Have a prescription? Buy Mayzent from Canada and experience numerous advantages, including:

  • Significant Cost Savings: Buy Mayzent at lower prices compared to the US.
  • Bulk Discounts: Enjoy additional savings with bulk orders of Mayzent .
  • Dependable Express Delivery: Fast and efficient shipping directly to your doorstep.
  • Secure Ordering Process: Order online or by phone at 1-888-513-2294
  • SAVE 10% on first order with coupon code: FIRST10
Buy Mayzent from Canada
Buy Mayzent (Siponimod)

Starting from $3999
Order up to a 3-month supply

Mayzent FCT
Select product strength & quantity:
Mayzent FCT
Select product strength & quantity:

Prescription Required.

Product of Canada.

Shipped from Canada.

Prescription Required.Product of Canada.Shipped from Canada.

Multiple sclerosis (MS) is a challenging and unpredictable disease, affecting millions worldwide. It’s a condition that can impact every aspect of life, from physical abilities to emotional wellbeing. In the quest to manage and mitigate the effects of MS, medical science has made significant strides. One such advancement is the development of Mayzent (Siponimod), a medication designed to provide relief and improve the quality of life for those living with this condition. This article delves into the world of Mayzent, exploring its uses, benefits, and the science behind its effectiveness.

Mayzent represents a beacon of hope for many, offering a new avenue for treatment. It’s not just a medication; it’s a testament to the progress in MS research and treatment. As we explore Mayzent in detail, we aim to provide valuable insights for patients, caregivers, and healthcare professionals alike, shedding light on how this medication fits into the broader landscape of MS management.

What is Mayzent?

Mayzent, known scientifically as Siponimod, is a medication specifically approved for the treatment of multiple sclerosis. It falls under the category of selective sphingosine 1-phosphate receptor modulators. This class of drugs works by targeting specific receptors in the immune system, leading to a reduction in the movement of lymphocytes (a type of white blood cell) in the body. By doing so, Mayzent plays a crucial role in managing the immune system’s activity, which is particularly important in MS, a disease where the immune system mistakenly attacks the protective covering of nerves.

The mechanism of action of Mayzent is both unique and sophisticated. It helps in controlling the overactive immune response, thereby reducing inflammation and the subsequent damage to nerve fibers in the central nervous system. This action is vital in slowing down the progression of MS and in reducing the frequency of flare-ups or relapses.

Mayzent is specifically indicated for relapsing forms of multiple sclerosis, which include clinically isolated syndrome, relapsing-remitting MS (RRMS), and active secondary progressive MS (SPMS). This makes it a versatile option for a broad range of MS patients, addressing various stages and forms of the disease.

The development and approval of Mayzent mark a significant milestone in MS treatment. It offers a novel approach to managing the disease, different from traditional therapies. Its targeted action on the immune system provides a new pathway to potentially reduce the impact of MS on patients’ lives, making it a critical component in the arsenal against this challenging condition.

Key Information About Mayzent

Indications for Use

Mayzent (Siponimod) is specifically designed for the treatment of various forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. Its primary role is to manage the frequency of disease flare-ups and slow the progression of physical disability associated with these conditions.

Mechanism of Action

The medication operates by modulating the immune system. It selectively targets sphingosine 1-phosphate (S1P) receptors, which play a critical role in the movement and function of lymphocytes, a type of white blood cell. By binding to these receptors, Mayzent effectively reduces the migration of these cells to the central nervous system, thus mitigating damage and inflammation.

Suitability and Precautions

Mayzent is not universally suitable for all patients. It is contraindicated in individuals with certain pre-existing conditions like severe cardiac issues, untreated sleep apnea, or severe respiratory conditions. A comprehensive medical evaluation is essential before initiating treatment with Mayzent.

Monitoring and Follow-up

Regular monitoring, including blood tests for liver function and white blood cell counts, as well as heart function assessments and eye examinations, are crucial for patients on Mayzent. These tests help in ensuring the safe and effective use of the medication.

Vaccination and Immune Response

Patients planning to start Mayzent should complete necessary vaccinations at least 4 weeks prior to the commencement of the treatment. This precaution is due to the medication’s potential impact on the immune system’s response to vaccines.

How is Mayzent Used?

Dosage and Administration

Mayzent is administered orally, typically once a day, with or without food. The treatment begins with a lower dose, which is gradually increased to the full maintenance dose over a period of days. This titration process is crucial for minimizing cardiac-related side effects.

Combination with Other Therapies

While Mayzent can be effective as a standalone treatment, it may also be used in conjunction with other MS therapies. However, potential interactions with other medications should be carefully considered and discussed with a healthcare provider.

Managing Missed Doses

In case a dose is missed, it should be taken as soon as remembered. However, if the time for the next dose is near, the missed dose should be skipped, and the regular dosing schedule should be resumed. Doubling doses to make up for missed ones is not recommended.

Treatment Discontinuation and Reinitiation

If treatment with Mayzent is interrupted for more than a week after the first month, re-titration from the initial dose is necessary upon resumption. This is due to the medication’s specific interaction with the immune system and the potential for side effects upon restarting the treatment.

Patient Education and Compliance

Educating patients on the importance of adhering to the prescribed dosage schedule is essential. Patients should be made aware of the significance of regular monitoring, understanding potential side effects, and the necessity of consistent follow-up appointments.

Storage Information for Mayzent

Temperature and Environment

Mayzent (Siponimod) requires storage at room temperature, specifically between 68°F to 77°F (20°C to 25°C). This range is crucial to maintain the medication’s integrity. Extreme temperatures, both hot and cold, should be avoided to prevent any degradation of the drug’s efficacy.

Packaging and Handling

The medication is provided in packaging designed to protect it from light and moisture. It is important for patients to keep Mayzent in its original container and ensure it is tightly closed. This practice helps in maintaining the medication’s stability and effectiveness.

Safe Storage Practices

Storing Mayzent securely and out of reach of children and pets is essential. A secure location, away from direct sunlight and moisture-prone areas like bathrooms and kitchens, is ideal. This precaution not only ensures the safety of the medication but also prevents accidental ingestion by children or pets.

Disposal Guidelines

Proper disposal of expired or unused Mayzent is important for environmental safety and health. Patients should not dispose of the medication in household trash or sewage systems. Instead, they should utilize pharmacy take-back programs or follow specific disposal instructions provided with the medication or by healthcare professionals.

Instructions for Patients Using Mayzent

Pre-Treatment Consultation

Before initiating treatment with Mayzent, a thorough consultation with a healthcare provider is necessary. This discussion should cover the patient’s medical history, current medications, and any allergies to ensure the safe use of Mayzent.

Understanding the Medication

Patients need to be well-informed about Mayzent, including its purpose, mechanism of action, benefits, and potential side effects. This understanding is crucial for patient adherence and the success of the treatment.

Adherence to Dosage

Strict adherence to the prescribed dosage schedule is vital. The gradual increase in dosage from a lower initial dose to the full dose is designed to minimize potential side effects, particularly those affecting heart health.

Importance of Regular Monitoring

Regular medical check-ups and monitoring are integral parts of the treatment process. Patients should be aware of the necessity of these appointments, which often include blood tests and heart function assessments.

Side Effect Awareness

Educating patients on the potential side effects of Mayzent and the importance of seeking medical attention when necessary is crucial. This includes recognizing symptoms of serious side effects and understanding when they warrant immediate medical intervention.

Lifestyle Considerations

Patients should receive advice on lifestyle choices that can impact their treatment with Mayzent. Dietary choices, physical activity levels, and avoidance of harmful habits like smoking or excessive alcohol consumption can significantly influence the effectiveness of the treatment and overall health.

Emergency Preparedness

In emergency situations, it is important for patients to inform medical personnel that they are taking Mayzent. This information is critical in guiding emergency treatment, especially in scenarios where the patient might be unable to communicate their medical history.

Potential Side Effects of Mayzent

Common Side Effects

Patients taking Mayzent may encounter several side effects, typically ranging from mild to moderate in severity. These include:

  • Headache
  • High blood pressure
  • Liver function test abnormalities
  • Lymphopenia (a decrease in white blood cells)
  • Respiratory tract infections

Serious Side Effects

There are also serious side effects associated with Mayzent, which necessitate immediate medical attention:

  • Severe infections, due to immune system suppression
  • Cardiovascular effects, especially in patients with existing heart conditions
  • Macular edema, a condition affecting vision

Managing Side Effects

Patients are advised to promptly report any side effects to their healthcare provider. While some side effects may lessen as the body adjusts to the medication, persistent or worsening symptoms might require an adjustment in dosage or a switch to alternative treatments. Regular follow-ups and open communication with a healthcare provider are key to effectively managing these side effects.

Drug Interactions with Mayzent

Interaction with Immune System Modulators

Mayzent can interact with other medications that modulate the immune system. This can lead to an increased risk of infections or other immune-related issues. Patients should inform their healthcare providers about all the medications they are taking, including over-the-counter drugs and supplements.

Impact on Vaccine Efficacy

Due to its immunomodulatory effects, Mayzent can impact the efficacy of vaccines. Patients should complete any necessary vaccinations at least 4 weeks before starting Mayzent. Live vaccines should be avoided during treatment and for a period after discontinuing the medication.

Other Medication Interactions

Mayzent may also interact with a range of other medications, including those metabolized by certain liver enzymes. This can affect the levels of Mayzent or the other drugs in the bloodstream, potentially leading to increased side effects or decreased efficacy. Regular monitoring and consultation with a healthcare provider are essential to manage these interactions effectively.

Warnings and Precautions for Mayzent

Cardiovascular Health

Patients with a history of cardiac issues should exercise caution when starting Mayzent. The medication can have effects on heart rate, particularly upon initiation of treatment. It’s recommended that patients undergo a cardiac evaluation before starting Mayzent and be monitored during the initial dosing period.

Infection Risks

Due to its immunomodulatory effects, Mayzent can increase the risk of infections. Patients should be monitored for signs of infection, and any symptoms like fever, sore throat, or fatigue should be reported to a healthcare provider immediately.

Liver Function

Regular liver function tests are advised as Mayzent can cause elevations in liver enzymes. Patients should be aware of symptoms indicative of liver issues, such as jaundice, nausea, or loss of appetite, and seek medical attention if these occur.

Pregnancy and Breastfeeding

Women of childbearing age should use effective contraception during treatment with Mayzent and for some time after the last dose due to potential risks to the fetus. The effects of Mayzent on breastfed infants are unknown, so women should discuss the risks and benefits of breastfeeding with their healthcare provider while on this medication.


Patients should complete any necessary vaccinations before starting treatment with Mayzent. Live vaccines are generally not recommended during treatment and for a period after discontinuation due to the medication’s impact on the immune system.

Studies on Mayzent (Siponimod)

Overview of Clinical Trials and Approvals

Mayzent (siponimod) has been a significant development in the treatment of multiple sclerosis (MS), particularly for relapsing forms of the condition. Developed by Novartis, a Swiss multinational pharmaceutical company, Mayzent has received approval from various health authorities, including the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), Health Canada, and the Japanese Ministry of Health, Labour, and Welfare.

Key Clinical Trial: EXPAND Study

The FDA’s approval of Mayzent was largely based on the results of the Phase III EXPAND clinical trial. This randomized, placebo-controlled study involved 1,652 patients with secondary progressive MS (SPMS) from 31 countries. The primary endpoint was the three-month confirmed disability progression (CDP) events. Mayzent demonstrated a significant reduction in the risk of three-month CDP by 21% compared to placebo. Additionally, a 33% reduction in three-month CDP risk was observed in patients with relapse activity two years before screening. The drug also showed a 26% reduction in six-month CDP risk and a 55% reduction in the annualized relapse rate (ARR).

Long-Term Efficacy and Safety

Further insights into the long-term effectiveness and safety of Mayzent were gained from the EXPAND open-label extension trial. Over five years, treatment with Mayzent resulted in a 52% reduction in ARR compared to placebo. The drug also showed significant benefits in reducing demyelination and supporting remyelination.

Adverse Effects Observed

Common adverse events reported during the EXPAND trial included headaches, high blood pressure, and increases in transaminase levels. These findings are crucial for understanding the risk-benefit profile of Mayzent in treating SPMS.

Regulatory Approvals

Mayzent’s journey to approval saw the EMA accepting its marketing authorization application in October 2018, followed by FDA approval in March 2019. The European Commission authorized Mayzent for treating adult patients with SPMS with active disease in January 2020. Subsequent approvals by Health Canada and the Japanese Ministry of Health, Labour, and Welfare further established its global presence in MS treatment.

Impact on Multiple Sclerosis Treatment

Mayzent’s approval marked a significant milestone in MS therapy, particularly for SPMS, a form of MS characterized by a gradual worsening of the nervous system function over time. The drug’s mechanism, which involves modulating the sphingosine 1-phosphate (S1P) receptor, has opened new avenues in MS treatment, offering hope to many patients worldwide.

Buy Mayzent: Price & Coupons

For many Americans, the high cost of prescription medications can be a significant burden. A prime example of this is the drug Mayzent, used for treating multiple sclerosis. In the U.S., the price for Mayzent can be prohibitively expensive, making it challenging for many patients to access the medication they need. However, there is a cost-effective solution available through Pharma Giant (PG), allowing Americans to save significantly on their prescription medications.

By obtaining a prescription from a doctor, U.S. patients can order their medications securely and conveniently from PG. Pharma Giant partners with trusted and licensed Canadian pharmacies to ensure the highest standards of quality and safety. Medications are express shipped across the U.S., typically arriving within 3-5 business days, ensuring prompt delivery and minimal disruption to treatment plans.

Pharma Giant offers significant savings, and patients can save even more when they order in larger quantities thanks to bulk pricing. To make this deal even more attractive, PG offers a special discount for first-time customers. By using the coupon code FIRST10, new customers can save an additional 10% on their first order, further lowering the financial barrier to accessing essential medications like Mayzent.

Mayzent Pricing

StrengthQuantityPG PricePrice per Tablet
0.25mg120 tabs$4,199.00$35.00
240 tabs$8,300.00$34.58
360 tabs$12,300.00$34.17
2mg28 tabs$3,900.00$139.29
56 tabs$7,700.00$137.50
84 tabs$11,400.00$135.71

By purchasing Mayzent through Pharma Giant, U.S. patients can significantly reduce their medication costs, especially when taking advantage of bulk pricing, while benefiting from a reliable and expedited service.

Frequently Asked Questions

Mayzent (Siponimod) is a medication used to treat adults with various forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. It works by modulating the immune system to decrease the action of immune cells that may cause nerve damage.

Mayzent is a sphingosine 1-phosphate (S1P) receptor modulator. It works by binding to S1P receptors, which are involved in the movement and function of certain immune cells (lymphocytes). This action helps reduce the migration of these cells to the central nervous system, thereby reducing inflammation and nerve damage.

Mayzent is not suitable for individuals with certain heart conditions like “sick sinus syndrome” or “AV block” (unless they have a pacemaker), or those who have recently had heart failure, heart attack, stroke, or other serious heart problems. It’s also not recommended for people with a specific genotype, which can be determined through genetic testing.

Common side effects include headaches, increased blood pressure, and abnormal liver function tests. Some people may also experience swelling in the arms or legs, nausea, and dizziness.

Yes, Mayzent can cause serious side effects such as decreased lung function, vision problems, liver problems, infections, and a decrease in heart rate. In rare cases, it may lead to severe increase in disability when stopping treatment.

Mayzent is taken orally, once a day. The dosage is gradually increased over the first 5 to 6 days of treatment. It’s important to follow the prescribed dosage schedule strictly.

Yes, Mayzent can weaken the immune system, increasing the risk of infections, some of which can be serious or even fatal. Symptoms of infection include fever, chills, body aches, and tiredness.

Mayzent can slow down the heart rate, especially after the first dose. Patients may need to be monitored for at least 6 hours after the first dose to ensure their heartbeat does not go too slow.

Avoid receiving live vaccines while using Mayzent and for 4 weeks after stopping treatment. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Mayzent may harm an unborn baby. Women of childbearing potential should use effective contraception while using Mayzent and for at least 10 days after the last dose.

It’s not known if Mayzent passes into breast milk. Consult your doctor before breastfeeding while using this medication.

Unopened Mayzent tablets should be stored in the refrigerator. After opening, they can be stored at room temperature in the original container for up to 3 months.

If you miss a dose of Mayzent, take it as soon as you remember. However, if you miss taking your medication for more than 4 days in a row, you’ll have to restart the dosing from day 1.

Yes, Mayzent can interact with other medications, especially those that weaken the immune system or affect heart rate. Inform your doctor about all medications you are taking.

As of now, Mayzent is available only as a brand-name medication. There is no generic version available.

Mayzent is generally prescribed as a long-term treatment for MS. The duration of treatment will depend on your individual condition and response to the medication.

Mayzent is approved for treating relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS.

Before starting Mayzent, inform your doctor about your complete medical history, especially if you have heart problems, liver disease, breathing problems, or a history of infections.

Clinical trials have shown that Mayzent is effective in reducing the rates of MS relapses and slowing the progression of disability in people with active SPMS.

Yes, Mayzent can cause liver problems, including increased levels of liver enzymes. Symptoms of liver issues include nausea, vomiting, upper stomach pain, and jaundice.