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Eliquis (apixaban)

Prescription Required.

Product of Canada.

Shipped from Canada.

Prescription Required.Product of Canada.Shipped from Canada.

What is Eliquis?

Eliquis, known generically as Apixaban, is a highly effective oral anticoagulant medication that falls under the category of direct Factor Xa inhibitors. It is primarily prescribed to prevent and treat thromboembolic conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. By selectively inhibiting Factor Xa, an essential enzyme in the coagulation cascade, Eliquis effectively reduces the body’s ability to form dangerous blood clots.

This medication represents a significant advancement in anticoagulant therapy, offering several benefits over traditional anticoagulants like warfarin, including fewer dietary restrictions, reduced need for regular monitoring, and a lower risk of certain types of bleeding. Eliquis is available in tablet form and is taken twice daily, with or without food, making it a convenient option for long-term management of thromboembolic disorders.

Eliquis is a critical tool in the management of conditions that pose a risk of major cardiovascular events, providing patients with a safer, more manageable option for anticoagulation therapy. Its development and approval have marked a significant milestone in cardiovascular medicine, offering hope and improved quality of life for millions of patients worldwide.

How Eliquis Works to Prevent Blood Clots

Eliquis is taken orally and inhibits Factor Xa. Factor Xa is an enzyme that forms part of the body’s clotting system. It is the last enzyme in the clotting cascade and is responsible for creating the fibrin found in blood clots. Fibrin helps to keep newly formed clots stable. It inhibits the formation of fibrin, preventing the formation of blood clots.

When to Use Eliquis: Indications and Applications

Eliquis is indicated for:

Treatment of Deep Vein Thrombosis and/or the Treatment of Pulmonary Embolism

Eliquis is used in patients who have been diagnosed with a new clot in their veins (deep vein thrombosis). It is also used in patients with a lung clot (pulmonary embolism). It prevents clots from becoming more extensive and prevents a new clot from forming. It may be started as a first-line therapy in clinically stable patients and those with few blood clots. It is safe in patients who have active cancer and are receiving chemotherapy.

Prevention of Deep Vein Thrombosis

Patients having major joint replacement surgery (total hip replacement or total knee replacement) are at risk of developing blood clots. Eliquis is started 12 to 24 hours after surgery to prevent the formation of these clots.

Prevention of Systemic Embolism and Stroke in Patients with Atrial Fibrillation

Patients with atrial fibrillation risk having clots form in the heart. Eliquis is used to prevent these clots from forming in the heart.

Long Term Anticoagulation

Patients who have had a blood clot or a pulmonary embolism may require long-term anticoagulation (>6 months). Eliquis can be used in these cases to ensure adequate anticoagulation.

Determining Your Eliquis Dosage

Treatment of Deep Vein Thrombosis or the Treatment of Pulmonary Embolism

In these cases, Eliquis is given as 10 mg twice a day for seven days and then 5 mg twice a day.

Prevention of Deep Vein Thrombosis

In these cases, Eliquis is given as 2.5 mg twice a day, starting treatment 12 to 24 hours after surgery.

Prevention of Systemic Embolism and Stroke in Patients with Atrial Fibrillation

In these cases, Eliquis is given 5 mg twice daily. Where patients have any two of the following risk factors (bodyweight 60 kg, age 80 years of age, or a serum creatinine 1.5 mg/dl), the dose is reduced to 2.5 mg daily.

Eliquis Safety: Warnings and Precautions

Major bleeding

Eliquis increases the chance of having major bleeding that may, in some cases, be fatal. Risk factors for a major bleed include a history of stroke, gastrointestinal bleeding, prior bleeding, renal or liver impairment, older patients (>80 years of age), hypertension, alcohol use, diabetes, and malignancy. Of note, there is a high risk for spinal or epidural bleeding in patients who have neuraxial anesthesia or spinal puncture while being treated with Eliquis. Patients having surgery should inform their doctor that they are taking the medication.


Stopping Eliquis prematurely increases the risk of developing clots. Only stop taking under the guidance of a doctor. Consider using an alternative anticoagulant.

Antiphospholipid syndrome

Eliquis is not recommended for use in patients with antiphospholipid syndrome. Compared to a vitamin K antagonist anticoagulant such as warfarin, a higher incidence of thrombosis has been reported when using Eliquis.

Hepatic impairment

Take care when using Eliquis in patients with liver impairment. There is insufficient evidence to guide dosing accurately.

Renal impairment

Take care when using Eliquis in patients with renal impairment or with worsening renal function. There is insufficient evidence to guide dosing accurately. Dosing adjustments may be needed in patients with renal impairment.

Valvular heart disease

Eliquis should not be used in patients who require anticoagulation for mechanical heart valves.

Reversal of Eliquis

There is no specific way to reverse the effects of Eliquis. The effects will persist for approximately 24 hours after taking the last dose.

Eliquis Guidance for Special Populations

Acutely ill patients

Patients suffering from acute illness, such as respiratory failure or heart failure, are more likely to develop blood clots. Using Eliquis in these patients for an extended period (> 30 days) increases the risk of a bleeding complication without significantly decreasing the risk of developing a blood clot.

Elderly patients

The dose of Eliquis should be reduced in patients who are 80 years of age and have a serum creatinine level of 1.5 mg/dl or who weigh 60 kg.


Eliquis has not been tested extensively in persons under 18 years of age. As a result, its use is not recommended in this age group.


Eliquis has not been tested extensively in pregnant women. As a result, its use is not recommended during pregnancy. Should you fall pregnant while on Eliquis, contact your doctor as soon as possible.


The safety of Eliquis has not been tested in breastfeeding mothers. Taking Eliquis may affect your baby. If you wish to breastfeed, contact your doctor to discuss your options.

Navigating Eliquis Side Effects

Common side effects of Eliquis include:

  • Bleeding:
    • More bleeding than usual from minor cuts or scrapes
    • A tendency to bruise and swell more than usual after minor bumps
    • Nosebleeds
    • Bleeding from the gums
  • Nausea
  • Headache

Less common side effects (<1%) include:

  • Bleeding:
    • Rectal bleeding
    • Excessive bleeding and bruising from wounds after injury or surgery
    • Eye bleeding (conjunctiva and retina)
    • Heavy menstrual bleeding
    • Urinary tract bleeding
    • Intracranial bleeding
  • Increase in liver enzymes (serum alkaline phosphates, serum transaminases, increased serum bilirubin)
  • Allergic angioedema
  • Anaphylaxis

Eliquis and Drug Interactions: What You Need to Know

Certain drugs may interact with Eliquis to increase risk of bleeding. These include:

  • antibiotics (e.g., fucidin, clarithromycin)
  • anticoagulants (e.g., warfarin, dabigatran, rivaroxaban, heparin)
  • antifungals (e.g., itraconazole, ketoconazole, voriconazole)
  • antiplatelet agents (e.g., aspirin, P2Y12 inhibitors)
  • carbamazepine
  • dexamethasone
  • estrogens
  • herbal products (e.g., alfalfa, anise, garlic, omega-3 fatty acids, grapefruit juice, ginger, ginseng)
  • NSAIDs (e.g., naproxen, ibuprofen)
  • prostacyclin
  • SSRIs (e.g., citalopram, escitalopram, fluoxetine)
  • thrombolytic agents (e.g., alteplase, streptokinase, urokinase)

Choosing Between Eliquis and its Generic Equivalent

Eliquis, a leading anticoagulant medication, is widely prescribed to prevent blood clots in patients with atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). Its active ingredient, Apixaban, is available both as the well-known brand-name Eliquis and as a generic version. Understanding the differences and similarities between the branded medication and its generic equivalent can help patients and healthcare providers make informed decisions about treatment options.

Effectiveness and Use

Eliquis works by inhibiting Factor Xa, an enzyme crucial to the blood clotting process. This action helps prevent the formation of harmful clots in the blood vessels. Clinical studies have shown that the generic equivalent has the same pharmacological effects and safety profile. People taking it can expect similar outcomes in terms of efficacy and safety from both versions of the medication.


Generic Apixaban has been approved by regulatory authorities in several countries including Canada, offering a more accessible option for patients needing anticoagulation therapy. The availability of generic versions can vary based on location and insurance coverage, so patients are encouraged to consult with their healthcare provider or pharmacist to determine the best and most cost-effective option for their specific situation.

Buy Eliquis Canada: How to Save on Your Prescription

For patients in the US, the cost of Eliquis, a leading blood thinner used to prevent stroke and blood clots in people with atrial fibrillation, can pose a significant financial challenge, especially for those without medical insurance coverage. In the US, the price for Eliquis 2.5mg / 60 tablets can exceed $700, making it difficult for many to afford this vital medication.

However, there’s a cost-effective alternative available through Pharma Giant, a trusted Canadian pharmacy partner. Pharma Giant offers Eliquis at a considerably lower price, enhancing accessibility to this essential blood thinner. The cost for Eliquis through this service is $157 per 60 tablets, offering substantial savings for individuals requiring this medication but lacking insurance coverage.

Patients can achieve even greater savings by ordering in bulk. For instance, 180 tablets of Eliquis are priced at $432, offering an even better value. Additionally, the generic version is available for purchase, presents an alternative for cost-conscious patients, with 60 tablets of 2.5mg available for $89.99 and 180 tablets for $248.97.

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By opting to purchase Eliquis through Pharma Giant, US patients can access this crucial medication at a more budget-friendly price, without compromising quality. This option is particularly advantageous for those uninsured and seeking effective ways to manage their healthcare costs.

Choosing Pharma Giant not only means you can order Eliquis at a more affordable price but also enjoy the convenience and reliability of a reputable Canadian pharmacy partner. This service ensures patients in the US can manage their health effectively, with the added benefit of significant cost savings.

Frequently Asked Questions

Eliquis is manufactured as a round, yellow 2.5 mg tablet; and as a pink, oval 5 mg tablet.





For patients taking Eliquis to prevent blood clots in atrial fibrillation, the usual dose is 5 mg taken twice a day. If you weigh ? 60 kg, have problems with your kidneys, or are older than 80 years of age, you may be prescribed a lower dose.

The dose of Eliquis to treat a blood clot (deep vein thrombosis) or a clot in the lungs (pulmonary embolism) is 10 mg taken twice a day for seven days. This dose is then reduced to 5 mg twice a day, taken for a minimum of 6 months. After completing treatment, your doctor may prescribe a dose of 2.5 mg twice a day to prevent a new blood clot or a clot in the lungs.

The dose of Eliquis in patients having knee replacement or hip replacement surgery to prevent blood clots is 2.5 mg taken twice a day. The first dose is generally taken 12 to 24 hours after surgery.

Take Eliquis by mouth. You can take it on an empty stomach or with food. If you cannot swallow the tablet, it can be crushed and mixed with water. If you have prepared Eliquis in this way, it is essential to take it immediately.

If you miss a dose of Eliquis, try to take it as soon as possible, then continue with the usual medication schedule. However, if you are due to take your next dose in less than 3 hours, skip the dose you missed and continue with your regular medication schedule. Under no circumstances should you take a double dose of the medication to make up for the missed dose. If you are unsure about what to do, contact your doctor or local pharmacist to obtain advice.

Eliquis is a blood thinner. The most common side effects reported are related to this action and include bleeding, bruising, or swelling after minor bumps or cuts. Most of these side-effects are not severe and will resolve on their own. However, some side effects are potentially severe and require medical attention. Contact your doctor immediately if you notice any of the following:

  • ongoing bleeding from the nose
  • ongoing bleeding from the gums
  • ongoing bleeding from any wound
  • blood in your stool or urine
  • vomiting or coughing blood
  • bleeding in or around your eyes
  • symptoms consistent with a stroke:
    • difficulty speaking
    • dizziness or confusion
    • paralysis of any part of your body

If you experience severe bleeding side effects, immediately contact your doctor or go to the nearest emergency health care facility.


Eliquis should be stored away from children. There are no specific storage conditions required.