What is Erleada?
Erleada (apalutamide) is a prescription medicine used to treat certain types of prostate cancer.
It is effective for two main conditions: metastatic castration-sensitive prostate cancer (mCSPC), where cancer has spread to other parts of the body but still responds to treatments that lower testosterone, and non-metastatic castration-resistant prostate cancer (nmCRPC), where cancer has not spread but no longer responds to testosterone-lowering treatments.
Erleada helps manage these cancers by blocking the effects of testosterone, a hormone that can fuel prostate cancer growth.
Before starting Erleada, inform your healthcare provider about any existing health issues, such as heart disease, high blood pressure, diabetes, or a history of seizures or brain problems.
If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your doctor, as Erleada may impact pregnancy and might pass into breast milk. Men with partners who can become pregnant should use effective birth control during treatment and for three months afterwards.
How Does Erleada Work?
Erleada works by blocking the action of testosterone, a hormone that can fuel the growth of prostate cancer. It contains an ingredient called apalutamide, which targets and attaches to the androgen receptor (AR) in cancer cells.
By doing this, Erleada prevents the androgen receptor from moving to the cell nucleus, where it normally helps cancer cells grow and divide.
This blockage stops the cancer cells from receiving signals that they need to grow.
As a result, Erleada helps reduce tumor growth and can lead to smaller tumors and fewer cancer cells.
In clinical studies, Erleada has been shown to lower prostate-specific antigen (PSA) levels, which is a marker used to monitor prostate cancer, more effectively when used with other treatments compared to those treatments alone.
Dosage Information and Usage
Dosage Form and Strengths of Erleada
- 240 mg Tablets: Bluish grey to grey, oval, film-coated, and marked with “E240”.
- 60 mg Tablets: Slightly yellowish to greyish green, oblong, film-coated, and marked with “AR 60”.
Usage
Erleada should be taken once daily, either as one 240 mg tablet or four 60 mg tablets. Swallow the tablets whole without crushing or splitting them.
It can be taken with or without food. Erleada can be dispersed in non-carbonated water and taken with orange juice, applesauce, or additional water for those who have difficulty swallowing tablets.
It can also be administered through a feeding tube if needed. Patients should also receive a gonadotropin-releasing hormone (GnRH) analog or have had a bilateral orchiectomy (surgical removal of the testicles).
If a dose is missed, take it as soon as possible on the same day but do not take extra tablets to make up for the missed dose.
Storage Information
Store Erleada at room temperature, between 68°F and 77°F (20°C to 25°C). Keep it in its original container to protect it from light and moisture.
The bottle includes a desiccant packet, which helps keep the medicine dry. Make sure not to discard the desiccant, as it is important for preserving the quality of your medication.
Side Effects
Common Side Effects
- Fatigue
- Joint pain
- Rash
- Decreased appetite
- Weight loss
- High blood pressure
- Hot flashes
- Diarrhea
- Falls
- Fractures
Serious but Rare Side Effects
- Heart disease, stroke, or mini-stroke
- Fractures and falls due to weakened bones
- Seizures
- Severe skin reactions, such as rash, fever, swollen lymph nodes, or blistering
- Lung problems, including shortness of breath, cough, or fever
Warnings and Precautions
- Cerebrovascular and Ischemic Cardiovascular Events: Erleada can cause serious heart and brain problems, including stroke and heart attack. Monitor for symptoms like chest pain, shortness of breath, or sudden weakness. Patients with a history of heart issues should be carefully watched, and Erleada may need to be stopped if severe events occur.
- Fractures: Erleada may weaken bones, increasing the risk of fractures. Patients should be evaluated for fracture risk and may need bone-strengthening treatments.
- Falls: Increased risk of falls has been observed, especially in elderly patients. Evaluate patients for their risk of falling.
- Seizure: Erleada can cause seizures. If a seizure occurs, Erleada should be stopped. Patients should be cautious about activities that could be dangerous if a seizure happens.
- Severe Cutaneous Adverse Reactions: Erleada can cause severe skin reactions like Stevens-Johnson syndrome. Watch for symptoms such as severe rash or mucosal lesions, and discontinue Erleada if a serious skin reaction occurs.
- Interstitial Lung Disease (ILD)/Pneumonitis: Erleada may lead to serious lung issues. Monitor for symptoms like cough or shortness of breath and stop Erleada if ILD or pneumonitis is suspected.
- Embryo-Fetal Toxicity: Erleada can harm a fetus if taken by a pregnant woman. Males should use effective contraception during and for three months after treatment.
Overdosage
If you take too much Erleada, there is no specific antidote available. In case of an overdose, stop taking Erleada immediately.
Seek medical attention and follow general supportive care to manage any symptoms until the effects of the overdose lessen or resolve.
Your doctor will guide you on the best course of action to ensure your safety and recovery.
Drug Interactions With Other Medications
- Strong CYP2C8 or CYP3A4 Inhibitors: Taking a strong inhibitor of CYP2C8 or CYP3A4 with Erleada may increase the levels of Erleada in your body. While no initial dose adjustment is required, your doctor might reduce the Erleada dose based on how you tolerate the medication.
- Mild or Moderate CYP2C8 or CYP3A4 Inhibitors: These are not expected to affect Erleada levels significantly, so no special precautions are usually needed.
- CYP3A4, CYP2C9, CYP2C19, and UGT Substrates: Erleada can reduce the effectiveness of medications metabolized by CYP3A4, CYP2C19, or CYP2C9. If you are taking these medications, your doctor might suggest alternatives or monitor for reduced effectiveness.
- UGT Substrates: Erleada can also lower the levels of drugs processed by UDP-glucuronosyl transferase (UGT). If you need to take these drugs, use caution and check for reduced activity.
- P-gp, BCRP, or OATP1B1 Substrates: Erleada may decrease the levels of drugs that are substrates for P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), or organic anion transporting polypeptide 1B1 (OATP1B1). Be cautious if these drugs are used together and monitor for reduced effectiveness.
Alternative Medications
- Lupron Depot (leuprolide)
- Casodex (bicalutamide)
- Zytiga (abiraterone acetate)
- Xtandi (enzalutamide)
- Eligard (leuprolide)
Cost & Coupons
At Pharma Giant, we know how important it is for you to get the right medications without worrying about high costs.
Erleada is a medication used to treat two types of prostate cancer: metastatic castration-sensitive prostate cancer (mCSPC) and non-metastatic castration-resistant prostate cancer (nmCRPC). Many people depend on it for their health.
In the U.S., Erleada can be expensive, costing about $15,713 for 120 tablets. We’re here to help make it more affordable so you can focus on your health.
Affordable Options for Erleada
Your health shouldn’t come at a high price. Pharma Giant is dedicated to providing quality medications like Erleada at reasonable prices.
Here are our available Erleada options:
- 60mg – 120 tablets – $5,705.45
- 240mg – 30 tablets – $5,705.45
With us, you can manage your health without financial stress. Let Pharma Giant help you take control of your treatment today!
Special Discount Offer
- Coupon Code: Enter PGSAVE10 at checkout for a 10% discount on your Erleada order. This is a special, limited-time offer that allows you to save on essential medications without sacrificing quality.
- Offer Details: This discount can be used one time per customer, so don’t miss your chance to save!
How to Order
- Prescription Needed: You will need a valid prescription to buy Erleada, to ensure your safety and adherence to medical standards.
- Bulk Ordering: You can order up to a 90-day supply to ensure you have what you need for your ongoing treatment.
Quality Assurance & Timely Delivery
At Pharma Giant, we promise to deliver high-quality medication with quick delivery straight to your door.
- Fast Shipping: We provide express shipping from Canada, ensuring your order reaches you within 3-5 business days, so you don’t have to wait long.
- Secure Packaging: All orders are shipped in safe, tamper-proof packages to keep your medication secure from the moment it leaves our facility.
By choosing Pharma Giant, you can focus on your health without worrying about high costs.
We combine exceptional savings with a commitment to quality and customer care.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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