What is Skyrizi?
SKYRIZI is approved for moderate-to-severe plaque psoriasis, psoriatic arthritis, and moderate-to-severe Crohn’s disease in adults.
HOW IT WORKS?
SKYRIZI is a biological agent (humanized immunoglobulin monoclonal antibody) that blocks the action of interleukin-23. Interleukin-23 plays a vital role in the immunological dysfunction that causes the development of plaque psoriasis.
INDICATIONS
- Moderate-to-severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
- Active psoriatic arthritis (PsA) in adults, alone or in combination with non-biologic disease-modifying antirheumatic drugs (DMARDs).
- Moderate-to-severe Crohn’s disease in adults who have had an inadequate response or intolerance to conventional or biologic therapy.
DOSAGE
Plaque Psoriasis & Psoriatic Arthritis:
- 150 mg subcutaneously at week 0, week 4, then every 12 weeks
- PsA patients can take it as one 150 mg injection or two 75 mg injections per dose.
Crohn’s Disease:
- IV Induction Phase: 600 mg intravenously at weeks 0, 4, and 8.
- Maintenance Phase: 180 mg or 360 mg subcutaneously every 8 weeks.
Warnings & Precautions
Infections
SKYRIZI increases the risk of developing fungal and bacterial infections. Patients taking SKYRIZI have reported increased upper respiratory infections and tinea infections. While the overall risk of serious infections is low, cases of pneumonia, cellulitis, and sepsis have been reported. Patients should be monitored for signs of infection. Do not start SKYRIZI in patients with active infections. In patients with a history of chronic or recurrent infections, the risk of starting SKYRIZI should be weighed against its possible benefits.
Testing for tuberculosis before starting SKYRIZI
SKYRIZI has its effect by inhibiting the action of interleukin-23. Unfortunately, a side-effect of this is that patients become more prone to bacterial infections. As a result, patients must be tested for latent tuberculosis infections before starting treatment with SKYRIZI. In addition, once starting SKYRIZI, patients should be monitored for active TB infections.
Immunizations
Before starting SKYRIZI, healthcare providers should ensure that patients have been fully immunized according to current immunization guidelines. Where possible, avoid using live vaccines in patients who are taking SKYRIZI.
Special Populations
Hepatic impairment
SKYRIZI is not affected by patients with moderate hepatic impairment. Therefore, no dose adjustments are necessary.
Renal impairment
There are no significant increases in the blood levels of SKYRIZI in patients with severe renal dysfunction. No dose adjustments are therefore required in this population.
Children
SKYRIZI has not been tested in children under the age of 18 years. As a result, its use is not recommended in this age group.
Pregnancy
SKYRIZI has not been extensively studied in pregnant women, and its use in this population should be avoided.
Breastfeeding
The safety of SKYRIZI has not been tested in breastfeeding mothers. Therefore, the risk to the infant should be weighed up against the benefit for the mother. This should be discussed with a doctor.
Use in the elderly
Data suggest that no dosage adjustments are required when prescribing SKYRIZI for elderly patients.
Contraindications
Skyrizi is contraindicated in patients with a known hypersensitivity to risankizumab or any of its inactive ingredients.
Side Effects of Medication
The most common side effects seen with SKYRIZI are:
- Headache
- Fatigue
- Sinusitis
- Rhinitis
- Tonsillitis
- Throat infections
- Tinea infections
- Injection site reactions (bruising, bleeding, infection, inflammation, irritation)
Less common side effects include:
- Serious infections
The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.
Drug Interactions
Where possible, avoid using live vaccines in patients being treated with SKYRIZI.
Buy Skyrizi: Price & Special Offer
The cost of prescription medicines can be a significant burden, especially in the United States where costs are often high. A prime example of this is the drug Skyrizi. In the U.S., the cost for Skyrizi, particularly the various dosages, can exceed $7,599 for individuals without insurance coverage. These high prices can make it challenging for many patients to access the medication they need.
However, there is a cost-effective solution available through Pharma Giant (PG). By obtaining a prescription from a doctor, Americans can buy Skyrizi online securely and conveniently from a licensed & trusted Canadian pharmacy through PG. At Pharma Giant, the cost for Skyrizi is significantly lower, available starting at $7,199.00 per vial. This presents a substantial saving opportunity for those requiring this medication.
Pharma Giant operates as a reliable and efficient service. It serves as a bridge connecting U.S. patients with licensed pharmacies. The fulfillment process is streamlined for efficiency and reliability, ensuring that once orders are placed, a licensed pharmacy will promptly fulfill the prescription, maintaining the highest standards of quality and safety.
One of the key aspects of this service is the expedited shipping process. Drugs are express shipped to the United States, typically arriving within 3-5 business days. This quick turnaround time ensures that patients receive their medicaton promptly, minimizing any potential disruption to their treatment plans.
Coupon Offer
To make this deal even more attractive, PG offers a special discount for first-time customers. By using the coupon code SKYRIZI10, new customers can save 10%. This additional discount further lowers the financial barrier, making essential medicine like Skyrizi more accessible to those in need.
By choosing Pharma Giant, patients in the U.S. can manage their health effectively while also making significant savings on their medication costs.
| Quantity | Strength | Total Cost | Cost per Unit |
|---|---|---|---|
| 1 vial | 60mg/mL | $7,199.00 | $7,199.00 |
| 2 vials | 60mg/mL | $14,200.00 | $7,100.00 |
| 3 vials | 60mg/mL | $21,000.00 | $7,000.00 |
| 1 prefilled pen | 150mg/mL/mL | $7,599.00 | $7,599.00 |
| 2 prefilled pens | 150mg/mL/mL | $15,000.00 | $7,500.00 |
| 3 prefilled pens | 150mg/mL/mL | $21,900.00 | $7,300.00 |
| 1 kit | 360mg/2.4mL | $7,199.00 | $7,199.00 |
| 2 kits | 360mg/2.4mL | $14,200.00 | $7,100.00 |
| 3 kits | 360mg/2.4mL | $21,000.00 | $7,000.00 |
| 1 prefilled syringe | 150mg/mL | $7,599.00 | $7,599.00 |
| 2 prefilled syringes | 150mg/mL | $15,000.00 | $7,500.00 |
| 3 prefilled syringes | 150mg/mL | $21,900.00 | $7,300.00 |
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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