What is Evenity?
Evenity (romosozumab) is a medication prescribed to treat osteoporosis in women who have gone through menopause.
Osteoporosis is a condition where bones become weak and more likely to break. Evenity is especially for women at high risk of fractures, or for those who can’t use other osteoporosis medicines or didn’t get good results from them.
It’s important to note that Evenity is not approved for use in children. You should not use Evenity if you have low levels of calcium in your blood or are allergic to any of its ingredients, including romosozumab.
Before starting Evenity, inform your doctor about any medical conditions, like heart or blood vessel issues, low blood calcium, kidney problems, or if you plan to have dental surgery.
Also, tell your doctor about all other medications, vitamins, and supplements you’re taking. Evenity use is limited to 12 monthly doses, after which other treatments may be considered if necessary.
Indications and Benefits of Evenity
Evenity is a prescription injection used to treat osteoporosis in postmenopausal women who face a high risk of fractures. It is recommended for women who have not responded well to other osteoporosis treatments or who have stopped them due to side effects.
The active ingredient, romosozumab, works by building new bone and slowing down bone breakdown, making bones stronger and less likely to fracture.
Doctors may prescribe Evenity when bone strength needs rapid and targeted support to lower the chance of serious breaks.
What Are the Benefits of Evenity?
- Evenity helps strengthen bones in postmenopausal women who have osteoporosis and are at high risk of fractures. It works by increasing bone formation and reducing bone breakdown.
- Evenity has been shown to significantly improve bone density, especially in the spine and hips, which lowers the chance of painful and disabling fractures.
- Evenity is an option for women who have tried other osteoporosis treatments but stopped because they did not work well enough or caused difficult side effects.
- Evenity works faster than many other treatments, with measurable improvements in bone health seen within weeks of starting the injections.
- Evenity is given only once a month as two small injections under the skin, making it a convenient option compared to daily or weekly treatments.
- Evenity reduces the risk of future fractures, which supports long-term mobility, independence, and overall quality of life for women after menopause.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Romosozumab-aqqg |
| Medication Class | Monoclonal antibody |
| Primary Use | Treatment of osteoporosis in postmenopausal women at high risk of fracture |
| Additional Benefit | Increases bone density and lowers the risk of spine and hip fractures |
| Available Form | Prefilled syringe for subcutaneous injection |
| Method of Administration | Injection under the skin (subcutaneous) by a healthcare professional |
| Frequency | Two injections once a month for 12 months |
| Storage Instructions | Store in the refrigerator at 2 to 8 degrees Celsius in the original carton; do not freeze; may be kept at room temperature up to 25 degrees Celsius for 30 days; discard if not used after that time |
| Pregnancy and Breastfeeding | Not recommended during pregnancy or breastfeeding due to lack of safety data |
| Drug Interactions | No known interactions, but patients should inform doctors of all medications, supplements, and vitamins being taken |
| Manufacturer | Amgen Inc. |
How It Works
Evenity works by blocking the action of a protein called sclerostin, which plays a role in bone metabolism.
By inhibiting sclerostin, Evenity helps the body build new bone and also slows down the breakdown of existing bone, though it mainly focuses on building new bone.
In studies with animals, the active ingredient in Evenity, romosozumab, was shown to stimulate bone-forming cells called osteoblasts.
This leads to an increase in bone mass and improves bone structure and strength, making bones less likely to fracture.
Dosage
Evenity is prescribed for the treatment of osteoporosis in postmenopausal women who are at high risk of fracture.
It is given as an injection under the skin and should only be administered by a trained healthcare professional.
The recommended treatment period is 12 months, and patients are advised to take calcium and vitamin D supplements during therapy to maintain healthy bone strength.
Dosage Form and Strengths of Evenity
Evenity is available in the form of an injection, with each prefilled syringe containing 105 mg of medication in 1.17 mL of solution.
A full Evenity dose consists of two prefilled syringes, each containing 105 mg.
The solution is clear to slightly cloudy and may range from colorless to light yellow.
Dosage Chart
| Population / Condition | Recommended Dosage |
| Postmenopausal women with osteoporosis are at high risk of fracture | 210 mg once monthly, given as two consecutive injections of 105 mg each under the skin (abdomen, thigh, or upper arm) |
| Treatment duration | 12 months (a total of 12 doses) |
| Supplementation | Calcium and vitamin D should be taken daily as advised by the healthcare provider |
| Patients with hypocalcemia (low calcium) | Correct calcium levels before starting treatment |
| Severe renal impairment or on dialysis | Higher risk of low calcium; monitor closely and ensure adequate calcium and vitamin D intake |
Usage Guide
Preparation:
- Your healthcare provider will administer Evenity.
- Each dose requires two injections, using two separate prefilled syringes.
- The medication should be injected under the skin in the abdomen, thigh, or upper arm.
- Evenity should be stored properly and allowed to reach room temperature for 30 minutes before use.
Injection:
- Clean the injection sites with alcohol wipes.
- Use a new site for each injection to avoid irritation.
- Remove the gray needle cap from the first syringe when ready to inject.
- Inject the full amount from each syringe subcutaneously (under the skin), not into a muscle or vein.
- Dispose of syringes and needle caps in a sharps container after use.
Dental Care:
- Maintain good oral hygiene and inform your dentist that you are receiving Evenity before undergoing any dental procedures.
Storage Information
If you need to store Evenity after picking it up from the pharmacy, keep it in its original carton in the refrigerator at 36°F to 46°F (2°C to 8°C) to protect it from light.
Do not freeze or shake the medication.
If you remove Evenity from the refrigerator, you can keep it at room temperature up to 77°F (25°C) for up to 30 days, but it must be used within that time.
If it isn’t used within 30 days, it should be thrown away.
Always keep Evenity and all other medications out of reach of children.
Side Effects
Common Side Effects
- Joint pain
- Headache
Serious but Rare Side Effects
- Serious allergic reactions:
-
- Rash
- Hives
- Swelling of the face, lips, mouth, tongue, or throat
- Difficulty swallowing or breathing
- Low calcium levels in your blood (hypocalcemia):
-
- Muscle spasms, twitches, or cramps
- Numbness or tingling in the fingers, toes, or around the mouth
- Severe jaw bone problems (osteonecrosis):
- Potentially severe jaw issues
- Importance of a dental check-up before starting treatment
- Maintaining good oral hygiene
- Unusual thigh bone fractures:
-
- New or unusual pain in the hip, groin, or thigh
Missed Dose
If you miss your scheduled Evenity injection, contact your doctor right away to reschedule. You should receive the missed dose as soon as possible, and future injections will be scheduled one month from the new date.
Keeping regular appointments is important for the treatment to be effective, so setting reminders can help avoid missed doses.
Overdose
If too much Evenity is given, seek medical help immediately.
Warnings and Precautions
- Major Adverse Cardiac Events (MACE): Evenity may increase the risk of serious heart problems, including heart attacks and strokes. It should not be used in patients who have had a heart attack or stroke in the past year. Patients with other heart disease risks should be monitored for symptoms like chest pain or difficulty breathing and should seek medical help if these occur. Evenity should be stopped if a heart attack or stroke happens during treatment.
- Hypersensitivity Reactions: Some patients may experience severe allergic reactions to Evenity, such as swelling (angioedema), skin rashes, and hives. If a serious allergic reaction occurs, treatment with Evenity should be discontinued, and appropriate medical therapy should be given.
- Hypocalcemia: Evenity can cause low calcium levels in the blood. It’s important to correct low calcium before starting the medication. Patients should take calcium and vitamin D supplements during treatment, especially those with severe kidney problems, as they are at higher risk. Signs of low calcium include muscle cramps, tingling in fingers, toes, or around the mouth.
- Osteonecrosis of the Jaw (ONJ): ONJ is a condition where the jawbone starts to die, often linked to tooth extraction or infection. Patients should have a dental check-up before starting Evenity and maintain good oral hygiene. Those on medications like chemotherapy or with conditions like cancer are at higher risk. If ONJ develops, consult a dentist or oral surgeon, and consider stopping Evenity based on a benefit-risk assessment.
- Atypical Subtrochanteric and Diaphyseal Femoral Fractures: These unusual fractures in the thigh bone can occur with little or no trauma. Patients should report any new or unusual pain in the thigh, hip, or groin areas, as these could be early signs of a fracture. If a fracture is suspected, Evenity treatment may need to be paused while the patient is evaluated.
Contraindications
Evenity should not be used in people with low calcium levels in the blood (hypocalcemia). This condition must be treated before starting therapy.
It is also contraindicated in individuals with a history of severe allergic reactions to romosozumab or any of its ingredients.
Reported reactions include swelling (angioedema), skin rash (erythema multiforme), and hives (urticaria).
Interactions
Currently, there are no known interactions between Evenity and other medications. However, this does not rule out the possibility of interactions being identified in the future, especially as new drugs become available.
Before starting treatment with Evenity, it is important to inform your doctor about all the medications you are taking, including prescription drugs, over-the-counter products, and any supplements, herbs, or vitamins.
This information can help healthcare providers identify and manage any potential interactions.
If you have concerns about drug interactions while taking Evenity, consult your doctor or pharmacist for personalized advice.
Alternative Medications
If Evenity is not suitable, there are other medications available that can help manage bone health.
These alternatives include drugs that either help rebuild bone or slow down bone breakdown:
- Tymlos (abaloparatide)
- Forteo (teriparatide)
- Prolia (denosumab)
- Fosamax (alendronate)
- Binosto (alendronate)
- Actonel (risedronate sodium)
- Atelvia (risedronate)
- Boniva (ibandronate)
- Reclast (zoledronic acid)
- Evista (raloxifene)
- Miacalcin (calcitonin salmon)
Cost & Coupons
Your health is important, and getting the right medication shouldn’t be expensive. That’s where Pharma Giant comes in. We’re focused on making healthcare affordable and accessible, ensuring you don’t have to compromise on your well-being due to financial concerns.
Evenity Pricing Options
Pharma Giant offers quality medication at reasonable prices. Explore our Evenity options below:
| Strength | Package Size | Price |
|---|---|---|
| 105MG/1.17ML | 2 syringes | $1,030.00 |
| 105MG/1.17ML | 4 syringes | $2,040.00 |
| 105MG/1.17ML | 6 syringes | $3,030.00 |
Note: The U.S. price for Evenity is $3,224.59 for 2 syringes according to SingleCare. With a valid prescription, Americans can order Evenity from a licensed and trusted Canadian pharmacy starting at just $1,300. Medications are express shipped from Canada to the U.S. within 3-5 business days, using thermal packaging to maintain the medication’s integrity during transit.
Special Discount Offer
Reduce your medication costs with Pharma Giant’s exclusive discount. Apply the code PGSAVE10 at checkout to receive a 10% discount on your Evenity purchase. This limited-time promotion allows you to save on essential healthcare products, maintaining both quality and affordability.
Hurry—this offer is available for one-time use per customer. Experience excellent value with Pharma Giant now.
Ordering Information
Evenity is available exclusively with a valid prescription to ensure patient safety and adherence to medical standards. Patients can obtain up to a 90-day supply, providing convenience for ongoing treatment and cost management.
Quality Assurance and Prompt Delivery
Pharma Giant is dedicated to offering high-quality medication paired with dependable and timely delivery services. Through our express shipping, your order will reach you within 3-5 business days anywhere in the U.S. We ensure your medication is safely transported by shipping in secure containers with thermal protection, giving you peace of mind during transit.
Why Choose Pharma Giant?
When you choose Pharma Giant, you are partnering with a trusted ally that prioritizes your health and convenience. We’re committed to providing you with affordable, high-quality medication and exceptional service.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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