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Dapagliflozin (Generic) Dapagliflozin Propanediol Monohydrate
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Dapagliflozin (Generic) Dapagliflozin Propanediol Monohydrate
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What is Dapagliflozin?

Dapagliflozin is a treatment used to manage type 2 diabetes, heart failure, and chronic kidney disease. It works by helping the kidneys remove extra sugar from the blood through urine.

This process helps lower blood sugar levels and can also support heart and kidney health.

The dapagliflozin generic name is the same as its active ingredient, which belongs to a group called SGLT2 inhibitors.

It is not used for type 1 diabetes or diabetic ketoacidosis. If you want to buy dapagliflozin in Canada, you can find it in tablet form, usually in 5 mg or 10 mg doses.

Indications and Benefits of Dapagliflozin

Dapagliflozin is prescribed to help adults with type 2 diabetes reduce high blood sugar when diet and exercise are not enough.

It is also used to lower the risk of hospitalization and death from heart failure, and to slow the progression of chronic kidney disease.

This treatment plays an important role in improving overall heart and kidney function while helping control blood sugar levels.

When considering the dapagliflozin indication, it is important to follow your doctor’s instructions and be aware of dapagliflozin contraindications, side effects, and possible drug interactions.

What Are the Benefits of Dapagliflozin?

  • Dapagliflozin helps lower blood sugar by allowing more glucose to leave the body through urine.
  • Dapagliflozin reduces the risk of heart failure and lowers the chance of being hospitalized.
  • Dapagliflozin slows down the progression of kidney disease and helps preserve kidney function.
  • Dapagliflozin lowers blood pressure by removing extra fluid and salt from the body.
  • Dapagliflozin supports weight management by helping the body release excess sugar and calories.
  • Dapagliflozin improves circulation and supports overall heart performance in people with heart failure.
  • Dapagliflozin helps reduce the risk of nerve and eye complications linked to diabetes.
  • Dapagliflozin eases swelling and breathing problems in people with heart conditions.
  • Dapagliflozin improves energy and helps maintain balanced blood sugar levels throughout the day.
  • Dapagliflozin offers flexible dosing, with a typical dapagliflozin dose starting at 5 mg and increasing to 10 mg as needed.

Fact Table

Fact Category Fact Details
Generic Name Dapagliflozin
Dapagliflozin Class Sodium-glucose co-transporter 2 (SGLT2) inhibitor
Primary Use Lowers blood sugar levels in adults with type 2 diabetes
Additional Benefit Reduces the risk of hospitalization and death from heart failure and slows kidney disease progression
Available Form Tablet form in 5 mg and 10 mg strengths
Method of Administration Taken by mouth with or without food
Frequency Once daily, preferably at the same time each day
Storage Instructions Store at room temperature, away from heat and moisture, and keep tightly closed in the original container
Pregnancy and Breastfeeding Not recommended during pregnancy or breastfeeding; inform your doctor if you are pregnant or planning to become pregnant
Drug Interactions May interact with diuretics, insulin, or other drugs that lower blood sugar; inform your doctor about all medications and supplements you take
Manufacturer AstraZeneca

How It Works

Dapagliflozin works by helping the kidneys remove extra sugar from the blood through urine. 

Normally, the kidneys filter sugar and send most of it back into the bloodstream. Dapagliflozin blocks this process by targeting a natural protein in the kidneys called SGLT2, which is responsible for reabsorbing sugar.

By blocking this protein, more sugar leaves the body through urine, which helps lower blood sugar levels.

This process also helps reduce strain on the heart and kidneys, supports healthy blood pressure, and can lead to slight weight loss over time.

Brand Name Options

Combination Products

  • Qtern (contains Dapagliflozin and Saxagliptin)
  • Qternmet XR (contains Dapagliflozin, Metformin, and Saxagliptin)
  • Xigduo XR (contains Dapagliflozin and Metformin)

Dosage

Dapagliflozin comes in tablet form and is taken once a day by mouth, with or without food. The typical dapagliflozin dose depends on the condition being treated and the person’s kidney function.

For adults with type 2 diabetes, the usual starting dose is 5 mg daily, which can be increased to 10 mg if the body tolerates it well and better blood sugar control is needed. For heart failure or chronic kidney disease, the recommended dose is 10 mg once daily.

This treatment should only be started if kidney function is adequate. People with severe liver problems or dehydration should consult their doctor before use.

What Dosage Strengths Does Dapagliflozin Come In?

  • 5 mg tablets
  • 10 mg tablets

Dosage Chart

Condition Recommended Dose Notes
Type 2 Diabetes Start with 5 mg once daily May increase to 10 mg once daily if needed for better blood sugar control
Heart Failure with Reduced Ejection Fraction 10 mg once daily Make sure fluid levels are stable before starting treatment
Chronic Kidney Disease 10 mg once daily Avoid use if you have polycystic kidney disease or have recently taken immunosuppressant medicine
Kidney Function 45 or Higher (Type 2 Diabetes) No dose change needed Continue with your usual prescribed dose
Kidney Function Below 45 (Type 2 Diabetes) Not recommended The medicine may not work as well
Kidney Function Above 25 (Other Conditions) No dose change needed Continue with 10 mg once daily
Kidney Function Below 25 (Other Conditions) Not recommended to start Those already using it may continue taking 10 mg daily
Mild to Moderate Liver Problems No dose change needed Safe for most people with mild liver issues
Severe Liver Problems Use with caution Doctor supervision is required

Usage Guide

Take dapagliflozin exactly as your doctor prescribes it. This medicine helps control blood sugar and certain heart and kidney conditions, but it does not cure them.

To get the best results, use it regularly and follow your doctor’s instructions closely. Staying consistent with your dose helps keep your blood sugar steady and supports your heart and kidney health.

How do you take Dapagliflozin?

  • Take dapagliflozin once a day, either with food or on an empty stomach.
  • Try to take it at the same time every day to keep a steady amount of medicine in your body.
  • Swallow the tablet whole with a glass of water. Do not crush or chew it.
  • Follow your doctor’s prescribed dose. Do not change the amount or timing without medical advice.
  • Your doctor may start you on a lower dose and adjust it depending on how your body responds.
  • Keep taking dapagliflozin even if you feel well. It works best when taken consistently.
  • Drink plenty of fluids while taking dapagliflozin, as the medicine can make you urinate more often. Staying hydrated helps prevent dehydration.
  • Monitor your blood sugar regularly as advised by your doctor to make sure the medicine is working effectively.

Side Effects

Dapagliflozin can cause both mild and serious side effects. Some are common and go away with time, while others need immediate medical attention.

Common Side Effects

  • Frequent urination
  • Nighttime urination
  • Stuffy or runny nose
  • Sore throat
  • Arm or leg pain
  • Constipation

Serious Side Effects

  • Painful or frequent urination
  • Cloudy or discolored urine
  • Strong-smelling urine
  • Fever or back pain
  • Nausea or vomiting
  • Dry mouth
  • Dark urine
  • Dry or warm skin
  • Decreased sweating
  • Pelvic or rectal pain
  • Vaginal odor or discharge
  • Vaginal itching
  • Redness or swelling of the penis
  • Rash or pain around the penis
  • Foul-smelling penile discharge
  • Fatigue with fever or genital swelling
  • Rash or hives
  • Itching or difficulty breathing
  • Swelling of the face, throat, or lips
  • Stomach pain
  • Vomiting or nausea
  • Difficulty breathing due to ketoacidosis

Missed Dose

If you forget to take a dose of dapagliflozin, take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and continue with your regular schedule. Do not take two doses at the same time.

If you are unsure about what to do, ask your doctor or pharmacist for guidance to avoid taking too much of the drug.

Overdose

Taking more dapagliflozin than prescribed can be harmful and may cause serious health issues. Signs of overdose can include extreme thirst, frequent urination, weakness, dizziness, or low blood pressure.

It can also lead to dehydration or changes in your body’s fluid balance. If you think you have taken too much dapagliflozin, get medical help immediately or contact your local emergency service.

Storage Information

Store dapagliflozin at room temperature and keep it in its original container with the lid tightly closed.

Place it in a dry area away from moisture, heat, and direct sunlight. Do not store it in the bathroom or any damp place. Keep it out of reach of children and pets to prevent accidental use.

Always check the packaging for any special instructions from the manufacturer. If you have unused tablets, ask your pharmacist or healthcare provider how to dispose of them properly.

Warnings

Before taking dapagliflozin, make sure your doctor knows your full medical history and current health condition. This drug affects how your body handles sugar and fluids, so it may not be suitable for everyone.

Following all safety advice helps lower the risk of serious health problems. Always use dapagliflozin exactly as prescribed and never change your dose without medical guidance.

  • Tell your doctor if you are allergic to dapagliflozin or any of its ingredients to avoid allergic reactions.
  • Inform your doctor about all other drugs, supplements, or herbal products you are using to prevent harmful dapagliflozin drug interactions.
  • Let your doctor know if you drink alcohol often or in large amounts, as it can affect blood sugar control.
  • Inform your healthcare provider if you have kidney or liver disease, heart failure, or any pancreatic problems.
  • Avoid dapagliflozin if you have a history of diabetic ketoacidosis, which is a serious condition caused by high acid levels in the blood.
  • Tell your doctor if you are on a ketogenic or low-carbohydrate diet, as this may increase the risk of ketoacidosis.
  • Drink enough water to prevent dehydration since dapagliflozin can cause increased urination and fluid loss.
  • Be cautious when standing up quickly from a sitting or lying position because dapagliflozin may cause dizziness or low blood pressure.
  • Let your doctor know if you are pregnant, planning to get pregnant, or breastfeeding, since dapagliflozin may not be safe during these times.
  • Inform your doctor before any surgery, including dental procedures, because dapagliflozin should usually be stopped three days before surgery.
  • Monitor for urinary tract infections or genital infections, as dapagliflozin may increase the risk of these problems.
  • Contact your doctor right away if you experience fever, infection, or unusual tiredness, as these may affect blood sugar control.

Boxed Warning and Precautions for Dapagliflozin

Dapagliflozin carries important safety warnings that should be taken seriously. This drug may increase the risk of ketoacidosis, a dangerous buildup of acid in the blood, especially in people with type 1 diabetes or those who are dehydrated. It can also raise the chance of urinary tract infections, genital infections, and low blood pressure due to fluid loss. Rare but serious infections like Fournier’s gangrene can also occur. People taking dapagliflozin should be closely monitored for side effects and maintain good hydration.

Contraindications

Dapagliflozin should not be used by people who have had a severe allergic reaction to it or any of its ingredients.

This includes serious conditions such as anaphylaxis or angioedema, which can cause swelling of the face, lips, throat, or tongue. It is also not recommended for individuals with type 1 diabetes, diabetic ketoacidosis, or severe kidney problems, as it may worsen these conditions.

People with very low blood pressure, dehydration, or active bladder infections should use caution.

Interactions

  • Metformin
  • Insulin
  • Diabetes treatments, including Janumet, Januvia, Jardiance, Ozempic, Trulicity, and Victoza
  • Blood pressure drugs
  • Cholesterol-lowering drugs
  • Heart drugs such as Lantus and Lipitor
  • Anticoagulants or blood thinners
  • Pain relievers like paracetamol
  • Antidepressants
  • Vitamins such as B12, C, and D3
  • Fish oil supplements
  • Aspirin
  • Conditions affecting the kidneys
  • Conditions affecting the liver
  • Low blood pressure
  • Ongoing infections

Alternatives

  • Jardiance (empagliflozin)
  • Invokana (canagliflozin)
  • Steglatro (ertugliflozin)
  • Remo, Remozen (remogliflozin)
  • Zynquista (sotagliflozin)

Cost & Coupons

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Frequently Asked Questions

Dapagliflozin is used to help control blood sugar levels in adults with type 2 diabetes. It is also used to treat heart failure and chronic kidney disease to reduce the risk of hospitalization or worsening symptoms.
The most common side effects include increased urination, urinary tract infections, genital infections, and dehydration. Some people may also experience dizziness or low blood pressure.
Dapagliflozin helps the body remove extra salt and water through urine, which reduces fluid buildup and makes it easier for the heart to pump. This helps lower pressure on the heart and improves symptoms in people with heart failure.
  Yes, dapagliflozin tablets can be crushed and mixed with water or soft food if you have difficulty swallowing them whole.
  Dapagliflozin begins to lower blood sugar levels within about 2 hours after taking it, but it may take up to a week to feel its full effect.
You should not stop taking dapagliflozin without talking to your doctor first. Stopping it suddenly can cause your blood sugar, heart failure, or kidney condition to worsen.
Dapagliflozin may lead to some weight loss as it helps your body remove excess sugar through urine, but it is not meant to be used mainly for weight loss.
The usual dose of dapagliflozin is 10 mg taken once a day for adults and children aged 10 years and older. Your doctor may adjust the dose based on your condition and response to treatment.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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