Buy Retevmo from Canada

What is Retevmo (selpercatinib)?

Retevmo (selpercatinib) is a prescription medication used to treat certain types of cancer caused by abnormal genes called RET (rearranged during transfection).

Retevmo is mainly used for the treatment of:

• Non-small cell lung cancer (NSCLC): Used in adults with locally advanced or metastatic NSCLC with a RET gene fusion.
• Medullary thyroid cancer (MTC): Used in adults and children aged 2 years or older with advanced MTC requiring systemic therapy.
• Thyroid cancer: Used in adults and children aged 2 years or older with advanced or metastatic thyroid cancer with a RET gene fusion, especially if radioactive iodine treatment has been ineffective.
• Other solid tumors with RET gene fusion: Used when cancer has spread or progressed after prior treatment, or if no other satisfactory treatment options are available.

Before starting Retevmo, your healthcare provider will perform tests to confirm whether this medication suits you.

Important: Retevmo is not recommended for children under 2 years old and should not be used during pregnancy or while breastfeeding.

How Does Retevmo Work?

Retevmo works by blocking the RET gene, which is involved in the growth and spread of certain cancers.

When the RET gene undergoes mutations or changes, it sends signals that cause cancer cells to grow and divide uncontrollably.

By targeting and inhibiting the RET gene, Retevmo helps prevent these harmful signals, slowing or stopping tumor growth in cancers such as lung, thyroid, and other solid tumors.

Dosage Information and Usage

Retevmo is available in different dosage forms, such as tablets and capsules taken orally.

The specific dosage and schedule for Retevmo depends on the patient’s age, weight, and the condition being treated.

Dosage Form and Strengths of Retevmo

Retevmo comes in different forms and strengths to fit your needs.

Here are the available forms and strengths:

• Capsules:
  • 40 mg
  • 80 mg
• Tablets:
  • 40 mg
  • 80 mg
  • 120 mg
  • 160 mg

These dosage forms are designed for easy oral administration. Swallow Retevmo tablets or capsules whole without crushing or chewing them.

How to Use Retevmo?

When using Retevmo, take it exactly as your doctor has prescribed.

Here are some important instructions on how to take Retevmo:

• You can take Retevmo with or without food, but if you are taking a proton pump inhibitor (PPI), you should take it with food.
• Do not crush or chew Retevmo tablets or capsules. Discuss other options with your doctor if you cannot swallow the capsules.
• If you miss a dose, skip it if it is less than 6 hours until your next dose. If it is more than 6 hours, take the missed dose immediately. Never take an extra dose if you vomit after taking Retevmo. Just continue with your next scheduled dose.
• If you experience side effects, your healthcare provider may adjust your dosage or temporarily stop the medication. It is important not to change your dosage without their guidance.

Retevmo Side Effects

While effective, Retevmo may cause a range of side effects. These can include common side effects like fatigue, diarrhea, and elevated liver enzymes, as well as more severe ones, such as heart problems, lung issues, and liver damage.

Common Side Effects

• Swelling in the arms, legs, hands, and feet (edema)
• Diarrhea
• Tiredness (fatigue)
• Dry mouth
• Stomach-area (abdominal) pain
• Constipation
• Rash
• Nausea
• Headache

Severe Side Effects

• Liver problems:
  • Yellowing of skin or eyes
  • Dark “tea-colored” urine
  • Sleepiness
  • Nausea
  • Vomiting
  • Stomach pain

• Lung issues:
  • Shortness of breath
  • Persistent cough
  • Fever (which can be life-threatening)

• High blood pressure:
  • Increased blood pressure
  • Headaches
  • Dizziness
  • Chest pain
  • Shortness of breath

• Heart rhythm changes (QT prolongation):
  • Fainting
  • Dizziness
  • Irregular heartbeats

• Bleeding problems:
  • Vomiting blood
  • Coughing up blood
  • Unusual bruising
  • Nosebleeds

• Tumor lysis syndrome (TLS):
  • Weakness
  • Swelling
  • Shortness of breath
  • Muscle cramps
  • Seizures
• Wound healing problems: Difficulty healing wounds, particularly during surgery
• Low thyroid hormone levels (hypothyroidism):
  • Weight gain
  • Cold sensitivity
  • Extreme tiredness

Warnings and Precautions

Retevmo is an effective medication for certain types of cancer, but it comes with potential risks and side effects.

The following warnings and precautions should be considered to ensure safe use of the Retevmo medication.

• Retevmo can affect the liver. Patients may experience increased liver enzymes, which could indicate liver damage. It is important to monitor liver function regularly during treatment.
• Retevmo causes serious lung problems, including interstitial lung disease or pneumonitis, which can be life-threatening. Immediately address symptoms like shortness of breath, cough, and fever.
• Some patients may develop high blood pressure while using Retevmo. It is important to monitor the patient regularly and treat the condition if necessary to prevent complications.
• Retevmo can cause changes in heart rhythm, leading to a condition called QT prolongation. This can cause dizziness, fainting, and irregular heartbeats. Monitoring of heart rhythm is necessary during treatment.
• Retevmo can cause bleeding, including serious or fatal events. Symptoms like vomiting blood, unusual bruising, and nosebleeds should be immediately reported to a healthcare provider.
• TLS can occur in patients with rapidly growing tumors, especially those with high tumor burden or kidney issues. It is important to monitor and treat TLS early.
• Retevmo may affect wound healing, especially after surgery. It is important to pause treatment before elective surgeries and wait until healing is sufficient before resuming the medication.
• Hypothyroidism can occur during Retevmo treatment. Symptoms include weight gain, fatigue, and sensitivity to cold. Regular thyroid monitoring is necessary, and thyroid hormone replacement may be required.

Drug Interactions With Other Medications

Retevmo may interact with other treatments, potentially causing adverse reactions. Certain combinations can impact how Retevmo works or increase the risk of side effects.

Below are some drug interactions to be aware of:

• Acid-reducing treatments: These can lower the amount of Retevmo in the body, making it less effective. It is best to avoid using them together, or take Retevmo with food or at a different time if you cannot prevent it.
• Strong or moderate CYP3A inhibitors: These can raise the level of Retevmo in your body, which can increase the risk of side effects. Avoid using them together, or lower the dose of Retevmo and check your heart health more often if necessary.
• Strong or moderate CYP3A inducers: These can lower the amount of Retevmo in the body, reducing its effect. It is best to avoid using these together.
• CYP2C8 and CYP3A drugs: Retevmo can increase the amount of these drugs in your body, which may cause more side effects. It is best to avoid using them together or monitor them closely.
• P-gp and BCRP drugs: Retevmo can also increase the amount of these drugs in your body, leading to a higher risk of side effects. It is best to avoid using them together or carefully monitor them if you must.
• Drugs that affect the heart: Some treatments can worsen heart problems when taken with Retevmo.

Alternative Medications to Retevmo

Other medications, besides Retevmo, can help the body fight cancer in various ways. Doctors select the best treatment for each patient based on the type of cancer and its specific effects. Below are some alternatives that may be used instead of Retevmo.

• Keytruda (pembrolizumab)
• Opdivo (nivolumab)
• Tagrisso (osimertinib)
• Alimta (pemetrexed)
• Avastin (bevacizumab)
• Imfinzi (durvalumab)

Order Retevmo from a Licensed & Trusted Canadian Pharmacy

The high cost of Retevmo can feel overwhelming, but you do not have to face it alone.

Pharma Giant offers affordable options to help you access your medication without financial stress.

Here are all the more reasons to choose Pharma Giant when purchasing Retevmo:

• Save more on your medication: The Retevmo price in Canada is significantly lower than in the U.S., allowing you to receive the same high-quality treatment at a fraction of the cost.
• Transparent pricing: We offer clear and upfront pricing, so you will never encounter hidden fees or unexpected charges.
• Additional savings with bulk purchases: You can save even more by purchasing a three-month supply at a reduced rate.
• Convenient ordering: In the United States, you do not need to visit a pharmacy or pay high prices. You can easily order Retevmo from Canada from the comfort of your home.

Pharma Giant makes it simple to access affordable Retevmo prices without stress. You deserve reliable and cost-effective treatment.

How to Order Retevmo Online?

1. Search for Retevmo in the search bar at the top of the website. Select the correct strength and click “Buy” to add it to your cart. Add any other medications you need.
2. Once you are ready, go to checkout. Enter your contact, payment, and shipping details. If you are new, create an account with your email and password. If you are a returning customer, just log in. Use coupon code PGSAVE10 for 10% off your first order. After filling in the information, submit your order. You will get a confirmation email.
3. Upload or send your prescription to us. After placing your order, you can upload it, email it to info@pharmagiant.com, or fax it to 1-888-562-8159.

Frequently Asked Questions

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.