What is Linzess (linaclotide)?

Linzess (linaclotide) is a prescription medication used to treat certain gastrointestinal disorders, such as irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).

It belongs to the drug class called guanylate cyclase-C agonists. This medication works by increasing fluid secretion and muscle contraction in the intestine, which helps to relieve constipation and improve bowel movements.

Linzess

Prescription Required.

Product of Canada.

Shipped from Canada.

Prescription Required.Product of Canada.Shipped from Canada.

What is Linzess (linaclotide)?

Linzess (linaclotide) is a prescription medication used to treat certain gastrointestinal disorders, such as irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC).

It belongs to the drug class called guanylate cyclase-C agonists. This medication works by increasing fluid secretion and muscle contraction in the intestine, which helps to relieve constipation and improve bowel movements.

What are the Indications for Linzess?

Linzess is primarily used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). IBS-C is a condition that causes abdominal pain and discomfort, along with constipation and infrequent bowel movements. CIC, on the other hand, is a chronic condition characterized by difficulty passing stools, infrequent bowel movements, and abdominal discomfort.

Linzess is not recommended for use in children under the age of 2, if you have a bowel blockage, or if you are allergic to any of its ingredients.

How is Linzess used?

Storage

Linzess should be stored at room temperature between 68° – 77°F(20° – 25°) in a tightly closed container, away from light and moisture.

Keep out of reach of children and pets.

Instruction

Linzess should be taken on an empty stomach at least 30 minutes before the first meal of the day, as directed by your doctor. The capsule should be swallowed whole with water and should not be broken or chewed.

If you are unable to swallow the capsule, the capsule can be opened and poured into a mixture of applesauce or water for easier consumption. The mixture must be consumed right away. Do not mix and use at a later time.

If the medication needs to be administered through a feeding tube, the capsule can be opened and poured into a clean cup with 30 mL of water. Carefully mix the medication for 20 seconds and administer it with the use of a syringe. If there is any medication left over in the cup, an additional 30 mL of water can be added to the cup and administered with the syringe again. Flush the feeding tube with water.

Dosage

Linzess is available in capsule form in the following strengths: 72 mcg, 145 mcg, and 290 mcg.

For irritable bowel syndrome with constipation (IBS-C), the recommended dose of Linzess is 290 mcg once daily.

For chronic idiopathic constipation (CIC), the recommended dose is dependent on tolerance and can be either 72 mcg or 145 mcg once daily.

Side Effects

It’s important to understand that although this medication is FDA-approved, it comes with side effects that may or may not affect you.

Before starting, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts to Linzess, side effects may go away.

Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own:

  • Diarrhea
  • Abdominal pain
  • Gas or bloating
  • Headache
  • Nausea

Serious Side Effects

Severe adverse reactions while using Linzess can occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

  • Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.
  • Severe diarrhea
  • Dehydration
  • Electrolyte imbalances
  • Severe abdominal pain
  • Bloody stools

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

Warnings & Precautions

Before using Linzess, tell your doctor or pharmacist:

  • If you are allergic to any medications
  • If you have a bowel blockage
  • If you are pregnant or expect to become pregnant
  • If you are breastfeeding or plan to breastfeed

Pediatric Patients

Children under the age of 2 years old should not take Linzess. Studies have shown taking it can cause severe diarrhea and dehydration which can cause severe consequences in patients under 2 years of age.

Bowel Blockage

Do not take Linzess if you have bowel blockage or suspect you might have a bowel blockage. Taking it can increase the motility of the intestines, which can cause the blockage to become worse or even cause the bowel to rupture.

Pregnant or Planning to Become Pregnant

There is not enough data to determine if taking Linzess during pregnancy can harm your unborn child. If you are pregnant or become pregnant while taking, speak with your doctor to determine if therapy of change is needed.

Breastfeeding

There is limited data that shows it does not pass into breast milk. If you are breastfeeding or considering breastfeeding while taking Linzess, talk to your doctor for the best course of action before taking.

Interactions & Contraindications

Before using, speak with your doctor or pharmacist if you take any medications, herbal supplements, or vitamins.

High-Fat Food

Taking it with food, especially high-fat food can result in diarrhea or more frequent diarrhea. It should not be taken with food and should be taken on an empty stomach.

The active ingredient in Linzess is linaclotide.

Linzess may contain the following inactive ingredients for the 145 mcg and 290 mcg strengths: calcium chloride dihydrate, hypromellose, Lleucine, and microcrystalline cellulose.

Linzess may contain the following inactive ingredients for the 72 mcg strength: calcium chloride dihydrate, L-histidine, microcrystalline cellulose, polyvinyl alcohol, and talc.

The capsule shell may contain gelatin and titanium dioxide.

Linzess works by increasing the movement of stool through the intestines, which helps to relieve constipation.

Linzess is generally safe when used as directed by a healthcare provider. However, it may cause side effects in some people, so it’s important to talk to your doctor about any concerns you have.

Linzess should not be taken by people who have a bowel blockage or who are allergic to any of its ingredients.

Linzess is taken by mouth once a day, usually in the morning before eating.

Linzess typically starts working within a few hours of taking the first dose.

It is recommended to take Linzess without food to avoid frequent or more frequent diarrhea.

Linzess should be taken for as long as directed by a healthcare provider. It’s important to follow the instructions on the prescription label.

If you miss a dose of Linzess, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

It’s not known if Linzess is safe to take during pregnancy, so it’s important to talk to your doctor if you’re pregnant or planning to become pregnant.

It’s not known if Linzess passes into breast milk, so it’s important to talk to your doctor if you’re breastfeeding.

Linzess can interact with some medications, so it’s important to tell your doctor about all the medications you’re taking before starting.

Linzess is not addictive and is not classified as a controlled substance.

Taking Linzess can result in frequent loose stools. Weight loss is a possible side effect of Linzess, but it’s not a guaranteed effect.

Linzess is not recommended for use in children under the age of 2 years old.

Drinking alcohol while taking Linzess may increase the risk of certain side effects, so it’s best to avoid alcohol while taking this medication.

Linzess is not approved for the treatment of diarrhea. It may be prescribed by your doctor for off-label uses.

Dizziness is a possible side effect of Linzess, so it’s important to be careful when driving or operating machinery while taking this medication.

Linzess can be taken long-term, but it’s important to follow the instructions of your healthcare provider and to report any side effects you experience.

Yes, you can purchase Linzess online. Buying medications online is convenient and often less expensive than purchasing at your local pharmacy.