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Invokamet Canagliflozin, Metformin Hydrochloride
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What is Invokamet?

Invokamet is a medication prescribed to control blood sugar, along with a proper diet and exercise, in adults 18 years or older with type 2 diabetes. Uncontrolled blood sugar levels can cause kidney damage, blindness, nerve problems, loss of limbs, sexual function problems, heart attack, and stroke.

Invokamet contains two medications, including canagliflozin and metformin, which work together to help regulate blood sugar. Both medications are considered antidiabetic medications, but belong to different drug classes. Canagliflozin is considered a sodium-glucose co-transporter 2 (SGLT2) inhibitor, while metformin is classified as a biguanide.

Canagliflozin increases the amount of glucose that the kidneys remove from the body through urination, while Metformin decreases the amount of glucose that the liver produces and improves the body’s response to insulin.

Invokamet is not recommended:

  • If you are allergic or have had an allergic reaction to Invokamet or ingredients in Invokamet.
  • If you have type 1 diabetes, it can increase the risk of diabetic ketoacidosis.
  • For patients younger than 18 years of age.
  • If you have severe kidney problems or diabetic ketoacidosis.

What are the Indications for Invokamet?

Invokamet is a combination medication approved for the treatment of high blood sugar in people with type 2 diabetes, and to lower the risk of cardiovascular or diabetic kidney disease.

How is Invokamet used?

Storage

Invokamet should be stored in its original packaging at room temperature between 68°F and 77°F (20°C and 25°C) with excursions permitted between 59°F and 86°F (15°C and 30°C).

Keep out of reach of children.

Instruction

Invokamet is taken orally twice a day with meals. Drink plenty of fluids while taking it, unless directed otherwise by your doctor.

If you miss a dose, skip the dose and take the next dose at the regular time. Do not catch up by taking two doses at once.

Do not change your dosage, take more than what is prescribed, or stop using Invokamet without consulting your doctor. If you took more than prescribed, contact your doctor immediately or seek emergency medical care.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

Dosage

Invokamet is available as a film-coated tablet in the following strengths:

  • Canagliflozin 50 mg and metformin hydrochloride 500 mg
  • Canagliflozin 50 mg and metformin hydrochloride 1,000 mg
  • Canagliflozin 150 mg and metformin hydrochloride 500 mg
  • Canagliflozin 150 mg and metformin hydrochloride 1,000 mg

SIDE EFFECTS

It’s important to understand that although Invokamet is FDA-approved, it comes with side effects that may or may not affect you.

Before starting Invokamet, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts to Invokamet, side effects may go away. Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own.

  • Change in urination
  • Diarrhea
  • Nausea/vomiting
  • Gas
  • Weakness
  • Indigestion
  • Upset stomach
  • Headache

Serious Side Effects

Severe adverse reactions while taking Invokamet may occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

  • Severe allergic reaction: a rash over your whole body, sweating, extreme drowsiness, swelling of your face, tongue, or throat, difficulty breathing or swallowing, feeling faint, dizziness, rapid heartbeat, shortness of breath, or becoming confused.
  • Serious urinary tract infection: burning feeling while urinating, need to urinate often, blood in the urine, cloudy urine, lower stomach/back/pelvis pain, fever, nausea/vomiting.
  • Low blood sugar: headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, shaking, feeling jittery.
  • Necrotizing fasciitis (serious bacterial infection between and around the anus and genitals): weakness, tiredness, pain, tenderness, swelling, or redness of the skin around the anus.
  • Broken bones/fractures
  • Increased risk of losing a lower limb: pain/tenderness/redness/swelling/sores on your legs and feet.
  • Vitamin B12 deficiency
  • Dehydration: feeling dizzy/faint/lightheaded/weak.
  • Vaginal yeast infection: vaginal odor, white/yellowish vaginal discharge/itching.
  • Yeast infection of the penis: redness/itching/rash/swelling of the penis, foul-smelling discharge, and pain in the skin around the penis.

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

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WARNINGS & PRECAUTIONS

Before using Invokamet, tell your doctor or pharmacist:

  • If you are allergic to Invokamet or any of its ingredients.
  • If you are pregnant or plan to become pregnant.
  • If you are breastfeeding or plan to breastfeed.

Lactic acidosis

Invokamet can increase your risk of getting lactic acidosis. Let your doctor know if you feel cold in your hands/feet, feel very weak/tired, have unusual muscle pain, have trouble breathing, have unusual sleepiness or sleep longer than usual, have stomach pains, nausea/vomiting, feel dizzy/lightheaded, have a slow/irregular heartbeat, or have a history of osteoporosis.

Amputations

Invokamet may increase your risk of lower-limb amputations. Let your doctor know if you have any pain/tenderness/sores/ulcers/infections in your leg or foot.

Ketoacidosis

Invokamet can cause an increase in the ketones in the blood or urine. Contact your doctor if you experience nausea/vomiting, pain in the stomach area, tiredness, or trouble breathing.

Dehydration

Invokamet can cause some people to become dehydrated. Contact your doctor if you experience dizziness/light-headedness or feel faint. Make sure you drink enough liquids to avoid dehydration.

Pregnant or Planning to Become Pregnant

Tell your doctor if you are pregnant or planning to become pregnant, as it may harm your unborn baby. Speak to your doctor about the best way to control your blood sugar levels while you are pregnant.

Breastfeeding or Planning to Breastfeed

Invokamet may pass into breast milk and could harm your baby. Speak to your doctor if you are breastfeeding or planning to start breastfeeding.

INTERACTIONS & CONTRAINDICATIONS

Before using Invokamet, tell your doctor or pharmacist if you take any medications, herbal supplements, or vitamins.

Do not use medication if you have too much acid in the blood (ketoacidosis), or you are allergic to it or any of its ingredients.

Frequently Asked Questions

Invokamet contains the active ingredients canagliflozin and metformin hydrochloride. Inactive ingredients: croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, Macrogol/PEG, polyvinyl alcohol, talc, and titanium dioxide.

Invokamet is a combination medication approved for the treatment of high blood sugar in people with type 2 diabetes, and to lower the risk of cardiovascular or diabetic kidney disease.

Invokamet is available as a film-coated tablet in the following strengths:
  • Canagliflozin 50 mg and metformin hydrochloride 500 mg
  • Canagliflozin 50 mg and metformin hydrochloride 1,000 mg
  • Canagliflozin 150 mg and metformin hydrochloride 500 mg
  • Canagliflozin 150 mg and metformin hydrochloride 1000 mg

Invokamet is approved for use in adults over the age of 18 years.

Invokamet should not be used if you are allergic to Invokamet or any ingredients in Invokamet, or in people younger than 18 years. Serious allergic reactions include severe rash or itching, swelling in the face, lips, tongue, or throat, severe dizziness, and trouble breathing.

Avoid drinking alcohol, or consuming a lot of it in a short period of time as it can increase the possibility of getting serious side effects.

Invokamet is taken orally twice a day with meals. Drink plenty of fluids while taking it, unless directed otherwise by your doctor.

If you miss a dose, skip the dose, and take the next dose at the regular time. Do not catch up by taking two doses at once. Yes, with a prescription, you can purchase Invokamet online. Buying medications online is convenient and often less expensive than purchasing them at your local pharmacy.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.