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What is Kesimpta?

Kesimpta (ofatumumab) is a prescription medication used to treat adults with certain types of multiple sclerosis (MS).

MS is a disease where the immune system attacks the protective covering of nerve fibers, leading to problems with movement and other functions. Kesimpta is specifically used for:

  • Clinically isolated syndrome: A first episode of MS symptoms.
  • Relapsing-remitting disease: MS with periods of worsening symptoms followed by periods of improvement.
  • Active secondary progressive disease: MS that starts with relapses and then gradually worsens.

Before starting treatment, tell your doctor if you have any infections, have taken immune system-affecting medicines, or if you’re planning any vaccinations.

Kesimpta may affect your immune system, therefore, certain vaccines need to be given before starting the medicine. If you’re pregnant or breastfeeding, discuss with your doctor whether Kesimpta is safe for you.

How Does Kesimpta Work?

Kesimpta works by targeting a specific protein called CD20 found on certain immune cells, particularly B cells, which are involved in multiple sclerosis (MS).

Although the exact way Kesimpta helps with MS isn’t fully understood, it is believed that the medicine binds to CD20 on B cells.

This binding leads to the destruction of these B cells through processes involving other immune system components.

By reducing the number of B cells, Kesimpta helps lessen the activity of MS and its symptoms.

After starting Kesimpta, B cell counts drop significantly, showing that the medicine is effectively targeting and reducing these cells in the body.

Dosage Information and Usage

Dosage Form and Strengths of Kesimpta

Kesimpta is available in the following forms and strengths:

  • Injection: 20 mg/0.4 mL in a single-dose prefilled Sensoready Pen
  • Injection: 20 mg/0.4 mL in a single-dose prefilled syringe

Usage

Kesimpta is administered through a subcutaneous injection, meaning it is injected under the skin.

You or a caregiver can give the injection in three areas: the thigh, the stomach area (abdomen), or the outer upper arm.

Your doctor will guide you on how to properly prepare and administer Kesimpta.

  • Initial Dosing: The starting dosage is 20 mg of Kesimpta injected at Weeks 0, 1, and 2. There is no injection at Week 3.
  • Ongoing Dosing: Beginning at Week 4 and continuing monthly, you will administer a 20 mg dose of Kesimpta.
  • Missed Doses: If you miss a dose, take it as soon as you remember. After that, return to your regular monthly schedule.
  • Injection Site: Avoid injecting into areas where the skin is tender, bruised, or has moles, scars, or stretch marks.

Preparation for Injection:

  • Before Injection: Take the Kesimpta Sensoready Pen out of the refrigerator 15 to 30 minutes before use to reach room temperature. Check the liquid through the viewing window; it should be clear to slightly cloudy. Do not use it if it contains visible particles or is cloudy. Verify the expiration date and discard the pen if it has expired.
  • Cleaning: Clean the chosen injection site with an alcohol wipe and let it dry completely before injecting.

During Injection:

  • Cap Removal: Remove the cap from the Kesimpta Sensoready Pen only when ready to use it. Twist off the cap and discard it. Use the pen within 5 minutes of removing the cap.
  • Injection Process: Hold the pen at a 90-degree angle to the cleaned skin. Press firmly to start the injection; you will hear two clicks. Keep the pen in place until the green indicator fills the window and stops moving.

After Injection:

  • Site Care: You may see a small amount of blood at the injection site. Press a cotton ball or gauze over it for 10 seconds. You may use an adhesive bandage if needed.
  • Disposal: Dispose of used Kesimpta Sensoready Pens in an FDA-cleared sharps disposal container. Do not throw them in household trash. For detailed disposal instructions, refer to the FDA’s website or local regulations.

Storage Information

Refrigeration Requirements

Store Kesimpta and Kesimpta Sensoready Pen in the refrigerator at 2ºC to 8ºC (36ºF to 46ºF).

Keep them in their original cartons to protect them from light. Avoid freezing and shaking the products.

Room Temperature Storage

If necessary, Kesimpta and Kesimpta Sensoready Pen can be stored at room temperature, up to 30ºC (86ºF), for up to 7 days.

Mark the date of removal from the refrigerator on the carton. If stored below 30ºC (86ºF), they may be returned to the refrigerator and must be used within 7 days or discarded if not used in that time.

Side Effects

Common Side Effects

  • Upper respiratory tract infection (e.g., sore throat, runny nose)
  • Headache

Serious but Rare Side Effects

  • Injection-related reactions
    • redness
    • swelling,
    • itching,
    • pain
    • fever,
    • headache,
    • muscle pain,
    • chills,
    • tiredness,
    • rash, hives,
    • trouble breathing,
    • facial swelling,
  • Low immunoglobulins (low antibody count)

Warnings and Precautions

  • Infections: Serious infections, including bacterial, fungal, and viral, can occur during or after treatment with Kesimpta. In clinical studies, the infection rates for Kesimpta were similar to those for another MS drug, teriflunomide. Common infections with Kesimpta included upper respiratory and urinary tract infections. It’s important to delay Kesimpta administration if you have an active infection until it is resolved.
  • Possible Increased Risk of Immunosuppressant Effects with Other Immunosuppressants: Combining Kesimpta with other immunosuppressive therapies might increase the risk of overall immune suppression. Kesimpta has not been studied in combination with other MS treatments, so this interaction is a potential concern.
  • Hepatitis B Virus (HBV) Reactivation: Although no HBV reactivation has been reported with Kesimpta in MS patients, it has occurred with similar drugs used for other conditions. HBV can cause severe liver problems and even death. Patients should be tested for HBV before starting Kesimpta. Those who test positive or are carriers should be monitored closely by liver disease experts.
  • Progressive Multifocal Leukoencephalopathy (PML): PML is a serious brain infection caused by the JC virus, which affects those with weakened immune systems. No cases were reported in Kesimpta MS studies, but PML has occurred with other anti-CD20 drugs. Symptoms of PML include sudden weakness, vision problems, and changes in thinking. If PML is suspected, Kesimpta should be stopped immediately.
  • Vaccinations: Get all recommended vaccines at least 4 weeks before starting Kesimpta, especially live vaccines. Kesimpta may affect how well-inactivated vaccines work. Live or live-attenuated vaccines are not recommended during Kesimpta treatment or until B-cells are back to normal. Infants born to mothers who used Kesimpta should not receive live vaccines until their B-cell counts are normal.
  • Injection-Related and Hypersensitivity Reactions: Kesimpta can cause serious reactions at the injection site or more severe allergic reactions. Common reactions include fever and headache, often within 24 hours of the first injection. Serious reactions such as anaphylaxis or difficulty breathing may occur.
  • Reduction in Immunoglobulins: Kesimpta can lower levels of immunoglobulins, which are crucial for fighting infections. Decreased levels of immunoglobulin M (IgM) were observed more often with Kesimpta compared to another drug, teriflunomide.
  • Fetal Risk: Kesimpta can harm the fetus by reducing B-cells and antibody responses in the baby. Pregnant women or those planning to become pregnant should use effective contraception while on Kesimpta and for at least 6 months after their last dose.

Drug Interactions With Other Medications

Using Kesimpta together with other immunosuppressive or immune-modulating therapies, such as systemic corticosteroids, may raise the risk of infections due to the combined effects on the immune system.

It is important to consider these additive immune effects when combining Kesimpta with other drugs that affect immune function.

When switching from other immune-modulating treatments to Kesimpta, consider the duration and effects of these prior therapies. They could add to the immunosuppression when beginning Kesimpta.

Alternative Medications

For individuals seeking alternatives to Kesimpta, the following medications may be considered:

Cost & Coupons

Managing multiple sclerosis requires consistent treatment, which can often be costly. At Pharma Giant, we understand the financial burden of essential medications, and we’re committed to providing affordable solutions for your healthcare needs.

We are a trusted provider dedicated to making high-quality medications accessible to everyone.

In the United States, the cost of Kesimpta (20 mg/0.4 mL) subcutaneous solution is approximately $9,208 for a 0.4-milliliter supply.

With a prescription, patients in the US can order Kesimpta in 20mg/0.4mL pens from a trusted & licensed Canadian pharmacy for significantly less. Below are prices available through Pharma Giant:

  • 20mg/0.4mL – 1 pen: $3299.00
  • 20mg/0.4mL – 2 pens: $6398.00
  • 20mg/0.4mL – 3 pens: $9297.00

Exclusive Discount Code and Limited-Time Offer

Take advantage of Pharma Giant’s exclusive offer to reduce your medication costs!

Simply enter the code PGSAVE10 at checkout to receive a 10% discount on your Kesimpta purchase.

This limited-time offer allows you to save on healthcare medications without compromising on quality or affordability. Note that this offer is valid for one-time use per customer only.

Experience exceptional value and care with Pharma Giant today!

Ordering Information

To order Kesimpta, a valid prescription is required to ensure patient safety and compliance with medical standards. Patients have the option to make bulk purchases, allowing them to obtain up to a 90-day supply. This option provides convenience for ongoing treatment and helps manage expenses more effectively.

Assurance of Quality and Timely Delivery

At Pharma Giant, we prioritize high-quality pharmaceuticals and efficient delivery right to your doorstep. Thanks to our expedited shipping options, you can anticipate receiving your order within 3-5 business days anywhere in the United States. We take extra measures to package your medications securely, ensuring they remain safe during transit.

Why Choose Pharma Giant?

By choosing Pharma Giant, you select a reliable partner dedicated to prioritizing your health and convenience. We are committed to providing high-quality products and services that meet your needs.

Frequently Asked Questions

Kesimpta may increase the risk of serious infections, including reactivation of the Hepatitis B virus (HBV) and progressive multifocal leukoencephalopathy (PML), a severe brain infection. You will be tested for HBV before starting Kesimpta, and if you’ve had HBV, it could reactivate. Kesimpta can also heighten the risk of infections when used with other immune-suppressing drugs.

Kesimpta is a once-monthly treatment that can be administered at home. It is effective in reducing relapses and active lesions in relapsing MS, and it also helps slow the progression of disability. Kesimpta has a safety profile comparable to Aubagio (teriflunomide). To determine if Kesimpta is suitable for you, consult your doctor.

You should not take Kesimpta if you have an active Hepatitis B Virus (HBV) infection or if you have experienced an allergic reaction to ofatumumab or a life-threatening injection-related reaction to Kesimpta.

Before starting Kesimpta, your doctor will perform a blood test for hepatitis B virus (HBV) to check if you have or have had an HBV infection, which may reactivate during or after treatment. Blood tests will be done to monitor your immunoglobulin levels, as Kesimpta may decrease some types of antibodies.

Kesimpta works in relapsing MS by targeting and reducing specific B-cells that are part of the immune system. In relapsing MS, these B-cells wrongly attack the myelin, the protective nerve covering the brain and spinal cord. While the exact mechanism isn’t fully understood, Kesimpta is believed to go to the lymph nodes and decrease the number of these troublesome B-cells.

It is not known if Kesimpta passes into breast milk. If you are breastfeeding or planning to breastfeed, talk to your doctor.

It is not known if Kesimpta can harm an unborn baby. If you are pregnant, think you might be pregnant, or plan to become pregnant, inform your doctor before starting Kesimpta. There is a pregnancy registry for women who become pregnant while taking Kesimpta to help understand its effects.

You will take Kesimpta once a week for the first 3 weeks, then skip a week. After that, you switch to a maintenance dose of one injection per month.

If you miss an injection of Kesimpta during the first 3 weeks, contact your doctor. If you miss a monthly dose, take it as soon as possible without waiting until the next scheduled dose.

After the first dose of Kesimpta, some people may experience injection-related reactions within 24 hours, including fever, headache, muscle pain, chills, and fatigue. These symptoms often lessen with subsequent doses. You may also notice reactions at or near the injection site, such as redness, swelling, itching, and pain.

The most common side effects of Kesimpta include upper respiratory tract infections, which may cause symptoms like a sore throat, runny nose, and headache.

Uncommon side effects of Kesimpta include serious allergic reactions. If you experience symptoms such as a rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing, seek medical help immediately.

Yes, Kesimpta is an immunosuppressant that weakens the immune system. It reduces the activity of specific immune cells to ease multiple sclerosis (MS) symptoms.

You should not receive live vaccines while taking Kesimpta until your doctor confirms that your immune system has recovered. Live vaccines should be administered at least 4 weeks before starting Kesimpta. Non-live vaccines should ideally be given at least 2 weeks before beginning treatment.

Store Kesimpta in the refrigerator at a temperature of 36°F to 46°F (2°C to 8°C). Keep it in the original carton to shield it from light and avoid freezing. If needed, Kesimpta can be at room temperature up to 86°F (30°C) for up to 7 days. Remember to date when Kesimpta is taken out of the fridge. If the room temp is below 86°F (30°C), Kesimpta can go back in the fridge and should be used within 7 days, or discarded if not used by then.

Kesimpta is administered as an injection. For the first three weeks, you will give yourself one injection per week. After that, you will switch to a monthly injection. It’s important to follow your doctor’s instructions on how to properly administer the injection and schedule.

To safely get rid of your Kesimpta Sensoready Pen, use an FDA-cleared sharps container. If you don’t have one, ask your doctor for a free container and a pre-paid return label to send it back. Don’t toss the Sensoready Pen in your household trash. If you can’t access an FDA-cleared container, use a sturdy plastic household container with a secure lid, leak resistance, and proper hazardous waste labeling.

For your first Kesimpta dose, your healthcare team will guide you. Later, you can self-administer Kesimpta at home or elsewhere, keeping it between 36°F and 46°F in its original carton. When taking Kesimpta on the go, use a cooler for storage and carry a sharps container, alcohol swabs, and cotton balls. Remember not to freeze or shake Kesimpta to prevent foaming.

You need to be tested for Hepatitis B Virus (HBV) before starting Kesimpta because if you’ve had HBV in the past, Kesimpta could potentially reactivate it. A simple blood test will be done to check for HBV before you begin treatment.

Kesimpta’s side effects are generally temporary and may last from a few days to a few weeks.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

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