What is Estalis?
Estalis (estradiol/norethindrone acetate) is a medication designed for women who are experiencing menopause and still have their uterus.
Menopause can cause uncomfortable symptoms like hot flashes, night sweats, and vaginal issues such as dryness, itching, or burning. Estalis helps to relieve these symptoms.
Because Estalis involves hormone replacement, it’s important to use it under the guidance of a doctor.
Before starting Estalis, it’s important to discuss the risks and benefits with your doctor. Not everyone can use this medication.
It’s not suitable if you are pregnant, breastfeeding, or if you have a history of certain cancers, blood clots, heart disease, liver problems, or migraines.
How Does Estalis Work?
Estalis works by releasing two hormones into your body through a patch you wear on your skin.
The first hormone, estradiol, is a type of estrogen that helps to relieve menopause symptoms like hot flashes and vaginal dryness.
The second hormone, norethindrone acetate (NETA), is a type of progestin that works to protect the lining of your uterus.
Together, these hormones help balance the changes your body goes through during menopause, making you feel more comfortable.
Dosage Information and Usage
Dosage Form and Strengths of Estalis
Estalis is available as a transdermal patch that is applied to the skin.
Each pack contains 8 patches, and there are two strengths available.
Your doctor will decide the appropriate strength based on your specific needs.
- Estalis 140/50:
-
- Patch size: 9 cm²
- Releases: 50 micrograms of estradiol and 140 micrograms of norethindrone acetate per day
- Estalis 250/50:
-
- Patch size: 16 cm²
- Releases: 50 micrograms of estradiol and 250 micrograms of norethindrone acetate per day
Usage
Estalis patches are typically used in a continuous regimen, meaning you wear them all the time. You apply a new patch twice a week, on the same two days each week.
Each patch should stay on for 3 to 4 days before being replaced with a new one.
The patch should be applied to clean, dry skin on your abdomen or buttocks, avoiding areas where clothing might rub it off.
It’s important to rotate the application site each time you put on a new patch to avoid skin irritation.
Do not apply the patch to your breasts, as this can cause unwanted side effects.
Always follow your doctor’s instructions on how to use the patches and do not change or stop your treatment without consulting your doctor.
Storage Information
Store Estalis patches at room temperature (20-25°C) and use them within 6 months of purchase or by the expiry date on the pack, whichever comes first.
You can also keep them in the refrigerator (2-8°C) and use them before the expiry date.
Let the patches reach room temperature before applying them.
Do not freeze the patches. Keep them in their original package and make sure they are out of the reach of children and pets.
Side Effects
Common Side Effects
- Back pain or menstrual-like pain
- Breast tenderness
- Excessive vaginal secretions
- Headache
- Itching or redness under the patch
- Nervousness
- Pain in extremities
- Pelvic pain
- Skin irritation, rash, or acne
- Change in weight
Serious but Rare Side Effects
- Breast lump
- Crushing chest pain or chest heaviness
- Pain or swelling in the leg
- Sudden severe headache or worsening migraine
- Unexpected or excessively heavy vaginal bleeding
- Yellowing of the skin or eyes (jaundice)
- Signs of a severe allergic reaction (e.g., rash, itching, swelling)
Warnings and Precautions
- Breast Cancer: Women with a personal or family history of breast cancer or abnormal mammograms should consult their doctor before starting hormone replacement therapy (HRT). Regular breast exams and mammograms are recommended.
- Overgrowth of the Uterus Lining (Endometrial Hyperplasia) and Uterus Cancer: Estrogen therapy alone can increase the risk of endometrial hyperplasia, which may lead to endometrial cancer. Adding progestin can reduce this risk. Women should report any unusual vaginal bleeding to their doctor.
- Ovarian Cancer: Long-term use of estrogen or estrogen plus progestin therapy (5 years or more) may increase the risk of ovarian cancer.
- Heart Disease and Stroke: HRT may increase the risk of heart disease and stroke, particularly in postmenopausal women. The risk varies depending on the type of HRT and whether the woman has had a hysterectomy.
- Abnormal Blood Clotting: The risk of blood clots in the lungs and large veins increases with HRT, especially in older women, smoke, are overweight, or have a family history of blood clots.
- Gallbladder Disease: Estrogen use in postmenopausal women has been linked to an increased risk of gallbladder disease, which may require surgery.
- Dementia: Women over 65 using oral combined estrogen plus progestin may have a higher risk of dementia (memory loss). This risk was not observed in women using estrogen alone.
- Severe Allergic Reactions: If you have a history of severe allergic reactions or hereditary angioedema (swelling of hands, feet, or throat), discuss this with your doctor before starting treatment.
- Unexplained Vaginal Bleeding: Any unexplained or unusual vaginal bleeding should be reported to your doctor immediately, as it may indicate a serious condition.
- Liver Disease: Women with a history of liver disease, jaundice, or liver tumors should be cautious when using estrogen and should discuss this with their doctor.
- Migraine Headaches: If you have a history of migraines, especially with aura (visual disturbances), consult your doctor, as HRT may worsen these symptoms.
- High Blood Pressure: Women with a history of high blood pressure should monitor their blood pressure regularly while using HRT.
- Blood Clots and Cardiovascular Conditions: If you have a history of blood clots, heart disease, or stroke, or if you smoke, your risk of these conditions may increase with HRT.
- Kidney Disease or Asthma: Discuss with your doctor if you have a history of kidney disease or asthma, as HRT may affect these conditions.
- Bone Disease: If you have bone disease, particularly those that affect calcium and phosphorus levels, consult your doctor before starting HRT.
- Diabetes: Women with diabetes should monitor their blood sugar levels, as HRT may affect glucose control.
- Porphyria: If you have been diagnosed with porphyria (a blood disorder), HRT may affect this condition.
- Lupus: Women with lupus should be cautious with HRT, as it may exacerbate symptoms.
- Depression: Women with a history of depression should monitor their mood, as HRT may affect mental health.
- Hearing Loss: Women with hearing loss due to otosclerosis (a condition affecting the bones in the ear) should consult their doctor.
- Epilepsy or Neurological Disorders: If you have epilepsy or other neurological conditions, HRT may affect seizure control.
- High Cholesterol or Triglycerides: Women with a history of high cholesterol or triglycerides should monitor their lipid levels during HRT.
- Pregnancy and Breastfeeding: HRT should not be used if you are pregnant or breastfeeding.
- Hysterectomy: If you have had a hysterectomy (removal of the uterus), discuss with your doctor whether you need progestin in addition to estrogen.
- Smoking: Smoking increases the risk of serious side effects from HRT, including blood clots, heart disease, and stroke.
- Surgery or Long Bed Rest: HRT may increase the risk of blood clots during periods of immobilization, such as after surgery or long bed rest. Discuss preventive measures with your doctor.
- Hypothyroidism: If you have hypothyroidism and are on thyroid hormone replacement therapy, your doctor may need to monitor and adjust your treatment during HRT.
Overdosage of Estalis
If you use too much Estalis, you might experience symptoms like nausea, sore breasts, swelling, bloating, or vaginal bleeding.
Using too much of the progestin part of the patch can lead to feeling sad, tired, acne, or more hair growth than usual.
If you think you’ve used too much, take off the patch and contact your doctor, the nearest emergency department, or a poison control center right away.
Drug Interactions With Other Medications
Here are the following medications/drugs that may have an interaction with Estalis:
- Acetaminophen: Used to relieve pain and reduce fever.
- Aminoglutethimide with Medroxyprogesterone Acetate (MPA): Used to treat certain types of cancer and reduce hormone production.
- Anti-anxiety Medicines (Meprobamate, Temazepam): Prescribed to manage anxiety and help with sleep.
- Cyclosporin: An immunosuppressant drug often used to prevent organ rejection after a transplant.
- Anti-epileptic Medicines (e.g., Phenobarbital, Phenytoin, Carbamazepine): Used to control seizures in people with epilepsy.
- Anti-inflammatory Medicine (Phenylbutazone): Used to reduce inflammation and pain in conditions like arthritis.
- Antibiotics and Other Anti-infective Medicines (e.g., Ketoconazole, Erythromycin, Rifampicin, Rifabutin, Nevirapine, Efavirenz, Ritonavir, Nelfinavir): Used to treat various bacterial and viral infections.
- Herbal Medicines (e.g., St John’s Wort): Often used to treat mild depression and anxiety.
- Morphine: A strong pain reliever often used to manage severe pain.
- Prednisone: A corticosteroid used to reduce inflammation in various conditions, including allergies and asthma.
- Salicylic Acid: Commonly used to treat skin conditions like acne and warts.
- Theophylline: Used to treat lung diseases such as asthma and COPD by relaxing the muscles in the airways.
- Vitamin C: An essential vitamin often used to boost the immune system and support overall health.
Cost & Coupons
At Pharma Giant, we understand that your health is a top priority, and accessing the right medication shouldn’t be a financial burden. Our mission is to ensure that high-quality medications like Estalis are available at competitive prices, making healthcare more affordable for everyone.
Estalis Pricing at Pharma Giant
| Strength | Quantity | Price (USD) |
|---|---|---|
| 50mcg/140mcg | 8 patches | $54.95 |
| 16 patches | $106.00 | |
| 24 patches | $153.00 | |
| 50mcg/250mcg | 8 patches | $48.95 |
| 16 patches | $94.00 | |
| 24 patches | $135.00 |
Special Discount Promotion
Promo Code: Enter PGSAVE10 during checkout to enjoy a 10% discount on your Estalis order. This exclusive, limited-time opportunity allows you to save on vital medications without sacrificing quality.
Promotion Details: The discount is applicable for a single use per customer, so make sure to seize this chance while it’s available.
Purchase Information
Prescription Required: Estalis can only be obtained with a valid prescription to ensure patient safety and compliance with medical regulations.
Bulk Orders: Patients may order a maximum of a 90-day supply, offering ease for ongoing treatment and budget management.
Commitment to Quality and Prompt Delivery
At Pharma Giant, we dedicate ourselves to delivering high-quality medication with the added advantage of quick delivery right to your home.
- Fast Shipping: Medications are shipped expressly from Canada to anywhere in the U.S. within 3-5 business days, ensuring your order arrives quickly.
- Safe Packaging: Every shipment is sent in secure, tamper-evident containers, guaranteeing that your medication remains secure and undamaged throughout its transit.
Why Opt for Pharma Giant?
With Pharma Giant, you can focus on your health without the worry of high costs. Discover outstanding value and premium service today!
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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