What is Dupixent?
Dupixent (dupilumab) is used to help people with long-lasting health problems involving swelling or inflammation.
Dupixent is FDA-approved for the following conditions:
- Atopic dermatitis (eczema) in adults and children 6 months and older
- Asthma in adults and children 6 years and older
- Eosinophilic esophagitis in adults and children 1 year and older who weigh at least 15 kilograms
- Chronic sinus problems with nasal polyps in adults and children 12 years and older
- Prurigo nodularis (a skin condition with itchy bumps) in adults
- Eosinophilic COPD (a type of lung condition) in adults
- Chronic spontaneous urticaria (hives that do not go away with antihistamines) in adults and children 12 years and older
Doctors may also use Dupixent off-label, which means they give it for a condition not officially approved, like hair loss or other rare eczemas.
Dupixent is mainly used for people who have not had good results with creams or pills. It can be given through a Dupixent pen, an easy-to-use device for self-injection.
This makes it simple for people to take their Dupixent shot at home. However, not everyone should use this medication.
Dupixent contraindications include people who are allergic to any of its ingredients. Before starting, always talk to your doctor to ensure it is safe. Dupixent helps many people feel better by calming down the body’s immune system when it overreacts, which helps reduce swelling, itching, and trouble breathing.
How Does Dupixent Work?
Dupixent works by blocking certain proteins in the body called interleukins. These proteins cause inflammation, leading to skin problems, breathing issues, and other symptoms.
By blocking these proteins, Dupixent helps lower inflammation and makes symptoms easier to manage.
- Dupixent helps clear dry, itchy skin in atopic dermatitis by calming the immune system.
- In asthma, it reduces swelling in the lungs and helps with breathing.
- Eosinophilic esophagitis lowers inflammation in the esophagus, making it easier to swallow.
- In chronic sinusitis with nasal polyps, Dupixent reduces swelling in the nose and sinuses.
- In prurigo nodularis, it helps reduce itchy skin bumps by calming overactive immune responses.
- Dupixent targets the root cause of inflammation, helping people feel better and breathe easier.
Dupixent Dosage and Administration
The dose you need depends on your age, weight, and the condition being treated, such as atopic dermatitis, asthma, eosinophilic esophagitis, or chronic rhinosinusitis with nasal polyps. Dupixent pediatric dosing varies based on the child’s age and body weight.
Dosage Form and Strengths of Dupixent
- 200 mg in a 1.14 mL single-use prefilled syringe or pen
- 300 mg in a 2 mL single-use prefilled syringe or pen
- Given as a subcutaneous injection (under the skin)
Dupixent Administration
General Administration Tips
Dupixent is given as an injection under the skin. The injection sites should be rotated between the abdomen, thigh, and upper arm. Avoid injecting into tender, bruised, or scarred areas.
Atopic Dermatitis (Adults)
Adults with atopic dermatitis usually start treatment with two injections of 300 mg, taken at the same time, for a total of 600 mg. After that, they continue with one 300 mg injection every other week to maintain the effect.
Atopic Dermatitis (Children)
The dose for children aged 6 months to 5 years depends on body weight. Children weighing between 5 and 15 kilograms receive 200 mg every 4 weeks, and those weighing 15 to 30 kilograms receive 300 mg every 4 weeks.
Children aged 6 to 17 years follow a different schedule. If they weigh between 15 and 30 kilograms, they start with two 300 mg injections and then continue with 300 mg every 4 weeks.
If they weigh between 30 and 60 kilograms, they start with two 200 mg injections and then take 200 mg every other week. For those over 60 kilograms, two 300 mg injections are followed by 300 mg every other week.
Asthma (Adults and Children 12 and Older)
Two dosing options exist for asthma in adults and children aged 12 and older. The first option is to begin with two 200 mg injections, then continue with 200 mg every other week.
The second option starts with two 300 mg injections and 300 mg every other week.
People with more severe asthma or those with different conditions, such as atopic dermatitis, may need a higher dose.
Asthma (Children 6 to 11 Years)
Children aged 6 to 11 are dosed based on weight. Those weighing between 15 and 30 kilograms receive 300 mg every four weeks, and those over 30 receive 200 mg every other week.
Eosinophilic Esophagitis (Adults)
Adults with eosinophilic esophagitis are treated with a 300 mg injection once every week.
Eosinophilic Esophagitis (Children 1 and Older)
The dose for children aged 1 year and older depends on weight. Children weighing between 15 and 30 kilograms get 200 mg every other week, those between 30 and 40 kilograms receive 300 mg every other week, and if the child weighs over 40 kilograms, the dose is 300 mg weekly.
Chronic Rhinosinusitis with Nasal Polyps
Adults and children 12 years and older with chronic rhinosinusitis with nasal polyps are given a 300 mg injection every other week.
Prurigo Nodularis (Adults)
Adults with prurigo nodularis start with two 300 mg injections, for 600 mg. After the first dose, they continue with one 300 mg injection every other week.
COPD (Adults)
For adults with chronic obstructive pulmonary disease, Dupixent is given as a 300 mg injection every other week.
Dupixent in Pregnancy
If you are pregnant or planning to become pregnant, talk to your doctor before using Dupixent. It is not fully known whether Dupixent is safe to use during pregnancy, so your doctor will need to weigh the benefits and risks carefully.
Dupixent Overdose
Taking more Dupixent than prescribed may lead to a Dupixent overdose. While Dupixent is not known to cause severe overdose symptoms in most cases, it is still important to follow the dosing instructions carefully.
If you think you have received too much, contact your doctor if you have severe Dupixent overdose symptoms.
Dupixent Missed Dose
If you miss a scheduled Dupixent injection, take it as soon as you remember. Then go back to your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your next scheduled injection.
Do not inject a double dose to compensate for the one you missed. Talk to your doctor or pharmacist for guidance on the Dupixent missed dose, especially if you are unsure how to adjust your schedule.
Dupixent Storage
Keep Dupixent in the refrigerator between two and eight degrees Celsius. Always store it in the original carton so it stays protected from light. If needed, you can keep Dupixent at room temperature, up to twenty-five degrees Celsius, for no more than fourteen days.
If it has been out of the fridge for more than fourteen days, it should not be used and must be thrown away.
Never freeze Dupixent, and do not shake it. Also, do not expose it to heat or direct sunlight. If any medication is left in the syringe or pen, it should not be saved or reused.
Dupixent Side Effects
Dupixent injection side effects can range from mild skin reactions to more serious problems.
The most common Dupixent side effects include redness or swelling during the injection, sore throat, and eye irritation.
However, some people may experience severe reactions, such as allergic responses, joint pain, or even issues with blood vessels.
Dupixent’s long-term side effects are still being studied, but regular follow-up with your doctor can help monitor any changes in your health.
Common Side Effects
These side effects are usually mild and go away with time:
- Redness, swelling, or pain at the injection site
- Sore throat or hoarseness
- Stuffy or runny nose
- Red or itchy eyes
- Dry eyes
- Cold sores on the lips or in the mouth
- Headache
- Back pain
- Muscle pain
- Diarrhea
- Trouble sleeping
- Toothache
- Dizziness
- Mild skin rash
- Common cold symptoms
- Viral or parasitic infections
- Increased white blood cell count
- Eye and eyelid swelling or irritation
Severe Side Effects
Contact your doctor right away if you notice any of these more serious symptoms:
- Breathing trouble, wheezing, or a fast heartbeat
- Swelling of the face, lips, tongue, or throat
- Hives or intense itching
- Feeling faint or dizzy
- Nausea, vomiting, or stomach cramps
- Joint pain that makes it hard to walk or move
- New or worsening eye problems like blurred vision or eye pain
- Skin rash that spreads or worsens
- Persistent fever or feeling very unwell
- Chest pain or dark-colored urine
- Numbness or tingling in the arms or legs
- Signs of blood vessel inflammation
- Facial rash or redness that does not go away
Warnings and Precautions for Dupixent
Dupixent has some important safety warnings and precautions that patients need to know. It may cause severe allergic reactions, eye problems, and other health issues.
You should talk to your doctor before starting Dupixent, especially if you have a history of allergies, eye issues, asthma, or infections.
Being careful with vaccines and other treatments while using Dupixent is also important. Always report any new or worsening symptoms to your doctor right away.
- Some people have had severe allergic reactions like swelling, rash, or trouble breathing while using Dupixent. Stop using it and get medical help right away if this happens.
- Dupixent may cause eye problems such as red eyes, blurry vision, or discomfort. Tell your doctor if you have any eye issues during treatment.
- Dupixent can lead to specific lung problems caused by too many white blood cells called eosinophils. Watch for signs like worsening cough, shortness of breath, chest pain, or fever.
- Do not use Dupixent during an asthma or COPD attack. It does not work fast enough to treat sudden breathing problems.
- Do not suddenly stop using corticosteroids when starting Dupixent. Reducing steroids too quickly can cause health problems. Your doctor will guide you on how to lower the dose safely.
- If you have both asthma and another condition like eczema or nasal polyps, do not stop your asthma treatments without talking to your doctor.
- Some people using Dupixent have developed new skin problems, such as psoriasis. If you notice new red, scaly patches on your skin, let your doctor know.
- Some patients using Dupixent have experienced joint pain or swelling, which may include new cases of psoriatic arthritis. Tell your doctor if you have joint pain or trouble moving.
- If you have or get a parasitic infection like worms, treat it before starting Dupixent. If you get one during treatment and it does not go away, you may need to stop Dupixent until the infection clears.
- Get all needed vaccines before starting Dupixent. Do not get live vaccines while using Dupixent; they may not work correctly or cause side effects.
Dupixent Drug Interactions
Dupixent may interact with specific treatments, especially vaccines. Before you start using Dupixent, it is important to tell your doctor and pharmacist about all the drugs, supplements, vitamins, and vaccines you use. This helps avoid any possible problems. Dupixent is known to affect how live vaccines work in the body.
You may need to get certain vaccines before starting Dupixent. Always talk to your healthcare provider before getting any shots while using Dupixent.
- Measles vaccine
- Mumps vaccine
- Rubella vaccine
- Chickenpox vaccine
- Rotavirus vaccine
Dupixent Alternatives
If you are looking for Dupixent alternatives or an alternative to Dupixent, other options may help treat your condition. Talk with your doctor to determine which option is best for you.
Here are some common alternatives to consider:
Budget-Friendly Dupixent from Canada
If you are looking for a budget-friendly way to get Dupixent, buying from Canada can help you save a lot. The cost of Dupixent in Canada is often much lower than in the United States.
This means you can get the same trusted treatment at a better price. The Dupixent price from Canadian pharmacies can be much lower, making it easier for many people to afford their medication.
Buying from a reliable Canadian source means you get quality Dupixent without worrying about high costs.
The cost of Dupixent can be a barrier for many patients, but ordering online from Canada helps remove this worry. You can order Dupixent from home and have it delivered quickly and safely. Many services offer express shipping, so you get your medication in a few days.
This way, you save both time and money.
Plus, you can often buy Dupixent in bulk to lower your overall cost even more. Choosing budget-friendly Dupixent from Canada is a smart way to manage your health and budget.
How to Order Dupixent Online?
- Find Descovy on the website, choose your desired dosage, and click Buy to add it to your cart. You can also add other medications before you check out.
- Click Continue Checkout, then fill in your name, shipping address, and payment details. Enter the code PGSAVE10 at checkout to get 10% off your first purchase.
- You can send your prescription by uploading it directly on the website, emailing it to info@pharmagiant.com, or faxing it to 1-888-562-8159.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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