- What is Copaxone Injection Used for?
- Indications and Benefits
- Fact Table
- How Does Copaxone Injection Work?
- Copaxone Dose Information
- Usage Guide
- Side Effects
- Missed Dose
- Storage Information
- Warnings and Precautions
- Contraindications
- Drug Interactions With Other Medications
- Alternative Medications to Copaxone
- Buy Copaxone Online From Canada: Cost & Coupons
- Frequently Asked Questions
- Disclaimer
- Price Match Guarantee
What is Copaxone Injection Used for?
Copaxone (glatiramer acetate) is a prescription medication used to treat relapsing forms of multiple sclerosis (MS) in adults. It is prescribed for clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Copaxone is not used to directly treat symptoms such as muscle weakness or fatigue. Instead, it works to reduce the frequency of relapses and slow the progression of relapsing forms of MS. Even if you have never had an allergic reaction, Copaxone can cause severe, life-threatening reactions. These reactions may occur at any time during treatment.
If you experience symptoms like a widespread rash, swelling of the face, shortness of breath, or trouble swallowing, stop using Copaxone and seek emergency medical help immediately.
Indications and Benefits
Copaxone is used to help reduce relapse activity in adults with certain forms of multiple sclerosis and may support long-term nerve health.
FDA-Approved Indications
- Copaxone is approved for clinically isolated syndrome, which refers to a first episode of symptoms caused by inflammation or damage in the nerves and may later develop into multiple sclerosis.
- It is also indicated for relapsing remitting multiple sclerosis, a condition where symptoms appear in episodes and may improve between attacks.
- Adults with active secondary progressive multiple sclerosis may also use Copaxone when relapses continue alongside gradual worsening of symptoms.
Key Clinical Benefits
- Research studies found that glatiramer acetate helped decrease the frequency of MS relapses compared to placebo treatment.
- In clinical trials, patients treated with Copaxone had nearly 30% fewer relapses over one year than those who did not receive active treatment.
- Copaxone may help limit the development of new lesions in the brain, which are areas of nerve injury commonly seen on MRI scans.
- Treatment with Copaxone usually does not require regular blood testing, which may make ongoing treatment management simpler for some patients.
Common Off-Label Uses
- Some healthcare providers may prescribe glatiramer acetate for patients showing early MRI changes or symptoms suggestive of multiple sclerosis before the condition is fully confirmed.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Glatiramer acetate |
| Copaxone Class | An immunomodulator used to help manage multiple sclerosis by affecting the immune system |
| Primary Use | Used to treat relapsing forms of multiple sclerosis in adults |
| Additional Benefit | May help reduce relapse frequency and lower the formation of new brain lesions seen on MRI scans |
| Available Form | Solution for injection supplied in single-dose prefilled syringes |
| Method of Administration | Given as a subcutaneous injection, which means the injection is placed under the skin |
| Frequency | Usually injected once daily for the 20 mg strength or 3 times weekly for the 40 mg strength, depending on the prescribed treatment plan |
| Storage Instructions | Store in a refrigerator between 36°F and 46°F or 2°Cand 8 °CC. If needed, Copaxone may be kept at room temperature between 59°F and 86°F or 15°Cando 30°C for up to 1 month. Keep away from heat, light, and freezing temperatures. |
| Pregnancy and Breastfeeding | Patients who are pregnant, planning pregnancy, or breastfeeding should speak with their healthcare provider before starting treatment. It is not fully known whether glatiramer acetate passes into breast milk. |
| Drug Interactions | No major specific drug interactions are listed in the FDA prescribing information. Patients should still inform their healthcare provider about all prescription products, supplements, vitamins, and herbal products they use. |
| Manufacturer | Manufactured for Teva Neuroscience, Inc. |
How Does Copaxone Injection Work?
Copaxone affects the immune system to reduce inflammation that damages the nerves in people with MS. This helps decrease the number of relapses and slow the progression of disability.
By reducing nerve inflammation, Copaxone helps improve the overall quality of life for people with relapsing MS. It is usually given as an injection under the skin and should be used precisely as a healthcare provider prescribes.
Copaxone Dose Information
The recommended dose for Copaxone 20 mg per mL is once daily, while for Copaxone 40 mg per mL, it is given three times a week, at least 48 hours apart. Always use Copaxone exactly as your healthcare provider instructs.
Dosage Form and Strengths of Copaxone
Copaxone injection is available in prefilled syringes for subcutaneous injection. It comes in two strengths:
- 20 mg per mL: Single-dose prefilled syringe with a white plunger, used once daily.
- 40 mg per mL: Single-dose prefilled syringe with a blue plunger, used thrice a week and at least 48 hours apart.
Dosage Chart
| Condition | Initial Dose | Ongoing Dose | Highest Recommended Dose |
| Relapsing forms of multiple sclerosis | 20 mg injected under the skin once each day | Continue 20 mg once daily as directed by the healthcare provider | 20 mg daily |
| Relapsing forms of multiple sclerosis | 40 mg injected under the skin 3 times per week with at least 48 hours between doses | Continue 40 mg 3 times weekly on nonconsecutive days | 40 mg per injection, 3 times weekly |
Usage Guide
Use Copaxone exactly as prescribed by your healthcare provider. Before using your injection for the first time, review the Instructions for Use and ask for training if you are unsure how to inject it properly.
How To Use Copaxone?
- Take one prefilled syringe out of the refrigerator and let it warm naturally at room temperature for around 20 minutes before injecting.
- Wash your hands thoroughly and prepare a clean injection site on the abdomen, thighs, hips, or back of the upper arms.
- Inspect the liquid inside the syringe before use. The solution should appear clear and may range from colorless to slightly yellow.
- Wipe the selected injection area with alcohol and allow the skin to fully dry before injecting.
- Inject Copaxone under the skin using the technique recommended by your healthcare provider.
- Throw away the used syringe in a proper sharps disposal container after a single use.
Copaxone may be used with or without food. Using your injections on a consistent schedule may help you stay on track with treatment.
Important Safety Reminders
- Do not inject Copaxone directly into a vein.
- Do not use syringes that have been frozen.
- Rotate injection sites regularly to help reduce skin irritation or skin damage.
- Only use injection devices that are approved for use with Copaxone.
When To Expect Results
Copaxone does not work immediately. Over time, it may help lower the number of MS relapses and reduce new areas of nerve damage seen on MRI scans. Many patients require several months of regular treatment before noticing benefits.
Side Effects
Copaxone injection can cause side effects ranging from mild to severe.
Common Copaxone side effects include reactions at the injection site and other mild symptoms. However, some people may experience severe side effects requiring immediate medical attention.
Common Side Effects
- Redness, pain, or swelling at the injection site
- Lumps or itching at the injection site
- Rash
- Flushing (warmth and redness in the face)
- Shortness of breath
- Chest pain
Severe Side Effects
- Immediate post-injection reactions (flushing, chest pain, fast heartbeat, anxiety, breathing problems)
- Severe allergic reactions (swelling, rash, hives, or itching)
- Chest pain not related to the injection reaction
- Damage to skin or fatty tissue under the skin (lipoatrophy or necrosis)
- Liver problems (nausea, tiredness, yellowing of the skin or eyes, dark urine, pale stools)
Missed Dose
If you forget to use a dose of Copaxone, take the missed injection as soon as you remember, unless your next scheduled dose is coming up soon. If it is almost time for your next injection, skip the missed dose and continue following your regular treatment schedule.
Do not inject 2 doses at the same time or give extra injections to make up for a missed dose. For patients using the 40 mg 3 times weekly schedule, injections should always remain at least 48 hours apart to help lower the risk of side effects and injection problems.
Using the correct injection device and following the prescribed schedule carefully may help prevent missed or incomplete doses.
Storage Information
Store Copaxone injection in the refrigerator between 36°F and 46°F (2°C and 8°C). If refrigeration is not possible, you can keep it at room temperature between 59°F and 86°F (15°C and 30°C) for up to one month.
Protect it from light and high temperatures. Do not freeze Copaxone. If a syringe freezes, dispose of it in a sharps container. Keep Copaxone out of the reach of children.
Warnings and Precautions
Copaxone has some important warnings and precautions.
Severe allergic reactions, including life-threatening anaphylaxis, can occur at any time, even after the first dose. Some people may also experience chest pain or immediate post-injection reactions like flushing and shortness of breath.
In rare cases, it can cause skin issues like lipoatrophy or liver damage. Copaxone may also affect the immune system, impacting the body’s ability to fight infections.
- Anaphylactic reactions: Life-threatening allergic reactions can happen at any time, even after the first dose. Patients should know the signs and seek emergency help if needed.
- Immediate post-injection reactions: Some people may feel flushing, chest pain, or shortness of breath right after injection. These symptoms are usually short-lived but can be severe.
- Chest pain: This can happen even without other symptoms and may start months after beginning treatment.
- Lipoatrophy and skin necrosis: Long-term injection use can cause permanent dents in the skin or, in rare cases, skin damage.
- Immune response effects: Copaxone changes how the immune system works, which might affect the body’s ability to fight infections or detect tumors.
- Hepatic injury: Liver damage, including liver failure, has been reported. Discontinuation may be necessary if liver issues occur.
- Administration errors: Using the wrong autoinjector can cause dosing mistakes. Always check compatibility before use.
Contraindications
Copaxone should not be used by patients with a known allergy to glatiramer acetate or any of the ingredients found in the injection.
Reusing the treatment after an allergic reaction may increase the risk of serious reactions, including anaphylaxis, which is a severe and potentially life-threatening allergic response.
Patients with a known sensitivity to mannitol should also avoid Copaxone because this ingredient is included in the injection formula and may trigger allergic symptoms in some individuals.
Patients who previously developed severe allergic reactions after using Copaxone, including difficulty breathing or swelling of the throat, should not restart treatment unless a healthcare provider determines another factor caused the reaction.
Emergency medical attention is needed if symptoms such as facial swelling, chest tightness, severe rash, fainting, dizziness, or trouble breathing occur after an injection.
Drug Interactions With Other Medications
Copaxone can interact with other medications, which may increase the risk of side effects or reduce its effectiveness.
Talk to your doctor before taking Copaxone with other drugs. Do not stop or change any medications without medical advice.
- Amgevita (Adalimumab)
- Humira
- Abatacept
- Alefacept
- Aldesleukin
- Adenovirus type 7 vaccine
Alternative Medications to Copaxone
If you are considering alternatives to Copaxone, it is essential to consult your doctor. These medications come with their own set of side effects, drug interactions, and potential allergic reactions. Your doctor will guide you in choosing the most appropriate treatment.
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Frequently Asked Questions
Buying Copaxone from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
Adverse Reactions
Food & Drug Interactions
Storage & Travel
Drug Comparison
Disclaimer
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