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What is Fasenra?

Fasenra is a monoclonal antibody asthma treatment that was developed to significantly reduce the occurrence of asthma attacks. It improves lung function by reducing levels of eosinophils, a type of white blood cell that might contribute to symptoms of asthma.

Eosinophilic asthma primarily impacts your immune system. With this condition, cells mistakenly attack your body’s airways, causing swelling and common asthma symptoms, such as:

  • coughing
  • shortness of breath
  • difficulty breathing
  • tightness in your chest
  • runny or stuffy nose
  • reduced sense of smell

Fasenra is for people whose asthma is not well controlled with other medications. It is generally taken in combination with other asthma treatments, and not meant as a solo treatment for acute asthma attacks. A rescue inhaler is still needed for treatment of sudden asthma attacks.

How does Fasenra work?

Asthma is often treated with a combination of medicines. Fasenra is used as an add-on in maintenance therapy of patients with severe asthma.

Fasenra is a biologic that is designed to target eosinophils, a key cause of severe asthma. Fasenra contains the active drug benralizumab, an ingredient that emulates a biologic. A biologic is made with of from parts of living organisms.

Fasenra works by attaching to the eosinophils, sending signals to other cells in your body to destroy them. By lowering the level of eosinophils in the body, the likelihood of inflammatory symptoms experienced with eosinophilic asthma is reduced. As a result, patients are less likely to experience eosinophilic asthma attacks, or may experience a decrease in severity of symptoms.

Fasenra is not a rescue medication for asthma attacks. Use of fast-acting inhalation medication (e.g. rescue inhalers) is still necessary for attacks. If a fast-acting medicine does not work, seek immediate medical attention.


Fasenra is administered via injection and used with other asthma medications to control severe asthma in adults and children at least 12 years of age. It comes in a single-dose pre-filled syringe, to be injected in the upper arm, thigh, or abdomen, by a healthcare provider.

A typical dose of Fasenra is 30 mg, delivered subcutaneously via injection once every four weeks for the first 3 doses, and once every 8 weeks following.

If your provider decides that you or a caregiver can give the injection, you should receive training on proper administration of Fasenra using the pen autoinjector. Be sure to follow your doctor’s instructions carefully when preparing and giving the injection.

Frequent tests may be required to help your provider determine the result of your treatment and how long you should take Fasenra.

Do not change your dose or schedule without consulting your medical provider first. Your dose may need changes due to surgery, illness, stress, or a recent asthma attack. Notify your provider if any of your medications seem to stop working.


Do not take more Fasenra than is prescribed. Given Fasenra is administered by a professional in a controlled medical setting, overdose is unlikely. If you are directed to administer this drug at home, be sure to follow the treatment schedule determined by your provider.

Missed Doses

Contact your doctor for instructions if you miss an injection. They will advise the next best course of action and adjust your dosage schedule if needed.

Side Effects

Before taking Fasenra, tell your doctor about your medical history, allergies, all medications you are currently taking, and whether you are pregnant or breast-feeding.

Common side effects may include sore throat, fever, or headache. Injection site soreness might also occur following administration of Fasenra. These mild side effects tend to dissipate after a few days. If they worsen of become bothersome, talk with your doctor or pharmacist. Be sure to contact your doctor if you have new or worsening asthma symptoms after receiving Fasenra.

Keep in mind that side effects may vary from person to person, and can depend on variables like age, pre-existing health conditions, and other medications you may be taking.

If pregnant, follow your doctor’s instructions about taking this medicine. Forgoing asthma treatment while pregnant could cause harm to both mother and baby. If you are pregnant, breast-feeding, or plan to become pregnant, be sure to let your doctor know.

Serious allergic reactions to this drug are uncommon. However, if you noticed symptoms of an allergic reaction, such as: itchiness, rash, swelling/inflammation, dizziness, or trouble breathing, seek emergency help immediately.

Your doctor or pharmacist can advise more about the potential risks and benefits of taking Fasenra.

Warnings & Precautions

You should not take Fasenra if you are allergic to benralizumab.

Notify your doctor if you have ever had a parasitic infection like roundworms or tapeworms; or if you have used an oral or inhaled steroid medication.

Storage & Safety

Store your prescription at room temperature. Keep it away from light and high moisture (e.g. away from your bathroom). Keep all medications out of reach from children and pets.

Do not flush or pour medications down the toilet or drain (unless you are told to do so). If this product is no longer needed or expired, consult your pharmacist or local waste disposal company on how to properly discard your medication.

Drug Interactions

Fasenra may not be a good fit for you if you have certain conditions or other factors that affect your health. Before taking a new medication, be sure to consult with your provider on all other medications you are currently on. This includes supplements and over-the-counter medications, as they might have active ingredients that interact with the drug.

Other factors to discuss with your provider are whether you’ve had a parasitic infection or allergic reaction. It is not known whether Fasenra treatment affects one’s ability to fight parasitic infection. If you do have a parasitic infection, your doctor will likely try to treat this first before prescribing Fasenra.

Consulting with a medical professional can help limit unwanted side effects or drug interactions that may be very risky or even fatal. Be sure to keep a list of all the products you use and share it with your doctor or pharmacist so they can determine the right dosage for you.

Alternative Medications

There is no lower-cost generic alternative for Fasenra, but there are comparable medications which are used for maintenance treatment of asthma, including Dupixent, Singulair, and Montelukast.

Dupixent is another biologic medication that is made to treat for severe eosinophilic asthma in adults. Dupixent is also prescribed for treating conditions beyond eosinophilic asthma.

Singulair is used with other treatments for the maintenance treatment of asthma. It does not relieve immediate attacks and can cause neuropsychiatric effects in a small number of people.

Additionally, Montelukast may be used daily for maintenance treatment of asthma or allergic rhinitis. This medication will not relieve acute asthma attacks, and some experience unwanted neuropsychiatric effects on this drug.

To learn more about how these drugs are alike and different, consult your doctor or pharmacist. As always, be sure to bring a current list of medications and health conditions so they can advise the best, most beneficial course of treatment for you.

Fasenra works by depleting eosinophils, the type of blood cells and part of your immune system that helps fight infection and cancer. No major safety concerns have been identified to date.

Since Fasenra is administered via injection, you can receive a dosage with or without food. Food will not affect how your body absorbs a dose. If you get nervous about injections, eating prior to your dosage may help calm your nerves.

There is no known interaction between alcohol and Fasenra, However, alcohol may trigger asthma attacks for some. If you have asthma, be sure to discuss whether alcohol consumption is safe with your doctor.

The safety and efficacy of taking Fasenra while pregnant or breastfeeding is unknown. If taken while pregnant, patients can join the Fasenra pregnancy registry.

These registries gather data on the safety of using certain medications while pregnant or breast-feeding. This information helps doctors to make recommendations about dosage, safety, and best practices for taking medication while pregnant and/or breastfeeding.

If you are pregnant, breast-feeding, or planning to become pregnant, discuss the risks and benefits of taking this medication with your provider.

Yes. Fasenra’s manufacturer recommends taking your pen out of the refrigerator around 30 minutes before administering your dose. This allows the medication to warm to room temperature and make for a more comfortable injection. Cold medication can be more painful to administer.

In studies for safety and efficacy, Fasenra is not known or documented to cause major side effects.

Fasenra is not currently approved as treatment for COPD flare-ups. Recent studies have not proven conclusively whether Fasenra is an effective treatment for COPD.

Fasenra starts working as soon as a dose is delivered. Fasenra significantly decreases eosinophils in the blood within 24 hours of the initial injection. It may take several weeks before you notice significant improvement in your asthma symptoms. After four weeks of treatment, asthma exacerbations are lowered, and lung function should improve.

If you and your doctor agree that Fasenra is safe and working well for you, you can likely stay on Fasenra on a long-term basis.