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Jentadueto Metformin Hydrochloride, Linagliptin
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Jentadueto Metformin Hydrochloride, Linagliptin
Select product strength & quantity:
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Product of Canada
from$129
$630
Jentadueto Metformin Hydrochloride, Linagliptin
Select product strength & quantity:
Jentadueto Metformin Hydrochloride, Linagliptin
Select product strength & quantity:
Prescription Required
Ships within 10-20 Business Days
Express Ships from UK
Product of UK

What is Jentadueto?

Jentadueto is a prescription medication that helps lower blood sugar in adults with type 2 diabetes. It contains two medicines, linagliptin and metformin HCl, used alongside diet and exercise.

Jentadueto is not suitable for people with type 1 diabetes or those with severe kidney problems, metabolic acidosis, or allergies to its ingredients. If you have a history of pancreatitis, kidney, liver, or heart problems, or if you are pregnant or breastfeeding, you should talk to your doctor before taking Jentadueto.

It is also important to tell your doctor if you drink alcohol frequently or are going to have an x-ray procedure with contrast dye.

How Does Jentadueto Work?

Jentadueto works by combining two medicines, linagliptin and metformin, to help control blood sugar levels in people with type 2 diabetes.

Linagliptin increases certain hormones that help your body produce more insulin when your blood sugar is high and reduces the amount of sugar your liver makes.

Metformin helps lower blood sugar by decreasing the amount of sugar your liver releases, reducing the absorption of sugar from your food, and improving how your body uses insulin.

Together, these medicines help keep your blood sugar levels more stable.

Dosage Information and Usage

Dosage Form and Strengths of Jentadueto

  • 2.5 mg linagliptin / 500 mg metformin HCl
    • Light yellow, oval, biconvex tablets
    • Debossed with “D2/500” on one side and the Boehringer Ingelheim symbol on the other side
  • 2.5 mg linagliptin / 850 mg metformin HCl
    • Light orange, oval, biconvex tablets
    • Debossed with “D2/850” on one side and the Boehringer Ingelheim symbol on the other side
  • 2.5 mg linagliptin / 1,000 mg metformin HCl
    • Light pink, oval, biconvex tablets
    • Debossed with “D2/1000” on one side and the Boehringer Ingelheim symbol on the other side

Usage

Jentadueto is used to improve blood sugar control in adults with type 2 diabetes. It should be taken twice daily with meals.

Your doctor will decide the right dose for you based on how well you respond to and tolerate the medication. If you have never taken metformin before, you will start with the lowest dose.

If you are already on metformin, your dose will be adjusted to include linagliptin. If you have kidney problems, your doctor will check your kidney function before and during treatment.

You should stop taking Jentadueto if you are having certain types of x-ray procedures and restart it only after your doctor confirms that your kidney function is stable.

Storage Information

Store Jentadueto at room temperature, between 68°F and 77°F (20°C to 25°C). It can handle short-term changes in temperature between 59°F and 86°F (15°C to 30°C). Keep the medication away from high humidity.

Side Effects of Jentadueto

Common Side Effects

  • Stuffy or runny nose
  • Sore throat
  • Diarrhea

Serious but Rare Side Effects

  • Low blood sugar (hypoglycemia):
    • Headache
    • Fast heartbeat
    • Irritability
    • Dizziness
    • Drowsiness
    • Sweating
    • Hunger
    • Confusion
    • Weakness
    • Shaking or feeling jittery
  • Allergic reactions:
    • Swelling of face, lips, tongue, or throat
    • Hives
    • Difficulty swallowing or breathing
    • Skin rash, itching, flaking, or peeling
  • Low vitamin B12 levels
  • Severe joint pain
  • Skin reaction (bullous pemphigoid):
    • Blisters
    • Skin erosion
  • Heart failure symptoms:
    • Increasing shortness of breath
    • Swelling in feet, ankles, or legs
    • Rapid weight gain
    • Unusual tiredness

Warnings and Precautions

  • Lactic Acidosis: Metformin can cause a rare but serious condition called lactic acidosis, which is a buildup of lactic acid in the blood. Symptoms include feeling weak, muscle pain, trouble breathing, stomach pain, and feeling sleepy.
  • Renal Impairment: Jentadueto can be dangerous for patients with severe kidney problems. It is not recommended for those with an eGFR (a measure of kidney function) below 30 mL/min/1.73 m².
  • Age 65 or Greater: Older adults are at higher risk for lactic acidosis due to potential kidney, liver, or heart issues. Their kidney function should be checked more often.
  • Radiological Studies with Contrast: Imaging procedures using contrast dye can affect kidney function and increase the risk of lactic acidosis. Jentadueto should be stopped before such procedures and restarted only after confirming stable kidney function.
  • Surgery and Other Procedures: During surgeries or procedures that limit food and fluid intake, Jentadueto should be temporarily discontinued to prevent dehydration and kidney problems.
  • Hypoxic States: Conditions causing low oxygen levels, like heart failure or infections, can increase the risk of lactic acidosis. Jentadueto should be stopped if such conditions occur.
  • Excessive Alcohol Intake: Drinking too much alcohol can increase the risk of lactic acidosis. Patients should avoid heavy alcohol use while taking Jentadueto.
  • Hepatic Impairment: Patients with liver problems are at higher risk for lactic acidosis and should not use Jentadueto.
  • Pancreatitis: Linagliptin, one of the components of Jentadueto, has been linked to inflammation of the pancreas. If symptoms like severe stomach pain occur, the medication should be stopped immediately.
  • Hypoglycemia with Insulin Use: Combining Jentadueto with insulin or insulin-releasing drugs can cause low blood sugar. Doses of these medications may need to be adjusted.
  • Hypersensitivity Reactions: Serious allergic reactions, including swelling, rash, and difficulty breathing, can occur. Jentadueto should be discontinued if these symptoms appear.
  • Vitamin B12 Deficiency: Long-term use of metformin can lower vitamin B12 levels, leading to anemia. Vitamin B12 levels should be monitored periodically.
  • Severe Joint Pain: Linagliptin may cause severe joint pain. If this occurs, stopping Jentadueto may be necessary.
  • Bullous Pemphigoid: A skin condition causing blisters has been reported with linagliptin. Patients should stop Jentadueto if blisters or skin erosion develop and consult a doctor.
  • Heart Failure: There is a potential risk of heart failure with DPP-4 inhibitors like linagliptin, especially in patients with previous heart or kidney problems. Symptoms such as shortness of breath and swelling should be monitored and reported immediately.

Overdosage of Jentadueto

If you take too much Jentadueto, call the Poison Help line at 1-800-222-1222 or seek medical help immediately.

An overdose of metformin in Jentadueto can lead to a serious condition called lactic acidosis, which affects about one-third of overdose cases.

Symptoms include muscle pain, trouble breathing, stomach pain, and feeling very weak or tired. Metformin can be removed from the body using a process called hemodialysis, which helps clear the drug from the bloodstream.

However, linagliptin, another component of Jentadueto, cannot be effectively removed through dialysis.

Drug Interactions With Other Medications

  • Carbonic Anhydrase Inhibitors: Drugs like topiramate can cause changes in blood acidity, increasing the risk of lactic acidosis when taken with Jentadueto. Monitor patients more frequently if they are taking these medications together.
  • Drugs that Reduce Metformin Clearance: Medications such as ranolazine and cimetidine can interfere with how metformin is eliminated from the body, raising the risk of lactic acidosis. Weigh the benefits and risks before using these drugs with Jentadueto.
  • Alcohol: Alcohol can enhance the effect of metformin on lactate metabolism, leading to lactic acidosis. Advise patients to avoid excessive alcohol intake while on Jentadueto.
  • Insulin or Insulin Secretagogues: Combining Jentadueto with insulin or sulfonylureas increases the risk of low blood sugar. Patients may need lower doses of these medications to prevent hypoglycemia.
  • Drugs Affecting Glycemic Control: Certain drugs, such as diuretics and corticosteroids, can cause high blood sugar, reducing the effectiveness of Jentadueto. Closely monitor blood sugar levels when starting or stopping these drugs in patients taking Jentadueto.
  • Inducers of P-glycoprotein or CYP3A4 Enzymes: Drugs like rifampin can decrease the effectiveness of linagliptin by lowering its levels in the body. Consider alternative treatments if taking Jentadueto with these enzyme inducers.

Alternative Medications

Here are some alternatives to Jentadueto:

Cost & Coupons

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500mg/2.5mg

  • 60 tablets: $139.00
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  • 60 tablets: $139.00
  • 112 tablets: $240.00
  • 120 tablets: $260.00
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1000mg/2.5mg

  • 56 tablets: $144.50
  • 60 tablets: $139.00
  • 112 tablets: $240.00
  • 120 tablets: $260.00
  • 168 tablets: $330.00
  • 180 tablets: $360.00

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Frequently Asked Questions

Jentadueto is FDA-approved to help control blood sugar levels in adults with type 2 diabetes. It is taken along with diet and exercise to improve blood sugar control.

Jentadueto may lead to serious side effects like lactic acidosis, a rare yet severe condition. Signs include extreme weakness, muscle pain, breathing difficulty, nausea, and slow heartbeat. If you notice these symptoms, discontinue the medication and seek immediate medical assistance. Higher risk factors include severe kidney or liver issues, excessive alcohol consumption, or age over 65. It can also trigger pancreatitis, pancreas inflammation that can be severe. Notify your healthcare provider if you have a history of pancreatitis or high triglycerides. If you have intense stomach pain spreading to your back, stop Jentadueto and contact your healthcare provider.

You should not take Jentadueto if you:
  • Have severe kidney problems.
  • Have metabolic acidosis or diabetic ketoacidosis.
  • Are allergic to linagliptin (Tradjenta), metformin, or any other ingredient in Jentadueto. Signs of an allergic reaction include rash, itching, hives, or swelling of the face, lips, tongue, or throat.

Before using Jentadueto, tell your healthcare provider if you:
  • Have or have had pancreatitis.
  • Have kidney or liver problems.
  • Have heart problems, including congestive heart failure.
  • Are 65 years of age or older.
  • Drink alcohol frequently or binge drink.
  • Will receive an injection of dye for an x-ray; you may need to stop Jentadueto temporarily.
  • Have type 1 diabetes mellitus (Jentadueto is not for type 1 diabetes).
  • Have low vitamin B12 levels.
  • Are pregnant, planning to become pregnant, or breastfeeding.
  • Are premenopausal and not having regular periods; Jentadueto can affect ovulation.
  • Take other medicines, including over-the-counter drugs, vitamins, and herbal supplements.

Jentadueto may cause common side effects like a stuffy or runny nose, sore throat, and diarrhea. Serious but rare side effects include lactic acidosis, which can cause weakness, muscle pain, trouble breathing, stomach problems, and dizziness. Pancreatitis is another serious side effect, leading to severe abdominal pain that might extend to the back. Allergic reactions could involve rash, itching, or swelling of the face and throat. Some people might also experience vitamin B12 deficiency, severe joint pain, or skin reactions like blisters.

Jentadueto does not typically cause weight gain. However, if you experience unusual or sudden weight gain, along with symptoms like shortness of breath, swelling in your ankles or feet, or unusual tiredness, you should contact your healthcare provider immediately.

Jentadueto combines two medications to control blood sugar levels. Metformin lowers blood sugar by improving insulin handling and reducing liver glucose production. Linagliptin increases insulin release and decreases glucose production by blocking an enzyme that breaks down a blood sugar-regulating hormone.

It’s best to limit alcohol while taking Jentadueto. Drinking alcohol can increase your risk of serious side effects like lactic acidosis, pancreatitis, and low blood sugar.

Yes, you can take Jentadueto and Glimepiride together, but it may increase your risk of low blood sugar (hypoglycemia). You might need a dose adjustment or more frequent monitoring of your blood sugar levels.

Jentadueto is manufactured by Boehringer Ingelheim and Eli Lilly.

Take Jentadueto exactly as prescribed by your healthcare provider. It is usually taken by mouth in the form of a tablet. Swallow the tablet whole with a glass of water. You can take Jentadueto with or without food, but try to take it at the same time each day to help remember. Follow your provider’s instructions on dosage and frequency. If you miss a dose, take it as soon as you remember unless it’s almost time for your next dose. Do not double up on doses.

The best time to take Jentadueto is with a meal unless your doctor advises otherwise.

Jentadueto should be taken by mouth with meals, usually twice daily, as directed by your doctor. Be sure to drink plenty of fluids while using this medication unless your doctor tells you otherwise.

Jentadueto is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73 m²) and those with acute or chronic metabolic acidosis, including diabetic ketoacidosis.

Jentadueto is a combination therapy that includes two types of diabetes medications: linagliptin, which is a DPP-4 inhibitor, and metformin, which is a biguanide.

No, you should not crush, split, dissolve, or chew Jentadueto tablets. They must be swallowed whole to ensure proper absorption and effectiveness.

Jentadueto was approved by the U.S. Food and Drug Administration (FDA) in January 2012.

The active ingredients in Jentadueto are linagliptin and metformin hydrochloride.

No, Jentadueto is not available in generic form.

Yes, you can overdose on Jentadueto. Overdose may lead to lactic acidosis, which can cause severe drowsiness, nausea, vomiting, diarrhea, rapid breathing, and slow or irregular heartbeat.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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