Humalog Kwikpen 100
Humalog KwikPen 100
Insulin Lispro
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Humalog KwikPen 100 (insulin lispro)

What is the Humalog KwikPen?

The Humalog KwikPen (Humalog), also known as an insulin lispro injection, is a medication prescribed for both children and adult patients to treat diabetes. Humalog belongs to the drug classes, antidiabetics, and insulins. These medications work by improving and controlling your glucose levels.

What are the Indications for Humalog?

Humalog is approved to treat types 1 and 2 diabetes and control your blood sugar levels.

Your doctor may prescribe Humalog along with another longer-acting insulin. Do not change your dosage without consulting with your doctor. Your doctor or pharmacist will teach you how to adjust the dosage if you are ill or perform more strenuous physical activities.

Humalog is not recommended:

  • If you are allergic to insulin lispro or any ingredients in Humalog
  • If you suffer from low blood sugar (hypoglycemia)

How is Humalog used?

Storage

  • Unused pens should be stored in the refrigerator at 36°F to 46°F (2°C to 8°C).
  • Do not freeze your pens, or use them if it has been frozen.
  • Open pens can be stored at room temperature, below 86°F (30°C), for up to 28 days.
  • Store it away from heat and light.
  • Keep out of reach from children.
  • Do not dispose of the medicine in wastewater or household trash.

Instruction

Patients should inject themselves 15 minutes before or immediately after a meal. Have food ready and do not postpone eating.

Preparation

  • Check your pen to make sure you are taking the right type of insulin.
  • It should appear clear and colorless and not cloudy, discolored, or contain particles
  • Make sure it is at room temperature before use. Injecting cold insulin can be painful.
  • Wash your hands with soap and water.
  • Use a new, clean needle.
  • Check to make sure there are no air bubbles in the pen.

Injecting Humalog

  • Turn the dose knob to select the number of units you need to inject.
  • Choose an injection site on your upper arm, thigh, buttock or abdomen.
  • Make sure the spot is at least half an inch (1 cm) from the last injection site.
  • Clean your skin with an alcohol swab and let it dry.
  • Insert the into the skin, not directly into a vein.
  • Push the dose knob in and continue to hold it for five seconds.
  • Pull the needle out.
  • Do not rub the injected site.

After injecting

  • Replace the outer needle shield.
  • Unscrew the needle using the cap.
  • This will keep the insulin sterile, and stop it from leaking, air entering the pen, and your needle from clogging.
  • Replace the cap on your pen.

Dosage

Humalog is available as a disposable pre-filled pen with 100 units of insulin lispro in each milliliter. Each Humalog KwikPen contains 300 units – 3 ml (300 units, 100 units/ml).

It comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). Each injection can provide up to 60 units of Humalog.

There is no specific starting dose and varies from person to person. Your doctor will usually start you on the lowest dosage and adjust it until your blood sugar levels are at the desired levels.

Your dosage may have to be reviewed if:

  • you start exercising or there is a change in your physical activity
  • you gain or lose weight
  • experience an increase in stress
  • suffer from an illness
  • change your diet
  • take other medications

Side Effects

It’s important to understand that although Humalog is FDA approved, it has side effects that may or may not affect you.

Before starting Humalog, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts to Humalog, side effects may go away. Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own:

  • Low blood sugar
  • Reactions where you have injected insulin
  • Swollen hands or feet
  • Itching
  • Allergic reactions
  • Changes in fat tissue at the injection site
  • Weight gain
  • Rash

Serious Side Effects

Severe adverse reactions while using Humalog may occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

  • Low blood sugar: dizziness or light-headedness, headache, shakiness, irritability, sweating, blurred vision, rapid heartbeat, mood change, confusion, slurred speech, anxiety, and hunger.
  • Severe allergic reaction: a rash over your whole body, sweating, extreme drowsiness, swelling of your face, tongue, or throat, difficulty breathing, feeling faint, dizziness, rapid heartbeat, shortness of breath, or become confused.
  • Low potassium in your blood: severe breathing problems, irregular heartbeat, muscle pain or cramps, weakness or fatigue, and even death.
  • Heart failure: shortness of breath, swelling of ankles and feet, and sudden weight gain.

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

Warnings & Precautions

Before taking Humalog, tell your doctor or pharmacist:

  • If you take any other prescription medication, especially thiazolidinediones (TZDs)
  • If you take any medications, including non-prescription medications, vitamins, and herbal supplements
  • If you suffer from heart failure
  • If you suffer from any illness
  • If you have other heart, liver or kidney problems
  • If you are pregnant or plan to become pregnant
  • If you are breastfeeding or plan to breastfeed
  • If you are exercising more than usual

Using Humalog can cause your blood sugar levels to drop dangerously low. These are possible reasons for low blood sugar:

  • If you are more physically active than usual
  • If you take too much of your diabetes medication
  • If you eat at the wrong time for your medication taken
  • If you take other medications with Humalog
  • If you don’t finish your meals or snacks

Driving or using heavy machinery

You may experience reduced concentration and a slower reaction time if you have low blood sugar. Please consider any situation where you might put yourself and others at risk. Contact your doctor if you drive or use machinery and you:

  • Regularly suffer from low blood sugar
  • Experience lower blood sugar levels or become hypoglycemic without any warning signs

Needles

Always be very careful when using needles. Put your used needles in a sharps container

If you don’t have one, use a household container that is:

  • made of a heavy-duty plastic
  • can be closed with a tight-fitting, puncture-resistant lid
  • upright and stable during use
  • leak-resistant
  • properly labeled

Dispose of your sharps container according to community guidelines and don’t throw them in the trash.

Never reuse needles or share them with other people. It can cause a serious infection for both of you.

Hypoglycemia or hyperglycemia

  • Always keep extra insulin injection supplies with you.
  • Always carry sugar with you.
  • Always carry something with you that shows you have diabetes.
  • Always keep a spare syringe, vial, pen, and cartridge with you in case you lose your KwikPen or it gets damaged.
  • Always carry something to show you are diabetic.

Pregnant or planning to become pregnant

Your insulin requirements may reduce in the first 3 months of your pregnancy, and increase for the remaining 6 months. It is important to speak to your doctor if you are pregnant or planning a pregnancy so that he can monitor your insulin levels and adjust your dosage if needed. Do not change your dosage and take more than what is prescribed without consulting with your doctor.

Breastfeeding or planning to breastfeed

Humalog can be used while breastfeeding however, patients may be required to alter their insulin dosage and/or diet. Patients should always speak their doctor before starting to breastfeed.

Alcohol

Do not drink alcohol or use other medicines that contain alcohol when using Humalog, as it can affect your blood sugar levels.

Interactions & Contraindications

Before you use the Humalog KwikPen, tell your doctor or pharmacist if you take any medications, herbal supplements, or vitamins.

Medications

Insulin lispro may interact with a number of medications and cause side effects from moderate to severe, especially ones to treat hypoglycemia and lower glucose levels.

Thiazolidinediones (TZDs)

If used with Humalog it could lead to heart failure in some people, even if you haven’t had heart problems before. If you have heart failure, it may get worse if you take TZDs together with Humalog. Tell your doctor immediately if you have any new symptoms of heart failure, or if they get worse. Your doctor may need to change or stop treatment with TZDs and your Humalog KwikPen. Examples of thiazolidinedione drugs include rosiglitazone (Avandia) and pioglitazone (Actos).

Alcohol

Do not drink alcohol or use other medicines that contain alcohol when using Humalog, as it can affect your blood sugar levels.

Diseases/conditions

These conditions are contraindicated with Humalog, so please let your doctor know if you suffer from any of these:

  • low blood sugar
  • low amount of potassium in the blood
  • liver problems
  • decreased kidney function

Frequently Asked Questions

The active ingredient in Humalog is insulin lispro.

Other inactive ingredients are glycerin, tromethamine, metacresol, zinc oxide (zinc ion), trace amounts of phenol, and water for injection. Sodium hydroxide or hydrochloric acid may have been used to control the acidity.

The Humalog KwikPen is available as a disposable, prefilled injection pen.

Humalog is approved to treat diabetes in:

  • Adults with type 1 diabetes
  • Adults with type 2 diabetes
  • Children with type 1 diabetes over the age of 3 years

Humalog is not recommended if you are having an episode of low blood sugar.

You should not take Humalog if you are allergic to insulin lispro or any ingredients in Humalog.

Common side effects are low blood sugar, reactions or changes in the fat tissue around the injection site, swollen hands or feet, itching, allergic reactions, weight gain or a rash.

Humalog is administered through an injection pen. Take it exactly as prescribed, including how much and when.

If you forget to take a dose, and it’s been more than 1 hour since you ate, you should wait until it’s time for your next scheduled dose.

Please check your blood sugar as soon as you realize you’ve missed a dose.

If you use Humalog more than 1 hour after eating, your blood sugar levels could drop.

If you took more Humalog than prescribed, contact your doctor or seek emergency medical care right away.

  • Do not drive or operate heavy machinery, until you know how Humalog affects you.
  • Drink alcohol or take prescription or over-the-counter medicines that contain alcohol.

Humalog should be taken as directed until discontinued by your doctor. It is meant to be used as a long-term treatment, and if it is safe and effective for you, you’ll likely use it long term.

Yes, with a prescription, you can purchase Humalog online. Buying medications online is convenient and often less expensive than purchasing at your local pharmacy.