different mechanisms of action and side effect profiles.

  • Other TNF Blockers: Medications like Infliximab, Etanercept, and Certolizumab pegol are alternatives for conditions like rheumatoid arthritis and Crohn’s disease.
  • Non-TNF Biologics: Drugs like Ustekinumab, which targets interleukins, can be used for psoriasis and psoriatic arthritis.
  • JAK Inhibitors: For rheumatoid arthritis, Janus kinase inhibitors like Tofacitinib offer an oral medication alternative.
  • Traditional DMARDs: Disease-modifying antirheumatic drugs like methotrexate are long-standing treatments for rheumatoid arthritis and other autoimmune conditions.
  • Corticosteroids: Used for their potent anti-inflammatory effects in various conditions, though typically not as a long-term solution due to side effects.

It’s important for patients to discuss with their healthcare provider to determine the most appropriate treatment option based on their specific condition, medical history, and lifestyle.

AMGEVITA is used to treat various inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, plaque psoriasis, and hidradenitis suppurativa. It works by targeting and inhibiting TNF-alpha, a substance that causes inflammation in these conditions.

AMGEVITA is administered as a subcutaneous injection, typically into the thigh or abdomen. Patients are often trained to self-administer the medication, although it can also be given by a healthcare professional.

The effects of AMGEVITA during pregnancy are not fully known. If you are pregnant or planning to become pregnant, discuss the potential risks and benefits with your healthcare provider.

Common side effects include injection site reactions, upper respiratory infections, headaches, and rash. These are usually mild and manageable.

Yes, AMGEVITA can increase the risk of serious infections like tuberculosis and bacterial, fungal, or viral infections. It’s important to monitor for symptoms of infection and report them to your doctor.

Some medications may interact with AMGEVITA, including other immunosuppressants and live vaccines. Always inform your healthcare provider about all medications and supplements you are taking.

Store AMGEVITA in a refrigerator at 2°C to 8°C and protect it from light. Do not freeze. Allow the medication to reach room temperature before injecting.

If you miss a dose of AMGEVITA, take it as soon as you remember. Then continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

AMGEVITA is approved for use in children for certain conditions like juvenile idiopathic arthritis and Crohn’s disease. The dosage and administration depend on the child’s weight and condition.

AMGEVITA is not a cure but helps manage symptoms and slow the progression of inflammatory conditions. Continuous treatment is often necessary.

The duration of treatment with AMGEVITA varies depending on your condition and response to therapy. Some patients may require long-term treatment.

There is no direct interaction between AMGEVITA and alcohol, but it’s best to consult your healthcare provider regarding alcohol consumption.

If you suspect an overdose, seek immediate medical attention. Symptoms may include heightened side effects or allergic reactions.

Yes, there are alternative treatments including other TNF blockers, non-TNF biologics, and traditional DMARDs. Discuss with your doctor to find the best option for you.

The response time varies, but some patients may notice improvements within a few weeks, while for others, it may take several months.