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What is Ocrevus?

Ocrevus (ocrelizumab) is an FDA-approved medication used to treat adults with multiple sclerosis (MS), which is a disease that affects the central nervous system, including the brain and spinal cord.

It is specifically used for different types of MS, such as relapsing forms, where symptoms come and go, and primary progressive MS, where symptoms continuously worsen.

Ocrevus helps to manage the symptoms and slow the progression of the disease. It is important to talk to your doctor before starting Ocrevus, especially if you have infections, hepatitis B, or have had allergic reactions to this medication before.

Also, certain vaccinations should be timed properly with the treatment.

How Does Ocrevus Work?

Ocrevus works by targeting and attaching to a specific protein called CD20 found on the surface of certain immune cells called B cells.

B cells are part of the immune system and can mistakenly attack the nervous system in people with multiple sclerosis (MS).

When Ocrevus binds to CD20, it helps destroy these B cells, which may reduce the immune attack on the nervous system.

Although the exact way Ocrevus works is not fully understood, this action is believed to help manage MS symptoms and slow the progression of the disease.

Dosage Information and Usage

Dosage Form and Strengths of Ocrevus

Ocrevus comes in the form of a clear or slightly opalescent, colorless to pale brown solution for injection.

Each vial contains 300 mg of the drug in 10 mL of liquid (30 mg/mL).

The medication is administered through an intravenous infusion, meaning it’s given directly into a vein through a needle.

Usage

Ocrevus is administered by a healthcare professional through an infusion into your vein.

Before each infusion, you’ll receive a corticosteroid and an antihistamine to reduce the chance of infusion reactions, which are side effects that can happen during or after the infusion.

The first dose is split into two infusions given two weeks apart, each lasting about 2.5 hours.

Following that, you’ll get one infusion every six months. The duration ranges from 2 to 3.5 hours based on your healthcare provider’s recommendation.

Storage Information

Ocrevus injection is available in a preservative-free, sterile solution that is clear to slightly opalescent, and colorless to pale brown.

It comes in a single-use vial containing 300 mg/10 mL (30 mg/mL) of the drug.

Store the Ocrevus vials in their original outer carton at a temperature between 2°C to 8°C (36°F to 46°F) to protect them from light. Do not freeze or shake the vials.

Side Effects

Common Side Effects

  • Itchy skin
  • Rash
  • Hives
  • Tiredness
  • Coughing or wheezing
  • Trouble breathing
  • Throat irritation or pain
  • Feeling faint
  • Fever
  • Redness on your face (flushing)
  • Nausea
  • Headache
  • Dizziness
  • Shortness of breath
  • Fatigue
  • Fast heartbeat
  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Skin infections
  • Herpes infections (cold sores, shingles, genital sores, skin rash, pain, itching)

Serious but Rare Side Effects

  • Severe infusion reactions, potentially requiring hospitalization
  • Serious infections, which can be life-threatening or cause death
  • Hepatitis B reactivation, leading to serious liver problems or death
  • Weakened immune system, increasing the risk of infections
  • Progressive Multifocal Leukoencephalopathy (PML) – a rare brain infection leading to severe disability or death
  • Decreased immunoglobulins, affecting the immune system
  • Risk of cancers, including breast cancer
  • Inflammation of the colon (colitis), causing severe abdominal pain, black or bloody stools, or diarrhea

Warnings and Precautions

  • Infusion Reactions: Infusion reactions can cause itching, rash, throat irritation, difficulty breathing, and low blood pressure, occurring in 34-40% of patients, especially during the first infusion; patients should be monitored during and for one hour after the infusion.
  • Infections: Ocrevus raises the risk of serious bacterial, viral, fungal, and parasitic infections; delay treatment if the patient has an active infection until it resolves.
  • Respiratory Tract Infections: Respiratory tract infections are more frequent in Ocrevus-treated patients compared to other medications or placebo; monitor for signs of infection.
  • Herpes Infections: Ocrevus-treated patients have a higher rate of herpes infections, including serious cases like encephalitis and meningitis; stop treatment until the infection resolves if serious herpes infections occur.
  • Hepatitis B Virus (HBV) Reactivation: Ocrevus can reactivate hepatitis B in previously infected patients, leading to serious liver problems or death; screen patients for hepatitis B before starting treatment.
  • Possible Increased Risk of Immunosuppressant Effects: Using Ocrevus with other immunosuppressive drugs can heighten the risk of immune system suppression, making infections more likely.
  • Vaccinations: Administer live vaccines at least 4 weeks and non-live vaccines at least 2 weeks before starting Ocrevus; avoid live vaccines during treatment.
  • Vaccination of Infants Born to Mothers Treated with Ocrevus: Infants of mothers treated with Ocrevus should not receive live vaccines until B-cell counts recover; non-live vaccines can be given with response monitoring.
  • Progressive Multifocal Leukoencephalopathy (PML): A rare and severe brain infection called PML can occur in Ocrevus-treated patients; monitor for symptoms like weakness and vision problems, and stop treatment if PML is diagnosed.
  • Reduction in Immunoglobulins: Ocrevus can lower immunoglobulin levels, increasing the risk of serious infections; regular blood tests are needed, and treatment should be reconsidered if severe infections occur.
  • Malignancies: Ocrevus may increase the risk of cancers, including breast cancer; patients should adhere to standard cancer screening guidelines.
  • Immune-Mediated Colitis: Ocrevus can cause severe inflammation of the colon (colitis), requiring hospital care or surgery; monitor for persistent diarrhea and abdominal pain, and evaluate promptly if symptoms occur.

Drug Interactions With Other Medications

  • Immunosuppressive or Immune-Modulating Therapies: Using Ocrevus with other drugs that suppress or alter the immune system, including high doses of corticosteroids, can increase the risk of weakening the immune system further; consider the additive effects when combining these therapies.
  • Vaccinations: When taken with Ocrevus, vaccines like tetanus, pneumococcal, and seasonal flu may not work as well; the safety of live vaccines with Ocrevus is unknown, so they should be avoided during treatment.

Alternative Medications

If you are looking for alternative treatments to Ocrevus for multiple sclerosis, here are some options:

Cost & Coupons

At Pharma Giant, we understand that your health is a top priority, and accessing the right medication shouldn’t be a financial burden. Our mission is to ensure that high-quality medications like Ocrevus are available at competitive prices, making healthcare more affordable for everyone.

Exceptional Savings on Ocrevus

  • Competitive Pricing: We offer Ocrevus 30mg/mL – 1 vial x 10 ml for only $12,836.25 through PharmaGiant.com. This is significantly lower than the typical U.S. price, which can exceed $20,000 for a single vial, equating to over $2,000 per mL.
  • Price Per mL: This translates to substantial savings per milliliter, allowing you to focus on your health without financial stress.

Exclusive Discount Offer

  • Coupon Code: Use PGSAVE10 at checkout to receive a 10% discount on your Ocrevus purchase. This exclusive, limited-time offer lets you save on essential medications without compromising on quality.
  • Offer Details: The discount is valid for one-time use per customer, so take advantage of it while it lasts.

Ordering Information

  • Prescription Required: Ocrevus can only be purchased with a valid prescription to ensure patient safety and adherence to medical guidelines.
  • Bulk Purchases: Patients can order up to a 90-day supply, providing convenience for ongoing treatment and cost management.

Assurance of Quality and Timely Delivery

At Pharma Giant, we are committed to providing top-quality medication with the added convenience of swift delivery right to your doorstep.

  • Express Shipping: Medications are express shipped from Canada to anywhere in the US within 3-5 business days, ensuring you receive your order promptly.
  • Secure Packaging: Each order is dispatched in secure, tamper-proof containers, ensuring that your medication remains safe and intact throughout its journey.

Why Choose Pharma Giant?

With Pharma Giant, you can prioritize your well-being without worrying about exorbitant costs. Experience exceptional value and top-notch care today!

Frequently Asked Questions

Ocrevus is a prescription medication used to treat multiple sclerosis (MS). This medication works by targeting and depleting certain immune cells that contribute to the damage of nerves in MS.

Ocrevus treats two types of multiple sclerosis (MS): relapsing forms, such as clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS; and primary progressive MS, which shows a gradual symptom worsening without distinct relapses or improvement periods.

You can stay on Ocrevus as long as it is effective and well-tolerated for you. The medication is administered every six months, with at least five months between doses.

Ocrevus is administered as an intravenous (IV) infusion. The first dose is given in two separate infusions, each 300 mg, spaced two weeks apart. Subsequent doses are given as a single 600 mg infusion every six months.

You should not receive Ocrevus if you have had a life-threatening allergic reaction to Ocrevus or any of its ingredients.

Ocrevus was approved by the FDA on March 28, 2017.

Ocrevus is administered every 6 months. It is an infusion therapy given through an IV placed in your arm.

Ocrevus is manufactured by Genentech.

Yes, Ocrevus can cause heart problems. It has been associated with cardiovascular adverse conditions such as coronary artery disease, cardiac failure, and atrial fibrillation.

When you stop taking Ocrevus, your multiple sclerosis (MS) symptoms may worsen, especially if you are under 65 or have had recent relapses or MS-related inflammation or damage. Studies suggest that stopping disease-modifying medications can lead to earlier disability and increased MS activity, particularly in younger adults with relapsing-remitting multiple sclerosis (RRMS).

Ocrevus can potentially increase the risk of breast cancer, although this risk is rare. Clinical trials have shown a slight increase in the incidence of breast cancer in people taking Ocrevus, but such cases are uncommon.

While on Ocrevus, take the following precautions: monitor for signs of infection like fever or cough and report them to your doctor. Avoid live vaccines and complete other vaccinations at least 4 weeks before starting Ocrevus. You will likely receive pre-medications to reduce infusion reactions. Regular blood tests are needed to monitor your immune system and liver function. Inform your doctor about all medications you are taking, especially other immunosuppressants. Follow standard cancer screening guidelines due to a slight increase in cancer risk.

Before starting Ocrevus, inform your healthcare provider about all your medical conditions. This includes any history of infections, liver problems, or previous treatments. Discuss any upcoming non-live (inactivated) vaccines, such as the seasonal flu vaccine, with your doctor.

After your Ocrevus infusion, you will be monitored for at least 1 hour for any side effects or infusion reactions. It’s important to stay in contact with your doctor and report any signs or symptoms that occur up to 24 hours after the infusion.

The most common side effects of Ocrevus are upper or lower respiratory infections, such as colds or pneumonia, and herpes infections, including shingles or cold sores.

Ocrevus begins to work after your initial infusion, but the time it takes to show results can differ. While some may experience a decrease in MS symptoms after one dose, others may need more time to see changes.

Most side effects from Ocrevus are mild and typically resolve within a few days. However, some side effects may persist longer and continue to affect you even after you stop the medication.

Steroids are given before an Ocrevus infusion to lower the chances of infusion reactions like itching or rash. Antihistamines may also be given for the same purpose. These medicines help reduce possible side effects and make the infusion process successful.

Ocrevus is not a chemotherapy drug, but it is an immunosuppressant. Unlike chemotherapy, which targets rapidly growing cancer cells, Ocrevus works by suppressing the immune system. Specifically, it is a monoclonal antibody that reduces the number of B cells, a type of white blood cell, to help manage multiple sclerosis (MS) symptoms.

Yes, you should avoid certain vaccines while on Ocrevus. Live vaccines should not be given during Ocrevus treatment or at least 4 weeks before starting it because Ocrevus can weaken your immune system, making you more susceptible to the diseases these vaccines are designed to prevent. Live vaccines to avoid include:
  • Typhoid
  • Measles, mumps, and rubella (MMR)
  • Yellow fever
  • Smallpox
  • Intranasal flu
  • Chickenpox
  • Rotavirus

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Price Match Guarantee

Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

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  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone prior to completing your order.

Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.