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What is Azopt (Brinzolamide)?

Azopt is a prescription medication that consists of a 1% liquid solution of Brinzolamide that comes in either 10mL or 15mL dropper bottle. This means that each mL of solution contains 10mg of the active, generic drug Brinzolamide. This is the only strength available. It is approved by the FDA to treat ocular hypertension and open-angle glaucoma by reducing the pressure inside the eye.

How does it work?

It works by inhibiting carbonic anhydrase, an enzyme involved in aqueous humor production in the eye. By preventing this enzyme from working, it reduces the amount of fluid produced by the eye, reducing the pressure inside the eye. Increased pressure in the eye can cause pain and, if left untreated, can permanently damage vision.

How to use Azopt

Eye drops can be administered alone or with the help of someone else.

Remove any contact lenses before applying eye drops. A preservative in this medicine can cause staining of soft contact lenses. Any contact lenses can be replaced 15 minutes after administration of medication.

Shake the bottle before use.

1. Wash your hands and dry thoroughly.
2. Remove the cap and place it in a clean area.
3. Tilt your head back and gently pull down on the lower lid of the affected eye.
4. Using your other hand, apply one drop to the space created by pulling down on the lower lid.
5. Do not touch the eye or the skin with the tip of the dropper. A contaminated dropper could result in an infection of the eye.
6. Repeat with the other eye if advised to do so by your doctor.
7. Replace the cap and ensure a tight seal.
8. Wash your hands again to remove any medication that may have transferred to your hands.

Storage

This medication should be stored at room temperature, between 39°F and 86°F (or between 4°C and 30°C). Keep out of reach of children. Avoid storing in areas that could become damp or wet. Do not ingest this medication orally.

Dosage

The recommended dose is one drop of solution to the affected eye(s), two times daily. Your doctor may prescribe Azopt up to three times per day depending on your situation.

Side Effects

If you experience an allergic reaction,  stop taking the medication immediately and seek medical attention. Signs of a severe allergic reaction can show up in the form of hives, difficulty breathing and/or swelling of the face or throat.

Stop taking the medication immediately and seek medical attention if you experience a skin reaction to this medication. This can include blistering, peeling of the skin, or a rash that covers a large area, spreads quickly or is associated with a fever.

Blurred vision and altered taste are common side effects. These typically affect 5-10% of people using Azopt.

Uncommon side effects, reported in 1-5% of those using Azopt, are chest discomfort, cough, diarrhea, dizziness, headache, eye discomfort, dryness, or redness of the eye, nasal, or throat discomfort

Rare side effects seen in <1% of people include alopecia, angina, drowsiness, irritability, optic nerve dysfunction, respiratory disorders, blood disorders, and tinnitus.

You may experience side effects other than those listed above. If you are concerned, always check with your doctor.

Warnings and Precautions

It is important to let all of your healthcare providers know all of the medication that you are taking, diagnosed medical conditions and any allergies. Remember to include any over-the-counter medications, vitamins, supplements, herbal medicines, and recreational drugs.

It is advised against using Azopt in patients with hepatic impairment.

Use with caution if patients have renal tubular immaturity or abnormality, due to the risk of metabolic acidosis. This medication should not be used by patients with severe impairment of kidney function. Azopt can lead to systemic sulfonamide-like side effects in very rare cases. This includes lethargy, dizziness, nausea, vomiting, headache, and photosensitivity. Serious skin rashes may also occur, such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Discontinuation of Azopt may be required if severe side effects occur, and you should consult your physician.

The safety and efficacy of Azopt have not been established in children under the age of 18.

Avoid using medication if pregnant, since the possible side effects are unknown.

Since it is unclear if Azopt is passed through breastmilk, it is best to avoid for breastfeeding mothers.

Interactions

Medications known to interact with Azopt include:

• Acetazolamide
• Alpha/Beta-agonists (e.g. epinephrine, norepinephrine)
• “Azole” antifungals (e.g. itraconazole, ketoconazole, voriconazole)
• Aspirin
• Bismuth subsalicylate
• Boceprovir
• Choline salicylate
• Clarithromycin
• Conivaptan
• Delavirdine
• Dichlorphenamide
• Diflunisal
• Dorzolamide
• HIV protease inhibitors (e.g. atazanavir, darunavir, lopinavir, ritonavir)
• Magnesium salicylate
• Methazolamide
• Nelfinavir
• Telaprevir
• Salsalate
• Sodium salicylate
• Sodium thiosalicylate
• Topiramate
• Zonasamide

If you are currently taking any medications mentioned above, consult with your doctor or pharmacist. It may be necessary to stop taking one of the medications; change one of the medications to an alternative; change how or when you take one or both medications, or your healthcare professional may decide it is best to leave all medications as they are.

The list above may not contain all medications known to interact with Azopt. It is important that you inform your doctor of all medications, herbal medications, supplements, over-the-counter medications, and recreational drugs that you are taking.

Contraindications

• Do not use during pregnancy
• Do not use if you are breastfeeding
• If you have a known allergy to brinzolamide
• If you have a known allergy to any drug in the sulfonamide group
• If you have hyperchloremic acidosis (an increase in the acidity of the blood)
• If you are taking oral carbonic anhydrase inhibitors – e.g., acetazolamide or methazolamide.
• Do not use if you have severe kidney disease. This can reduce the ability of the body to process the active ingredient of Azopt.
• Do not use if you are allergic to any of the listed ingredients in the solution.

Inform your doctor if any of the contraindications mentioned above apply to you.

Frequently Asked Questions

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.