Latuda (Lurasidone Hydrochloride)
Latuda
Lurasidone Hydrochloride
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:

Latuda (Lurasidone Hydrochloride)

What is Latuda (lurasidone hydrochloride)?

Latuda is an atypical antipsychotic medication that works by changing the chemicals in your brain to help you control your mood and behaviors.

What are the Indications for Latuda?

Latuda may be prescribed with another medication to treat:

  • Bipolar depression in patients 10 years of age and older
  • Schizophrenia in patients 13 years of age or older

Latuda is not recommended:

  • If you are allergic to Latuda or any ingredients in Latuda
  • For the treatment of dementia-related psychosis

How is Latuda used?

Storage

Latuda should be stored at room temperature between 68°F and 77°F (20°C – 25°C).

Keep out of reach of children.

Instruction

Take Latuda by mouth once daily, as directed by your doctor, with food (minimum 350 calories).

Dosage

Latuda is available in tablet form in the following strength: 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg.

Bipolar depression

  • For pediatric patients 10 – 17 years, the recommended starting dose is 20 mg daily up to 80 mg.
  • For adult patients, the recommended starting dose is 20 mg daily up to 120 mg.

Schizophrenia

  • For pediatric patients 13 – 17 years, the recommended starting dose is 40 mg daily up to 80 mg.
  • For adult patients, the recommended starting dose is 40 mg daily up to 160 mg.

Do not change your dosage and take more than what is prescribed without consulting with your doctor. If you took more than prescribed, contact your doctor or seek emergency medical care right away.

Kidney and liver failure

  • For patients with moderate to severe kidney failure, the recommended starting dose is 20 mg daily up to 80 mg.
  • For patients with moderate to severe liver failure, the recommended starting dose is 20 mg daily up to 40 mg for severe liver failure or up to 80 mg for moderate liver failure.

Side Effects

It’s important to understand that although Latuda is FDA approved, it comes with side effects that may or may not affect you.

Before starting Latuda, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts to Latuda, side effects may go away.

Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own.

Adult patients

  • Restlessness
  • Sleepiness or drowsiness
  • Slow or difficult movement

Pediatric patients

  • Weight gain
  • Sleeping problems
  • Nausea

Serious Side Effects

Severe adverse reactions while taking Latuda can occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

  • Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.
  • High blood pressure: blurred vision, pounding in ears or neck, severe headache.
  • Stroke or seizures
  • Neuroleptic malignant syndrome (NMS): high fever, increased sweating, confusion, changes in heart rate or breathing, and still muscles.
  • Manic episodes
  • Difficulty swallowing
  • Weight gain
  • High blood sugar
  • Low white blood cell count
  • Decreased blood pressure
  • Uncontrolled body movements (tardive dyskinesia)

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

Warnings & Precautions

Before taking Latuda, tell your doctor or pharmacist:

  • If you are allergic to any medications such as Latuda
  • If you have or have had heart problems such as stroke
  • If you have, have had, or have a family history of diabetes or high blood sugar
  • If you have or have had high or low blood pressure
  • If you have or have had high prolactin levels
  • If you have or have had a low white blood cell count
  • If you have or have had high levels of cholesterol or triglycerides
  • If you have or have had seizures
  • If you have liver or kidney problems
  • If you are pregnant or plan to become pregnant
  • If you are breastfeeding or plan to breastfeed

Uncontrolled body movements (tardive dyskinesia)

Taking Latuda can result in uncontrolled movements of your body including your face and tongue. This condition may start even after you’ve stopped using Latuda and may not go away.  If swelling occurs in your tongue or larynx, discontinue use and seek emergency medical attention.

Metabolism issues

Taking Latuda can result in the development of high blood sugar, diabetes, increased cholesterol and triglycerides in your blood, and weight gain.

Symptoms of high blood sugar include feeling very thirsty, need to urinate often, feeling hungry, weak, or tired, feeling sick to your stomach, or confused. Contact your doctor if you exhibit any of these symptoms.

Low white blood cell count

Taking Latuda can result in low white blood cell count. Your doctor may require blood tests to monitor your white blood cells during the initial start of your treatment on Latuda.

Low Blood Pressure

Taking Latuda can decrease your blood pressure when you get up too quickly resulting in dizziness.

Prone to Falls

Taking Latuda may slow your motor skills, cause lightheadedness or dizziness, and decrease your blood pressure making you more susceptible to falling which can cause injuries.

Neuroleptic malignant syndrome (NMS)

Taking Latuda may lead to a serious condition such as Neuroleptic malignant syndrome (NMS) which can result in death.

Symptoms include stiff muscles, confusion, high fever, changes in heart rate, breathing, and blood pressure. Contact your doctor right away if you exhibit any of these symptoms.

Mania or hypomania

If you have or have had a history of bipolar disorder, taking Latuda may cause manic episodes.

Symptoms include increased energy, reckless behavior, racing thoughts, unusual ideas, excessive irritability or happiness, excessive talking, or problems sleeping. Contact your doctor right away if you exhibit any of these symptoms.

Increased prolactin levels in your blood

Taking Latuda may increase the prolactin levels in your blood. Your doctor may require blood tests to monitor your prolactin levels during your treatment on Latuda.

Symptoms include in females, the absence of your menstrual period and secretion of breast milk when not breastfeeding or in males, enlargement of breasts, and erectile dysfunction.

Pregnant or planning to become pregnant

Studies have not been conducted on pregnant women. Consult with your doctor to determine if treatment is appropriate and register with the National Pregnancy Registry for Atypical Antipsychotics. Registration can be completed by calling 1- 866-961-2388 or online through http://womensmentalhealth.org/clinical-and-researchprograms/pregnancyregistry/.

Breastfeeding or planning to breastfeed

Studies have not been conducted to determine if Latuda will pass through to human milk. However, studies show Latuda passes through rat milk. Consult with your doctor to determine if the benefit of taking Latuda outweighs the risks.

Interactions & Contraindications

Before taking Latuda, tell your doctor or pharmacist if you take any medications, herbal supplements, or vitamins.

CYP3A4 inhibitors

Taking Latuda with a CYP3A4 inhibitor increases the effect of Latuda. You should not take Latuda with a strong CYP3A4 inhibitor such as ketoconazole, clarithromycin, ritonavir, voriconazole, and mibefradil.

If you are taking a moderate CYP3A4 inhibitor such as diltiazem, atazanavir, erythromycin, and fluconazole with Latuda, your doctor may lower your dose of Latuda.

CYP3A4 inducers

Taking Latuda with a CYP3A4 inducer decreases the effect of Latuda. You should not take Latuda with a strong CYP3A4 inducer such as Rifampin, avasimibe, St. John’s wort, phenytoin, and carbamazepine.

If you are taking a moderate CYP3A4 inducer such as Bosentan, efavirenz, etravirine, and modafinil with Latuda, your doctor may increase your dose of Latuda.

Grapefruit

Eating or drinking grapefruit while on treatment with Latuda may affect how much Latuda is absorbed. Grapefruit should be avoided while on treatment with Latuda.

Frequently Asked Questions

The active ingredient in Latuda is lurasidone hydrochloride.

Latuda may contain the following inactive ingredients: mannitol, pregelatinized starch, croscarmellose sodium, hypromellose, magnesium stearate, Opadry®, and carnauba wax. Additionally, the 80 mg tablet contains yellow ferric oxide and FD&C Blue No. 2 Aluminum Lake.

Latuda is only available in tablet form.

Latuda may be prescribed with another medication to treat bipolar depression in patients 10 years of age and older or schizophrenia in patients 13 years of age or older.

Latuda is not recommended if you are allergic to Latuda or any ingredients in Latuda or for the treatment of dementia-related psychosis.

Serious allergic reactions include severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.

Take Latuda by mouth, as directed, with food (minimum 350 calories).

You may start to see improvements in your symptoms within weeks. Results will vary with each individual.

You should not stop using Latuda without consulting your doctor. You should take Latuda every day as prescribed even if you are not seeing improvements in your symptoms. It can take 4-8 weeks before you see improvements.

If it has not been more than 12 hours since you missed your dose, take your missed dose immediately. If it has been more than 12 hours, skip this dose and take your next dose as scheduled.

If you took more than prescribed, contact your doctor or seek emergency medical care right away.

Do not drive or use heavy machinery until you know how you will react to Latuda. Do not place yourself in situations where you may overheat or become dehydrated. Do not eat grapefruit or drink grapefruit juice while using Latuda.

Yes, with a prescription, you can purchase Latuda online. Buying medications online is convenient and often less expensive than purchasing at your local pharmacy.

It is recommended to take Latuda at night due to the risk of drowsiness associated with this medication. It can cause trouble sleeping, however, this is more common in children ages 10 to 17.

This medication has not been linked to clinically apparent acute liver damage of any kind. There are dosing suggestions for those with liver conditions. Your doctor will help you to find the right dose of this medication for your hepatic condition.

There is a higher risk of kidney problems related to taking Latud when taken for long periods of time. This can be more of a risk for those who are seniors. Consult with a physician about dosage requirements should to protect your kidneys from damage. If you have pre-existing kidney conditions, you may need to be on a reduced dose of this medication.

Latuda can cause vomiting and nausea in some patients. This is one of the most commonly reported side effects related to this medication. This side effect may worsen if you are taking additional medications to manage your serotonin.

Latuda is a white, round tablet. It is imprinted with the indicator L 40. This medication appears the same way for all doses that can be prescribed.

There are many medications that Latuda might interact with. Make sure to tell your doctor if you are taking any other medications and also let them know if you are taking an anti-depressant or other mood-stabilizing medication of any kind. The full list of medications that this product can interact with is long, and you should be sure that your doctor is advised about all of your existing medications.

Like all mood-stabilizing medications and can lead to thoughts of self-harm in some patients. Report these feelings to your doctor right away so that they can help you to change your dosage and other medications to prevent this symptom. You will need to be careful not to take your doses incorrectly or to forget them, as this can lead to varying levels of serotonin in the brain, which can lead to suicidal feelings.

You should speak with your doctor if you are considering not taking this medication anymore. Mood-stabilizing drugs should not just be halted. It is recommended to slowly withdraw from these medications over time to prevent side effects and problems with mood and brain function.

Many patients do take Latuda along with lithium, valproate, or other medications to help stabilize their mood. This is a process that must be managed by a doctor. You should not combine these medications with Latuda without speaking with your doctor first as they may choose to adjust dosages.

This medication can make you more prone to heat sensitivity and increase the risk of sunstroke. Drink plenty of water and limit time under the sun.