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Fragmin Dalteparin Sodium
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What is Fragmin?

Fragmin (dalteparin) is a medication used to prevent and treat blood clots.

It helps reduce the risk of serious conditions like deep vein thrombosis (DVT) and pulmonary embolism (PE), which can occur after surgeries or in people with limited movement due to illness.

Fragmin is also used to manage venous thromboembolism (VTE) in people with cancer and children with VTE.

It is given as an injection and works by slowing down the blood clotting process.

However, Fragmin should not be used in people with active major bleeding, certain types of allergic reactions to heparin, or those undergoing specific types of anesthesia.

How Does Fragmin Work?

Fragmin works by helping to prevent blood clots. It contains a substance called dalteparin, which is a type of heparin.

Heparin is a blood thinner that affects how blood clots form.

Specifically, Fragmin enhances the action of proteins in the blood that block clotting factors, mainly Factor Xa and thrombin.

Factor Xa and thrombin are key factors in the clotting process.

By boosting the inhibition of these factors, Fragmin helps keep the blood from clotting too much.

Fragmin has a minimal effect on other blood tests related to clotting, like the activated partial thromboplastin time (APTT), ensuring it mainly targets the clotting factors it is designed to affect.

Dosage Information and Usage

Dosage Form and Strengths of Fragmin

  • Injection: 2,500 IU/0.2 mL
  • Injection: 5,000 IU/0.2 mL
  • Injection: 7,500 IU/0.3 mL
  • Injection: 12,500 IU/0.5 mL
  • Injection: 15,000 IU/0.6 mL
  • Injection: 18,000 IU/0.72 mL
  • Injection: 10,000 IU/mL (graduated syringes)
  • Injection: 95,000 IU/3.8 mL (multiple-dose vials)
  • Injection: 10,000 IU/4.0 mL (single-dose vials)

Usage

Fragmin is used in different ways depending on the condition being treated.

For preventing complications in unstable angina or non-Q-wave myocardial infarction, the usual dose is 120 IU per kilogram of body weight, up to a maximum of 10,000 IU, given every 12 hours along with aspirin until the patient is stabilized, usually for 5 to 8 days.

For preventing deep vein thrombosis (DVT) after hip or abdominal surgery, doses vary based on the timing related to surgery and risk level, typically ranging from 2,500 IU to 5,000 IU once daily for 5 to 10 days.

In cancer patients with symptomatic venous thromboembolism (VTE), Fragmin is administered at 200 IU per kilogram of body weight once daily for the first month, then adjusted to about 150 IU per kilogram daily for the next five months.

For children with VTE, doses are adjusted based on age and monitored with anti-Xa levels to ensure effectiveness.

Storage Information

Store Fragmin at room temperature between 20°C and 25°C (68°F to 77°F).

It is also acceptable for the temperature to range from 15°C to 30°C (59°F to 86°F).

After the first use of the multiple-dose vials, keep them at room temperature for up to 2 weeks.

Do not use any Fragmin that has been stored outside these conditions or for longer than the specified time.

For the prefilled and graduated syringes, discard any unused portion after each use.

Be aware that the needle shield of the prefilled syringes may contain natural rubber latex, which can cause allergic reactions in some individuals.

Side Effects

Common Side Effects

  • Hematoma at injection site: Bruising or swelling where the injection was given.
  • Bleeding complications: May include minor bleeding from various sites.
  • Injection site pain: Discomfort or pain at the area where the drug is injected.
  • Elevations in liver enzymes: Increase in AST or ALT levels in blood tests.

Serious but Rare Side Effects

  • Major bleeding: Severe bleeding events, which may include:
    • Spinal/Epidural hematomas: Bleeding around the spinal cord or in the epidural space, which can lead to paralysis.
    • Intracranial hemorrhage: Bleeding within the brain.
    • Retroperitoneal hemorrhage: Bleeding behind the abdominal cavity.
  • Thrombocytopenia: Low platelet count, which can lead to increased bleeding risk.
  • Allergic reactions: Severe allergic reactions, including anaphylaxis.
  • Osteoporosis: Weakening of the bones with long-term use.
  • Skin necrosis: Severe skin damage or death in the area of injection.

Warnings and Precautions

  • Risk of Hemorrhage including Spinal/Epidural Hematomas: Hemorrhage or bleeding can occur with Fragmin when used alongside spinal or epidural anesthesia. The risk increases with procedures like spinal puncture or the use of indwelling epidural catheters. Patients should be monitored for bleeding symptoms and report any unusual back pain or leg weakness immediately.
  • Thrombocytopenia: Fragmin can cause a decrease in platelet count, known as thrombocytopenia. This condition may lead to severe complications such as clotting issues or, in extreme cases, amputation. Regular blood tests are necessary to keep track of platelet levels during treatment.
  • Risk of Serious Adverse Reactions in Neonates and Infants due to Benzyl Alcohol Preservative: Benzyl alcohol, used as a preservative in some Fragmin formulations, can cause serious reactions in infants, including “gasping syndrome.” This condition involves severe respiratory and metabolic issues. Use preservative-free Fragmin for infants to avoid these risks.
  • Laboratory Tests: Routine blood tests are required to monitor for side effects while on Fragmin. Standard tests like Prothrombin Time (PT) are not effective for monitoring Fragmin’s activity; anti-Xa levels are more appropriate. This is crucial for patients with kidney problems or abnormal bleeding.

Overdosage

Taking too much Fragmin can lead to serious bleeding complications.

To treat an overdose, a medication called protamine sulfate is used, which helps reverse the effects of Fragmin.

Typically, 1 mg of protamine is given for every 100 units of Fragmin administered. If bleeding continues, a second dose of protamine may be needed.

However, even with this treatment, the blood’s ability to clot may not fully return to normal.

It’s important to administer protamine sulfate carefully, as it can cause severe reactions like low blood pressure or allergic responses.

Always ensure emergency procedures are ready when using protamine sulfate.

Drug Interactions With Other Medications

Using Fragmin with other medications that affect blood clotting, such as oral anticoagulants, platelet inhibitors, and thrombolytic agents, can increase the risk of bleeding.

Oral anticoagulants are medicines taken by mouth to prevent blood clots.

Platelet inhibitors prevent blood cells called platelets from sticking together and forming clots. Thrombolytic agents help dissolve blood clots.

Combining Fragmin with these drugs makes it more likely that bleeding will occur.

It’s important to monitor for signs of bleeding and adjust medications as needed when using Fragmin with these other treatments.

Alternative Medications

Cost & Coupons

At Pharma Giant, we know how important your health is, and getting the right medication shouldn’t cost too much.

We aim to make sure you can buy top-notch medications, like Fragmin, at prices that are fair for everyone.

Exceptional Savings on Fragmin

Fragmin is a medication used to prevent blood clots, a serious health issue. It is often prescribed for patients who have undergone certain surgeries or have medical conditions that increase the risk of clots.

In the United States, the cost of Fragmin can be prohibitively expensive, with 10 syringes sometimes costing over $1,500. At Pharma Giant, we offer a more affordable solution, ensuring that you can access this essential medication without breaking the bank.

Fragmin (Dalteparin Sodium) Pricing Table

Strength Quantity Price
2500IU 10 x 0.2mL $84.95
2 x 10 x 0.2mL $164.00
3 x 10 x 0.2mL $240.00
5000IU 10 x 0.2mL $147.95
2 x 10 x 0.2mL $290.00
3 x 10 x 0.2mL $426.00
7500IU 5 x 0.3mL $115.95
2 x 5 x 0.3mL $226.00
3 x 5 x 0.3mL $330.00
10000IU 5 x 0.4mL $148.95
2 x 5 x 0.4mL $290.00
3 x 5 x 0.4mL $420.00
15000IU 5 x 0.6mL $217.95
2 x 5 x 0.6mL $430.00
3 x 5 x 0.6mL $630.00
18000IU 5 x 0.72mL $246.95
2 x 5 x 0.72mL $484.00
3 x 5 x 0.72mL $714.00

Exclusive Discount Offer

  • Coupon Code: Enter PGSAVE10 at checkout to enjoy a 10% discount on your Fragmin purchase. This exclusive, limited-time deal allows you to save on essential medications without sacrificing quality.
  • Offer Details: This discount applies to one-time use per customer, so be sure to take advantage of it while it’s available.

Ordering Information

  • Prescription Required: To purchase Fragmin, a valid prescription is necessary to ensure patient safety and compliance with medical guidelines.
  • Bulk Purchases: Patients can order up to a 90-day supply, offering convenience for continual treatment and better cost management.

Assurance of Quality and Timely Delivery

At Pharma Giant, we are dedicated to providing high-quality medication along with the convenience of fast delivery straight to your home.

  • Express Shipping: Medications are sent expressly from Canada to anywhere in the US within 3-5 business days, ensuring you receive your order quickly.
  • Secure Packaging: Each order is shipped in secure, tamper-proof containers, ensuring your medication remains safe and intact during transit.

Choosing Pharma Giant means prioritizing your health while enjoying competitive pricing.

Our commitment to excellence ensures you have access to affordable medications delivered efficiently and safely, allowing you to focus on what truly matters—your well-being.

Experience the difference with Pharma Giant today!

Frequently Asked Questions

Fragmin is used to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also used to reduce the risk of blood clots in certain surgical procedures and to manage blood clots in patients with certain types of heart conditions.

Avoid using Fragmin if you have serious active bleeding, certain bleeding or blood disorders, or a history of artificial heart valves. Be cautious with high blood pressure, eye problems like hypertensive or diabetic retinopathy, and infections of the heart. Inform your doctor about any kidney disease or other medical conditions before using Fragmin.

For patients undergoing abdominal surgery, inject Fragmin 1 to 2 hours before the procedure. Continue with daily injections for 5 to 10 days after surgery.

Fragmin should not be used if you have severe active bleeding, serious bleeding disorders, or certain conditions like artificial heart valves or severe kidney disease. It is also contraindicated in individuals with a history of hypersensitivity to heparin or low platelet counts.

Adverse reactions to Fragmin can include bleeding complications, such as easy bruising or more severe hemorrhage. Other potential reactions are allergic responses, including rash or itching, and thrombocytopenia (low platelet count).

If you miss a Fragmin injection, take it as soon as you remember, unless it is less than 6 hours until your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not administer a double dose.

No, Fragmin does not need to be refrigerated. Store Fragmin syringes at room temperature, between 15 and 30°C. Keep them in a safe place that is out of reach of children.

Fragmin works by inhibiting specific proteins in the blood that are essential for blood clotting. It primarily blocks Factor Xa, a key enzyme in the clotting process, reducing the formation of clots and helping to prevent and treat deep vein thrombosis (DVT) and other blood clots.

Fragmin is typically administered once daily. The exact dosage depends on your body weight, and it is given as a single subcutaneous injection, usually into the abdomen or outer thigh.

Keep Fragmin syringes in their original pack until use to ensure proper storage. Store at room temperature, up to 25°C (77°F). Avoid removing syringes from the pack until you are ready to use them.

If you suspect an overdose, seek immediate medical attention. Treatment may include administering protamine sulfate to help reverse the effects. Monitor for signs of bleeding and follow your doctor’s instructions closely.

Yes, Fragmin can interact with other medications, particularly those that affect blood clotting, such as oral anticoagulants, platelet inhibitors, and thrombolytic agents. Inform your doctor about all the medications you are taking to avoid increased risk of bleeding or other complications.

Before starting Fragmin, inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Mention any blood thinners, NSAIDs, or medicines for pain, gout, or cancer, as these can affect how Fragmin works. Also, tell your doctor if you are using medications for heart conditions, antibiotics, or if you smoke, as these can influence Fragmin’s effectiveness.

For elderly patients, the maximum dose of Fragmin is 10,000 IU every 12 hours. If you are bedridden, the typical dose is 5,000 IU daily. The duration of treatment is usually up to 14 days, based on your specific condition.

Yes, Fragmin is considered safe to use during pregnancy because it does not cross the placenta and does not affect the baby.

Minor bleeding, bruising, or swelling at the injection site is common with Fragmin. If you experience unusual or excessive bleeding, contact your doctor.

Fragmin should be used with caution in patients with severe kidney dysfunction. Kidney problems can alter blood clotting and increase the risk of bleeding.

You should stop taking Fragmin and contact your doctor immediately if you experience severe allergic reactions, such as difficulty breathing or swelling of the lips, mouth, throat, or eyes.

Fragmin is given as a subcutaneous injection, which means it is injected just under the skin. It is typically injected into a fold of skin in your abdomen or thigh.

Yes, Fragmin can be used for long-term treatment, especially for managing venous thromboembolism (VTE) in people with cancer.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Price Match Guarantee

Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online pharmacy with a verifiable address.
  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone prior to completing your order.

Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.
Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.