What Is Evista (Raloxifene)?
Evista (raloxifene) is a prescription medication used to treat and prevent osteoporosis in postmenopausal women. Osteoporosis is a condition in which bones become weak and are more likely to break.
Evista works by helping to strengthen bones. It is also used to lower the risk of invasive breast cancer in postmenopausal women who have osteoporosis or are at high risk of developing breast cancer.
However, it does not completely remove the chance of getting breast cancer.
Evista is not meant for premenopausal women, as it is designed for those who have gone through menopause. This medication is also not used to treat active breast cancer or prevent its recurrence.
Before starting Evista, you must talk to your doctor to ensure the benefits outweigh any potential risks based on your health history.
How Does Evista Work?
Evista works as a selective estrogen receptor modulator (SERM), meaning it acts like estrogen in some body parts and blocks estrogen in others.
This dual action helps strengthen bones while preventing bone loss. Evista acts as an estrogen agonist in bone tissue, reducing bone breakdown and increasing bone density, lowering the risk of fractures.
This makes Evista effective in treating and preventing osteoporosis in postmenopausal women.
In other tissues, such as the uterus and breasts, Evista works as an estrogen antagonist, meaning it blocks estrogen’s effects, helping reduce the risk of breast cancer. Unlike estrogen, Evista does not stimulate growth in breast or uterine tissue.
By regulating bone turnover, Evista helps maintain bone strength, especially in women who have lost estrogen after menopause, reducing the risk of vertebral fractures.
Dosage Information and Usage
Dosage Form and Strengths
Evista is available in a convenient 60 mg dosage as a white, elliptical, film-coated tablet.
One side of each tablet is imprinted with the number 4165, making it easy to identify.
The film coating helps with swallowing and ensures that the active ingredient, raloxifene, is released effectively in your body.
Take this tablet once daily to maintain a simple and consistent dosing schedule for better adherence.
When used as directed, the 60 mg strength is ideal for therapeutic effects while minimizing the risk of side effects.
How to Use Evista?
Take one 60 mg tablet of Evista once a day. You can take it at any time of the day, with or without food, as it does not depend on meal timing.
Take the tablet simultaneously daily to make it part of your routine for the best results.
If you forget to take a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Never take two doses at once.
Evista should be taken with calcium and vitamin D supplements unless dietary intake is adequate. Follow your doctor’s advice on dosage and supplementation.
Storage Information
Store Evista at room temperature, between 68°F and 77°F (20°C to 25°C). Ensure the tablets are in their original packaging to protect them from moisture and light.
Always store Evista and all medications in a secure place, out of the reach of children, to prevent accidental ingestion.
Avoid storing the medication in places with excessive heat or humidity, such as bathrooms.
Side Effects
Evista can cause a range of side effects, from mild and common issues to more severe and potentially life-threatening conditions.
Common side effects include hot flashes, leg cramps, and swelling in the feet, ankles, and legs.
These are usually manageable and may go away over time. However, some users may experience more serious side effects, such as an increased risk of blood clots (deep vein thrombosis or pulmonary embolism), which can lead to life-threatening complications like stroke.
Women who have had blood clots, heart attacks, or strokes may face a higher risk when taking Evista.
Common Side Effects
- Hot flashes
- Leg cramps
- Swelling of the feet, ankles, and legs
- Flu-like symptoms
- Joint pain
- Sweating
Severe Side Effects
- Increased risk of blood clots (deep vein thrombosis or pulmonary embolism)
- Stroke or increased risk of dying from stroke, especially in women with a history of heart attack
- Vision problems related to blood clots in the eyes
- Unexplained chest pain or shortness of breath
Overdosage
If you take too much Evista, seek medical help right away. While no severe overdoses have been reported in studies, some people who took doses over 180 mg experienced side effects like leg cramps and dizziness.
In rare cases, children who accidentally ingested 180 mg experienced symptoms like vomiting, rash, and diarrhea. There is no specific antidote for Evista overdose.
What if I Miss a Dose?
If you miss a dose of Evista, take it as soon as you remember. However, if your next scheduled dose is almost due, skip the missed dose and take your next dose at the regular time.
Avoid taking two doses simultaneously to make up for the missed one.
This prevents taking too much medication at once, reducing the risk of side effects.
If you miss multiple doses or have concerns about your dosage, contact your healthcare provider for guidance.
Warnings and Precautions for Evista
Evista (raloxifene) is an effective medication for treating certain health conditions in postmenopausal women.
Before starting the medication, consider some important warnings and precautions.
Below are some key points to keep in mind.
- Venous Thromboembolism: Evista increases the risk of blood clots in the legs (deep vein thrombosis) and lungs (pulmonary embolism). The highest risk occurs during the first four months of treatment. If you are planning prolonged periods of immobility (e.g., after surgery), talk to your doctor and stop Evista at least 72 hours before, resuming it only after you are fully active again.
- Stroke Risk: Evista increases the risk of death from stroke in postmenopausal women with coronary heart disease or those at higher risk for heart issues. Doctors must carefully assess the risk-benefit balance for women with a history of stroke or risk factors like hypertension and smoking.
- Cardiovascular Disease: Do not use Evista to prevent cardiovascular disease. Clinical trials have shown no cardiovascular benefits.
- Premenopausal Use: Premenopausal women should not use Evista. This group has not been proven safe, and the drug could harm a fetus if the woman becomes pregnant.
- Hepatic Impairment: Exercise caution when prescribing Evista to individuals with liver impairment, as its safety and effectiveness remain unconfirmed in these patients.
- Concomitant Estrogen Therapy: Do not combine Evista with estrogen-based therapies, as their safety together has not been established.
- Hypertriglyceridemia: Women who have had very high triglycerides from estrogen therapy should have their triglyceride levels checked when using Evista.
- Renal Impairment: Exercise caution when prescribing Evista to patients with moderate or severe kidney impairment.
- History of Breast Cancer: Evista has not been well-studied in women who have had breast cancer.
- Use in Men: Evista is not indicated for men and has not been studied for safety or efficacy in this group.
- Unexplained Uterine Bleeding: Investigate any unexplained uterine bleeding. Although Evista does not significantly increase the risk of endometrial cancer, assess the cause of any bleeding during treatment.
- Breast Abnormalities: Any unexplained breast changes should be evaluated. Evista does not eliminate the risk of breast cancer.
Drug Interactions With Other Medications
Evista may interact with several other medications, affecting its effectiveness or increasing the risk of side effects.
It is important to know these interactions when using Evista alongside other treatments.
- Cholestyramine: Do not take Evista with cholestyramine or other anion exchange resins, as they may reduce effectiveness.
- Warfarin: If you take warfarin or similar blood thinners, closely monitor your INR when starting or stopping Evista.
- Highly Protein-Bound Drugs: Use Evista with caution if you are also taking drugs like diazepam, diazoxide, or lidocaine, as Evista may affect how these drugs bind to proteins in the blood.
- Systemic Estrogens: Avoid combining Evista with systemic estrogen therapy, as researchers have not established the safety of this combination.
- Other Medications: You can safely use Evista with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin. However, researchers have not studied its interaction with lipid-lowering agents.
Alternative Medications to Evista
If Evista is not suitable for you or you are looking for alternative treatment options, several medications can help manage conditions like osteoporosis.
These alternatives may work differently to address bone health and other related concerns.
- Fosamax (alendronate)
- Prolia (denosumab)
- Evenity (romosozumab)
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- Use the search bar at the top of the website to find Evista. Once you locate the correct medication and dosage, click the ‘Buy’ button to add it to your cart. If you order multiple medications, continue searching and add them to your cart.
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- For prescription medications, upload a scanned or digital copy of your prescription using the RX document uploader tool or fax it to 1-888-562-8159. If your order does not include prescription medications, your order will be processed without additional documentation.
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Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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