Buy Constella from Canada
From$148.95
$378
Constella Linaclotide
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Prescription Required
Ships within 4-10 Business Days
Express Ships from Canada
Product of Canada
From$145
$378
Constella Linaclotide
Select product strength & quantity:
Prescription Required
Ships within 10-14 Business Days
Express Ships from UK
Product of UK

What is Constella?

Constella medication is a prescription treatment for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC) in adults, as well as functional constipation (FC) in children and adolescents aged 6 to 17. 

It contains linaclotide, which belongs to a class of medications called guanylate cyclase-C agonists. Constella works by increasing fluid secretion in the intestines, which helps soften stool and stimulate bowel movements.

This process helps relieve symptoms like bloating, abdominal pain, and infrequent or difficult bowel movements, making digestion more comfortable.

How Does Constella Work?

Constella medication works by attaching to a receptor in the gut called guanylate cyclase-C.

This process increases fluid secretion in the intestines, making stool softer and easier to pass.

Constella helps relieve constipation, bloating, and abdominal pain by improving bowel movements.

Some people may notice better bowel function within a week, while pain and discomfort may take longer.

Constella Dosage Information and Usage

Constella medication is available in different strengths and is used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).

The correct dosage depends on the condition being treated, and it is important to take this medication correctly for the best results. 

Constella should be taken once daily on an empty stomach, at least 30 minutes before the day’s first meal.

Dosage Form and Strengths of Constella Medication

Constella comes in capsule form with the following strengths:

  • 72 mcg: Approved for functional constipation (FC) in children aged 6–17 years and sometimes used in adults with chronic idiopathic constipation (CIC).
  • 145 mcg: Typically prescribed for chronic idiopathic constipation (CIC) in adults
  • 290 mcg: Commonly used for irritable bowel syndrome with constipation (IBS-C) in adults

How to Take Constella?

Take Constella medication once daily on an empty stomach, at least 30 minutes before your first meal. Swallow the capsule whole with water. 

Do not chew, split, crush, or break it. If you miss a dose, take the next scheduled dose at the usual time. 

Do not take an extra dose to make up for the missed one, which may increase the risk of side effects. Follow your doctor’s instructions carefully for the best results.

Side Effects of Constella

Constella medication affects the digestive system and may cause side effects in some people. 

Common side effects are mild and may improve as the body adjusts to the medication. 

However, severe side effects can occur rarely and require immediate medical attention. If any side effects persist or worsen, contact your doctor.

Common Side Effects

  • Diarrhea
  • Passing gas
  • Abdominal pain
  • Bloating or a feeling of fullness
  • Nausea
  • Vomiting
  • Fatigue
  • Indigestion
  • Stomach flu

Severe Side Effects

  • Persistent watery diarrhea that does not go away
  • Intense or new abdominal pain
  • Severe bloating or discomfort
  • Signs of dehydration, such as dizziness or dry mouth

If you experience severe side effects, stop taking Constella and seek medical help immediately.

Warnings and Precautions

Before taking Constella medication, inform your doctor about any medical conditions, allergies, or medications you use. 

Constella is approved for adults with IBS-C and CIC, and for children aged 6–17 with functional constipation. It must not be used in children under 6 years old due to the risk of severe dehydration. 

Diarrhea is a common side effect, and in severe cases, it may lead to dehydration. If you experience persistent watery diarrhea, stop taking Constella and consult your doctor.

  • Not for children: Constella should not be used by children under 6, as it may cause severe dehydration. It is also not recommended for anyone under 18.
  • Allergic reactions: Do not take Constella if you are allergic to linaclotide or its ingredients.
  • Intestinal obstruction: Do not use this medication if you have a bowel blockage, as it can worsen the condition.
  • Diarrhea risk: Mild diarrhea may occur in the first two weeks. If diarrhea becomes severe or leads to dehydration, stop taking Constella and seek medical help.
  • Pregnancy and breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It is unclear if Constella affects unborn babies or passes into breast milk.
  • Medication interactions: To avoid interactions, tell your doctor about all medications, supplements, or vitamins you take. Do not start new medications without consulting your doctor.

Drug Interactions With Other Medications

Before starting Constella, it is important to inform your doctor about any medications, vitamins, supplements, or herbal products you are currently taking or planning to take.

Certain substances may interact with Constella, potentially affecting its effectiveness or increasing the risk of side effects.

Substances such as nicotine, caffeine, alcohol, and street drugs can interfere with the medication and may worsen side effects like dehydration or digestive discomfort.

Always consult your doctor before beginning or stopping any medications while using Constella.

Alternative Medications

There is no generic alternative to Constella, as it is only available as a brand-name drug. 

However, there are alternative medications that may be considered for similar conditions. 

Alternatives for IBS-C and CIC include other prescription medications such as plecanatide (Trulance), lubiprostone (Amitiza), or prucalopride (Motegrity, in some regions). Over-the-counter options include fiber supplements and osmotic laxatives. Although dicyclomine may not help with constipation, it can be used for IBS-related cramping.  

Always consult your healthcare provider to determine the most appropriate treatment option for your condition.

Buy Affordable Constella from Pharma Giant

Pharma Giant is the place to go to buy affordable Constella medication.

They work with licensed Canadian pharmacies to offer up to 90% savings on Constella and other medications.

The website is easy to use, and you can see the total cost of your medication before you pay. You can also save more with bulk pricing for up to three months of your prescription.

Pharma Giant delivers your medication right to your door within 3-5 business days, ensuring safe shipping for all medications.

With prescriptions verified by doctors and pharmacists, you can trust that your health is in good hands.

How to Order Constella Online?

  1. Start by searching for Constella on Pharma Giant’s website. Click the search icon at the top and type the medication’s name. Once you find the correct medication and strength, click “Buy” to add it to your cart. If you have more medications to add, click “Continue shopping” and repeat the process.
  2. After your cart is complete, click “Continue Checkout.” Enter your contact, payment, and shipping details. If you’re a new customer, create an account with your email and a password. Don’t forget to use the coupon code PGSAVE10 to save 10% on your first order. If you are an existing customer, simply log in with your email and password. Once everything is filled in, click “Submit” to confirm your order, and you’ll receive a confirmation email.
  3. To complete your order, upload or send your prescription. You can upload your prescription directly on the website using the RX document uploader, email a scanned copy or photo to info@pharmagiant.com, or fax it to 1-888-562-8159. You can skip this step if your order does not include prescription medication. Pharma Giant will contact you directly if the prescription is not on file to ensure they receive it.

Frequently Asked Questions

Constella is a medication used to treat chronic constipation and IBS-C. It contains linaclotide, which helps increase fluid in the intestines to ease bowel movements.

You can take Constella for 6 to 12 months, depending on your response to the treatment. However, if the desired therapeutic effect is not achieved, consider discontinuing the medication with your doctor’s guidance.

Constella works by attaching to a receptor in the gut called guanylate cyclase C. This helps relieve abdominal pain, allows liquid to enter the gut, and promotes more frequent and softer bowel movements.

To take Constella, swallow the capsule whole with water on an empty stomach at least 30 minutes before your first meal. Do not chew, split, break, or crush the capsule. Follow your doctor’s prescribed dosage and schedule. If you miss a dose, continue with your regular schedule and do not take an extra dose to compensate.

Constella should be taken 30 minutes before a meal. Be cautious if you are also taking proton pump inhibitors, laxatives, or NSAIDs, as these medications may increase the risk of diarrhea.

Constella may take several days to start working. It is typically used to treat irritable bowel syndrome and ease constipation.

Constella is a trademark owned by Ironwood Pharmaceuticals, Inc.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

Have a prescription?

Order Constella online today and enjoy a host of benefits, including:

 Customer Reviews
  • Cost Savings: Buy Constella at LOWER PRICES compared to the US
  • Bulk Order Discounts: Enjoy additional savings with bulk orders of Constella (up to 90-day supply)
  • Reliable Express Shipping: Fast and discreet delivery shipped directly to your doorstep
  • Exceptional Customer Service: Have a question? We’re delighted to help via live chat, email, or phone
  • Easy & Secure Ordering: Seamless online or phone ordering at 1-888-513-2294
  • SAVE 10% on first order with coupon code: PGSAVE10

Price Match Guarantee

Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online pharmacy with a verifiable address.
  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone prior to completing your order.

Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.
Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.