What is Felodipine?
Felodipine is a prescription treatment that doctors use to treat high blood pressure and chest pain caused by angina. The main felodipine indication is to lower blood pressure by helping blood vessels relax and widen.
This makes it easier for the heart to pump blood and reduces the risk of heart problems such as a heart attack or stroke. Common felodipine uses include long-term control of high blood pressure and relief from angina.
Some common side effects of felodipine are headache, dizziness, flushing, and swelling in the ankles or feet. In rare cases, people may experience long-term side effects such as gum swelling or changes in heart rate.
If you stop taking felodipine abruptly, it may lead to felodipine withdrawal symptoms like a rapid increase in blood pressure or return of chest pain.
For safe use, follow your doctor’s advice and avoid grapefruit products while taking this medicine.
Indications and Benefits of Felodipine
Felodipine is commonly prescribed for high blood pressure and angina. The main felodipine indication is to lower blood pressure by relaxing and widening blood vessels.
This makes it easier for the heart to pump blood and helps prevent complications such as stroke, heart attack, and heart failure.
Other felodipine uses include improving blood circulation, reducing chest pain, and supporting overall heart health.
By providing long-term blood pressure control, felodipine reduces strain on the heart and lowers the risk of serious cardiovascular problems.
What Are the Benefits of Felodipine?
- It lowers high blood pressure and reduces the risk of stroke and heart attack.
- It relaxes and widens blood vessels, which improves blood circulation.
- It helps reduce the number and intensity of chest pain episodes in people with angina.
- It supports long-term control of blood pressure with once-daily dosing.
- It improves exercise tolerance in people with angina by reducing strain on the heart.
- It helps maintain a steady heart rate without interfering with heart function.
- It can be used alone or with other treatments if blood pressure is difficult to manage.
Branded Name Options
Felodipine is sold under several brand names in different regions. Knowing these names helps patients and healthcare providers find the right medication.
Some brands also combine felodipine with other ingredients to improve treatment.
Here are a few examples:
- Plendil
- Lexxel (a combination of enalapril and felodipine)
How It Works
Felodipine blocks calcium from entering the smooth muscle cells in blood vessel walls. Normally, calcium makes these muscles tighten, which narrows the vessels and raises blood pressure. By blocking calcium, felodipine helps the vessels relax and widen.
This leads to better blood flow, lower blood pressure, and less strain on the heart. As a result, the heart gets more oxygen, and people with angina have fewer episodes of chest pain.
Felodipine is a calcium channel blocker that mainly works on the arteries, not the veins, making it a good option for long-term control of high blood pressure and angina.
Dosage
Felodipine is usually prescribed as an extended-release tablet that is taken once a day. The correct felodipine dosage depends on the condition being treated, the patient’s age, and overall health.
Doctors often start with a lower dose and adjust slowly to find the right balance between effectiveness and side effects.
Swallow the tablet whole without crushing or chewing it.
What Dosage Strengths Does Felodipine Come In?
- 2.5 mg
- 5 mg
- 10 mg
Dosage Chart
| Condition / Population | Recommended Felodipine Dosing | Important Note |
| Hypertension (Adults) | Start with 5 mg once daily | Adjust in steps of 2.5 mg every 2 weeks if needed |
| Usual range 2.5 mg to 10 mg daily | Helps manage blood pressure long-term | |
| Felodipine max dose 10 mg once daily | Do not exceed this amount | |
| Angina (Adults) | Start with 5 mg once daily | May increase based on response |
| Maximum 10 mg once daily | Reduces chest pain episodes | |
| Older patients (65 and above) | Start with 2.5 mg once daily | Close blood pressure monitoring is needed |
| Liver impairment | Start with 2.5 mg once daily | Requires careful monitoring due to higher drug levels |
| Kidney impairment | Usual adult dosing | No adjustment is usually required |
| Pregnancy | Preferred calcium channel blocker if needed | Use only under medical guidance |
| Breastfeeding | Not recommended | Safety not confirmed |
| Pediatric (6 years and older) | 2.5 mg once daily | Not FDA approved, but supported by pediatric guidelines |
Usage Guide
Felodipine is usually taken by mouth in the form of an extended-release tablet. It is designed to release the active ingredient slowly, helping to control blood pressure and chest pain throughout the day. The correct felodipine usage guide is important to follow so that treatment works safely and effectively.
How do you take Felodipine?
- Take felodipine once daily or as directed by your doctor.
- Swallow the tablet whole with water and do not crush, split, or chew it.
- Take it at the same time each day to keep steady levels in your body.
- You can take felodipine with or without food, but avoid grapefruit products.
- Do not stop taking felodipine suddenly without medical guidance.
- Keep taking it even if you feel well, since high blood pressure often has no symptoms.
- Tell your doctor about any other treatments or supplements you are using before starting felodipine.
Side Effects
Common side effects of felodipine may include headache, flushing, or swelling in the ankles, while rare but severe problems may involve chest pain or difficulty breathing. Long-term use can sometimes lead to gum changes or swelling.
Stopping felodipine suddenly may cause felodipine withdrawal symptoms such as a sudden rise in blood pressure or return of chest pain.
Taking too much can cause felodipine overdose symptoms like very low blood pressure, extreme dizziness, or fainting. Always seek medical help if severe symptoms occur.
Common felodipine side effects
- Headache
- Dizziness or lightheadedness
- Flushing or warmth in the face
- Swelling in the ankles or feet
- Fatigue or weakness
- Palpitations or rapid heartbeat
- Nausea
- Heartburn or constipation
Severe or rare felodipine side effects
- Chest pain that gets worse
- Rapid or irregular heartbeat
- Severe dizziness or fainting
- Gum overgrowth (gingival hyperplasia)
- Swelling of the face, lip, tongue, or eyes
- Trouble breathing or swallowing
- Rash or allergic reaction
Missed Dose
If you forget to take your felodipine dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take extra tablets to make up for a missed dose.
Following the correct felodipine dosage helps keep blood pressure under control and lowers the risk of complications.
Overdose
Taking too much felodipine can be dangerous. Felodipine overdose symptoms may include very low blood pressure, extreme dizziness, fainting, or trouble breathing.
If the person collapses, has a seizure, cannot wake up, or has severe breathing problems, call emergency services at 911 immediately.
Warnings
Before starting felodipine treatment, it is important to understand the main safety warnings and precautions. This helps reduce the chance of side effects and ensures that the treatment is used safely.
- Felodipine should be used with caution if you have liver disease because the liver processes the drug, and impaired function can increase side effects.
- People with heart failure or very low blood pressure should use felodipine carefully since it can worsen symptoms or lead to dizziness and fainting.
- Grapefruit and grapefruit juice should be avoided because they can interfere with how felodipine is broken down, which may cause dangerous levels in the body.
- Pregnant or breastfeeding women should consult a doctor before taking felodipine because its safety in these conditions is not fully confirmed.
- Swelling in the legs, ankles, or feet can happen while using felodipine. Persistent or severe swelling should be reported to your doctor.
- Felodipine should not be stopped suddenly without medical advice because this can lead to a sudden rise in blood pressure or worsening chest pain.
- You should inform your doctor about all other treatments or supplements you are using because some may interact with felodipine.
- If you are scheduled for surgery or dental procedures, tell your healthcare provider that you are taking felodipine.
Boxed Warning and Precautions for Felodipine
| Felodipine does not carry an official FDA boxed warning, but it does require careful monitoring in certain groups. The main precautions involve its effects on blood pressure, potential fluid retention, and drug interactions. Patients with liver problems, heart failure, or those at risk of low blood pressure must be closely monitored. Stopping felodipine suddenly may cause dangerous felodipine withdrawal symptoms such as rebound hypertension or chest pain. Overuse or accidental overdose may trigger serious felodipine overdose symptoms, including severe dizziness, fainting, or breathing difficulties, which require immediate medical attention. |
Contraindications
Felodipine should not be used in certain conditions because it can cause harm or make health problems worse. Below are the situations where its use is not recommended.
- People who are allergic to felodipine or its ingredients should not use it.
- People with liver failure cannot process felodipine, which leads to higher levels in the body.
- People with severe low blood pressure should not take it as it can make the condition worse and cause fainting.
- People with acute coronary syndrome should avoid it because it can increase heart rate and oxygen demand, making chest pain worse.
- Pregnant or breastfeeding women should not take it because studies in animals showed harmful effects on the baby.
Interactions
- Azole antifungals (Itraconazole, Ketoconazole)
- Macrolide antibiotics (Clarithromycin, Azithromycin)
- HIV protease inhibitors
- Immunosuppressants (Cyclosporine)
- Cimetidine
- Grapefruit juice
- Anticonvulsants (Phenytoin, Carbamazepine)
- St John’s wort
- Rifampicin
- Metoprolol
- Theophylline
- Statins (CYP3A4-metabolized)
- Norvasc (amlodipine)
- Cardizem (diltiazem)
- Erythrocin (erythromycin)
- Inderal (propranolol)
- Zestril (lisinopril)
Storage Information
Keep this product in its original container with the lid tightly closed. Store it at room temperature and away from too much heat and moisture. Avoid keeping it in the bathroom. Always place it in a safe spot that is high up and out of sight and reach of children.
When you no longer need this product, dispose of it safely so that children, pets, or others cannot access it. Do not throw it in the toilet.
Alternatives
- Plendil (felodipine)
- Norvasc (amlodipine)
- Adalat (nifedipine)
- Procardia (nifedipine)
- Cardizem (diltiazem)
- Verelan (verapamil)
- Zestril (lisinopril)
- Accupril (quinapril)
- Altace (ramipril)
- Cozaar (losartan)
- Diovan (valsartan)
- Micardis (telmisartan)
- Lotrel (amlodipine and benazepril)
- Exforge (amlodipine and valsartan)
- Tarka (trandolapril and verapamil)
Cost & Coupons
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Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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