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Grastek (Allergen Extract)
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Grastek Grass Pollen-Timothy, Standard
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What is Grastek?

Grastek is a prescription sublingual immunotherapy (SLIT) tablet used to treat allergic rhinitis (with or without conjunctivitis) caused by Timothy grass and related grass pollens. It works by gradually making the body less sensitive to allergens. 

Grastek is the tablet that you place under your tongue and is for people aged 5 to 65 years who have proven allergies to these allergens. It needs to be taken about 12 weeks before the grass pollen season starts and maintained during that season. 

However, it does not offer immediate relief from the allergy symptomatology, like sneezing or a runny nose.

It is also not prescribed for individuals with eosinophilic esophagitis, an illness that brings about inflammation of the esophagus, or patients allergic to any inactive ingredient in this medication. 

Therefore, a severe allergy to Grastek in some cases may lead to a doctor administering his or her patient with an auto-injectable epinephrine device, which the patient should always have on standby to treat any severe reaction resulting from ingestion of Grastek.

How Does Grastek Work?

Grastek is used to sensitize the body’s immune system progressively to grass pollen allergens, which include Timothy grass and others. Grastek works by gradually desensitizing the immune system to grass pollen allergens. Over time, repeated exposure helps reduce the immune response that causes allergy symptoms.

If you are under Grastek, your immune system will be conditioned to label pollen as harmless and not dangerous. This can reduce allergic signs and symptoms, including sneezing and a runny nose, during the grass pollen season.

 After several months of ingestion of Grastek, one will spend more time free of allergies and go about outdoor activities that would have otherwise been hindered by grass pollen.

Dosage Information and Usage

Grastek is an allergy medication that should be given appropriately so as to be effective. In this section, there are important details concerning the dosage forms and strengths, as well as how Grastek should be used appropriately.

Dosage Form and Strengths of Grastek

Grastek is available in 2800 BAU per tablet. Grastek tablets are white to off-white, cylindrically shaped, with a round detail on one side.

This formulation is intended for sublingual administration, as in it should be placed under the tongue to dissolve.

Usage

Use orally once a day for the treatment of Grastek. Administer the first dose in a healthcare setting directly supervised by a healthcare professional who shall monitor you for at least 30 minutes to observe for signs of anaphylaxis. 

You may administer the rest of your doses in your own home. Allow the tablet to dissolve in your mouth. 

Do not swallow the tablet. Dissolution should occur within at least one minute. Do not eat or drink anything for five minutes after taking the tablet. Administer Grastek at least 12 weeks before the onset of the grass pollen season, and continue it until the end of the grass pollen season. 

You can administer Grastek daily for three consecutive years to provide sustained relief throughout subsequent years of the grass pollen season. If you forget a dose, do not administer a double dose to make up for it. Take your next scheduled dose.

Side Effects of Grastek

Though some cause side effects to both children and adults, one can take Grastek for their grass pollen allergy. Most of them are minor and non-threatening.

However, sometimes it’s important to note the common and major side effects that might come along with taking Grastek. Should you feel any symptoms or reaction on your part after taking the said medicine, seek medical attention promptly.

Most side effects occur within the first week of treatment and often decrease with continued use.

Common Side Effects

  • Itching of the mouth, lips, or tongue
  • Swelling under the tongue
  • Throat irritation
  • Ear itching (pruritus)
  • Mouth swelling (edema)
  • Headache

Serious but Rare Side Effects

  • Difficulty breathing
  • Throat tightness or swelling
  • Trouble swallowing or speaking
  • Dizziness or fainting
  • Rapid or weak heartbeat
  • Severe stomach cramps, pain, vomiting, or diarrhea
  • Severe skin reactions, such as flushing or itching
  • High-pitched breathing sounds indicating airway trouble
  • Anaphylactic reactions (severe allergic reactions)

Warnings and Precautions

Grastek induces severe allergic reactions, including anaphylaxis, which could be life-threatening. Furthermore, it can provoke severe local reactions that can even lead to complications with respiration. 

Therefore, all patients should be informed of the symptoms of these reactions; they should refer to a doctor when these symptoms occur.

  • Severe Allergic Reactions: Anaphylaxis is a potentially life-threatening allergic reaction. Patients can be educated on the signs and receive emergency treatment.
  • Epinephrine Prescription: A patient should have available immediate access to an auto-injector epinephrine device for acute allergic reaction treatment and receive instruction in its proper use.
  • Medical Conditions: Patients with a history of medical conditions that compromise lung capacity, or poorly controlled hypertension, should not take Grastek.
  • Drug Interactions: Some other drugs can completely reverse the effects of epinephrine. Conversely, this reverses the severe reaction in a paradoxical way.
  • Upper Airway Compromise: Sensitivities in the oral cavity or pharynx may compromise breathing. Withdraw Grastek if such sensitivities persist or worsen.
  • Eosinophilic Esophagitis: Chest pain or difficulty in swallowing may be symptoms of eosinophilic esophagitis, and the Grastek should be stopped.
  • Asthma Considerations: Grastek has not been evaluated in patients with moderate or severe asthma. Patients with asthma should discontinue treatment during an asthma exacerbation.
  • Combination Allergen Immunotherapy: When coadministered with other allergens, the incidence of adverse reactions increases with Grastek. 
  • Oral Inflammation: Therapy must be discontinued if the patient displays oral inflammation or ulcers so that re-epithelialization can occur before continuing Grastek.

Alternative Medications

Cost & Coupons

Grastek is an essential medication for those suffering from grass pollen allergies, offering relief that has become widely used. However, in the United States, the cost of Grastek can reach as much as $399 for just 30 tablets, making it a financial burden for many.

At Pharma Giant, we are committed to making essential medications like Grastek accessible to everyone at affordable prices, ensuring that healthcare is within reach for all.

Huge Savings on Grastek

Pharma Giant aims to reduce the financial strain of healthcare by offering Grastek at significantly lower prices. Here are our affordable pricing options:

Strength Package Price (Canada)
2800 BAU 30 tablets $199.00
60 tablets $390.00
90 tablets $570.00

At Pharma Giant, we prioritize both quality and affordability, allowing you to manage your allergies without the high costs found in the U.S.

Special Discount Offer

Coupon Code: Use PGSAVE10 at checkout to receive 10% off on your Grastek purchase. This limited-time offer helps you save even more on essential medications without compromising on quality.

  • Offer Details: This discount is available for one-time use per customer, so take advantage while supplies last!

Simple Ordering Process

  • Prescription Required: A valid prescription is needed to order Grastek, ensuring safe and proper usage.
  • Bulk Buying Option: You can order up to a 90-day supply to simplify your treatment and save even more.

At Pharma Giant, we’re dedicated to helping you maintain your health without the worry of high costs. Choose us for affordable, high-quality healthcare solutions you can trust.

Frequently Asked Questions

Grastek is an immunotherapy for Timothy grass allergens as well as other similar grass pollen allergens. Grastek ends allergic rhinitis symptoms as sneezing, watery or runny nose, stuffed nose, red and watery eyes. Grastek is administered to people aged 5 to 65 years, given about 12 weeks before during the grass pollen season.

A specialist in allergies will first decide if the drug is suitable for the patient by doing skin or blood tests to establish whether you are allergic to Timothy or any related grass pollen. They then conclude whether Grastek is good enough to be used to treat.

If you are sensitive to the grasses of Timothy’s family known as Sweet Vernal, Orchard, Perennial Rye, Kentucky Blue, Meadow Fescue, or Redtop-grass-allergens are, Grastek can help your symptoms.

You should not get Grastek if you have severe, unstable, or uncontrolled asthma. Moreover, do not take Grastek if you have had a history of severe allergic reactions, including symptoms like trouble breathing; dizziness or fainting; and fast or slow heart rate, before. If you have had swelling of your throat or upper airway after sublingual immunotherapy treatment or eosinophilic esophagitis diagnosis, do not use Grastek. Finally, if you are allergic to the inactive ingredients of Grastek, such as gelatin, mannitol, or sodium hydroxide, then take Grastek.

Itching or swelling in the mouth; throat irritation, nausea, and abdominal pain have been reported as common Grastek side effects. In other people, allergic responses can be severe, therefore shortness of breath, tightness in the chest, or anaphylaxis.

Grastek works gradually. In clinical studies, patients who received Grastek twelve weeks prior to the beginning of grass allergy season experienced significantly fewer eye and nose symptoms during the season and took fewer doses of antihistamine medication.

You take Grastek daily for about 12 weeks before and throughout the grass pollen season. For long-term effects, you may take it daily for 3 years.

Take Grastek once a day by placing the tablet under your tongue and allowing it to dissolve completely.

If you miss a dose of Grastek, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time.

No, you do not need to take Grastek with water. Avoid eating or drinking for 5 minutes after taking the tablet.

Yes, Grastek can be used in children aged 5 and older. It is not for immediate allergy relief.

Grastek might not be the best course of treatment for a pregnant woman or lactating female. Inform your doctor if you or your child has asthma and are or will become pregnant or upon becoming pregnant or upon the initiation of nursing.

If you or your child experiences any signs of a serious allergic reaction while taking Grastek, stop taking the medication immediately and contact your doctor. This includes symptoms such as throat tightness, swelling of the tongue or throat, difficulty speaking, breathing, or swallowing, and any worsening asthma or breathing conditions.

Grastek, with time, sensitizes the immune system to grass allergens by pollen of such plants as Timothy grass and similar grasses. Eventually, such a body exposes the body to small quantities of such allergens, and an immunized body results that is, therefore, more insensible to the allergen that continues to intensify the symptoms like sneezing and watery eyes related to grass pollen season.

You shouldn’t stop treatment, even if the symptoms seem to have been better. Grass pollen allergens need to be built up over a long term by Grastek, and stopping your treatment before a recommended duration could reduce its effectiveness. You should receive advice from your allergy specialist regarding how long you must continue taking it even after symptoms are relieved.

Yes. Grastek works for seasonal allergies. It is used for 12 weeks into the season and through the grass pollen season. It can also be continued daily for three years to carry over the effect into the fourth year without having to continue with Grastek. It is just important to note that Grastek does not relieve symptoms of grass allergy.

If you miss a dose of Grastek, take it as soon as possible on the same day that you remember it. If it is near the time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take two doses at one time. Discuss any questions or concerns you may have with your health care provider.

A patient should be placed on a visit schedule, that is at least once a year, or as advised by the allergy specialist. The first year of treatment also forms a period of assessment.

Do not take Grastek if you, or a child for whom you are administering Grastek, have severe, unstable, or poorly controlled asthma. Inform your doctor of your history of any life-threatening or potentially serious allergic reaction or respiratory trouble that you may have.

Other than Grastek medications include over-the-counter antihistamines like Zyrtec or Allegra, nasal corticosteroid Fluticasone, and leukotriene receptor antagonists such as Singulair, and these drugs are prescribed as montelukast.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.