What is Mektovi?
Mektovi (binimetinib) is a prescription treatment for certain types of cancer. It is used with another medication called encorafenib to treat melanoma, a type of skin cancer, and non-small cell lung cancer (NSCLC).
For Mektovi to work, these cancers must have a specific change in a gene called BRAF. Doctors will test for this gene change before prescribing Mektovi.
For melanoma, Mektovi is administered to patients whose cancer has spread to other parts of the body or cannot be removed with surgery.
For NSCLC, it is used when the cancer has already spread. This medication does not work for all cases of melanoma or lung cancer, only those with the specific BRAF gene change.
People with heart problems, blood clots, eye issues, lung conditions, liver or kidney disease, muscle problems, or high blood pressure should tell their doctor before using this medication.
Pregnant women should avoid Mektovi because it may harm an unborn baby, and women who can become pregnant should use birth control while taking it. Breastfeeding is also not recommended while on this medication.
Before starting Mektovi medication, patients should tell their doctor about all other medications they are taking, including vitamins and herbal supplements.
How Does Mektovi Work?
Mektovi works by blocking specific proteins that help cancer cells grow. It targets two proteins called MEK1 and MEK2, which are part of a larger pathway that sends signals inside cells.
This pathway is always active in some cancers, like melanoma and non-small cell lung cancer, because of a gene change in BRAF.
Mektovi stops these signals, which slows down or even stops cancer cells from growing.
Mektovi is always used with another medication called encorafenib. Together, these two medications work better than either one alone.
They attack cancer cells from different angles, making it harder for the cancer to keep growing.
This combination also helps slow the cancer’s ability to resist treatment, which means the medication can keep working longer.
Dosage Information and Usage
If you are taking Mektovi, following the correct dose and schedule is important for the best results. Mektovi is used with another medication called encorafenib to treat certain types of melanoma and lung cancer.
Before starting treatment, your doctor will test your cancer to confirm that it has a BRAF V600E or V600K mutation. This helps make sure that Mektovi is right for you.
Dosage Form and Strengths of Mektovi
Mektovi comes as a tablet that contains 15 mg of binimetinib. The tablet is yellow and oval-shaped.
Each dose usually includes more than one tablet, depending on what your doctor prescribes.
Mektovi Administration
Mektovi should be taken the right way to help the medication work better and lower the chance of side effects.
- Take Mektovi orally twice daily (every 12 hours), with or without food.
- Always take Mektovi with encorafenib unless your doctor says otherwise.
- Swallow the tablets whole with a glass of water.
- If you miss a dose, take it as soon as you remember. But skip it if your next dose is less than 6 hours away.
- Do not take an extra dose if you vomit. Just take your next scheduled dose.
- If encorafenib is stopped, your doctor may also stop Mektovi.
- Store the tablets at room temperature and keep them in their original container.
Storage Information
Store Mektovi tablets at room temperature. Keep the tablets in their original bottle with the lid tightly closed. Protect the medication from moisture and heat.
Do not store Mektovi in the bathroom or places with high humidity. Keep it out of reach of children.
Mektovi Side Effects
Some Mektovi side effects are mild and often happen, like feeling tired, upset stomach, or muscle pain. Other side effects can be more serious, such as problems with the heart, liver, eyes, or muscles.
It is important to watch for changes in your feelings and let your doctor know if anything seems wrong. Some side effects may need quick medical help.
Common Side Effects
- Feeling tired
- Nausea
- Diarrhea
- Vomiting
- Stomach pain
- Muscle or joint pain
- Blurred vision or vision changes
- Constipation
- Rash
- Cough
- Shortness of breath
Severe Side Effects
- Fast heartbeat, swelling in the legs, or feeling lightheaded
- Chest pain or swelling in arms or legs from blood clots
- Vision loss, seeing halos or colored dots
- Trouble breathing or coughing
- Yellow skin, dark urine, or loss of appetite from liver problems
- Muscle weakness, pain, or dark red urine
- Bleeding in the brain or stomach, shown by headaches, vomiting blood, or black stool
Warnings and Precautions
Some people taking Mektovi with encorafenib have developed new cancers, heart problems, severe blood clots, and eye disorders. This combination can also cause lung inflammation, liver damage, severe muscle breakdown, bleeding, and harm to unborn infants. Regular monitoring is important to manage these risks.
- New skin and non-skin cancers may occur, and patients should be checked for new growths before, during, and after treatment.
- Heart muscle problems may develop, leading to decreased heart function and symptoms like shortness of breath or fatigue.
- Blood clots in veins, including in the lungs, have been reported and can be severe.
- Fluid buildup under the eye’s retina may cause blurred vision or other visual changes, so it should be checked regularly.
- Blockage of a retinal vein may happen and can lead to sudden vision loss.
- Inflammation of the eye (called uveitis) can cause redness, pain, or blurred vision.
- Lung inflammation, such as pneumonitis, may cause cough, shortness of breath, or chest pain.
- Liver problems may occur, shown by increased liver enzyme levels in blood tests, and should be monitored regularly.
- Serious muscle injury called rhabdomyolysis can happen, which may cause muscle pain or weakness and dark-colored urine.
- Bleeding events, including those in the digestive tract or brain, may occur and can be severe or even fatal.
- Mektovi may cause harm to an unborn baby, so effective birth control should be used during treatment and for one month after the last dose.
- Additional risks may arise when Mektovi is used with encorafenib, so patients should follow the full guidance for both drugs.
Drug Interactions With Other Medications
In clinical studies, Mektovi has not shown any interactions with other medications. This means it is not known to cause problems when taken with most other drugs.
However, telling your doctor about all the medications, vitamins, or supplements you are using before starting Mektovi is still important. This helps ensure it is safe and will work properly for you.
Alternative Medications
If Mektovi is not the right option, other treatments are available. These alternatives for Mektovi may work in similar ways or be used for similar types of cancer, such as melanoma or non-small cell lung cancer.
Your doctor can help you choose the best option based on your condition and health history.
Here are some alternatives:
- Keytruda (pembrolizumab)
- Avastin (bevacizumab)
- Opdivo (nivolumab)
- Tagrisso (osimertinib)
- Alimta (pemetrexed)
- Imfinzi (durvalumab)
Save Big on Mektovi from Pharma Giant
Many patients in the United States face serious challenges when it comes to affording life-saving medications like Mektovi.
At Pharma Giant, we believe that no one should have to choose between their health and their finances. That is why we offer a safe, affordable way to access Mektovi medication, delivered directly to your doorstep.
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Our platform is easy to use and clearly shows the total Mektovi price before you complete your order, so there are no surprises. We also offer bulk purchase options, allowing you to order up to a three-month supply at a reduced cost.
Pharma Giant is committed to helping people, patients managing cancer, families supporting loved ones, and anyone needing trusted medication access.
We provide fast shipping, secure temperature-controlled packaging, and strict safety standards.
Every order is verified by a licensed Canadian pharmacist based on a valid prescription, so you can feel confident in the care you receive.
How to Order Mektovi Online?
- To order Mektovi, search for it on the website, select the desired strength, and click “Buy” to add it to your cart. Add any other medications, then proceed to checkout. Enter your details and use coupon code PGSAVE10 for 10% off your first order.
- New customers can create an account, while returning customers can log in. After submitting your order, you will get a confirmation email.
- Upload or email your prescription to info@pharmagiant.com or fax it to 1-888-562-8159. Orders without a prescription will be processed right away. If needed, we will contact you for your prescription.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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