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What is Cibinqo?

Cibinqo (abrocitinib) is a prescription medication designed to treat moderate-to-severe eczema (atopic dermatitis) in adults and adolescents aged 12 years and older. It’s used when other treatments have not worked well or aren’t suitable, including biologic medications. 

Cibinqo works by inhibiting Janus Kinase (JAK), which helps to control the inflammation associated with eczema.

It’s important to note that Cibinqo’s safety and effectiveness haven’t been established for children under 12. If you are taking medications that prevent blood clots (except low-dose aspirin up to 81 mg daily during the first 3 months of Cibinqo treatment), you should avoid taking Cibinqo.

How Does Cibinqo Work?

Cibinqo, also known as abrocitinib, works by blocking an enzyme in the body called Janus kinase (JAK). This enzyme is crucial for causing inflammation, a key factor in eczema. 

By targeting and stopping JAK1, Cibinqo helps reduce inflammation and relieve eczema itching. This JAK inhibitor interrupts the inflammatory processes that worsen eczema symptoms, providing relief for those with unresponsive conditions.

Dosage Information and Usage

Dosage Form and Strengths of Cibinqo

  • 50 mg: Pink, oval, film-coated tablet with “PFE” on one side and “ABR 50” on the other.
  • 100 mg: Pink, round, film-coated tablet with “PFE” on one side and “ABR 100” on the other.
  • 200 mg: Pink, oval, film-coated tablet with “PFE” on one side and “ABR 200” on the other.


Cibinqo should be taken exactly as prescribed by your healthcare provider:

  • Take Cibinqo once daily, around the same time each day.
  • Swallow the tablets whole with water; do not crush, split, or chew them.
  • You can take Cibinqo with or without food.
  • It can be used alongside prescribed topical steroid medicines for eczema.
  • If you miss a dose, take it as soon as possible. If it’s less than 12 hours until your next dose, skip the missed dose and take the next one at your regular time.

Limitations of Use

Cibinqo should not be used together with other JAK inhibitors, biologic immunomodulators, or other immunosuppressants unless advised by your healthcare provider.

Storage Information

Store Cibinqo at 20°C to 25°C (68°F to 77°F), with short-term deviations allowed between 15°C to 30°C (59°F to 86°F). Keep it in its original, child-resistant packaging to maintain effectiveness and ensure safety.

Side Effects of Cibinqo

Common Side Effects

  • Common cold
  • Nausea
  • Headache
  • Herpes simplex (cold sores)
  • Increased blood level of creatine phosphokinase (a muscle enzyme)
  • Dizziness
  • Urinary tract infection
  • Tiredness
  • Acne
  • Vomiting
  • Mouth and throat pain
  • Flu
  • Stomach flu
  • Bacterial skin infection
  • High blood pressure
  • Allergic skin rash from contact with something
  • Stomach pain
  • Shingles
  • Low platelet count

Serious but Rare Side Effects

  • Serious infections:
    • serious infections such as tuberculosis (TB),
    • bacterial, fungal,
    • viral infections that may spread throughout the body
  • Major cardiovascular events:
    • chest discomfort,
    • severe chest pain,
    • weakness on one side of the body,
    • slurred speech,
    • shortness of breath
  • Blood clots

Warnings and Precautions

Cibinqo comes with important warnings due to serious risks:

  • Serious Infections: Cibinqo can increase the risk of severe infections like tuberculosis (TB), pneumonia, and herpes infections. These infections can lead to hospitalization or even be fatal. Avoid using Cibinqo if you have a serious infection and monitor for signs of infection during treatment.
  • Mortality: Another JAK inhibitor, similar to Cibinqo, has shown a higher rate of overall mortality, including sudden cardiovascular death, compared to TNF blockers in rheumatoid arthritis patients. Rheumatoid arthritis (RA) is a long-term disease-causing inflammation throughout the body, often resulting in joint pain. Cibinqo is not approved for use in RA patients.
  • Malignancy and Lymphoproliferative Disorders: There have been reports of cancers including lymphomas and skin cancers in patients using Cibinqo. Regular skin checks are recommended, and caution should be taken, especially in patients with a history of cancer or those who smoke.
  • Major Adverse Cardiovascular Events (MACE): Some patients using Cibinqo have experienced major heart-related events like heart attacks or strokes. This risk may be higher in patients with cardiovascular risk factors or those who smoke.
  • Thrombosis: Cibinqo has been linked to blood clot issues like deep vein thrombosis (DVT) and pulmonary embolism (PE). DVT occurs when a blood clot forms in one of the deep veins, usually in the legs. PE is a blood clot that develops in a blood vessel, often in the leg, and travels to a lung artery, blocking blood flow. This risk is higher in older patients with cardiovascular conditions.
  • Laboratory Abnormalities: Treatment with Cibinqo can affect blood cell counts and lipid levels. Regular blood tests are necessary to monitor for these abnormalities.
  • Immunizations: Before starting Cibinqo, ensure all recommended vaccinations are up to date, including herpes zoster vaccines. Live vaccines should be avoided during treatment with Cibinqo to prevent complications.

Drug Interactions With Other Medications

  • Strong CYP2C19 Inhibitors: Drugs such as fluconazole and fluvoxamine inhibit the CYP2C19 enzyme, which helps break down Cibinqo. Taking these drugs together can raise the levels of Cibinqo and its active forms (M1 and M2) in the body, potentially causing more side effects. To manage this, doctors may reduce the Cibinqo dose when used with these inhibitors.
  • Moderate to Strong Inhibitors of both CYP2C19 and CYP2C9: These drugs block the CYP2C19 and CYP2C9 enzymes, which help break down Cibinqo. When used with Cibinqo, they can increase its levels in the body and cause more side effects. To avoid this risk, it’s best not to use these inhibitors with Cibinqo.
  • Strong CYP2C19 or CYP2C9 Inducers: Drugs like rifampin and carbamazepine speed up the CYP2C19 or CYP2C9 enzymes, which help break down Cibinqo. When taken with Cibinqo, these inducers can lower its levels in the body, possibly reducing its effectiveness. It’s recommended to avoid using these inducers with Cibinqo to ensure they work properly.
  • P-glycoprotein (P-gp) Substrates: Cibinqo blocks the P-gp transporter, which usually removes drugs like digoxin from cells. When taken with these drugs, Cibinqo can cause their levels in the blood to rise since they aren’t being cleared from the body as effectively. This can lead to stronger drug effects or more side effects. Doctors may need to monitor and adjust the doses of these drugs when used with Cibinqo.
  • Antiplatelet Therapy Drugs: Using antiplatelet drugs with Cibinqo, other than low-dose aspirin, may increase the risk of bleeding. Cibinqo can lower platelet count, and combining it with other antiplatelet drugs can further raise bleeding risk. Avoid using these drugs together during the first 3 months of Cibinqo treatment to prevent bleeding complications.

Important Information or Questions to Tell Your Healthcare Before Taking Cibinqo

  1. Infections: Before starting Cibinqo, let your doctor know if you have any infections, are being treated for one, or have symptoms like fever, cough, or diarrhea. Cibinqo can increase the risk of infections or worsen existing ones. Your doctor may need to pause treatment if a serious infection develops.
  2. Cardiovascular Health: If you’re 50 years or older with heart disease risk factors, such as high blood pressure or diabetes, taking Cibinqo could increase your risk of serious cardiovascular events like a heart attack or stroke, especially if you’re a current or past smoker. Discuss your heart health history with your doctor before starting treatment.
  3. Cancer Risks: Cibinqo may affect your immune system and increase the risk of certain cancers like lymphoma and skin cancers. If you have a history of cancer or are a current or past smoker, your risk may be higher. Your doctor may recommend regular skin checks and precautions against sun exposure.
  4. Medical History: Inform your doctor about any medical conditions you have, including diabetes, chronic lung disease, HIV, weak immune system, tuberculosis (TB), shingles, hepatitis B or C, kidney or liver problems, abnormal blood tests, high cholesterol, eye problems, or past blood clots in your legs or lungs.
  5. Travel History: Tell your doctor if you’ve lived or traveled to areas where fungal infections are common, such as certain regions in the United States. Taking Cibinqo may increase your risk of these infections.
  6. Smoking History: If you’re a current or past smoker, discuss this with your doctor before starting Cibinqo, as it may affect your risk of certain side effects like cardiovascular events and cancers.
  7. Vaccinations: Before starting Cibinqo, ensure you’re up to date with all vaccinations recommended for your age. However, live vaccines should not be given while on Cibinqo. Discuss your vaccination history and plans with your doctor.
  8. Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your doctor. Cibinqo’s effects on pregnancy and breastfeeding are not fully known, and your doctor can provide guidance based on your specific situation.
  9. Medication and Supplements: Tell your doctor about all medications you’re taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Certain medications, especially antiplatelet therapies, can interact with Cibinqo and cause side effects.

Cost & Discounts

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StrengthQuantityPrice (USD)
50mg30 tablets$2,299.50
100mg30 tablets$2,299.50
200mg30 tablets$2,573.55

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Cibinqo is used to treat moderate to severe atopic dermatitis (eczema) in adults and adolescents.

Cibinqo works by blocking certain proteins in the body that are involved in the immune system’s inflammatory response, reducing symptoms of eczema like itching, redness, and swelling.

Cibinqo was FDA approved on January 14, 2022.

Yes, Cibinqo can make you tired. Fatigue is one of the possible side effects reported by some people taking this medication. 

Cibinqo can start working quickly, with some people feeling relief from itching in just 2 weeks. In clinical trials, 13% of those taking 100 mg and 25% of those taking 200 mg experienced significant itch relief within this time frame.

The main difference between Cibinqo and Rinvoq is their approved uses. Cibinqo is specifically approved for treating moderate-to-severe atopic dermatitis (eczema) in adults and adolescents. Rinvoq, however, has multiple approved uses including moderate to severe rheumatoid arthritis in adults, psoriatic arthritis in adults, and other inflammatory conditions.

Cibinqo is FDA-approved for adults and adolescents aged 12 and older with moderate to severe atopic dermatitis.

While taking Cibinqo, avoid being around people who have recently received live vaccines, like the nasal flu vaccine. Stay out of the sun as much as possible, and don’t use tanning booths or sunlamps. Also, don’t take Cibinqo with strong CYP2C19 or CYP2C9 inducers. CYP2C19 and CYP2C9 are enzymes in the liver that help break down many medications.

No, Cibinqo (abrocitinib) is not available over the counter. It is a prescription medication that requires a healthcare provider’s authorization to obtain and use.

Yes, Cibinqo (abrocitinib) is generally safe, but like all medications, it has risks. Those using Cibinqo, a Janus kinase (JAK) inhibitor, may face an increased risk of specific cancers like lymphoma and skin cancers, especially if they are current or former smokers.