What is Mavenclad?
Mavenclad (cladribine) is a prescription medication used to help people with a condition called multiple sclerosis (MS). MS is a condition that affects the brain and the spinal cord, which makes it harder for the nerves to send messages correctly.
It is used to treat relapsing forms of MS, which include conditions where the disease comes and goes or gets worse over time.
Mavenclad medication is generally given to adults who have not had good results with other MS treatments or who could not tolerate them.
This drug is not recommended for people who have had cancer, are pregnant, or are breastfeeding. Also, people with certain infections, like tuberculosis, should not take Mavenclad.
Before starting, inform your doctor about your medical history. This includes telling them if you have ever had problems with your heart, liver, or kidneys.
You should also mention if you have taken other medications affecting your immune system or blood cells. It is not safe to take Mavenclad with certain other treatments or if you have had live vaccinations recently.
How Does Mavenclad Work?
Mavenclad works by helping to reduce the effects of multiple sclerosis (MS) on the body. It targets specific immune system cells, called B and T lymphocytes, which help protect the body from infections.
In MS, these cells can mistakenly attack the body, causing harm. Mavenclad helps by stopping these cells from growing and doing damage.
It works by affecting their DNA, which prevents them from multiplying. Over time, this reduces the number of these harmful cells in the body.
As a result, the immune system becomes less active, helping to reduce the damage caused by MS.
However, this can also make it harder for the body to fight off infections, so doctors carefully monitor patients while taking Mavenclad.
Dosage Information and Usage
Mavenclad is prescribed in two yearly treatment courses, each with two cycles. The dosage depends on your weight.
Follow the prescribed mavenclad dosing instructions and take the medication exactly as your doctor tells you.
Dosage Form and Strengths of Mavenclad
Mavenclad comes in tablets, which are uncoated, white, round, biconvex, and engraved with a “C” on one side and “10” on the other.
As mentioned, Mavenclad dosage depends on your weight and is divided into two cycles, one for each yearly treatment course:
Here is your dosage guide based on patient weight:
- 40 – 50 kg: 40 mg (4 tablets) per cycle
- 50 – 60 kg: 50 mg (5 tablets) per cycle
- 60 – 70 kg: 60 mg (6 tablets) per cycle
- 70 – 80 kg: 70 mg (7 tablets) per cycle
- 80 – 90 kg:
- Cycle 1: 80 mg (8 tablets)
- Cycle 2: 70 mg (7 tablets)
- 90 – 100 kg:
- Cycle 1: 90 mg (9 tablets)
- Cycle 2: 80 mg (8 tablets)
- 100 – 110 kg:
- Cycle 1: 100 mg (10 tablets)
- Cycle 2: 90 mg (9 tablets)
- 110 kg or more: 100 mg (10 tablets) for both cycles
Each cycle involves taking the prescribed number of mavenclad tablets once daily over 4 or 5 consecutive days.
After completing two treatment courses, no additional Mavenclad should be taken for two years.
How to Use Mavenclad?
To use Mavenclad, take the prescribed mavenclad tablets with water. Swallow each tablet whole without chewing. You can take Mavenclad with or without food.
Take Mavenclad at least 3 hours apart from any other oral medications. Your doctor will guide you on when to start each cycle and how many tablets you need based on your weight.
If you miss a dose, take it the next day, but do not double it.
Side Effects of Mavenclad
Mavenclad side effects can include headaches, upper respiratory infections, and low white blood cell counts. However, it can also lead to more serious issues such as infections, liver problems, and heart failure.
Listed below are the common and severe side effects of Mavenclad:
Common Side Effects
- Upper respiratory infection
- Headache
- Low white blood cell counts
Severe Side Effects
- Low blood cell counts
- Serious infections (tuberculosis, hepatitis B or C, shingles)
- Progressive multifocal leukoencephalopathy (PML)
- Liver problems (yellowing of skin/eyes, dark urine)
- Allergic reactions (rash, swelling, trouble breathing)
- Heart failure (shortness of breath, fast heartbeat)
Warnings and Precautions
Mavenclad is a powerful medication, but it comes with serious risks that you should know about before starting treatment.
It can increase the risk of cancer, harm unborn babies, lower white blood cell counts, and make infections more likely.
You need regular medical tests and should follow safety precautions while taking Mavenclad.
- Mavenclad may increase the risk of cancer. Some patients developed serious cancers, including melanoma and ovarian cancer.
- Avoid using Mavenclad for at least two years after completing the first two treatment courses. Using it too soon may raise the risk of cancer.
- Pregnant women must not use Mavenclad. It can cause congenital disabilities and pregnancy loss. Women and men must use effective birth control during treatment and for six months after the last dose.
- Mavenclad lowers the number of white blood cells, which help fight infections. This can weaken the immune system and increase the risk of serious infections.
- Blood tests are needed before, during, and after treatment to check white blood cell levels. Treatment may need to be paused or adjusted if levels drop too low.
- Mavenclad can cause life-threatening infections. Patients have reported herpes, tuberculosis, and fungal infections while on treatment.
- Before starting Mavenclad, doctors check for HIV, hepatitis, and tuberculosis. If you have an active infection, treatment must wait until it is fully controlled.
- Avoid getting live vaccines while on Mavenclad. Get all required vaccinations at least four to six weeks before starting treatment.
- Progressive multifocal leukoencephalopathy (PML), a severe brain infection, has been linked to medications that weaken the immune system. Though no PML cases have been reported with Mavenclad, doctors monitor for any signs of this condition.
- Tell your doctor immediately if you develop new or worsening symptoms like weakness, vision, confusion, or personality changes. These could be signs of a serious condition like PML.
Drug Interactions With Other Medications
Mavenclad can interact with other medications, which may lead to serious health risks. Some drugs can worsen its side effects, while others can interfere with how it works in the body.
For example, taking Mavenclad with other medications that weaken the immune system can increase the risk of infections.
Specific antiviral drugs may reduce Mavenclad’s effectiveness, and some medications used for cancer or blood disorders can make its side effects more severe.
To ensure safety, doctors carefully review all medications before starting Mavenclad. Below is a list of drugs that may interact with it:
- Drugs that weaken the immune system (immunomodulatory, immunosuppressive, or myelosuppressive drugs): These medications can increase the risk of infections and worsen Mavenclad’s side effects.
- Interferon-beta: Using this drug with Mavenclad can lower white blood cell counts, increasing the risk of infections.
- Drugs that affect blood cells (hematotoxic drugs): These medications can increase the risk of blood-related side effects, such as a drop in blood cell counts.
- Certain antiviral and antiretroviral drugs (lamivudine, zalcitabine, ribavirin, stavudine, zidovudine) may interfere with Mavenclad’s ability to work correctly in the body.
- Medications that affect how Mavenclad is absorbed and removed from the body (ritonavir, eltrombopag, cyclosporine, nifedipine, sulindac, dipyridamole, and others): These drugs can alter Mavenclad’s effectiveness or cause unexpected side effects.
- Medications that speed up Mavenclad’s removal from the body (rifampicin, St. John’s Wort, corticosteroids): These drugs may reduce Mavenclad’s effectiveness, making it less useful in treating the condition.
Alternative Medications
Mavenclad is used to treat relapsing forms of multiple sclerosis (MS), but some people may need alternative options due to side effects, effectiveness, or personal preferences.
There are several other medications available that work differently to manage MS symptoms and relapses. Below are some alternative medications to Mavenclad:
Order Budget-Friendly Mavenclad from Canada
Getting the medication you need should not be stressful or expensive. You deserve access to Mavenclad at a price that will not leave you struggling to afford other necessities. But for many, the high cost of prescriptions makes it difficult to stay on treatment.
Pharma Giant understands this challenge and is here to help, making getting your medication without extra hassle easier and more affordable.
With Pharma Giant, you can save up to 90% on Mavenclad compared to what you might pay at your local pharmacy.
You can save more by ordering in bulk and taking advantage of extra discounts through referral programs and special offers.
Every prescription through Pharma Giant is verified by a Canadian pharmacist and prescribed by a US doctor, so you can trust that you are getting what you need.
You should not have to choose between your health and your budget. Pharma Giant is here to ensure you can afford the medication without unnecessary stress.
How to Order Mavenclad Online?
- Search for Vyndaqel and click the Buy button to add it to your cart. If you need more medications, click Continue Shopping to continue adding items.
- When you are ready, click Continue Checkout to proceed. Enter your contact, payment, and shipping details. If you are a new customer, create an account using your email and password. Use code PGSAVE10 to get a 10% discount on your first order.
- You can upload your prescription using the RX document uploader, email it to info@pharmagiant.com, or fax it to 1-888-562-8159. If no prescription is needed, your order will be processed right away.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
| Have a prescription?
Order Mavenclad online today and enjoy a host of benefits, including: |
 |
