What is Resotran?
Resotran (sold under the name Montegrity in the US) is a medication used to treat chronic idiopathic constipation in adult women, particularly when other laxatives have not provided adequate relief.
Chronic idiopathic constipation refers to long-term constipation without a known cause.
Restore helps increase the frequency of bowel movements by stimulating peristalsis, which are the muscular contractions of the gut necessary for bowel movements. This helps provide a feeling of complete evacuation.
For older adults over 65, a lower dose may be just as effective. Resotran is not recommended for children under 18.
People who should not use Resotran include those who are allergic to any of its ingredients, those requiring dialysis, and those with severe intestinal conditions such as blockages, holes in the intestine, Crohn’s disease, or ulcerative colitis.
Dosage Information and Usage
Dosage Form and Strengths of Resotran
Resotran is available as a film-coated tablet for oral use. The tablets come in two strengths: 1 mg and 2 mg, both containing the active ingredient prucalopride succinate. These tablets also contain lactose as a nonmedicinal ingredient.
Usage
The recommended dose of Resotran for adults is 2 mg once daily. If there is no bowel movement within 3-4 days, patients should inform their doctor, who may suggest an additional laxative for short-term use.
Elderly patients (over 65 years) usually start with a 1 mg dose once daily, which can be increased to 2 mg if necessary.
Patients with severe kidney problems should take 1 mg daily, while those with severe liver issues should also start with 1 mg, which can be increased if needed.
Resotran is not recommended for children under 18. The tablets can be taken with or without food at any time of the day. If Resotran does not work within the first 4 weeks, the treatment should be stopped.
Side Effects
Common Side Effects
- Headache
- Abdominal pain
- Nausea
- Diarrhea (usually occurs on the first day and goes away within a day or so)
- Passing gas
- Enlarged abdomen or stomach
- Upset stomach
- Dizziness
- Tiredness
- Back pain
- Sinusitis (inflammation of the sinuses)
- Kidney and urinary disorders
Serious but Rare Side Effects
- Severe, persistent, or bloody diarrhea
- Worsening abdominal symptoms (such as severe pain)
- Strong, irregular, or racing heartbeat
- Chest pain
Warnings and Precautions
- Liver, kidney, or lung diseases: Talk to your doctor if you have any diseases affecting these organs because Resotran can affect how these organs function, and your doctor may need to adjust your treatment.
- Neurological or psychiatric problems: Inform your doctor if you have any conditions affecting your nervous system or mental health, such as seizures or depression, as Resotran can interact with these conditions and may require careful monitoring.
- Cancer, AIDS, or endocrine disorders: Discuss with your doctor if you have any of these serious conditions because these diseases can complicate the use of Resotran and may need special consideration.
- Heart problems: Let your doctor know if you have a history of abnormal heartbeats (arrhythmia) or heart disease, as Resotran can potentially affect your heart rhythm and overall heart function.
- Insulin-dependent diabetes: Tell your doctor if you have diabetes and rely on insulin, as your blood sugar levels may need to be closely monitored while using Resotran.
- Using oral contraceptives: If you get severe diarrhea while taking Resotran, your birth control pills may not work as well, so use an additional method of contraception to prevent unintended pregnancy.
- Galactose intolerance or related conditions: Avoid Resotran if you have problems digesting certain sugars, such as galactose intolerance, Lapp lactase deficiency, or glucose/galactose malabsorption, because Resotran contains lactose which can cause digestive issues in these conditions.
- Driving and using machines: Be cautious if you need to drive or operate machinery, as Resotran can cause dizziness or tiredness, which may impair your ability to perform these tasks safely.
- Pregnancy and breastfeeding: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Resotran can pass into breast milk and may affect your baby. Your doctor will help you weigh the risks and benefits.
- Ketoconazole and erythromycin: These drugs can interact with Resotran and may increase its effects, leading to a higher risk of side effects. Your doctor may need to adjust your dose or monitor you more closely.
- Atropine-like substances: These medications can reduce the effectiveness of Resotran by affecting how it works in your body. Make sure to inform your doctor about all the medications you are taking.
Overdosage
If you suspect an overdose of Resotran, contact your regional Poison Control Centre immediately. In studies, even at doses up to 20 mg daily (which is ten times the recommended dose), Resotran was generally well tolerated.
However, taking too much Resotran can lead to exaggerated side effects such as headache, nausea, and diarrhea.
There is no specific treatment for a Resotran overdose, so care focuses on relieving symptoms and providing support as needed. If there is significant fluid loss due to diarrhea or vomiting, it may be necessary to correct electrolyte imbalances.
Drug Interactions With Other Medications
- Ketoconazole: This drug, which inhibits enzymes like CYP3A4 and P-glycoprotein (P-gp), can increase the levels of Resotran in the blood by about 40%. Other drugs like verapamil, cyclosporine A, and quinidine may have similar effects.
- Warfarin, alcohol, paroxetine, and oral contraceptives: Studies show that Resotran does not significantly affect the effectiveness of these medications.
- Digoxin: Resotran can decrease the bioavailability of digoxin by 10%, meaning the body absorbs less of this heart medication when taken with Resotran.
- Erythromycin: When taken with Resotran, the levels of erythromycin can increase by 40%, though this is likely due to the natural variability in how erythromycin is processed by the body.
- Probenecid, cimetidine, erythromycin, paroxetine: These drugs do not affect how Resotran is processed in the body, so they can be taken together without significant interaction.
- Alcohol: Resotran’s effectiveness is unlikely to be significantly affected by alcohol.
- Atropine-like substances: These drugs can reduce the effects of Resotran, as they work against the same receptors in the gut that Resotran stimulates (5-HT4 receptors).
Alternative Medications
- Trulance (plecanatide)
- Motegrity (prucalopride)
- Linzess (linaclotide)
- Amitiza (lubiprostone)
- Lactitol
Cost & Coupons
When it comes to managing chronic idiopathic constipation in adult women, especially when other laxatives have proven ineffective, Resotran offers a reliable solution. However, in the United States, Resotran (known as Montegrity) can be prohibitively expensive, costing as much as $700 for 30 tablets, which is about $23.33 per pill.
That’s where Pharma Giant steps in, dedicated to making essential healthcare medications accessible and affordable for everyone.
Explore our available Resotran options:
| Strength | Quantity | Price | Price per Pill |
|---|---|---|---|
| 1mg | 28 tabs | $124.00 | $4.43 |
| 56 tabs | $242.00 | $4.32 | |
| 84 tabs | $354.00 | $4.21 | |
| 2mg | 28 tabs | $136.00 | $4.86 |
| 56 tabs | $266.00 | $4.75 | |
| 84 tabs | $390.00 | $4.64 |
Exclusive Discount Code and Limited-Time Offer
Coupon Code: Use PGSAVE10 at checkout to enjoy a 10% discount on your Resotran purchase. This limited-time offer lets you save on essential medications without compromising on quality. Offer Details: The discount is valid for one-time use per customer, so be sure to take advantage of this opportunity while it’s available.
Ordering Information
Prescription Required: Resotran can only be obtained with a valid prescription to ensure patient safety and compliance with medical regulations. Bulk Purchases: Patients have the option to order up to a 90-day supply, ensuring convenience for ongoing treatment and effective cost management.
Assurance of Quality and Timely Delivery
At Pharma Giant, we prioritize delivering high-quality medications conveniently and efficiently to your doorstep.
- Fast Shipping: Our medications are shipped expressly from Canada to any location in the U.S. within 3-5 business days, ensuring that your orders arrive without delay.
- Safe Packaging: Each order is carefully packaged in secure, tamper-proof containers, guaranteeing the safety and integrity of your medication during transit.
Why Choose Pharma Giant?
Pharma Giant is committed to providing quality medication at reasonable prices, ensuring that financial constraints do not hinder your well-being.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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