What is Dabigatran?
Dabigatran is an anticoagulant used to prevent the formation of harmful blood clots. It is often prescribed to people with an irregular heartbeat, known as atrial fibrillation, to lower the risk of stroke.
This medication is also used to treat and prevent blood clots in the legs and lungs, especially after hip replacement surgery.
Dabigatran works by blocking thrombin, a natural protein in the body that helps blood to clot. It is taken by mouth in capsule form, usually twice a day.
If you plan to buy dabigatran online or buy dabigatran in Canada, make sure to get it from a licensed pharmacy to ensure safety and quality.
Follow your doctor’s instructions to prevent dabigatran side effects or complications.
Indications and Benefits of Dabigatran
Dabigatran is mainly prescribed to prevent stroke and blood clots in adults with non-valvular atrial fibrillation.
It is also used to treat and prevent deep vein thrombosis (DVT), which occurs when a blood clot forms in the leg, and pulmonary embolism (PE), which is a blood clot in the lung.
After hip replacement surgery, dabigatran helps reduce the risk of developing new clots. The dabigatran route of administration is oral, and it is available in different strengths, including 75 mg, 110 mg, and 150 mg.
While dabigatran is effective and convenient, it may cause some side effects like bleeding or stomach discomfort.
It is important to understand the dabigatran indications, dabigatran dosage, and dabigatran contraindications before starting treatment.
What Are the Benefits of Dabigatran?
- Dabigatran lowers the risk of stroke in people with irregular heartbeats.
- This medication prevents blood clots from forming in the legs and lungs after major surgeries.
- The treatment helps clear existing blood clots and reduces the chance of them returning.
- Patients using dabigatran do not need frequent blood tests, unlike those taking older anticoagulants.
- A consistent dabigatran dose makes it easier for patients to follow their treatment plan.
- The medication starts working quickly to stop new clots from forming.
- Regular use of dabigatran reduces the risk of deep vein thrombosis and pulmonary embolism.
- The capsules can be taken with or without food, providing flexibility and convenience.
- Fewer food and drug interactions make dabigatran safer for long-term use.
- Patients can use a dabigatran coupon to reduce dabigatran costs when buying dabigatran online.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Dabigatran |
| Dabigatran Class | Direct thrombin inhibitor (anticoagulant) |
| Primary Use | Prevents strokes and serious blood clots in people with non-valvular atrial fibrillation |
| Additional Benefit | Treats and prevents deep vein thrombosis (DVT) and pulmonary embolism (PE) in adults and children 3 months and older; also used to prevent blood clots after hip replacement surgery |
| Available Form | Capsules and oral pellets |
| Method of Administration | Oral (by mouth) |
| Frequency | Usually taken twice daily; may be taken once daily after hip replacement surgery as directed by a doctor |
| Storage Instructions | Store at room temperature, tightly closed, and away from heat and moisture. Do not store capsules in pillboxes. Use capsules within 4 months of opening the bottle, and use pellets within 6 months of opening the aluminum bag. Keep out of reach of children. |
| Pregnancy and Breastfeeding | Use only if clearly needed. Dabigatran may increase the risk of severe bleeding during labor and delivery. Consult a doctor before use if pregnant or breastfeeding. |
| Drug Interactions | May interact with blood thinners (warfarin, heparin), antiplatelet drugs (clopidogrel, aspirin, NSAIDs), and other anticoagulants. Always inform your doctor of all medications, vitamins, and supplements you are taking. |
| Manufacturer | Boehringer Ingelheim Pharmaceuticals, Inc. |
Fact Table
| Fact Category | Fact Details |
| Generic Name | Dabigatran |
| Dabigatran Class | Direct thrombin inhibitor (anticoagulant) |
| Primary Use | Prevents strokes and serious blood clots in people with non-valvular atrial fibrillation |
| Additional Benefit | Treats and prevents deep vein thrombosis (DVT) and pulmonary embolism (PE) in adults and children 3 months and older; also used to prevent blood clots after hip replacement surgery |
| Available Form | Capsules and oral pellets |
| Method of Administration | Oral (by mouth) |
| Frequency | Usually taken twice daily; may be taken once daily after hip replacement surgery as directed by a doctor |
| Storage Instructions | Store at room temperature, tightly closed, and away from heat and moisture. Do not store capsules in pillboxes. Use capsules within 4 months of opening the bottle, and use pellets within 6 months of opening the aluminum bag. Keep out of reach of children. |
| Pregnancy and Breastfeeding | Use only if clearly needed. Dabigatran may increase the risk of severe bleeding during labor and delivery. Consult a doctor before use if pregnant or breastfeeding. |
| Drug Interactions | May interact with blood thinners (warfarin, heparin), antiplatelet drugs (clopidogrel, aspirin, NSAIDs), and other anticoagulants. Always inform your doctor of all medications, vitamins, and supplements you are taking. |
| Manufacturer | Boehringer Ingelheim Pharmaceuticals, Inc. |
How It Works
Dabigatran works by blocking thrombin, an enzyme that helps form blood clots. By stopping thrombin from turning fibrinogen into fibrin, dabigatran prevents clots from forming.
This helps lower the risk of stroke, deep vein thrombosis, and pulmonary embolism. It allows blood to flow more smoothly and reduces the risk of dangerous clot formation.
Dabigatran is used to treat and prevent blood clots in the legs and lungs, to prevent them from coming back after treatment, and to lower the risk of stroke in people with irregular heartbeats.
It is also given after hip replacement surgery to help stop new blood clots from forming.
Brand Name Options
Dabigatran is available under the brand name Pradaxa. This brand offers the same active ingredient as the generic version and works in the same way to prevent and treat blood clots. Pradaxa is commonly prescribed to help reduce the risk of stroke and other clot-related conditions in people who need anticoagulant treatment.
Dosage
The dabigatran dosage depends on your medical condition, age, and overall health. It is important to follow your doctor’s instructions carefully when taking this medication.
Dabigatran is usually taken twice daily and can be taken with or without food. It helps prevent and treat blood clots, lowers the risk of stroke, and ensures smooth blood flow.
For those who buy dabigatran online, make sure to use it exactly as prescribed to achieve the best results and avoid side effects.
What Dosage Strengths Does Dabigatran Come In?
- 75 mg
- 110 mg
- 150 mg
Dosage Chart
| Condition or Use | Population | Recommended Dabigatran Dose | Frequency |
| Prevention of stroke and blood clots in nonvalvular atrial fibrillation | Adults | 75 mg to 150 mg | Twice daily |
| Prevention of blood clots after hip replacement surgery | Adults | 110 mg 1 to 4 hours after surgery, then 220 mg | Once daily for 28 to 35 days |
| Treatment and prevention of deep vein thrombosis (DVT) and pulmonary embolism (PE) | Adults | 150 mg | Twice daily |
| Treatment and prevention of DVT and PE | Children 8 years and above | Depends on body weight | Twice daily |
| Weight more than 81 kg | Children | 260 mg | Twice daily |
| Weight 61 to less than 81 kg | Children | 220 mg | Twice daily |
| Weight 41 to less than 61 kg | Children | 185 mg | Twice daily |
| Weight 26 to less than 41 kg | Children | 150 mg | Twice daily |
| Weight 16 to less than 26 kg | Children | 110 mg | Twice daily |
| Weight 11 to less than 16 kg | Children | 75 mg | Twice daily |
Usage Guide
Dabigatran should always be taken exactly as your doctor prescribes. This medication helps prevent and treat blood clots, so it is important to take it regularly for the best results.
The dabigatran dosage and schedule will depend on your condition and overall health. You can take dabigatran with or without food, but if it causes an upset stomach, it is better to take it with food.
Swallow the capsules whole with a full glass of water. Do not crush, chew, or break the capsules, as this can cause side effects.
If you buy dabigatran online, make sure to read the patient information leaflet and follow your doctor’s instructions carefully to ensure safe and effective use.
How do you take Dabigatran?
- Take dabigatran by mouth exactly as prescribed by your doctor.
- Swallow the capsules whole with a full glass of water.
- Do not crush, chew, or break the capsules.
- You may take dabigatran with or without food.
- Take it with food if it causes stomach upset.
- For children, give the first dose in the morning and the second in the evening about 12 hours apart.
- If your child uses dabigatran pellets, mix them only with soft food or apple juice and give them within 30 minutes.
- Do not mix the pellets with milk or foods containing milk.
- Take dabigatran at the same time every day to maintain steady levels in your body.
- Do not skip any doses, and do not stop taking the medication without your doctor’s advice.
- If you have trouble swallowing the capsules, tell your doctor for other options.
- Keep taking dabigatran even if you feel well, as stopping suddenly can increase your risk of blood clots or stroke.
Side Effects
Dabigatran may cause side effects in some patients. Most side effects are mild and go away on their own, but some can be serious and need immediate medical attention.
Inform your doctor if you notice any unusual symptoms while taking dabigatran or if you buy dabigatran online.
Common side effects dabigatran
- Stomach pain
- Upset stomach
- Heartburn
- Nausea
Severe side effects of dabigatran
- Unusual bruising or bleeding
- Pink or brown urine
- Red or black, tarry stools
- Coughing up blood
- Vomiting material that is bloody or looks like coffee grounds
- Bleeding from the gums
- Frequent nosebleeds
- Heavy menstrual bleeding
- Bleeding from a cut that lasts longer than normal
- Joint pain or swelling
- Headache
- Dizziness or feeling faint
- Weakness
- Hives, rash, or itching
- Difficulty breathing or swallowing
- Chest pain or tightness
- Swelling of the face, throat, tongue, lips, eyes, arms, hands, feet, ankles, or lower legs
Missed Dose
If you miss a dabigatran dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular dabigatran dosage schedule.
Do not take a double dose to make up for a missed dose. Try to take dabigatran at the same time each day to maintain steady levels in your body. Using reminders or apps can help prevent missed doses.
If you are unsure about when to take the next dabigatran dose, consult your doctor or pharmacist for guidance.
Overdose
Taking more than the prescribed dabigatran dose can be dangerous. If you accidentally take too much, seek emergency help immediately.
Symptoms of a dabigatran overdose may include unusual bruising or bleeding, pink or brown urine, red or black tarry stools, vomiting, or coughing up blood.
Follow your doctor’s instructions carefully to avoid dabigatran overdose symptoms and reduce the risk of serious complications.
Storage Information
Store dabigatran at room temperature in its original container. Keep it away from direct light, heat, and moisture, and do not place it in bathrooms or near sinks.
Do not freeze dabigatran and avoid transferring it to pill boxes.
Use the capsules within four months of opening the bottle and always check the expiration date before use. Keep dabigatran out of reach of children and pets. Do not flush dabigatran down the toilet.
Consult your doctor or pharmacist for proper disposal of any unused product.
Warnings
Dabigatran is effective for preventing blood clots and strokes, but it comes with important safety considerations.
Patients should be aware of the risks associated with bleeding, kidney problems, and certain heart conditions before starting dabigatran.
Monitoring for dabigatran side effects and understanding the long-term side effects of dabigatran can help ensure safe use.
Follow your doctor’s instructions for dabigatran dosage and dabigatran route of administration to reduce complications.
- Patients with active bleeding problems should not take dabigatran as it can worsen bleeding.
- People with hemophilia or other clotting disorders must consult a doctor before starting dabigatran.
- Patients with triple-positive antiphospholipid syndrome may face higher risks of blood clots while on dabigatran.
- Dabigatran should be used cautiously in people with chronic kidney disease as it can build up in the body and increase the risk of severe bleeding.
- Patients with mechanical heart valves should avoid dabigatran due to increased risk of clot formation.
- People with stomach ulcers should inform their doctor before taking dabigatran because it can worsen bleeding.
- Avoid activities that can lead to cuts, bruises, or injury, as dabigatran can cause excessive bleeding.
- Alcohol consumption may increase the risk of stomach bleeding while taking dabigatran.
- Patients should inform their doctor of all prescription, nonprescription, and herbal products they use to prevent dangerous drug interactions.
- Pregnant or breastfeeding women should consult a doctor before taking dabigatran, as it can pass into breast milk and affect the baby.
Boxed Warning and Precautions for Dabigatran
| Dabigatran carries a boxed warning because it can cause serious blood clots, known as hematomas, in or around the spine, especially if patients receive an epidural injection. In rare cases, these clots can lead to paralysis. Doctors may temporarily stop dabigatran before surgery to reduce this risk. Patients should never stop dabigatran on their own, as stopping suddenly increases the chance of stroke or clot formation. It is crucial to inform your doctor about any history of bleeding problems, kidney disease, heart valve issues, or other medical conditions before starting dabigatran. Following these precautions and monitoring for dabigatran overdose symptoms and other side effects ensures safer treatment. |
Contraindications
Dabigatran should not be used in certain patients due to serious health risks.
People with severe kidney problems, with a creatinine clearance below 15 mL per minute, should avoid taking dabigatran.
It is also not suitable for those who are allergic or have shown hypersensitivity to dabigatran.
Patients with active bleeding or problems with blood clotting, also called hemostasis issues, should not use dabigatran.
People with mechanical heart valves should avoid this drug because it can increase the risk of dangerous blood clots.
Interactions
Inform your healthcare provider about all the prescription, nonprescription, and herbal products you are taking before using dabigatran.
Some drugs and substances may interact with dabigatran and increase the risk of side effects or reduce its effectiveness.
- Aspirin
- Acetylsalicylic acid
- Ibuprofen
- Ketoprofen
- Flurbiprofen
- Celecoxib
- Salsalate
- Magnesium salicylate
- Ardeparin
- Heparin
- Rivaroxaban
- Warfarin
- Dronedarone
- Quinidine
- Rifampin
- Cyclosporine
- Ketoconazole
- Atorvastatin
- Carvedilol
- Phenytoin
- Carbamazepine
- Dexfenfluramine
- Dexamethasone
- Lomitapide
- Lonafarnib
- Venetoclax
- Asciminib
- Bosutinib
- Brigatinib
- Ibrutinib
- Neratinib
- Omacetaxine
- Tositumomab
- Ulipristal
- Treprostinil
- Ardeparin
- Deoxycholic acid
- Dexlansoprazole
- Hemin
- Nepafenac ophthalmic
- Omega-3 polyunsaturated fatty acids
- Tolvaptan
- Fluoxetine
Alternatives
Suppose dabigatran is not suitable for you due to side effects, contraindications, or cost. In that case, there are several other options available that help prevent blood clots and reduce the risk of stroke.
These alternatives include other anticoagulants and antiplatelet agents, which your doctor can help you choose based on your specific condition.
- Warfarin
- Coumadin
- Eliquis
- Apixaban
- Xarelto
- Rivaroxaban
- Argatroban
- Arixtra
- Plavix
- Aspirin
- Dablexa
- Afogatran
- Goodflo
Cost & Coupons
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Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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