Restasis (Cyclosporine)
Restasis
Cyclosporine
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Restasis Multidose
Cyclosporine (Ciclosporin)
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Restasis
(cyclosporine)

What is Restasis (cyclosporine)?

Restasis (cyclosporine) is an ophthalmic medication prescribed to increase tear production in patients with chronic dry eye or keratoconjunctivitis sicca. Chronic dry eye is a condition where the eyes swell or become inflamed, resulting in a decrease in tear production. Chronic dry eye is treatable with medication but cannot be cured.

Restasis may be prescribed by your doctor for other indications.

Restasis belongs to the drug class immunomodulators. These types of medications work by decreasing the inflammation or swelling in the eye, allowing for tear production.

Restasis is not recommended:

  • For patients under 16 years of age
  • If you are allergic or have had an allergic reaction to Restasis (cyclosporine) or ingredients in Restasis.

How is Restasis used?

Restasis is an ophthalmic emulsion that comes in a single-use vial or multidose bottle.

Storage

Restasis should be stored in the original container between 59°F and 77°F (15°C and 25°C).

Keep out of reach of children.

Instruction

Before using Restasis, turn the vial upside down and squeeze the emulsion out until it produces a white, opaque substance. Place one drop in each eye, careful not to touch the tip of the eye drop with your finger or your eye, to avoid contamination.

After application, close your eyes for 2-3 minutes tipping your head down. Do not blink or squeeze your eyes. Wipe any excess liquid with a tissue.

Use twice a day, approximately 12 hours apart. Do not use more drops than prescribed. If you missed a dose, take it as soon as you remember and ensure that your next dose is 12 hours later.

Single-use vials should be discarded right away after use. Do not reuse single-use vials once opened.

Ask your doctor or pharmacist for further direction if you do not understand the instruction.

Dosage

Restasis ophthalmic emulsion contains 0.5 mg/mL of cyclosporine.

SIDE EFFECTS

It’s important to understand that although Restasis is FDA approved, it comes with side effects that may or may not affect you.

Before starting Restasis, you should discuss possible side effects with your doctor or pharmacist.

Common Side Effects

Not all side effects require medical attention. As your body adjusts to Restasis, side effects may go away.

Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own:

  • Burning and stinging
  • Eye redness
  • Discharge
  • Watery eyes
  • Eye pain
  • Itching
  • Blurred vision
  • Feeling of something in your eye

Serious Side Effects

Severe adverse reactions while taking Restasis may occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:

  • Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

WARNINGS & PRECAUTIONS

Before using Restasis, tell your doctor or pharmacist:

  • If you are allergic to Restasis, cyclosporine, or any other medications
  • If you are pregnant or plan to become pregnant
  • If you are breastfeeding or plan to breastfeed

Eye Injury and Contamination

To avoid contamination and potential eye injury, do not touch the tip of the vial to your eye, with your hands, or any other object. For single-use vials, discard immediately after use. For multidose vials, immediately place the cap back on and store.

Contact Lenses

Restasis can be used even if you wear contact lenses. Before using Restasis, take out your contact lenses. Do not place Restasis drops in your eyes while you are weaning your contacts. Wait 15 minutes after administering Restasis before placing the contact lenses back in.

Pediatric Use

Restasis has not been established to be effective and safe for patients under 16 years of age. Consult with your doctor to determine if Restasis can or should be prescribed.

Pregnant or Planning to Become Pregnant

During clinical trials, it was determined there were minimal traces of Restasis remaining in the system of patients including pregnant patients. It is expected that Restasis will not pass on to the fetus of a pregnant patient.

Breastfeeding or Planning to Breastfeed

There is insufficient data to determine if Restasis (cyclosporine), which is administered ophthalmically, will pass through to breastmilk. Cyclosporine administered systemically (e.g. orally) has been known to have passed through to breastmilk. Consult with your doctor to evaluate the benefits and risks of taking Restasis while breastfeeding.

INTERACTIONS & CONTRAINDICATIONS

Before using Restasis, tell your doctor or pharmacist if you take any medications, herbal supplements, or vitamins.

During clinical trials, the most commonly observed adverse reaction with Restasis was ocular burning, an irritating or stinging feeling in the eye.

FREQUENTLY ASKED QUESTIONS

Restasis contains the active ingredient cyclosporine.

Restasis contains the inactive ingredients: glycerin, castor oil, polysorbate 80, carbomer copolymer type A, purified water, and sodium hydroxide to adjust pH.

Restasis is used to treat chronic dry eye, a condition where the eye becomes swollen or inflamed, reducing tear production. Lack of tears can create dry spots on the eye.

Dry eye results from a disturbance to the film of your eyes. The disturbance could be due to many reasons, including allergic eye disease, autoimmune disease, hormone changes, decrease in tear production, or increased evaporation of your tears.

Tear production may be decreased due to:

  • Allergies
  • Aging
  • Lasik eye surgery
  • Smoking
  • Medical conditions such as allergic eye disease, thyroid disorders, diabetes, rheumatoid arthritis, and sarcoidosis
  • Medications such as decongestants, antihistamines, antidepressants, birth control, hormone replacement therapy, high blood pressure medications, acne medications, and medications for Parkinson’s disease

Dry eyes occur when you do not produce enough tears or you are unable to produce enough tears to lubricate your eyes. Symptoms of dry eyes include:

  • Watery eyes
  • Scratchy, burning, or stinging feeling in your eyes
  • Mucous around or in your eyes
  • Light sensitivity
  • Redness
  • Feeling there is something in your eye
  • Difficulty or irritation weaning contact lenses
  • Tired eyes
  • Blurry vision

Pay attention to your surroundings and situation. Take precaution to:

  • Avoid being in a dry environment by using a humidifier.
  • Avoid using your eyes for long periods of time. Take short breaks to relieve your eyes.
  • Avoid smoking or stop smoking.
  • Avoid getting air blown into your eyes.
  • Use eye drops such as artificial tears to keep your eyes lubricated.

These eyedrops provide temporary relief; however, they do not help increase tear production in your eyes. Artificial tears can be used regularly to help lubricate your eyes in addition to using Restasis.

Restasis is only available in one strength; however, it is available as a single-use vial or multi-use bottle.

Restasis is approved for patients 16 years of age or older who are not allergic to Restasis or cyclosporine.

Restasis should not be used if you are allergic to Restasis, cyclosporine, or any ingredients in Restasis. Restasis is also not recommended for patients under 16 years of age. Restasis has not been established to be safe and effective for patients under 16 years of age.

Use Restasis as directed by placing one drop in each eye two times a day, exactly 12 hours apart. Be careful not to touch the tip to avoid contamination in your eyes.

Restasis may take a month up to 6 months to relieve symptoms, depending on how severe your dry eye condition is.

The duration is dependent on how much tears you can produce as chronic dry eye can be treated but cannot be cured.

Do not drive or use heavy machinery until you know how you will react to Restasis.

If you miss a dose, use your drops as soon as possible, making sure to time your next dose 12 hours out.

Restasis can be used in combination with other eye drops. You will need to wait 15 minutes in between using different eye drops.

Yes, you can use Restasis if you wear contact lenses. Restasis should not be administered directly onto contact lenses. Before using Restasis, take your contact lenses out, then administer Restasis. You will need to wait 15 minutes before placing your contact lenses back on.

Yes, with a prescription, you can purchase Restasis online. Buying medications online is convenient and often less expensive than purchasing at your local pharmacy.