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PRALUENT SINGLE USE PREFILLED PEN Alirocumab
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What is Praluent?

Praluent (alirocumab) is a type of cholesterol-lowering treatment that lowers bad cholesterol, also known as LDL-C, which stands for low-density lipoprotein cholesterol. This is the kind of cholesterol that can build up in the walls of blood vessels and increase the risk of heart problems like heart attacks and strokes.

Praluent is used to help adults who already have heart disease. It is used to reduce the risk of serious heart issues such as heart attack, stroke, or chest pain that requires a hospital stay.

It is also given to adults and children aged 8 years and older who have a type of inherited high cholesterol condition, like heterozygous familial hypercholesterolemia (HeFH).

This condition means your body naturally has a very high level of bad cholesterol, even if you eat healthy or take other treatments.

Praluent can also be used in people with another inherited condition called homozygous familial hypercholesterolemia (HoFH). This is a more serious form of inherited high cholesterol where standard treatments are often not enough.

The Praluent injection is usually given every two weeks or once a month under the skin.

How Does Praluent Work?

Praluent helps lower LDL cholesterol, also called bad cholesterol, by making the liver remove more of it from the blood. It contains alirocumab, which is a PCSK9 inhibitor. PCSK9 is a natural enzyme in the liver that slows down the removal of LDL.

Praluent blocks this enzyme, allowing the liver to clear more bad cholesterol than usual.

People with heart disease often have high LDL levels, which can cause serious problems like heart attack, stroke, or chest pain that requires hospital care.

Praluent starts working after each Praluent injection. Doctors usually check cholesterol levels with a blood test 4 to 8 weeks after starting treatment. If LDL levels do not drop enough, the Praluent pen dose may be adjusted.

Praluent Dosing and Administration

Praluent dosing is based on your condition, weight, and how your body responds to the treatment. The Praluent injection is usually given either once every 2 weeks or once every 4 weeks.

Healthcare providers often start with a lower dose and adjust as needed. Your doctor will guide you on the best Praluent dosing frequency for your needs.

You or your caregiver will be trained on Praluent administration so you can safely inject it at home.

Dosage Form and Strengths of Praluent

Praluent is available as a liquid solution in a single-use, prefilled pen for subcutaneous injection.

  • 75 mg/mL single-dose prefilled pen
  • 150 mg/mL single-dose prefilled pen

Each dose is administered subcutaneously using the Praluent pen. For a 300 mg dose, two 150 mg injections are given one after the other in two separate sites.

Praluent Administration

  • Inject Praluent under the skin (subcutaneously) in the thigh, abdomen (not near the belly button), or upper arm (only if given by a caregiver).
  • Do not inject into areas that are red, bruised, swollen, or tender.
  • Rotate injection sites each time to avoid irritation.
  • Allow Praluent to reach room temperature (30 to 40 minutes) before injection if it was stored in the refrigerator.
  • Always check the pen label to confirm the correct dose before injecting.
  • For a 300 mg dose, use two separate 150 mg injections at different sites.
  • Do not inject Praluent at the same site as other injectable drugs like insulin.

Recommended Praluent Doses by Condition and Population

Praluent Starting Dose for Adults with Heart Disease or Primary Hyperlipidemia (including HeFH)

The starting dose of Praluent is either:

  • 75 mg every 2 weeks, or
  • 300 mg every 4 weeks

Both doses are administered subcutaneously. If the LDL-C reduction is not enough, your doctor may increase the dose to 150 mg every 2 weeks.

People taking the 300 mg dose should have their cholesterol checked just before their next scheduled injection, as levels may change between doses.

Praluent Dosing for Adults with HoFH or Undergoing LDL Apheresis

For adults with homozygous familial hypercholesterolemia (HoFH) or those undergoing LDL apheresis, the recommended dose is:

  • 150 mg every 2 weeks

You can give the injection without adjusting for the timing of apheresis. Your doctor will monitor your LDL-C levels and may check them as early as 4 weeks after you start treatment.

Praluent Dosing for Children Aged 8 Years and Older with HeFH

For children under 50 kg:

  • Start with 150 mg every 4 weeks
  • If needed, increase to 75 mg every 2 weeks.

For children 50 kg or more:

  • Start with 300 mg every 4 weeks
  • If needed, adjust to 150 mg every 2 weeks.

A caregiver should give the injection to children aged 8 to 11. In children aged 12 to 17, an adult should supervise the injection.

Missed Praluent Doses

  • If you miss a dose by less than 7 days, take it as soon as possible and continue your original schedule.
  • If you miss a dose by more than 7 days:
    • For every 2-week dosing, wait for your next scheduled dose.
    • For every 4-week dosing interval, take the missed dose and restart the schedule from the day after the missed dose.

Praluent Side Effects

Praluent may cause both common and serious side effects. Most people experience mild issues like injection site reactions, muscle pain, or flu-like symptoms.

However, some people may develop severe allergic reactions that need urgent medical care. It is important to watch for any changes in your body after each Praluent injection and talk to your doctor if you have any concerns.

Being aware of the possible Praluent side effects, including long-term side effects, can help you manage your treatment more safely.

Common Side Effects

These side effects of Praluent are usually mild and go away on their own:

  • Redness, itching, or swelling where the injection was given
  • Pain or tenderness at the injection site
  • Muscle pain or spasms
  • Diarrhea
  • Flu or flu-like symptoms such as fever, body aches, or tiredness
  • Cold-like symptoms such as a sore throat or a runny nose
  • Bruising
  • A mild increase in liver enzymes
  • Very low levels of LDL (bad) cholesterol

Severe Side Effects

These Praluent injection side effects are rare but may require emergency care:

  • Severe allergic reaction
  • Rash or hives
  • Trouble breathing
  • Swelling of the face, lips, tongue, or throat
  • Intense itching or redness
  • Severe injection site reaction

If you experience any severe symptoms, stop using Praluent and seek immediate medical attention by going to the nearest emergency room or calling your doctor.

Warnings and Precautions for Praluent

Praluent may impose safety risks when taken. Consult your doctor before starting treatment to avoid potential medical concerns along the way.

While Praluent can lower bad cholesterol and protect your heart, it may not be safe for everyone.

  • Do not use Praluent if you have ever had a serious allergic reaction to alirocumab or any ingredient in Praluent.
  • Praluent may cause severe allergic reactions such as swelling of the face, lips, throat, or tongue, and difficulty breathing.
  • Some people may develop a rare condition called hypersensitivity vasculitis, which can cause inflammation in the blood vessels.
  • If you have signs of a serious allergic reaction while using Praluent, stop using it and get medical help right away.
  • It is not known if Praluent is safe to use during pregnancy, so tell your doctor if you are pregnant or planning to become pregnant.
  • It is not known if Praluent passes into breast milk. Therefore, inform your doctor if you are breastfeeding or planning to breastfeed.

Praluent Drug Interactions

Praluent is not known to interact with other medications, vitamins, herbs, or foods. Still, it is always best to be careful.

Drug interactions can sometimes change how a product works or increase the chance of side effects.

Before you start using Praluent, tell your doctor and pharmacist about everything you take, including prescription drugs, over-the-counter products, and any supplements.

This helps make sure Praluent works safely and effectively for you. If you have questions about possible interactions, ask your healthcare provider right away.

Praluent Alternatives

If Praluent is not the right choice for you, your doctor may recommend other options that also help lower bad cholesterol or reduce the risk of heart problems. Here are some alternatives to consider:

Get Budget-Friendly Praluent from Canada

Managing high cholesterol or heart disease is not easy, and the high Praluent cost should not make it harder.

If you are worried about how much your Praluent injection costs every month, you are not alone.

That is why ordering Praluent from Canada through a trusted source like Pharma Giant can help you access the treatment you need without the stress of high prices.

With Pharma Giant, you can focus more on your health and less on how to afford your medication.

Why order Praluent from Canada with Pharma Giant?

  • We offer one of the lowest Praluent prices available by working with licensed Canadian pharmacies.
  • You can see the full cost upfront before you place your order, with no hidden fees.
  • We provide Praluent coupons and bulk pricing options to help lower your total cost.
  • You can order online and receive fast, secure shipping in 3 to 5 business days.
  • Our team handles your Praluent injection with care using temperature-controlled packaging.
  • Every order is doctor-prescribed and pharmacist-verified for your safety and peace of mind.

If the Praluent price has been stopping you from getting the treatment you need, let Pharma Giant help. We are here to support your health with affordable, trusted options delivered straight to your home.

How to Order Praluent Online?

  1. Search for Praluent, choose your dose, and click Buy to add it to your cart.
  2. Enter your name, shipping address, and payment details at checkout. Use code PGSAVE10 for 10% off your first order.
  3. Send your prescription by uploading it online, emailing it to info@pharmagiant.com, or faxing it to 1-888-562-8159.

Frequently Asked Questions

Praluent injection helps lower bad cholesterol (LDL) and reduces the risk of heart attack, stroke, and other heart problems in adults with heart disease or high cholesterol.
Praluent blocks a liver enzyme called PCSK9, which helps the liver remove more bad cholesterol (LDL) from the blood.
Yes, Praluent is generally safe. Doctors have prescribed it since 2015 to lower bad cholesterol. Studies also show it may help the immune system fight cancer.
Praluent does not usually cause hair loss. Clinical studies did not report hair loss as a side effect.
Praluent may cause side effects such as redness, itching, pain, or swelling at the injection site. Some people may also experience flu-like symptoms, diarrhea, muscle pain, or muscle spasms. Although rare, serious allergic reactions, such as rash, hives, or trouble breathing, can occur.
Side effects of Praluent usually last a few days to a few weeks. If they do not go away or get worse, talk to your doctor.
Doctors usually prescribe Praluent once every two weeks or once every four weeks, depending on your prescribed dose and treatment plan.
No, Praluent is not an immunosuppressant. It is a PCSK9 inhibitor used to lower bad cholesterol and reduce the risk of heart-related problems.
The recommended injection sites for Praluent are the thigh, abdomen, or upper arm.
Each Praluent pen contains a single dose of 150 mg in 1 mL and is intended for single-use only.
Praluent can lower LDL cholesterol levels by 40% or more when used with the highest dose of statins in patients with familial hypercholesterolemia or those with heart disease.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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