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Myrbetriq (Mirabegron)
Myrbetriq
Mirabegron
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Select product strength & quantity:

Prescription Required.

Product of Canada.

Shipped from Canada.

Prescription Required.Product of Canada.Shipped from Canada.

What is Myrbetriq?

Myrbetriq, known by its generic name Mirabegron, is prescribed for treating overactive bladder (OAB) in adults in several countries. It belongs to a class of drugs known as beta-3 adrenergic agonists. It works by relaxing the smooth muscles in the bladder, reducing frequent urination, sudden urges to urinate, and urinary incontinence. By improving bladder control, it helps individuals regain their quality of life and confidence. It is typically taken once daily, with or without food, as directed by a healthcare professional. It is important to follow the prescribed dosage and discuss any potential side effects or interactions with other medications before starting treatment.

Myrbetriq may be prescribed with another drug to treat the symptoms of overactive bladder. Symptoms of overactive bladder include urgent or frequent urination and urinary incontinence.

The drug Myrbetriq may also be prescribed to treat neurogenic detrusor overactivity (NDO) in pediatric patients 3 years or older. Neurogenic detrusor overactivity (NDO) occurs in patients with conditions such as spina bifida, spinal cord injuries, and multiple sclerosis (MS).

It is not recommended:

  • If you are allergic to Myrbetriq or any ingredients in Myrbetriq
  • If you have severe kidney disease or failure
  • If you have severe uncontrolled high blood pressure

How is Myrbetriq used?

Storage

Myrbetriq tablets should be stored at room temperature between 68°F and 77°F (20°C – 25°C).

Myrbetriq should be stored at room temperature for up to 28 days. After 28 days, discard any unused portion.

Keep out of reach of children.

Instructions

Take Myrbetriq orally once daily, as directed by your doctor, with or without food.  Pediatric patients should take it with food. Do not chew or crush the extended-release tablet.

Dosage

Myrbetriq is available as:

  • Extended-release tablets: 25 mg and 50 mg
  • Granules/ oral suspension: 8 mg/mL after reconstitution

Do not change your dosage and take more than what is prescribed without consulting with your doctor. If you took more than prescribed, contact your doctor or seek emergency medical care right away.

Overactive bladder

The recommended dose is 25 mg by mouth once daily. Myrbetriq may be used with solifenacin succinate 5 mg. Your doctor may increase your dose after 4-8 weeks to 50 mg once daily.

Neurogenic detrusor overactivity (NDO)

The recommended starting dose for patients 3 years or older may be dependent on weight.

  • Less than 35 kg: Myrbetriq granules will be prescribed and administered based on the patient’s weight. The dose may be increased after 4-8 weeks.
  • 35 kg or more: the patient can be prescribed Myrbetriq 25 mg tablet or Myrbetriq granules 6 mL once daily. The dose may be increased after 4-8 weeks.

Side Effects

It’s important to understand that although Myrbetiq is FDA approved, it comes with side effects that may or may not affect you.

Before starting, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts, side effects may go away.

Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own:

  • Sinus pain
  • Sore throat
  • Headache
  • Constipation
  • Painful urination
  • Dry mouth
  • Fast heartbeats

Serious Side Effects

Severe adverse reactions while taking Myrbetiq can occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

  • Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.
  • High blood pressure: blurred vision, pounding in ears or neck, severe headache.
  • Pain or burning during urination
  • Unable to empty your bladder

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

Warnings & Precautions

Before taking Myrbetiq, tell your doctor or pharmacist:

  • If you are allergic to any medications such as Myrbetiq
  • If you have or have had heart problems such as heart failure
  • If you have uncontrolled high blood pressure
  • If you have kidney problems
  • If you have liver problems

Angioedema

Taking Myrbetiq can result in the swelling of your face (e.g. lips, tongue) and larynx that can be life-threatening. If swelling occurs in your tongue or larynx, discontinue use and seek emergency medical attention.

High Blood Pressure

Taking Myrbetiq can increase blood pressure. Myrbetiq is not recommended if you have uncontrolled high blood pressure. Your doctor may recommend regular blood pressure monitoring to ensure your blood pressure is under control.

Symptoms of high blood pressure include severe headaches, nosebleeds,  fatigue, vision problems or confusion, chest pain, difficulty breathing, or irregular heartbeat.

Liver Disease

If you have moderate hepatic dysfunction, your daily should not exceed 25 mg. Studies have not been completed for patients with severe hepatic dysfunction therefore Myrbetiq is not recommended for these patients.

Kidney Disease

If you have severe renal impairment, your daily dose should not exceed 25 mg. Studies have not been completed for patients with end-stage renal disease therefore Myrbetiq is not recommended for these patients.

Urinary Retention

If you have bladder outlet obstruction (BOO) or are taking a muscarinic antagonist drug

, taking Myrbetiq may result in the inability to completely empty your bladder.

Interactions & Contraindications

Before taking Myrbetiq, tell your doctor or pharmacist if you take any prescription drugs, herbal supplements, or vitamins.

Medications metabolized by CYP2D6

Taking Myrbetiq (a CYP2D6 inhibitor) in combination with medications metabolized by CYP2D6 such as antidepressants, sertraline, paroxetine, and thioridazine will increase the systemic exposure of CYP2D6. Your doctor will review and adjust your dose as needed.

Muscarinic antagonist medication

Taking Myrbetiq with muscarinic antagonist medications such as atropine, glycopyrrolate, and ipratropium bromide may cause you to be unable to completely empty your bladder. Consult with your doctor if you cannot empty your bladder to determine if your dose or therapy needs to be changed.

Oxybutynin

Taking Myrbetiq with oxybutynin may cause you to be unable to completely empty your bladder. Consult with your doctor if you cannot empty your bladder to determine if your dose or therapy needs to be changed.

Price & Coupons

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For patients in the US, the cost of Myrbetriq, a leading drug for the treatment of overactive bladder, can be a significant financial burden, especially for those without medical insurance coverage. In the US, Myrbetriq can cost over $500 for 30 tablets, making it challenging for many patients to afford this essential medication.

Through Pharma Giant’s prescription-referral service, US patients can access their prescription medicine through a reputable Canadian pharmacy, which offers a more cost-effective solution. Recognizing the need for affordable access to such crucial medications, Pharma Giant provides Myrbetriq at a significantly reduced price. Through Pharma Giant, the cost for Myrbetriq is $113.95 for the same 30 tablets, representing a savings of approximately 77% compared to the standard US price. This substantial saving offers relief for patients in need of this drug but who are not covered by insurance.

Pharma Giant also offers additional savings on quantity, as 90 tablets of Myrbetriq can cost $251.94, providing even greater value for those requiring long-term treatment. This price for 90 tablets translates to an even more remarkable saving, offering the medication at approximately 83% less than the cost of purchasing three times 30 tablets at the standard US price. This bulk purchasing option maximizes the financial support available to patients, making their healthcare expenses more manageable and ensuring continued access to necessary treatment without compromising on quality.

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By choosing to order Myrbetriq through Pharma Giant, US patients can access this important drug at a more affordable price, without compromising on quality. This service is particularly beneficial for those who are not covered by insurance and are looking for ways to manage their healthcare costs effectively.

Frequently Asked Questions

Yes, with a prescription, you can purchase the product Myrbetiq through online pharmacies or prescription-referral platforms such as Pharma Giant. Buying it online is convenient and often less expensive than purchasing it at your local pharmacy.

The active ingredient in Myrbetiq is mirabegron.

Myrbetiq tablets may contain the following inactive ingredients: butylated hydroxytoluene, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polyethylene oxide, red ferric oxide (25 mg MYRBETRIQ tablet only), and yellow ferric oxide.

Myrbetiq granules may contain the following inactive ingredients: acesulfame potassium, diluted hydrochloric acid, ethylparaben, hypromellose, magnesium stearate, mannitol, methylparaben, silicon dioxide, simethicone, sodium polystyrene sulfonate, and xanthan gum.

At present, a generic equivalent to Myrbetriq (mirabegron) does not exist.

It is available in tablet form and granule form to be mixed into a suspension.

Myrbetiq is approved to treat the symptoms of overactive bladder in adult patients and neurogenic detrusor overactivity (NDO) in pediatric patients 3 years or older.

An overactive bladder is a medical condition where you have a strong urge to urinate or your bladder may leak even if it isn’t full.

Myrbetriq (mirabegron) is not suitable for everyone, particularly those with specific health conditions or allergies. It is advised against use in individuals who:

  • Are allergic to Myrbetriq or any of its ingredients. Serious allergic reactions can include severe rash or itching, swelling of the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, and difficulty breathing or swallowing.
  • Have uncontrolled hypertension (high blood pressure), as Myrbetriq may elevate blood pressure levels, making it unsafe for those whose high blood pressure is not effectively managed with medication.
  • Suffer from severe kidney impairment or end-stage kidney disease. Myrbetriq may require dosage adjustments or might be contraindicated for those with significant kidney function issues.
  • Experience severe liver impairment. Like with kidney impairment, those with serious liver conditions may need adjusted doses or may be advised against using Myrbetriq.
  • Have a history of urinary retention. Myrbetriq can worsen urinary retention, rendering it unsuitable for patients who have previously encountered this issue.

Before starting Myrbetriq, patients must have a thorough discussion with their healthcare provider about their complete medical history, including any allergies and current medications, to ensure the safety and appropriateness of Myrbetriq for their condition. This conversation should cover potential interactions with other drugs and consider all health factors to avoid adverse effects.

Take Myrbetiq by mouth, as directed, with or without food. Pediatric patients should take this drug with food. Do not crush or chew the tablet.

You may start to see improvements in your symptoms within 4-8 weeks. Results will vary with each individual.

Consult your doctor before you stop using it. You should take it every day as prescribed even if you are not seeing improvements in your symptoms. It can take 4-8 weeks before you see improvements.

If it has not been more than 12 hours since you missed your dose, take your missed dose immediately. If it has been more than 12 hours, skip this dose and take your next dose as scheduled.

If you took more than prescribed, contact your doctor or seek emergency medical care right away.