What is Myrbetriq?
Myrbetriq, known by its generic name mirabegron, is prescribed for treating overactive bladder (OAB) in adults in several countries. It belongs to a class of drugs known as beta-3 adrenergic agonists. It works by relaxing the smooth muscles in the bladder, reducing frequent urination, sudden urges to urinate, and urinary incontinence. By improving bladder control, it helps individuals regain their quality of life and confidence. It is typically taken once daily, with or without food, as directed by a healthcare professional. It is important to follow the prescribed dosage and discuss any potential side effects or interactions with other medications before starting treatment.
Myrbetriq may be prescribed with another drug to treat the symptoms of an overactive bladder. Symptoms of overactive bladder include urgent or frequent urination and urinary incontinence.
Myrbetriq may also be prescribed to treat neurogenic detrusor overactivity (NDO) in pediatric patients 3 years or older. It is recommended that pediatric patients take the medication with food. Neurogenic detrusor overactivity (NDO) occurs in patients with conditions such as spina bifida, spinal cord injuries, and multiple sclerosis (MS).
It is not recommended:
- If you are allergic to Myrbetriq or any ingredients in Myrbetriq
- If you have severe kidney disease or failure
- If you have severe, uncontrolled high blood pressure
How is Myrbetriq used?
Storage
Myrbetriq tablets should be stored at room temperature between 68°F and 77°F (20°C – 25°C).
Once reconstituted, Myrbetriq granules should be used within 28 days. After 28 days, discard any unused portion.
Keep out of reach of children.
Instructions
Take Myrbetriq orally once daily, as directed by your doctor, with or without food. Pediatric patients should take it with food. Do not chew or crush the extended-release tablet.
Dosage
Myrbetriq is available as:
- Extended-release tablets: 25 mg and 50 mg
- Granules/ oral suspension: 8 mg/mL after reconstitution
Do not change your dosage and take more than what is prescribed without consulting your doctor. If you took more than prescribed, contact your doctor or seek emergency medical care right away.
Overactive bladder
The recommended dose is 25 mg by mouth once daily. Myrbetriq may be used with solifenacin succinate 5 mg. Your doctor may increase your dose after 4-8 weeks to 50 mg once daily.
Neurogenic detrusor overactivity (NDO)
The recommended starting dose for patients 3 years or older may be dependent on weight.
- Less than 35 kg: Myrbetriq granules will be prescribed and administered based on the patient’s weight. The dose may be increased after 4-8 weeks.
- 35 kg or more: the patient can be prescribed Myrbetriq 25 mg tablet or Myrbetriq granules 6 mL once daily. The dose may be increased after 4-8 weeks.
Side Effects
It’s important to understand that although Myrbetriq is FDA approved, it comes with side effects that may or may not affect you.
Before starting, you should discuss possible side effects with your doctor or pharmacist.
Common Side Effects
Not all side effects require medical attention. As your body adjusts, side effects may go away.
Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own:
- Sinus pain
- Sore throat
- Headache
- Constipation
- Painful urination
- Dry mouth
- Increased heart rate
Serious Side Effects
Severe adverse reactions while taking Myrbetiq can occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:
- Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.
- High blood pressure: blurred vision, pounding in ears or neck, severe headache.
- Pain or burning during urination
- Unable to empty your bladder
The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.
Warnings & Precautions
Before taking Myrbetiq, tell your doctor or pharmacist:
- If you are allergic to any medications, such as Myrbetiq
- If you have or have had heart problems such as heart failure
- If you have uncontrolled high blood pressure
- If you have kidney problems
- If you have liver problems
Angioedema
Taking Myrbetiq can result in the swelling of your face (e.g. lips, tongue) and larynx that can be life-threatening. If swelling occurs in your tongue or larynx, discontinue use and seek emergency medical attention.
High Blood Pressure
Taking Myrbetiq can increase blood pressure. Myrbetiq is not recommended if you have uncontrolled high blood pressure. Your doctor may recommend regular blood pressure monitoring to ensure your blood pressure is under control.
Symptoms of high blood pressure include severe headaches, nosebleeds, fatigue, vision problems or confusion, chest pain, difficulty breathing, or irregular heartbeat.
Liver Disease
If you have moderate hepatic dysfunction, your daily dose should not exceed 25 mg. Studies have not been completed for patients with severe hepatic dysfunction; therefore, Myrbetiq is not recommended for these patients.
Kidney Disease
If you have severe renal impairment, your daily dose should not exceed 25 mg. Studies have not been completed for patients with end-stage renal disease; therefore, Myrbetiq is not recommended for these patients.
Urinary Retention
If you have bladder outlet obstruction (BOO) or are taking a muscarinic antagonist drug, taking Myrbetiq may result in the inability to completely empty your bladder.
Interactions & Contraindications
Before taking Myrbetiq, tell your doctor or pharmacist if you take any prescription drugs, herbal supplements, or vitamins.
Medications metabolized by CYP2D6
Taking Myrbetiq (a CYP2D6 inhibitor) in combination with medications metabolized by CYP2D6, such as antidepressants, sertraline, paroxetine, and thioridazine, will increase the systemic exposure of CYP2D6. Your doctor will review and adjust your dose as needed.
Muscarinic antagonist medication
Taking Myrbetiq with muscarinic antagonist medications such as atropine, glycopyrrolate, and ipratropium bromide may cause you to be unable to completely empty your bladder. Consult with your doctor if you cannot empty your bladder to determine if your dose or therapy needs to be changed.
Oxybutynin
Taking Myrbetiq with oxybutynin may cause you to be unable to completely empty your bladder. Consult with your doctor if you cannot empty your bladder to determine if your dose or therapy needs to be changed.
Price & Coupons
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For patients in the US, the cost of Myrbetriq, a leading drug for the treatment of overactive bladder, can be a significant financial burden, especially for those without medical insurance coverage. In the US, Myrbetriq can cost over $500 for 30 tablets, making it challenging for many patients to afford this essential medication.
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Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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