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Mavyret
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Maviret Glecaprevir, Pibrentasvir
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What is Mavyret?

Mavyret (Glecaprevir/Pibrentasvir) is an oral, fixed-dose combination antiviral approved for treating chronic hepatitis C in adults and children aged 3 and above. Hepatitis C is liver inflammation caused by a virus, leading to acute or chronic hepatitis. The condition ranges from mild to severe, potentially causing liver cirrhosis and cancer.

Mavyret is effective against all six major HCV genotypes (1 through 6) and can be used in patients without cirrhosis or with compensated cirrhosis (Child-Pugh A).

It is also used for people with HCV genotype 1 who have been treated before with certain other HCV medications. Mavyret contains two active ingredients: glecaprevir and pibrentasvir.

It is not known if Mavyret is safe and effective for children under 3 years old. Before taking Mavyret, tell your doctor about any other medical conditions, including:

  • If you have had hepatitis B,
  • Liver problems,
  • HIV-1,
  • Pregnant, planning to become pregnant, or breastfeeding
  • If you are taking these medications: atazanavir or rifampin

Mavyret can reactivate hepatitis B, which can cause serious liver problems. Do not take Mavyret if you have certain liver problems or are taking the medicines atazanavir or rifampin.

How Does Mavyret Work?

Mavyret targets the hepatitis C virus directly to prevent its multiplication. It comprises glecaprevir and pibrentasvir.

Pibrentasvir blocks a key protein called NS5A needed for viral replication. Glecaprevir acts on another protein, NS3/4A, crucial for virus growth and spread in cells.

By blocking these viral proteins, Mavyret prevents the hepatitis C virus from multiplying. Over the course of treatment, this suppression allows the immune system and liver to clear the infection, often resulting in a sustained virologic response (SVR), which is considered a cure.

Dosage Information and Usage

Dosage Form and Strengths

Mavyret is available in two forms for oral use: tablets and pellets.

The tablets are pink, oblong-shaped, and have “NXT” marked on one side. Each tablet contains 100 mg of glecaprevir and 40 mg of pibrentasvir.

The oral pellets are pink and yellow and come in packets. Each packet contains 50 mg of glecaprevir and 20 mg of pibrentasvir.

Usage

Before starting Mavyret, your doctor will test you for hepatitis B to prevent complications. The dosage of Mavyret varies based on the patient’s age, weight, and whether they have liver scarring.

Adults and adolescents weighing at least 45 kg usually take three tablets once daily with food, for a treatment duration of 8 to 16 weeks, depending on prior treatment history and presence of cirrhosis. For children under 12 or weighing less than 45 kg, the dose is given as oral pellets based on their weight.

Do not change or stop your dose without consulting your doctor. If you miss a dose, take it as soon as possible if it’s within 18 hours. If more than 18 hours have passed, skip the missed dose and take the next dose at the usual time with food.

Side Effects

Common Side Effects

  • Headache
  • Tiredness

Serious but Rare Side Effects

In people with advanced liver problems, before starting Mavyret, there is a rare risk of:

  • Worsening liver problems
  • Liver failure
  • Death

Contact your doctor immediately if you experience:

  • Nausea
  • Extreme tiredness
  • Yellowing of your skin or eyes
  • Easy bleeding or bruising
  • Confusion
  • Dark, black, or bloody stool
  • Loss of appetite
  • Diarrhea
  • Dark or brown urine
  • Swelling or pain in the upper right side of your abdomen
  • Sleepiness
  • Vomiting blood
  • Lightheadedness

Warnings and Precautions

  • Risk of Hepatitis B Virus Reactivation in Patients Coinfected with HCV and HBV: Patients with both hepatitis C virus (HCV) and hepatitis B virus (HBV) infections may see HBV reactivation during or after using Mavyret. This can cause serious liver issues like failure and death. Reactivation shows a sudden rise in HBV replication, seen with higher HBV DNA levels in the blood. Even patients with past HBV infection (HBsAg negative and anti-HBc positive) can have reactivation.
  • Risk of Hepatic Decompensation/Failure in Patients with Advanced Liver Disease Evidence: Some patients with advanced liver disease, like cirrhosis or severe liver impairment (Child-Pugh B or C), may face liver decompensation or failure with Mavyret. This can lead to serious outcomes, including death. Decompensation may manifest shortly after starting treatment as jaundice, abdominal fluid buildup (ascites), confusion, or bleeding from enlarged esophageal veins (variceal hemorrhage).
  • Risk of Reduced Therapeutic Effect Due to Concurrent Use with Specific Medications: Taking Mavyret with drugs such as carbamazepine, efavirenz, or St. John’s wort can decrease glecaprevir and pibrentasvir levels in the blood, reducing Mavyret’s effectiveness against HCV. It’s advised not to use these medications together to maintain Mavyret’s efficacy.

Overdosage

If someone takes too much Mavyret, they should be closely watched for signs of possible side effects. Immediate treatment should be provided to manage any symptoms that occur. Hemodialysis, a process to remove substances from the blood, does not effectively remove glecaprevir and pibrentasvir from the body in case of overdose.

Drug Interactions With Other Medications

  • Mavyret’s Effect on Other Drugs: Mavyret can influence how other drugs are processed in the body. It inhibits proteins like P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and organic anion transporting polypeptide (OATP) 1B1/3, which are responsible for moving drugs in and out of cells. When these proteins are blocked, other drugs that rely on them might stay in the body longer, possibly boosting their effects.
  • Effect of Other Drugs on Mavyret: Drugs that either speed up or slow down the activity of P-gp, BCRP, or OATP1B1/3 can impact how Mavyret works in your body. For example, drugs that boost these proteins can lower Mavyret levels in the bloodstream, which might reduce its effectiveness against hepatitis C.
  • Specific Drug Interactions to Note: Certain medications like carbamazepine (used for seizures), phenytoin (also for seizures), efavirenz (for HIV), and St. John’s Wort (a herbal supplement) can lower Mavyret levels. This reduction may make Mavyret less effective in treating hepatitis C.
  • Medication-assisted treatment (MAT) for Opioid Use Disorder: Mavyret doesn’t need dose adjustments when taken with medications like buprenorphine/naloxone or methadone for opioid addiction treatment. However, there’s not enough data to confidently recommend using naltrexone with Mavyret.
  • Drugs with No Clinically Significant Interactions: Many medications, including abacavir (for HIV), caffeine, lamotrigine (for seizures), and others, do not affect Mavyret’s effectiveness and can be safely used together without needing dose adjustments.

Cost & Discounts

Your health is a priority, and getting the necessary medication shouldn’t be a financial burden. Dedicated to making healthcare both affordable and accessible, Pharma Giant ensures you don’t have to compromise on your well-being.

We offer 100mg/40mg packs with 84 tablets available for $30,600.00.

At Pharma Giant, we provide quality medication at prices that won’t break the bank. Choosing Pharma Giant means you can manage your health effectively and affordably.

Special Discount on Mavyret

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Superior Quality and Prompt Delivery

At Pharma Giant, we are committed to providing exceptional medication quality and expedient delivery to your doorsteps.

Our express shipping guarantees that your orders will arrive within 3-5 business days across the United States, securely packaged to ensure the integrity of your medication during transit.

Pharma Giant takes pride in our commitment to reliable, efficient, and timely service for all our customers.

Frequently Asked Questions

Mavyret is a prescription medication used to treat chronic hepatitis C virus (HCV) in adults and children aged 3 years and older. It’s effective against all major genotypes (1-6) of HCV, with or without compensated cirrhosis, and is particularly useful for patients who have previously tried other HCV treatments without success.

Mavyret contains two antiviral drugs, glecaprevir and pibrentasvir. Glecaprevir is a protease inhibitor that disrupts the production of virus particles, while pibrentasvir is an NS5A inhibitor that blocks a protein essential for viral replication. Together, they reduce and eventually stop the production of the HCV in the body.

The most common side effects of Mavyret include headache, fatigue, nausea, and diarrhea. These side effects are generally mild and temporary. It’s important for patients to stay hydrated and report any persistent or severe symptoms to their healthcare provider.

Mavyret is one of the preferred treatments for HCV in patients with kidney disease, including those on dialysis. Its safety and efficacy have been established in this patient group, making it a valuable option for those with mild to moderate kidney impairment.

Mavyret is safe and effective for individuals co-infected with HIV and HCV. It shows no significant interactions with most HIV medications, making it a suitable treatment option for this population. However, patients should discuss their HIV treatment regimen with their healthcare provider to manage potential interactions.

The duration of Mavyret treatment varies based on the patient’s HCV genotype, prior treatment history, and presence of cirrhosis. It typically ranges from 8 to 16 weeks, with 8 weeks often being sufficient for treatment-naive patients without cirrhosis.

If a dose of Mavyret is missed and it’s within 18 hours of the scheduled time, take it as soon as possible. If more than 18 hours have passed, skip the missed dose and take the next dose at the regular time. Avoid doubling up on doses.

Mavyret has a high cure rate, successfully treating over 95% of people with hepatitis C. A cure is defined as having no detectable hepatitis C virus in the blood 12 weeks after completing treatment, known as a sustained virological response (SVR).

There are no specific dietary restrictions while taking Mavyret. However, it should be taken with food to enhance absorption. Patients are advised to maintain a balanced diet and stay hydrated, especially if experiencing side effects like diarrhea or nausea.

Mavyret has a boxed warning for the risk of reactivating Hepatitis B in patients who have had the virus. Before starting treatment, patients are tested for Hepatitis B, and if positive, they may need treatment for Hepatitis B before starting Mavyret.

While there is no direct interaction between Mavyret and alcohol, patients with Hepatitis C are generally advised to avoid alcohol as it can exacerbate liver disease. Discuss alcohol consumption with your healthcare provider for personalized advice.

Mavyret is administered orally. The standard dosage for adults and children over 12 years old (or weighing at least 45kg) is three tablets taken at the same time once daily with food. Dosage for younger patients is based on weight and administered as oral pellets.

The effects of Mavyret during pregnancy are not well-established. Women who are pregnant or planning to become pregnant should consult their healthcare provider to weigh the potential risks and benefits of using Mavyret during pregnancy.

Yes, Mavyret is effective against all six major genotypes (1-6) of the Hepatitis C virus, making it a versatile and comprehensive treatment option for HCV.

Mavyret is approved for use in children who are 3 years or older and weigh at least 12 kg. The dosage and administration for children are adjusted based on body weight and age.

If you experience severe side effects while taking Mavyret, such as signs of allergic reaction or severe liver problems, seek immediate medical attention. Contact your healthcare provider right away for any new or worsening symptoms.

Mavyret should be stored at room temperature, away from moisture and light. Keep it in its original container and tightly closed when not in use.

Mavyret can interact with certain medications, which may affect its effectiveness or lead to adverse effects. Inform your healthcare provider about all medications, supplements, and herbal products you are taking to manage potential interactions.

Mavyret has a high success rate, with clinical trials showing a cure rate of over 95% in patients with Hepatitis C. This includes patients with various genotypes and those with or without cirrhosis.

Mavyret is generally considered safe for use in patients who have had a liver or kidney transplant. However, these patients may require close monitoring and possibly a different dosage. It’s important to discuss your transplant history with your healthcare provider before starting.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.