- What is Eucrisa?
- Indications and Benefits of Eucrisa
- Eucrisa Information Table
- How It Works
- Eucrisa vs. Other Atopic Dermatitis Treatments
- Eucrisa Dose
- Usage Guide
- Side Effects
- Storage Information
- Warnings
- Contraindications
- Interactions
- Alternatives
- Cost & Coupons
- Frequently Asked Questions
- Disclaimer
- Price Match Guarantee
What is Eucrisa?
Eucrisa is a prescription topical treatment that belongs to a group of drugs called phosphodiesterase-4 (PDE-4) inhibitors.
It is applied directly to the skin to help reduce inflammation linked to eczema. It is FDA-approved for treating mild to moderate atopic dermatitis (eczema) in adults and children as young as 3 months old.
It is commonly prescribed to patients who need a non-steroid option to manage eczema symptoms such as redness, itching, and irritation.
Eucrisa is used on affected areas of the skin as directed and may be part of a long-term care plan.
Many patients also look into options like Eucrisa in Canada when exploring access and affordability.
Indications and Benefits of Eucrisa
Eucrisa is a topical treatment used to manage eczema symptoms and improve skin condition over time.
FDA-approved indications:
- Treatment of mild to moderate atopic dermatitis (eczema) in adults and children 3 months of age and older
Clinical benefits:
- Around 31% to 33% of patients achieved clear or almost clear skin after 28 days, compared to about 18% to 25% with non-medicated ointment
- Some patients reported visible skin improvement as early as 8 days
- Helps reduce itching, with improvement seen in about 1 to 2 days in clinical studies
- Steroid-free option for long-term eczema management, including use in infants as young as 3 months
Off-label use:
- There are no widely established or FDA-recognized off-label uses; it is primarily prescribed for eczema based on current evidence.
Eucrisa Information Table
| Category | Details |
| Brand Name | Eucrisa |
| Generic Name | Crisaborole |
| Medication Class | PDE-4 inhibitor |
| Primary Use | Mild to moderate atopic dermatitis in patients 3 months and older |
| Additional Uses / Off-Label | None listed in FDA labeling |
| Available Forms | Topical ointment |
| Method of Administration | Apply a thin layer to the affected skin |
| Available Dosage Strengths | 2% ointment |
| Dosing Frequency | Twice daily |
| Storage Instructions | 20°C to 25°C; keep tube closed |
| Pregnancy & Breastfeeding | Risk unknown; limited human data |
| Major Drug Interactions | No clinically significant interactions expected |
| Manufacturer | Pfizer Inc |
How It Works
Eucrisa works by calming inflammation in the skin. It belongs to a group of treatments called PDE-4 inhibitors.
It blocks an enzyme in skin cells that normally breaks down a helpful signal called cAMP. When cAMP levels increase, it helps reduce the release of substances that cause redness, swelling, and itching. While the exact way it improves eczema is not fully known, this process helps soothe irritated skin over time.
Patients may start to notice relief from itching and irritation within the first few days of regular use, though full improvement can take a few weeks. It is usually applied twice daily to keep inflammation under control.
Because it works directly in the skin and not throughout the whole body, its effects are focused on the treated areas and continue as long as it is used consistently.
Eucrisa vs. Other Atopic Dermatitis Treatments
| Drug Name | Drug Class | Form | Dosing Frequency | Primary Use | Key Difference from Eucrisa |
| Eucrisa (crisaborole) | PDE-4 inhibitor | Topical ointment | Usually twice daily; after response, the label says clinicians may consider once daily | Mild to moderate atopic dermatitis in adults and children 3 months and older | Reference product: a non-steroid topical option for mild to moderate eczema. |
| Elidel (pimecrolimus) | Topical calcineurin inhibitor | Topical cream | Twice daily | Mild to moderate atopic dermatitis in non-immunocompromised patients 2 years and older | Also non-steroid, but labeled for short-term and intermittent long-term use, and positioned when other therapies are not advisable. |
| Protopic (tacrolimus) | Topical calcineurin inhibitor | Topical ointment | Twice daily | Second-line treatment for moderate to severe atopic dermatitis in non-immunocompromised adults and children 2 years and older | Generally used for more severe disease and is labeled as a second-line rather than a first topical choice. |
| Opzelura (ruxolitinib) | Janus kinase (JAK) inhibitor | Topical cream | Twice daily | Short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis in non-immunocompromised adults and children 2 years and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended | Another non-steroid topical, but its label limits use by body surface area and positions it after inadequate control with other topical prescription treatments. |
| Dupixent (dupilumab) | Interleukin-4 receptor alpha antagonist | Subcutaneous injection | Depends on age and weight; in adults, every other week after a loading dose | Moderate to severe atopic dermatitis in adults and pediatric patients 6 months and older, not adequately controlled with topical prescription therapies or when those therapies are not advisable | Unlike Eucrisa, this is a systemic injectable treatment used for more advanced disease. |
| Locoid Lipocream (hydrocortisone butyrate) | Topical corticosteroid | Topical cream | 2 to 3 times daily in adults; twice daily for pediatric mild to moderate atopic dermatitis | Corticosteroid-responsive dermatoses in adults; mild to moderate atopic dermatitis in pediatric patients 3 months and older | This is a topical steroid, while Eucrisa is steroid-free. |
Eucrisa Dose
The dosage of Eucrisa is simple and based on applying the ointment directly to affected skin areas.
Available Dosage Forms and Strengths
- Topical ointment: 2% (20 mg of crisaborole per gram)
Dosage Chart
| Condition | Starting Dose | Maintenance Dose | Maximum Dose |
| Mild to moderate atopic dermatitis | Apply a thin layer twice daily to affected areas | May be reduced to once daily after improvement | Not specified in FDA labeling |
What Dosage Strengths Does Eucrisa Come In?
Eucrisa is available in one strength only, which is a 2% topical ointment. This means each gram of ointment contains 20 mg of the active ingredient, crisaborole.
There are no other strengths or forms listed in the FDA prescribing information.
Usage Guide
Using Eucrisa is simple, but it is important to follow each step carefully for the best results.
Step-by-Step Instructions
- Wash and dry your hands before applying.
- Clean and dry the affected skin area.
- Apply a thin layer of Eucrisa to the affected areas.
- Gently rub it into the skin until fully absorbed.
- Wash your hands after applying, unless your hands are being treated. If someone else applies it, they should wash their hands after.
Timing and Use
- Apply at the same time each day, such as morning and evening.
- This treatment is used on the skin, so it is not affected by food or drink.
- It does not require water or swallowing.
Injectable Instructions
- Eucrisa is not an injectable treatment. It is only applied to the skin.
Important Things to Avoid
- Do not apply inside the eyes, mouth, or vagina.
- Do not use on areas where you have a known allergy to its ingredients.
- Avoid covering the treated area tightly unless advised.
- Do not share it with others, even if they have similar symptoms.
How to Know It Is Working
- You may notice less itching, redness, and irritation over time.
- Skin may start to look clearer and feel smoother with continued use.
- Improvement can take several days to a few weeks, so use it regularly as directed.
Side Effects
Common Side Effects
- Application site pain (burning or stinging): ~4% of patients in clinical trials
Serious Side Effects
- Allergic reactions (can occur at or beyond the application site)
- Trouble breathing or throat tightness
- Hives
- Chest tightness
- Severe itching
- Feeling faint
- Swelling of the face, lips, tongue, or throat
- Redness
Stop using Eucrisa and seek immediate medical attention if you experience any signs of an allergic reaction.
Storage Information
Eucrisa should be stored at 20°C to 25°C or 68°F to 77°F before and after opening. Short temperature changes between 15°C and 30°C or 59°F to 86°F are allowed.
Keep the tube tightly closed when not in use to protect it from air and moisture. Store it at room temperature in a dry place and away from excessive heat. Do not freeze.
The FDA label does not specify a time limit after opening, but it should be used before the expiration date on the package. Do not use expired product. Dispose of unused or expired ointment safely by following local guidelines or asking a pharmacist.
Warnings
Precautions
- Hypersensitivity reactions: Eucrisa may cause allergic reactions, including contact urticaria.
- Signs to watch for: Severe itching, swelling, or redness at the application site or even in areas away from where it was applied.
- Action required: If symptoms of a hypersensitivity reaction occur, stop using Eucrisa immediately and seek medical care.
Patients Who Need Extra Caution
- Patients with known allergy to crisaborole or any ingredient: Should not use this treatment.
- The FDA label does not specify additional precautions for elderly patients or those with renal or hepatic impairment.
Monitoring Requirements
- No routine lab tests or monitoring are required.
- Patients should be observed for signs of hypersensitivity, especially after starting treatment.
Contraindications
Eucrisa should not be used in the following situations:
- Known hypersensitivity to crisaborole or any ingredient in the formulation
- This means you have had an allergic reaction to Eucrisa or its components in the past. Using it again may trigger serious reactions such as swelling, redness, itching, or more severe allergic symptoms.
Who Should Not Use Eucrisa
- Patients with a history of allergy to crisaborole
- Patients with a known sensitivity to any inactive ingredients in the ointment
If you are unsure about past allergic reactions, speak with your doctor before starting treatment.
Interactions
| Drug / Substance | What Happens | What to Do |
| Warfarin | No meaningful interaction seen in studies | No change needed |
| Drugs processed by the liver (CYP enzymes) | Eucrisa does not affect how these drugs work | No action needed |
| Certain sensitive drugs (UGT1A9 substrates) | May slightly increase drug levels | Use with caution if advised by your doctor |
| Other common medications | No significant interactions expected | No action needed |
Alternatives
| Drug Name | Generic Name | Drug Class | Key Difference from Eucrisa | Best For (patient profile) |
| Dupixent | Dupilumab | Biologic IL-4 receptor antagonist | Injectable treatment that works throughout the body, not just the skin | Moderate to severe eczema not controlled with topical treatments |
| Ebglyss | Lebrikizumab | Biologic IL-13 inhibitor | Injectable biologic targeting immune pathways | Patients needing long-term control of moderate to severe eczema |
| Protopic | Tacrolimus | Topical calcineurin inhibitor | A non-steroid ointment is often used as a second-line treatment | Patients who cannot use steroids or need stronger topical control |
| Elidel | Pimecrolimus | Topical calcineurin inhibitor | Non-steroid cream used for mild to moderate eczema | Patients needing a steroid-free alternative for sensitive areas |
| Triamcinolone topical | Triamcinolone acetonide | Corticosteroid | Reduces inflammation quickly, but it is a steroid | Patients needing short-term relief from flare-ups |
Cost & Coupons
Buy Eucrisa Online From Canada
Pharma Giant helps patients access more affordable Eucrisa cost options by connecting you with licensed Canadian pharmacies. This allows you to get the same treatment at a lower price compared to typical U.S. retail pricing.
- Lower Eucrisa cream price compared to U.S. pharmacy costs
- Sourced from licensed and regulated Canadian pharmacies
- Shipped directly to your home across the U.S.
- Transparent pricing with no hidden fees
- Option to order up to a 3-month supply for added savings
- Orders reviewed by doctors and verified by pharmacists
- Proper packaging for safe delivery
Eucrisa Discounts and Coupons from Pharma Giant
Use code PGSAVE10 at checkout to receive 10% off your first Eucrisa order.
How to Order?
| Step 1: Search for your Eucrisa on the website, choose the correct strength and quantity, then add it to your cart.
Step 2: Enter your contact details, shipping address, and payment information. Create an account if you are a new customer or log in if you already have one. Step 3: If your order includes prescription Eucrisa, upload it directly to the site, email it, or fax it. Over-the-counter items do not require a prescription. Use PGSAVE10 to claim your 10% discount on your first order. |
Pharma Giant’s Guarantee
Pharma Giant works only with licensed pharmacies to ensure safe and reliable service. Every order is reviewed and verified before shipping. Patients can expect consistent quality, secure handling, and dependable access to treatment at a more manageable cost.
Pharma Giant gives you peace of mind, great service, and real savings all in one place.
Frequently Asked Questions
Buying Eucrisa from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
Adverse Reactions
Food & Drug Interactions
Storage & Travel
Drug Comparison
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
| Have a prescription?
Order Eucrisa online today and enjoy a host of benefits, including: |
 |
