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Braftovi (Encorafenib)
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Braftovi Encorafenib
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What is Braftovi?

Braftovi (encorafenib) is a special treatment for certain types of cancer, such as skin cancer (melanoma), colorectal cancer, and lung cancer.

It is often used with other treatments, like binimetinib or cetuximab, to help fight the cancer.

  • Melanoma: Braftovi is used with binimetinib to treat melanoma that cannot be removed by surgery or has spread to other body parts.
  • Colorectal Cancer: Braftovi is also used in combination with cetuximab and mFOLFOX6 to treat colorectal cancer that has spread.
  • Lung Cancer: In non-small cell lung cancer cases, Braftovi is combined with binimetinib to treat the cancer when it has spread to other parts of the body.

Before starting Braftovi, doctors test for a gene change called the “BRAF” mutation in the cancer cells. Braftovi can help slow down the cancer’s growth if this gene change is found.

Braftovi should not be used if the cancer does not have this specific gene change, so the test is important to ensure it is the proper treatment.

Also, Braftovi has not been tested or proven to work for children, so it is only used for adults with certain cancer conditions.

How Does Braftovi Work?

Braftovi works by blocking a signal inside cancer cells that helps them grow. Some cancers have a change in their BRAF gene, which makes the cells grow uncontrollably.

Braftovi targets this change to stop the cancer from spreading.

It blocks the BRAF protein that helps these cancer cells grow, especially in skin, colon, and lung cancers with a BRAF V600E mutation.

When Braftovi is used with other treatments like binimetinib, it can work even better by stopping multiple signals that cause the cancer to grow. This combination helps shrink tumors and can even stop the cancer from returning for a longer time.

Braftovi works by keeping the cancer cells from getting the signals they need to grow, slowing down or stopping the cancer’s progress.

Dosing Information and Usage

Braftovi comes in capsule form, and the correct dosage depends on the type of cancer and your health condition.

Dosage Form and Strengths of Braftovi

Braftovi dosing is available in 75 mg capsules, hard gelatin capsules with a beige cap and a white body.

The capsules are labeled with a stylized “A” on the cap and “LGX 75mg” on the body. For proper Braftovi dosage, following your healthcare provider’s instructions is essential.

How to Use Braftovi?

Before starting Braftovi, confirm the presence of a specific mutation (BRAF V600E or V600K) in the tumor. Your doctor will do tests to make sure you are the right candidate for Braftovi treatment.

Take Braftovi capsules once a day at the same time. You can take the capsules with or without food.

Do not take more than your prescribed dose. If you miss a dose, skip it and take your next dose at the regular time. Do not double the dose.

If you throw up after taking Braftovi, just skip the missed dose and continue with the next dose as planned.

Here are the recommended dosages for the different conditions:

  • For melanoma and lung cancer: The recommended dose is 450 mg (six 75 mg capsules) daily, taken with binimetinib.
  • For colorectal cancer: The recommended dose is 300 mg (four 75 mg capsules) daily, taken with cetuximab and mFOLFOX6 (fluorouracil, leucovorin, and oxaliplatin).

If you need to reduce the dose, your doctor will tell you to take fewer capsules.

Braftovi Side Effects

Braftovi is an effective medication for treating cancer, but like all medications, it may cause some side effects.

Common Braftovi side effects include fatigue, nausea, and vomiting, while more severe side effects can include heart problems, liver issues, and bleeding.

Common Side Effects

  • Fatigue
  • Nausea
  • Vomiting
  • Abdominal pain
  • Pain or swelling of joints (arthralgia)
  • Diarrhea
  • Decreased appetite
  • Rash

Severe Side Effects

  • Heart problems: Racing heart, shortness of breath, swelling in hands, ankles, or feet, feeling faint.
  • Liver issues: Yellowing of skin/eyes, dark urine, nausea, vomiting, loss of appetite, tiredness, bruising, and bleeding.
  • Bleeding problems: Headaches, dizziness, coughing up blood, vomiting blood, red/black stools, nosebleeds.
  • Eye problems: Blurred vision, eye pain, or swelling.
  • QT prolongation: Irregular heartbeats, dizziness, or lightheadedness.

Warnings and Precautions

Braftovi can cause serious side effects, so it is important to be careful and watch for warning signs.

Doctors will monitor you closely during treatment to make sure everything is safe.

Below are some things to watch out for when using Braftovi:

  • Braftovi can cause new types of skin cancer. This includes squamous cell carcinoma, basal cell carcinoma, and melanoma. You must check your skin before starting Braftovi and then every two months while on treatment.
  • Braftovi can worsen some cancers, especially those linked to changes in specific genes. Make sure your doctor checks for these problems during treatment.
  • Braftovi can harm your heart and cause problems like a weak heart. Your doctor will check your heart regularly with tests.
  • Braftovi can hurt your liver. Your doctor will check your liver function before you start and during treatment.
  • Braftovi can cause bleeding problems. Some people may have severe bleeding, including in the stomach or brain. Tell your doctor right away if you notice any bleeding.
  • Braftovi can affect your eyes and cause eye problems like uveitis. You should get your eyes checked regularly during treatment.
  • Braftovi can change how your heart beats and cause QT prolongation. If you have heart problems or take medications for heart issues, your doctor will monitor you closely.
  • Braftovi can hurt a baby in the womb. If you are pregnant or planning to get pregnant, Braftovi should not be used. If you can get pregnant, use birth control while taking Braftovi and for at least two weeks after your last dose.
  • If you use Braftovi by itself, it can cause more side effects than if you take it with other medications. Your doctor will adjust your dose if needed.
  • If you take Braftovi with other medications, like binimetinib, cetuximab, or mFOLFOX6, follow your doctor’s instructions carefully for those treatments.

Drug Interactions With Other Medications

When taking Braftovi, you need to be careful with other drugs. Some drugs can make Braftovi too strong, leading to more side effects. Others can make Braftovi too weak, so it may not work properly. Some drugs may also become stronger or weaker because of Braftovi.

Here is what you should know:

  • Strong or moderate CYP3A4 inhibitors (like grapefruit juice, certain antibiotics, antifungals, and antivirals): These drugs can increase the amount of Braftovi in your body, which may cause more side effects. It is best to avoid them. If you must take them, your doctor might lower your Braftovi dose.
  • Strong CYP3A4 inducers (like rifampin, phenytoin, carbamazepine, and St. John’s Wort): These drugs can weaken Braftovi, making it less effective. It is better to avoid taking them with Braftovi.
  • Sensitive CYP3A4 substrates (like hormonal contraceptives): Braftovi can make these drugs less effective. If you use birth control pills, they may not work well, so you might need another method to prevent pregnancy.
  • OATP1B1, OATP1B3, or BCRP substrates (like statins and some chemotherapy drugs): Braftovi can strengthen these drugs, which may cause more side effects. Your doctor may need to adjust your dose.
  • Drugs that prolong the QT interval (like some heart drugs, antidepressants, and antibiotics): Braftovi can affect your heart rhythm. If you take these together, your risk of heart problems may increase. It is safer to avoid them.

Braftovi Alternatives

If you need a different option instead of Braftovi, other drugs may help treat similar conditions. These Braftovi alternatives work in various ways, so your doctor can help you choose the best one.

  • Keytruda (pembrolizumab)
  • Opdivo (nivolumab)
  • Tagrisso (osimertinib)
  • Alimta (pemetrexed)
  • Avastin (bevacizumab)
  • Imfinzi (durvalumab)

Save on Braftovi from Canada

Fighting cancer is already one of the toughest battles anyone can face, and no one should have to struggle with the high cost of treatment on top of that.

But for many people, the price of Braftovi makes it hard to get the care they need. Worrying about whether you can afford your next dose is unfair when all you should focus on is getting better.

The good news is that there are ways to save, and patients in Canada can access Braftovi at much lower prices.

By choosing a trusted source, you can get the same safe and effective treatment without the stress of sky-high costs. No more skipping doses, stretching out prescriptions, or making impossible financial choices.

Instead, you can confidently focus on your health, knowing your treatment is affordable and delivered straight to your home. Fast, secure shipping makes it easy to stay on track, so you never have to worry about running out.

Everyone deserves access to life-saving treatment, no matter their budget. You should be able to fight your illness without the added stress of high prices.

With lower-cost options, you can control your health without breaking the bank. Your well-being should always come first.

How to Order Braftovi Online?

  1. To order Braftovi, search for it using the search bar at the top of the website. Once on the product page, select the desired strength and click “Buy” to add it to your cart. If you need other medications, continue adding them to your cart.
  2. When your cart is ready, proceed to checkout. Enter your contact, payment, and shipping details. If you are new to the site, create an account with your email and password. If you are a returning customer, log in. Apply the coupon code PGSAVE10 to get a 10% discount on your first order. After entering all the necessary information, submit your order, and you will receive a confirmation email.
  3. Next, upload or send us your prescription. You can upload it directly after placing your order, email a scanned copy to info@pharmagiant.com, or fax it to 1-888-562-8159. If no prescription is needed, your order will be processed without it. If we do not receive your prescription, our team will contact you.

Frequently Asked Questions

Braftovi is used to treat certain types of cancer, like melanoma (skin cancer) and colon cancer. It helps stop cancer cells from growing and spreading.

Yes, Braftovi is considered part of a chemotherapy regimen when used with Binimetinib to treat melanoma.

Braftovi blocks specific proteins in cancer cells that help them grow and spread. This helps stop or slow down cancer’s growth, especially melanoma.

Braftovi may take some time to show its effects. Continue using effective non-hormonal contraception during treatment and for at least 30 days after, as Braftovi can make hormonal contraceptives less effective.

In a study, people who took Braftovi with Mektovi lived for about 15 months, while people who took another medication lived for about 7 months. However, not everyone will get the same results. It works differently for different people.

Braftovi is taken by mouth. The usual dose is six 75 mg capsules, which equals 450 mg, once daily. It is taken along with another medication called binimetinib, and it is continued until the disease gets worse or if you have bad side effects.

The half-life of Braftovi is about 3.5 hours. This means it takes about 3.5 hours for half of the medication to leave your body. It works this way to keep the right amount of medication in your system.

Braftovi can make birth control pills not work as well, so it is important to use a different type of birth control, like a condom, while taking it and for 30 days after. Braftovi can also cause eye problems, like blurry vision, so tell your doctor immediately if your eyes feel different. It can also affect your skin, causing rashes or other issues, so let your doctor know if your skin changes. If you have heart problems or other health issues, tell your doctor before starting Braftovi.

Braftovi can cause temporary hair loss in some people. If this happens, your hair will likely return to normal once you stop taking the medication.

Yes, Braftovi can cause anemia in some people. In studies, about 34% of people taking Braftovi experienced anemia.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

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