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Lotrel Amlodipine Besylate, Benazepril Hydrochloride
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What is Benazepril?

Benazepril helps lower high blood pressure. Doctors often use it alone or with other medications to treat hypertension. It belongs to a group of drugs called ACE inhibitors. 

Benazepril relaxes blood vessels, making it easier for the heart to pump blood. This helps reduce the risk of serious health problems like stroke, heart failure, or kidney damage. It comes in tablet form and is available as a brand-name drug (Lotensin) and a more affordable generic version.

Do not take benazepril if you are pregnant or become pregnant, as it can harm or even end a pregnancy. This medication also risks severe swelling in the face, lips, tongue, throat, or stomach. 

Call your doctor right away if this happens. People with a history of allergic reactions to ACE inhibitors or those with specific kidney problems should avoid this medication.

Always talk to your doctor about your health history before using benazepril.

How Does Benazepril Work?

Benazepril helps lower high blood pressure by widening the blood vessels. It does this by blocking a natural chemical in the body that causes the vessels to tighten. When the vessels are more relaxed, blood can flow more easily.

This takes some pressure off the heart and helps it work better. With better blood flow, the heart gets more oxygen, which helps prevent serious problems like heart attacks or strokes. 

Benazepril is often used to keep the heart and blood pressure in a healthy range.

Benazepril Dose and Administration

Benazepril is an orally administered medication used to lower high blood pressure. The usual starting dose for adults is 10 mg once a day.

Over time, the dose may be increased to help control blood pressure better. It can be taken with or without food, but it should be taken at the same time each day.

The benazepril dose may be different for children and older adults based on weight, kidney function, or other health conditions.

Taking too much can lead to serious health problems, known as benazepril overdose, so always follow the directions given by your doctor.

Dosage Form and Strengths of Benazepril

Benazepril comes in tablet form and is available in different strengths. These are the most common benazepril dosage forms:

  • 5 mg
  • 10 mg
  • 20 mg
  • 40 mg

How to Take Benazepril?

It is important to follow each step when taking benazepril to make sure it works properly and safely:

  1. Take the tablet by mouth with a glass of water.
  2. Try to take it at the same time every day.
  3. You can take it with or without food.
  4. Do not skip doses or stop taking it without talking to your doctor.
  5. If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not take two doses at once.
  6. If you think you took too much, call your doctor or go to the emergency room right away. A benazepril overdose can be dangerous.

Recommended Dosage per Population or Condition

Dosage for benazepril depends on age, health, and kidney function.

  • Adults (18 to 64 years): The starting dose of Benazepril is 10 mg, taken once daily. The maintenance dose ranges from 20 to 40 mg daily, taken as a single dose or split into two smaller doses. This dose is intended to lower blood pressure and may be adjusted depending on how your body responds.
  • Children (6 to 17 years): The typical starting dose is 0.2 milligrams per kilogram of body weight once a day. The dose may be adjusted, but it should not exceed 0.6 milligrams per kilogram or 40 milligrams per day. Children with poor kidney function, defined as a creatinine clearance under 30 milliliters per minute, should not use benazepril.
  • Children (under 6 years): Benazepril is not recommended for children under 6.
  • Older adults (65 years and older): The kidneys may work more slowly in older adults. Therefore, the benazepril dose may be lower to avoid side effects. The doctor may begin with a smaller dose and monitor closely to prevent a benazepril overdose.
  • People with kidney problems: The dose is based on how well the kidneys work. A lower dose may be needed to keep benazepril safe and effective.

Benazepril Side Effects

Benazepril is used to help control high blood pressure, but like all drugs, it can cause side effects. Some Benazepril side effects are mild, such as headache or dizziness, while others can be more serious, like facial swelling or a severe skin reaction. Knowing what to watch for helps you stay safe while using this drug.

Common Side Effects

These Benazepri common side effects are usually mild and may go away on their own:

  • Headache
  • Dry cough
  • Dizziness, especially when standing up
  • Sleepiness or drowsiness
  • Feeling tired or weak
  • Nausea
  • Cold sweats
  • Confusion
  • Lightheadedness
  • Minor skin rash

Severe Side Effects

Long-term side effects of benazepril or serious reactions may need urgent care. Call your doctor right away if you notice any of these:

  • Swelling of face, lips, tongue, or throat (angioedema)
  • Trouble breathing
  • Blistering or peeling skin
  • Raised welts or hives
  • Chest pain or tightness
  • Rapid heartbeat
  • Severe dizziness or fainting
  • Fever or sore throat (signs of infection)
  • Pain in the stomach with nausea or vomiting
  • Red, irritated eyes or mouth sores
  • Itching or large hives
  • Joint or muscle pain
  • Erectile dysfunction or lower sex drive
  • Sudden weight gain or swelling in the legs or feet

If any of these serious Benazepril side effects happen, stop using it and get medical help right away. Even if you feel fine, monitor your body for any new symptoms during long-term use.

Warnings and Precautions for Benazepril

If you are taking benazepril, it is important to understand how it might affect your body. This medication helps control blood pressure, but it can also cause serious problems in some people.

You need to be careful if you have certain health conditions or if you take other medications. Always talk to your doctor about benazepril overdose, benazepril interactions, and benazepril contraindications before starting this treatment.

  • Do not take benazepril if you have had a serious allergic reaction, including swelling, rash, or peeling skin.
  • If you have kidney problems, benazepril can build up in your body and increase side effects.
  • If you have liver disease, benazepril may worsen your condition or cause liver damage.
  • Stop taking benazepril and call your doctor if you notice yellow skin or eyes, which may indicate liver problems.
  • If you are pregnant, do not take benazepril, because it can harm your unborn baby.
  • If you become pregnant while taking benazepril, stop the medication and call your doctor right away.
  • Benazepril can pass into breast milk and may not be safe while breastfeeding.
  • Older adults may process benazepril more slowly, raising the risk of side effects.
  • Children younger than 6 years should not take benazepril.
  • Do not take benazepril with sacubitril or within 36 hours of taking sacubitril or sacubitril-valsartan.
  • This medication can cause serious allergic reactions like anaphylaxis, which requires emergency medical care.
  • Call your doctor if you have swelling of the face, lips, tongue, or throat, especially if it affects breathing.
  • Call your doctor if you have severe stomach pain, even without nausea or vomiting.
  • This medication may lower your blood pressure too much, especially if you are also taking a water pill.
  • Be careful when standing up from sitting or lying down to avoid dizziness or fainting.
  • Drink plenty of water to avoid dehydration, especially during hot weather or exercise.
  • If you have ongoing nausea, vomiting, or diarrhea, call your doctor because it may lead to low blood pressure.
  • Tell your doctor if you get a sore throat, fever, or chills, as these may be signs of infection.
  • This medication can cause high potassium levels, which may lead to heart problems or weakness.
  • Talk to your doctor before using salt substitutes, potassium supplements, or other drugs that affect potassium.
  • If you notice dark urine, pale stools, or upper stomach pain, tell your doctor right away because it may be liver trouble.
  • Let your dentist or doctor know you use benazepril before surgery or medical tests.
  • This medication may not work as well in black patients and may increase the risk of allergic reactions.
  • Always check with your doctor before using any new prescription, over-the-counter, or herbal medications because of possible benazepril interactions.

Benazepril Interactions

Benazepril can interact with many other medicines, vitamins, or herbal products. These interactions can change how benazepril works or increase the likelihood of side effects.

Always tell your doctor about everything you are taking before you start using benazepril.

  • sacubitril
  • benazepril
  • captopril
  • enalapril
  • enalaprilat
  • fosinopril
  • moexipril
  • perindopril
  • qunapril
  • ramipril
  • trandolapril
  • irbesartan
  • losartan
  • olmesartan
  • telmisartan
  • valsartan
  • amlodipine
  • felodipine
  • nicardipine
  • nifedipine
  • bumetanide
  • furosemide
  • indapamide
  • torsemide
  • eplerenone
  • spironolactone
  • triamterene
  • chlorthiazide
  • chlorthalidone
  • hydrochlorothiazide
  • metolazone
  • imidapril
  • amiloride
  • pramlintide
  • metformin
  • exenatide
  • liraglutide
  • lixisenatide
  • saxagliptin
  • sitagliptin
  • insulin
  • nateglinide
  • repaglinide
  • glimepiride
  • glipizide
  • glyburide
  • canagliflozin
  • dapagliflozin
  • empagliflozin
  • pioglitazone
  • rosiglitazone
  • lithium
  • celecoxib
  • diclofenac
  • ibuprofen
  • indomethacin
  • ketoprofen
  • ketorolac
  • meloxicam
  • nabumetone
  • naproxen
  • potassium supplements
  • potassium-based salt substitutes
  • sodium thiomalate
  • temsirolimus
  • sirolimus
  • everolimus

Alternative Medications to Benazepril

If you cannot take Benazepril or it is not working well, other medications can help treat high blood pressure or heart conditions. These medications work in different ways but can provide similar benefits. Your doctor can help choose the one that is right for you.

  • Zestril (lisinopril)
  • Norvasc (amlodipine)
  • Cozaar (losartan)
  • Microzide (hydrochlorothiazide)
  • Lopressor (metoprolol)
  • Tenormin (atenolol)
  • Coreg (carvedilol)

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  3. Upload your prescription on the website, email it to info@pharmagiant.com, or fax it to 1-888-562-8159.

Frequently Asked Questions

Benazepril is used to treat high blood pressure. It helps lower the pressure in your blood vessels so your heart does not have to work as hard. Benazepril is also sometimes used to treat heart failure or to protect the kidneys in people with diabetes.
Taking benazepril in the morning is best, as morning doses have longer-lasting effects.
Benazepril is usually taken once or twice daily, depending on your prescribed dose.
You should not stop taking benazepril suddenly without talking to your doctor, even though it usually does not cause a sudden rise in blood pressure. It is best to prevent it gradually under medical supervision.
You should avoid taking benazepril with sacubitril, certain blood pressure medications, diabetes drugs, mood stabilizers like lithium, NSAID pain medications, potassium supplements or salt substitutes, gold-based medications, and transplant drugs such as sirolimus or everolimus, as these can cause harmful interactions.
Benazepril rarely causes erectile dysfunction. It works by widening blood vessels and increasing blood flow, which usually does not affect erectile function. Erectile dysfunction occurs in less than 1% of patients taking benazepril.
Benazepril itself does not usually cause weight gain. However, if it affects kidney function, especially in people with kidney problems, it may lead to swelling in the legs or ankles and unexplained weight gain.
Benazepril starts to work within 1 hour, with peak effects in 2 to 4 hours. Its effects usually last about 24 hours.
Anxiety is a possible but uncommon side effect of benazepril.
No, benazepril is not the same as amlodipine. Benazepril is an ACE inhibitor, while amlodipine is a calcium channel blocker. They lower blood pressure in different ways.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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