Amoxil (Amoxicillin)
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Amoxicillin (Generic) Amoxicillin
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Amoxil (Generic) Amoxicillin
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What is Amoxil (Amoxicillin)?

Belonging to a class of drugs called Penicillins, Amoxil is the brand name for amoxicillin, a bacteria-fighting penicillin antibiotic. Tonsillitis, pneumonia, and bronchitis are just some of the infections caused by bacteria that it helps to treat. Amoxil also helps to fight ear, nose, throat, skin, or urinary tract infections.

Amoxil can also be used in the treatment of stomach ulcers when used with Biaxin, another antibiotic. Specifically, they are used to treat stomach ulcers from Helicobacter pylori infections and are often used with lansoprazole, a stomach acid reducer.

Viral infections such as the common cold or flu, will not be treated by Amoxicillin.

The science behind Amoxil

Amoxicillin is a semisynthetic beta-lactam antibiotic that works by stopping bacteria from growing within the body by killing them. It is an analog of ampicillin, and its wide range of bactericidal qualities work on numerous Gram-positive and Gram-negative microorganisms. 

Available dosage, appearance and ingredients

In 250 mg or 500 mg capsule form: Each Amoxil capsule has an opaque form in royal blue and pink colors. Each capsule contains amoxicillin trihydrate equivalent to 250 mg or 500 mg of amoxicillin. The product name, AMOXIL, is printed onto the cap and body of each capsule, along with either 250 or 500 for the 250 mg or 500 mg version, respectively. The inactive ingredients include:

  • D&C Red No. 28
  • FD&C Blue No. 1
  • FD&C Red No. 40
  • gelatin
  • magnesium stearate
  • titanium dioxide

In 500 mg or 875 mg tablet form: As the trihydrate in each tablet, there is either 500 mg or 875 mg. Each tablet is debossed with AMOXIL. Below is either 500 or 875 for the 500 mg or 875 mg version, respectively. Additionally, the 875 mg tablet is scored on the back. Each tablet is pink, film-coated, and capsule-shaped.

The inactive ingredients include:

  • Colloidal silicon dioxide
  • Crospovidone
  • FD&C Red No. 30
  • aluminum lake
  • Hypromellose
  • magnesium stearate
  • microcrystalline cellulose
  • polyethylene glycol
  • sodium starch glycolate
  • titanium dioxide

Reconstituted suspension for oral treatment: The trihydrate will contain either 125 mg, 200 mg, 250 mg, or 400 mg of amoxicillin per 5 mL.

  • 125 mg of amoxicillin contains 2.51 mg of sodium per 5 mL.
  • 200 mg of amoxicillin contains 3.39 mg of sodium per 5 mL.
  • 250 mg of amoxicillin contains 3.36 mg of sodium per 5 mL.
  • 400 mg of amoxicillin contains 4.33 mg of sodium per 5 mL.

The inactive ingredients include:

  • FD&C Red No. 3
  • Flavorings
  • silica gel
  • sodium benzoate
  • sodium citrate
  • sucrose
  • xanthan gum

How should you take Amoxil?

Amoxil should be taken exactly as your doctor has prescribed. Pay attention to your prescription label and any instruction leaflets that accompany your medication. It is preferable that you take Amoxil at the same time each day of your course of treatment.

For the oral suspension, you should shake the bottle before measuring out a dose with either a dosing syringe or a medicine dose device, but do not use a regular cutlery spoon.

You may need frequent medical tests to check the efficacy of your course of treatment.

You should take the entire course of medication; do not stop because your symptoms have improved, as the infection may still be active.

How to store Amoxil

  • Amoxil should be stored at room temperature, make sure it is kept away from moisture, heat and light.
  • Amoxil can be stored in a refrigerator, but it shouldn’t be frozen. Discard any unused Amoxil 14 days after being mixed.

What are the potential side effects of Amoxil?

The most common side effects of Amoxil include nausea, vomiting, diarrhea, vaginal yeast infection and developing a rash.

Other possible side effects caused by Amoxil may include:

  • Hives
  • Breathing difficulties
  • Swelling of the face, lips, tongue, or throat
  • Fever
  • A sore throat
  • Burning eyes
  • Painful skin
  • Blistering and peeling skin with a red or purple rash
  • Severe stomach pain
  • Watery or bloody diarrhea, even months after your last dose

Warnings and precautions

Allergies and other conditions

  • If you are allergic to amoxicillin or any penicillin antibiotic, you should not use Amoxil. Other penicillin antibiotics include:
  • Ampicillin (Omnipen, Principen)
  • Dicloxacillin (Dycill, Dynapen)
  • Oxacillin (Bactocill)
  • Penicillin (beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids)
  • Others

You should make your doctor aware of any allergies to cephalosporins. These include:

  • Omnicef
  • Cefzil
  • Ceftin
  • Keflex
  • Others

You should also let your doctor know if you are asthmatic or have kidney disease. Also, tell them if you have a blood clotting disorder or mononucleosis (mono).

Birth control pills

Birth control pills can be rendered less effective by Amoxicillin, so you should seek a non-hormonal means of birth control. These include, but are not limited to:

  • Condoms
  • A diaphragm
  • Spermicide

Diarrhea

During the course of treatment, diarrhea can be caused by antibiotic medications, such as Amoxil, or can occur within a few months of the treatment ending. Diarrhea can indicate a new infection. If diarrhea is watery or bloody, patients should call their doctor and stop the course of Amoxil. Unless advised by your doctor, do not take any anti-diarrhea medications.

Anaphylactic Reactions

Hypersensitivity has been reported in some patients on penicillin, including amoxicillin. This can be serious, and fatalities have been reported. Anaphylaxis is more common after parenteral therapy, but it has also occurred among patients using oral penicillins. Patients with a history of penicillin hypersensitivity and sensitivity to different allergens are more likely to experience reactions. Some patients with penicillin hypersensitivity have experienced significant reactions when using cephalosporins.

Clostridium Difficile Associated Diarrhea

Almost all antibacterial agents, including Amoxil, have yielded reports of Clostridium Difficile Associated Diarrhea (CDAD). It can range from mild diarrhea to fatal colitis. Antibacterial agents can change the normal condition of the colon, resulting in an overflow of C. difficile, which can lead to CDAD. The use of antibiotics not targeting C. difficile should be ended if CDAD is suspected or has been detected. Protein, fluid, and electrolytes should be managed while C. difficile is treated with antibiotics.

Mononucleosis

An erythematous skin rash develops in a high number of patients on amoxicillin with mononucleosis.

Use In Pregnancy

While amoxicillin studies conducted in pregnant mice and rats showed no proof of harm to the fetus, there have not been enough studies on pregnant women. Animal reproductive behavior does not always closely reflect the human experience, so pregnant women should only be treated with amoxicillin when necessary.

Nursing Mothers

Since there is evidence that penicillins are excreted in human milk, it can cause sensitization in infants if used by nursing mothers. Doctors should be cautious about prescribing amoxicillin to nursing women.

Pediatric Use

Since renal function in neonates and young infants are still developing, the processing of amoxicillin may take longer. Amoxicillin dosing should be adjusted for patients who are 12 weeks old or younger.

Geriatric Use

Studies of Amoxil use amongst patients aged 65 or older have not yielded any evidence that the reaction is any different from that in younger patients. Despite that, a higher degree of sensitivity cannot be discounted amongst older patients. Extra consideration should be paid to how impaired renal function can mean the kidney takes longer to excrete the amoxicillin. Since it is more likely that elderly patients will suffer from compromised renal function, extra attention should be paid, and renal function should be monitored.

Interactions between Amoxil and other medications

Your doctor should be aware of all other medications you are taking. This is particularly important if you are taking:

  • Any other antibiotics
  • Allopurinol
  • Probenecid
  • A blood thinner, such as:
    • Warfarin
    • Coumadin
    • Jantoven

Disease interactions with Amoxil

There are 5 Amoxil disease interactions, and these include:

  • colitis
  • mononucleosis
  • diabetes
  • renal dysfunction
  • hemodialysis

Contraindications

Amoxil is contraindicated for:

Patients with a history of significant hypersensitivity reaction, such as anaphylaxis or Stevens-Johnson syndrome, after taking Amoxil or other similar antibiotics, penicillins, or cephalosporins.

Frequently Asked Questions

In its liquid form, Amoxil can be mixed with water, milk, baby formula or juice. Just be sure to immediately drink the entire mixture and do not save it for later use.

You should seek medical assistance immediately if you experience any of the mentioned side effects. You should also tell the doctor if you continue to experience side effects that upset you or that do not dissipate.

You should not share Amoxil with anyone else, even if your symptoms are the same.

Do not take Amoxil if you are allergic to any penicillin antibiotic. These include:
  • Ampicillin
  • Dicloxacillin
  • Oxacillin
  • Penicillin
  • Ticarcillin

For your own safety, your doctor should be made aware if you have:
  • kidney disease
  • mononucleosis (mono)
  • diarrhea caused by antibiotics
  • food or drug allergies (especially to cephalosporin antibiotics like:
    • Omnicef
    • Cefzil
    • Ceftin
    • Keflex
    • others

You should let your doctor know if you are taking any of the following:
  • Any other antibiotics
  • Allopurinol
  • Probenecid
  • A blood thinner, such as:
    • Warfarin
    • Coumadin
    • Jantoven
  • Other prescription and over-the-counter medicines
  • vitamins and herbal products
  • albuterol
  • amlodipine
  • aspirin
  • atorvastatin
  • Augmentin (amoxicillin / clavulanate)
  • Cipro (ciprofloxacin)
  • doxycycline
  • furosemide
  • gabapentin
  • ibuprofen
  • Lipitor (atorvastatin)
  • lisinopril
  • metformin
  • omeprazole
  • pantoprazole
  • Paracetamol (acetaminophen)
  • prednisone
  • ranitidine
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)

Amoxicillin kills bacteria, including bacteria that commonly cause tooth infections. Other antibiotics that are also good for fighting tooth infections include:
  • penicillin
  • cephalexin
  • clindamycin
  • azithromycin
The type of antibiotics your dentist prescribes will depend on any allergies or other issues you may have. However, Amoxicillin is usually the preferred choice as it is generally very effective and causes the fewest side effects concerning gastrointestinal issues.

Alcohol will not prevent amoxicillin from working, so yes, you may drink alcohol whilst taking Amoxicillin. Your doctor will advise that you refrain from drinking alcohol whilst taking Amoxicillin, this is so your body has the best possible chance of fighting your infection. Bear in mind that the body can become dehydrated due to alcohol consumption. Drinking alcohol can also interrupt your sleep patterns and interfere with your body’s natural healing process.

Alcohol should be avoided when you take particular antibiotics. This is due to the significant reaction that can occur from the combination of the antibiotic and alcohol. These include:
  • Metronidazole
  • Tinidazole
  • Bactrim
Taking alcohol with these antibiotics can result in side effects. These include:
  • Flushing
  • Headache
  • Nausea
  • Vomiting
  • Rapid heart rate
When it comes to taking amoxicillin, there are no side effects like these.

Whether in tablet or capsule form, amoxicillin will last roughly 2 years as long as it is kept in its original packaging and stored as advised. There is also usually a margin of safety beyond the expiry date. As for amoxicillin suspension, once it has been prepared, there is usually only a 7-10 day shelf life. It is important to remember that if you are prescribed a course of antibiotics, it is to be fulfilled, so there should not be any leftovers.

The most important difference between the two is that amoxicillin is more versatile as it fights a wider range of bacteria. Both belong to the same class of antibiotics: penicillins. The side effects of amoxicillin and penicillin are much the same:
  • abdominal pain
  • diarrhea
  • heartburn
  • nausea
  • vomiting
While amoxicillin may cause a rash, this is not necessarily indicative of an allergy. In combination with other medications, amoxicillin can treat:
  • genitourinary infections
  • acute, uncomplicated gonorrhea
  • pylori eradication
Penicillin can be used for treating or preventing:
  • rheumatic fever
  • chorea
  • bacterial endocarditis
  • bacterial meningitis
  • dental infections involving gum tissue

The medication should be discontinued immediately and the patient should be treated symptomatically. Introduce supportive measures as necessary. A study has shown that there are not usually any severe clinic symptoms associated with amoxicillin overdosages of less than 250 mg/kg.

If you miss a dose, simply skip it and take your next dose at your usual time. Do not attempt to take two doses at the same time to make up for it.

Depending on the dose prescribed by the doctor, patients may take Amoxil every 8 hours or every 12 hours.

Tap the container until all the powder shakes loose. Add around 1/3 of the total amount of water for reconstitution and then shake the container vigorously to wet the powder. Add the rest of the water and shake vigorously again.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.