Eliquis (apixaban)
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What is Eliquis?

Eliquis is a prescription medication used to help prevent and treat blood clots. Here’s how it works:

  • For Stroke Prevention: Eliquis is often prescribed to people with atrial fibrillation, a condition where the heart beats irregularly. This irregular heartbeat can lead to blood clots that may cause a stroke. Eliquis helps reduce this risk by preventing clots from forming.
  • Post-Surgery Clot Prevention: It’s also used to prevent blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism) after hip or knee replacement surgery. This helps prevent complications from these surgeries.
  • Treatment of Blood Clots: Eliquis treats existing blood clots in the veins of the legs and lungs and helps reduce the chance of these clots returning.

The safety and effectiveness of Eliquis in children are not known.

Before taking Eliquis, it’s important to inform your doctor if you have any kidney or liver problems, a history of bleeding issues, or if you are pregnant or breastfeeding. Your doctor will guide you on how to use Eliquis safely and whether any adjustments are needed for your treatment.

Eliquis is a blood thinner, which means it makes it harder for your blood to clot. This can help prevent dangerous clots, but it also means you need to be careful about bleeding. If you have unexpected bleeding or bruising, or if you need to stop taking Eliquis for any reason, you should consult your doctor right away.

For people who need spinal anesthesia or a spinal procedure, there is a risk of serious complications like bleeding in the spinal area, which can lead to long-term problems.

Indications and Benefits of Eliquis

Eliquis is a prescription treatment that helps lower the risk of harmful blood clots. Doctors often prescribe it to prevent stroke in people with atrial fibrillation, a heart condition that causes an irregular heartbeat.

It is also used after certain surgeries like hip or knee replacement to reduce the chance of clot formation. In addition, Eliquis treats existing blood clots in the legs and lungs and helps stop them from coming back.

What Are the Benefits of Eliquis?

  • Eliquis lowers the risk of stroke in people with atrial fibrillation by preventing clots from forming in the heart.
  • It helps prevent deep vein thrombosis and pulmonary embolism after hip or knee replacement surgery.
  • It treats existing blood clots in the legs or lungs and reduces the chance of these clots returning.
  • It works as a blood thinner that balances clot prevention while providing effective protection against dangerous conditions.
  • It offers a proven alternative to older blood thinners with fewer food interactions and no need for routine blood monitoring.

Fact Table

Fact Category Fact Details
Generic Name Apixaban
Medication Class Anticoagulant (blood thinner)
Primary Use To prevent stroke and blood clots in people with atrial fibrillation
Additional Benefit Prevents and treats deep vein thrombosis and pulmonary embolism
Available Form Oral tablet
Method of Administration By mouth with or without food
Frequency Usually taken twice daily, as prescribed by a doctor
Storage Instructions Store at room temperature, away from light and moisture
Pregnancy and Breastfeeding Not recommended during pregnancy or breastfeeding unless advised by a doctor
Drug Interactions May interact with other blood thinners, NSAIDs, certain antidepressants, and some antifungal or antiviral drugs
Manufacturer Bristol-Myers Squibb and Pfizer

How Does Eliquis Work?

Eliquis works by targeting a specific part of the blood clotting process. It blocks an enzyme called Factor Xa, which plays a key role in forming blood clots.

By inhibiting Factor Xa, Eliquis reduces the production of thrombin, another substance that helps blood clots form.

This makes it harder for clots to develop. Unlike some other blood thinners, Eliquis doesn’t directly affect platelets (the cells that help blood clot), but by stopping Factor Xa, it indirectly helps prevent the clumping of platelets.

This mechanism helps reduce the risk of strokes and blood clots in various conditions, like atrial fibrillation or after surgery.

Dosage

Dosage Form and Strengths of Eliquis

  • 2.5 mg tablets: Yellow, round, biconvex, film-coated with “893” on one side and “2½” on the other side.
  • 5 mg tablets: Pink, oval-shaped, biconvex, film-coated with “894” on one side and “5” on the other side.

Usage

Take Eliquis exactly as your doctor prescribes.

For most people, the dose is 5 mg twice a day. If you are older than 80 years, weigh less than 60 kg, or have certain kidney issues, your dose might be reduced to 2.5 mg twice daily.

If you are using Eliquis to prevent blood clots after hip or knee surgery, the starting dose is 2.5 mg twice daily, beginning 12 to 24 hours after surgery. For treating deep vein thrombosis (DVT) or pulmonary embolism (PE), take 10 mg twice daily for the first week, then switch to 5 mg twice daily.

To reduce the risk of DVT or PE coming back, take 2.5 mg twice daily after at least 6 months of treatment.

Restart taking Eliquis as soon as you are healed. If you need to switch from or to other anticoagulants, follow your doctor’s instructions carefully. If you have trouble swallowing tablets, ask your doctor about alternative ways to take Eliquis.

Side Effects of Eliquis

Common Side Effects

  • Bleeding
  • Nausea
  • Anemia
  • Contusion (bruising)
  • Hemorrhage (including hematoma)
  • Hematuria (blood in urine)
  • Epistaxis (nosebleeds)
  • Menorrhagia (heavy menstrual bleeding)
  • Hemoptysis (coughing up blood)

Serious but Rare Side Effects

  • Increased risk of thrombotic events after premature discontinuation
  • Severe bleeding events (such as intracranial bleeding, gastrointestinal bleeding)
  • Spinal or epidural anesthesia or puncture complications
  • Hypersensitivity reactions (such as severe allergic reactions)

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

Missed Dose

If you miss a dose, take it as soon as you remember, but do not double up on doses.

For any surgery or procedures, stop taking Eliquis 48 hours before if the bleeding risk is high, or 24 hours before if the risk is low.

Overdosage of Eliquis

If someone takes too much Eliquis, it increases the risk of bleeding. In clinical trials, doses of Eliquis up to 50 mg daily for several days did not cause serious problems in healthy individuals.

If an overdose occurs, activated charcoal might help reduce the amount of Eliquis in the body if given within a few hours.

There are also medications available to counteract the effects of Eliquis and help manage the situation.

Warnings and Precautions

  • Increased Risk of Thrombotic Events after Premature Discontinuation: Stopping Eliquis without starting another anticoagulant can lead to increased risk of blood clots and strokes. This was observed when transitioning from Eliquis to warfarin.
  • Bleeding: Eliquis can increase the risk of bleeding, including severe or life-threatening bleeding. Concurrent use with other drugs that affect blood clotting, such as aspirin, other anticoagulants, and NSAIDs, further increases this risk.
  • Reversal of Anticoagulant Effect: Eliquis’s effects can last at least 24 hours after the last dose. Agents like prothrombin complex concentrate may be used to reverse its effects, but their effectiveness is not well-studied. Monitoring for anticoagulation with tests is not recommended.
  • Spinal/Epidural Anesthesia or Puncture: Using Eliquis with spinal or epidural anesthesia increases the risk of serious spinal or epidural bleeding, which can cause long-term or permanent paralysis. Special care is needed with catheter removal and administration timing.
  • Patients with Prosthetic Heart Valves: Eliquis has not been tested in patients with artificial heart valves, so it is not recommended for these individuals.
  • Acute PE in Hemodynamically Unstable Patients or Patients who Require Thrombolysis or Pulmonary Embolectomy: Eliquis is not advised for the initial treatment of patients with pulmonary embolism who are unstable or need thrombolysis or surgery.

Drug Interactions

  • Combined P-gp and Strong CYP3A4 Inhibitors: Drugs like ketoconazole, itraconazole, and ritonavir increase apixaban levels, raising bleeding risk. For patients on Eliquis 5 mg or 10 mg twice daily, reduce the dose by 50% when using these inhibitors. For those on Eliquis 2.5 mg twice daily, avoid these inhibitors altogether.
  • Clarithromycin: Even though clarithromycin is a strong P-gp and CYP3A4 inhibitor, no dose adjustment is needed when taking Eliquis with it.
  • Combined P-gp and Strong CYP3A4 Inducers: Avoid drugs like rifampin, carbamazepine, phenytoin, and St. John’s wort with Eliquis, as they lower apixaban levels and may increase stroke risk.
  • Anticoagulants and Antiplatelet Agents: Using Eliquis with other blood thinners or antiplatelet agents (e.g., aspirin, NSAIDs) raises the risk of bleeding. Clinical studies showed that adding aspirin or other antiplatelet drugs to Eliquis significantly increases bleeding risk.

Storage Information

Eliquis should be stored at room temperature in a dry place, away from direct sunlight and moisture. Keep the tablets in their original container and make sure the lid is tightly closed. Do not store it in the bathroom, as humidity can damage the medication. Always keep Eliquis out of reach of children and pets to prevent accidental use.

Alternative Medications

Price & Discounts

At Pharma Giant, we make sure you get the medication you need without financial strain, which is what we aim for.

Eliquis, also known as Apixaban, is important for many people, helping with blood clot prevention. However, in the United States, Eliquis can be expensive, which is why we strive to offer it at prices you can manage.

Special Prices on Eliquis

We know your health is important, and getting essential medicine doesn’t need to cost too much. Pharma Giant makes healthcare easier on your wallet by providing these prices for Eliquis:

Eliquis (Apixaban)

  • 2.5mg – 60 tablets – $157
  • 2.5mg – 120 tablets – $308
  • 2.5mg – 180 tablets – $432
  • 5mg – 60 tablets – $157
  • 5mg – 120 tablets – $308
  • 5mg – 180 tablets – $432

Apixaban (Generic)

  • 2.5mg – 60 tablets – $89
  • 2.5mg – 120 tablets – $170
  • 2.5mg – 180 tablets – $249
  • 5mg – 60 tablets – $89
  • 5mg – 120 tablets – $170
  • 5mg – 180 tablets – $249

Get the quality medicine you need without the high price. Choose Pharma Giant to avoid financial stress and focus on your well-being!

Exclusive Discount Offer

  • Coupon Code: Enter PGSAVE10 when you check out to enjoy a 10% discount on your Eliquis order. This limited-time offer ensures you save on key medicines while maintaining quality.
  • Offer Details: The discount can be used once per customer, so take advantage of it now.

Ordering Information

  • Prescription Required: To keep you safe and ensure proper treatment, a valid prescription is needed to buy Eliquis.
  • Bulk Purchases: Order up to a 90-day supply for ongoing treatment with ease and save more.

Assurance of Quality and Timely Delivery

Pharma Giant promises top-notch medicine with the added benefit of fast delivery right to your home.

  • Express Shipping: Your medicine is quickly shipped from Canada to any location in the US in 3-5 business days, ensuring you get it fast.
  • Secure Packaging: Each package is carefully packed in secure, tamper-proof containers, ensuring your medicine reaches you safely.

How to Order?

Step 1: Search for your medication on the website, choose the correct strength and quantity, then add it to your cart.

Step 2: Enter your contact details, shipping address, and payment information. Create an account if you are a new customer or log in if you already have one.

Step 3: If your order includes prescription medication, upload it directly to the site, email it, or fax it. Over-the-counter items do not require a prescription.

Use PGSAVE10 to claim your 10% discount on your first order.

Pharma Giant’s Guarantee

Pharma Giant is your partner in health, offering affordable solutions that mean you don’t have to sacrifice when it comes to your well-being.

With excellent service, affordable prices, and trustworthy delivery, we make sure you receive the best care and value.

Make Pharma Giant your choice today and feel the difference of attentive healthcare without the heavy price.

Frequently Asked Questions

Buying Eliquis from Canada

Yes. Eliquis requires a valid prescription from a licensed healthcare provider. It is not sold over the counter. Your doctor will review your medical history, assess your risk of blood clots or stroke, and decide if Eliquis is the right treatment for you. They will also explain how to take it correctly and monitor your progress during treatment.

Yes. In many cases, Americans may order Eliquis from a licensed Canadian pharmacy for personal use with a valid prescription. It is important to choose a reputable and properly licensed pharmacy that requires a prescription and follows strict safety and handling standards to help ensure the product is authentic and stored correctly. Pharma Giant works with licensed international pharmacies and requires a valid prescription before dispensing Eliquis, helping support safe and compliant access for eligible patients.

To place an order for Eliquis, select the product and add it to your cart, then proceed to checkout. You will need to sign in or create an account and submit a valid prescription by uploading it or sending it by email or fax. Once the prescription is reviewed and approved, your order will be processed and shipped. You will receive tracking information after it has been dispatched.

You can submit your prescription for Eliquis by uploading it through the secure prescription upload section on our website. You may also send it to our pharmacy team by email or fax via this number: 1-888-562-8159. After we receive it, the prescription will be reviewed and verified before your order is approved and processed.

Yes. Refill requests for Eliquis can be made if your prescription allows additional fills. You can log in to your account to check your remaining refills and submit a request when you are eligible. Refills are reviewed and processed in line with the approved supply timeframe before shipment is arranged.

Yes. The Eliquis supplied is the same brand-name product provided at retail pharmacies. It contains the same active ingredient and is produced under the same strict manufacturing and quality standards. The difference is where it is dispensed and the price you may pay, not the formulation or effectiveness.

Shipping for Eliquis tablets is $14.99 per order. We accept major credit cards, including Visa and Mastercard, for secure and convenient payment.

Eliquis orders are sent with tracking via Canada Post Express and usually arrive within 4 to 10 business days. Occasional delays may occur due to U.S. customs. To ensure you do not run out, it is advised to order 30 to 45 days before your current supply runs out.

FDA-Prescription, Off-Label Information, and Limitations

The duration of Eliquis treatment depends on your specific condition. If you are taking Eliquis to prevent deep vein thrombosis (DVT) from recurring, it is typically prescribed for at least 6 months. In some cases, it may be needed for a longer period or even for life.

Eliquis should not be used during pregnancy as it may harm the unborn baby. It is also not recommended for breastfeeding, as it is not known if Eliquis passes into breast milk.

You might not feel different when Eliquis starts to work, but if you notice that you bruise more easily or have minor nosebleeds, it can be a sign that the medication is working. These side effects are generally expected and not usually concerning.

You should not stop taking Eliquis or change your dose without first consulting your doctor. Your doctor will determine the appropriate duration of treatment based on your condition. Discontinuing Eliquis without medical advice may increase your risk of stroke, especially if you’re using it to treat atrial fibrillation.

Dosage & Administration

Take Eliquis exactly as your doctor tells you. Most people take 5 mg twice a day, but some may take 2.5 mg twice daily if older, lighter, or have kidney issues. After hip or knee surgery, start 2.5 mg twice daily 12 to 24 hours after surgery. For DVT or PE, take 10 mg twice daily for one week, then 5 mg twice daily. Follow your doctor when switching from other blood thinners and ask about alternatives if swallowing tablets is hard.

If you miss a dose of Eliquis, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose, do not double up to make up for a missed dose.

When taking Eliquis, you should monitor for bleeding and bruising. Your healthcare provider will closely watch for these signs and work with you to ensure your safety and health while on this medication.

If you accidentally take too much Eliquis and experience serious symptoms like passing out or trouble breathing, call medical help immediately.

Adverse Reactions

The most common side effect of Eliquis is bleeding, which can range from minor bruising to more serious bleeding issues.

Signs of a serious bleeding problem while taking Eliquis include frequent or persistent nosebleeds, unusual tiredness or weakness, unexplained pain, swelling, or discomfort, unusual bruising, or prolonged bleeding from cuts or gums. It can also include heavier or longer menstrual periods than normal, pink or dark urine, and coughing up blood.

Yes, you should stop taking Eliquis 24 to 48 hours before any surgery or dental work to reduce the risk of excessive bleeding.

Yes, Eliquis can affect your liver and kidneys. In clinical trials, some people reported blood in their urine, which could indicate bleeding in the kidneys. While Eliquis is generally safe for most people, it can sometimes cause serious bleeding, including in these organs.

The life-threatening considerations of Eliquis include the risk of anaphylaxis, a severe allergic reaction. If you experience symptoms such as a rash, itching, difficulty breathing, trouble swallowing, or swelling of your hands, face, or mouth, seek immediate medical attention.

Yes, Andexxa (andexanet alfa) can rapidly reverse the anticoagulant effect of Eliquis in cases of major bleeding emergencies.

Food & Drug Interactions

There is no known interaction between Eliquis and alcohol, but both can increase the risk of bleeding. Drinking alcohol while taking Eliquis may further raise your risk of bleeding, so it’s best to limit alcohol consumption and consult your healthcare provider for personalized advice.

Eliquis can interact with other medications, which may increase the risk of bleeding or affect how well Eliquis works. Always inform your healthcare provider about all other medications, including over-the-counter drugs, supplements, and herbal products, before starting Eliquis.

Storage & Travel

Store Eliquis tablets at room temperature, ideally between 20 to 25 degrees Celsius, though 15 and 30 degrees Celsius is acceptable. Keep the tablets in their original container, tightly closed, in a dry place away from light and moisture, and out of reach of children.

Drug Comparison

Xarelto and Eliquis are both effective brand-name blood thinners used to prevent clots, and studies show they work similarly to reduce stroke risk. The main difference is in dosing: Xarelto is usually taken once a day, while Eliquis is taken twice daily, but this does not necessarily make one stronger than the other.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Price Match Guarantee

Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online pharmacy with a verifiable address.
  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone prior to completing your order.

Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.
Jakob Leaderbrand, PharmD, CSP

Jakob Leaderbrand, PharmD, is a licensed pharmacist with extensive experience in specialty pharmacy and clinical program management. Based in the Kansas City metro area, he holds a Doctor of Pharmacy degree from the University of Missouri-Kansas City and a Specialty Pharmacy Certification. Currently, Jakob works in Specialty Pharmacy, where he leverages his clinical expertise to drive adherence, improve patient outcomes, and ensure compliance through effective communication of complex data insights. Jakob is known for his commitment to operational excellence and for leading initiatives that streamline patient assessments and enhance audit compliance, making a significant impact on patient care and client relationships in the pharmacy sector.