Sprycel (dasatinib)

What is Sprycel?

Sprycel (dasatinib) is a medication used to treat certain types of blood cancers, such as chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).  Sprycel is used for adults and children at least one year old.

CML is a type of leukemia that progresses slowly, while ALL is a fast-growing form of leukemia. Sprycel medication is helpful for those who have not responded to or cannot tolerate other treatments, such as Imatinib.

Before taking Sprycel, inform your doctor about any health conditions, including heart problems, liver issues, or if you are pregnant or breastfeeding.

Sprycel can be harmful to an unborn baby. Hence, women should not become pregnant during treatment, and men with female partners who can become pregnant should use birth control.

If you are breastfeeding, you should avoid it during treatment with Sprycel. Talk to your doctor about any other medications to ensure Sprycel’s safety.

How Does Sprycel Work?

Sprycel blocks specific proteins in the body that help leukemia cells grow. These proteins, called kinases, send signals that make cancer cells multiply.

Sprycel targets a specific protein called BCR-ABL, which is found in Philadelphia chromosome-positive (Ph+) leukemia. By stopping this protein from working, Sprycel helps slow or stop the growth of cancer cells.

Dosing Information and Usage

Sprycel is available in tablet form in various strengths, including 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, and 140 mg.

The tablets should be taken once daily, with or without food, and swallowed whole with water.

Make sure to follow your Sprycel dosage and use the medication correctly.

Dosage Form and Strengths of Sprycel

Sprycel is available in the following strengths:

• 20 mg
• 50 mg
• 70 mg
• 80 mg
• 100 mg
• 140 mg

How to Use Sprycel?

• Take Sprycel once daily as your doctor has directed. The dosage will be determined based on your specific condition, so it is important to follow your prescribed amount.
• Depending on what works best for your routine, you can take Sprycel with or without food at any time, whether in the morning or evening.
• Swallow the tablet whole with a glass of water. Do not crush, cut, or chew it, as this may affect how the medication is absorbed.
• If you miss a dose, take it as soon as you remember on the same day. However, do not take two doses to make up for the missed one, as this can increase the risk of side effects.
• Avoid grapefruit juice while taking Sprycel, as it may interfere with the medication’s effectiveness.
• Consult your doctor for alternatives or different administration methods for children with difficulty swallowing the tablet.
• If you are taking Sprycel with a strong CYP3A4 inhibitor, your dose may need to be reduced. For example, reduce a 140 mg daily dose to 40 mg daily or a 100 mg or 70 mg daily to 20 mg daily. In some cases, you may need to pause treatment until you stop using the inhibitor.

Sprycel Side Effects

Sprycel can cause various side effects, ranging from mild to severe. Some common Sprycel side effects include diarrhea, headache, and nausea. 

However, serious complications such as low blood cell counts, severe bleeding, and heart problems may also occur. 

Both the common and long-term side effects of Sprycel can affect your treatment.

Common Side Effects

• Diarrhea
• Headache
• Skin rash
• Shortness of breath
• Fatigue
• Nausea
• Muscle pain
• Abdominal pain
• Vomiting
• Fever
• Constipation
• High blood pressure
• Low blood pressure
• Decreased appetite
• Swelling
• Infections
• Nosebleed
• Numbness or tingling in hands and feet
• Feeling confused or disoriented
• Abnormal heart rate
• Allergic reactions

Severe Side Effects

• Low blood cell counts

• • Anemia (low red blood cell count)
  • Neutropenia (low white blood cell count)
  • Thrombocytopenia (low platelet count)

• Bleeding problems

• • Unusual bruising or bleeding
  • Dark tar-like stools
  • Headache, confusion, or change in speech

• Fluid retention

• • Swelling throughout the body
  • Sudden weight gain
  • Shortness of breath
  • Dry cough
  • Chest pain when breathing deeply

• Heart and blood vessel issues

• • Chest pain
  • Shortness of breath
  • Fast or irregular heartbeat
  • Temporary vision changes
  • Slurred speech

• Pulmonary Arterial Hypertension (PAH)

• • Difficulty breathing
  • Unusual tiredness
  • Fluid buildup in the body

• Severe skin reactions

• • Fever
  • Blistering or peeling skin
  • Painful sores in the mouth or throat

• Tumor Lysis Syndrome (TLS)

• • Nausea
  • Vomiting
  • Weakness
  • Muscle cramps
  • Seizures
  • Swelling
  • Shortness of breath

• Slowed growth and development in children

• • Bone pain
  • Delayed height or weight growth

• Liver problems

• • Abdominal pain
  • Yellowing of the skin or eyes
  • Dark-colored urine
  • Loss of appetite
  • Easy bruising or bleeding

If you experience any severe side effects, seek medical attention immediately.

Warnings and Precautions

Sprycel can cause serious health problems, and it is important to know about them before taking it.

It can lower the number of blood cells that help fight infections, stop bleeding, and carry oxygen, making you feel weak or get sick. It can also cause severe bleeding, swelling in the body, heart problems, lung pressure issues, and changes in how the heart beats.

Here are the specific safety information you must know before taking Sprycel:

• Sprycel can lower blood cell counts, making fighting infections, stopping bleeding, or carrying oxygen harder.
• People taking Sprycel should get regular blood tests to check blood cell levels.
• Sprycel can cause severe bleeding, including in the brain or stomach, which can be life-threatening.
• Taking blood-thinning medications or affecting clotting can increase the risk of bleeding.
• Sprycel can cause swelling in the body, including in the lungs, making breathing hard.
• You should see a doctor immediately if you have trouble breathing, chest pain, or a dry cough.
• Some people taking Sprycel have had heart problems, including irregular heartbeats and blocked arteries.
• Sprycel can increase pressure in the lungs, which can cause breathing problems and swelling.
• If lung pressure problems happen, Sprycel should be stopped permanently.
• Sprycel can cause the heart’s electrical signals to change, leading to dangerous heart rhythms.
• People with low potassium or magnesium levels or certain heart conditions may have a higher risk of heart rhythm problems.
• Sprycel can cause severe skin reactions, including a rare but serious condition called Stevens-Johnson syndrome, which causes painful blisters and peeling skin.
• If a severe skin reaction happens, Sprycel should be stopped.
• When cancer cells break down too quickly, it can cause a dangerous condition called tumor lysis syndrome, which affects the kidneys and other organs.
• Drinking enough fluids and monitoring blood levels can help prevent tumor lysis syndrome.
• Sprycel can harm an unborn baby, so people who could become pregnant should use birth control while taking it and for 30 days after stopping it.
• Sprycel can affect children’s growth and development, including slowing down bone growth.
• Doctors should check children’s growth regularly while they are taking Sprycel.
• Sprycel can cause liver damage, which may lead to serious health problems.
• Regular liver tests are needed to check for signs of liver problems while taking Sprycel.

Drug Interactions With Other Medications

When taking Sprycel, it is important to be aware of potential drug interactions. Certain medications, supplements, or substances can affect how Sprycel works or increase the risk of side effects.

• Strong CYP3A4 inhibitors (ketoconazole, ritonavir) can increase Sprycel levels in the body, raising the risk of side effects. If you take these medications, your doctor may need to reduce the Sprycel dose.
• Strong CYP3A4 inducers (rifampin, phenytoin) can lower the levels of Sprycel in your body, which may reduce its effectiveness. If you need to take these medications, your doctor may increase the dose of Sprycel.
• Gastric acid-reducing agents (proton pump inhibitors, H2 antagonists) may lower Sprycel’s levels, making it less effective. It is recommended to avoid these medications and, if necessary, use antacids instead, taking them at least 2 hours before or after Sprycel.
• Alfentanil and fentanyl can interact with Sprycel and may require dose adjustments.
• Bosentan and conivaptan may affect how Sprycel works, requiring your doctor to monitor your treatment closely.
• Cyclosporine and dexamethasone can alter the levels of Sprycel in your body, which may require dose adjustments.
• Ergotamine can increase side effects when taken with Sprycel, so your doctor may need to adjust your treatment.
• Imatinib can affect the effectiveness of both Sprycel and Imatinib when used together, requiring careful monitoring.
• Isoniazid may lower the effectiveness of Sprycel and should be discussed with your doctor.
• Pimozide can increase the risk of side effects when used with Sprycel so a dosage adjustment may be needed.
• Rifabutin, rifampin, and rifapentine can decrease Sprycel’s effectiveness, so your doctor may need to adjust the dose.
• St. John’s wort can lower the levels of Sprycel, affecting how well it works.
• Antibiotics, antifungals, and antidepressants may interact with Sprycel, so informing your doctor about all your medications is important.
• Phenobarbital and other barbiturates can reduce the effectiveness of Sprycel so that dosage adjustments may be required.
• Aspirin and blood thinners may increase the risk of bleeding when taken with Sprycel, so your doctor may need to monitor you closely.
• Heart or blood pressure medications can interact with Sprycel and may require adjustments in your treatment.
• HIV/AIDS medications may affect the effectiveness of Sprycel, and your doctor will need to monitor your treatment carefully.
• Medications to treat narcolepsy, prevent blood clots, or prevent organ transplant rejection may interact with Sprycel, and your doctor should be informed.
• Seizure medications and stomach acid reducers may interact with Sprycel, and your doctor will need to monitor your treatment closely.

Sprycel Alternatives

If you are looking for Sprycel alternatives, there are other medications available for treating chronic myeloid leukemia (CML).

Your doctor may recommend a different treatment based on your medical condition, response to therapy, and potential side effects.

Here are some alternative medications:

• Tasigna (nilotinib)
• Iclusig (ponatinib)
• Gleevec (imatinib)
• Bosulif (bosutinib)
• Synribo (omacetaxine)
• Infergen (interferon alpha)
• Alferon (interferon alpha)
• Vincristine
• Cyclophosphamide
• Hydrea (hydroxyurea)
• Ara-C (cytarabine)
• Busulfex (busulfan)

Order Affordable Sprycel Online from Canada & SAVE

The cost of Sprycel should never be a barrier to receiving the life-saving treatment you need.

Sprycel is a medication for people with chronic myeloid leukemia (CML), but its high price can make it difficult to afford, especially without insurance coverage.

At Pharma Giant, we believe that everyone deserves access to affordable medication without sacrificing quality.

We are committed to offering budget-friendly Sprycel at significantly lower prices than conventional pharmacies.

Pharma Giant understands how stressful it can be to manage high prescription expenses, so we offer additional savings through a coupon for Sprycel and bulk purchase options.

Our platform is designed to help you save money without the hassle of long wait times or high pharmacy markups.

The cost of Sprycel should not prevent you from getting the treatment you need. Order online today from Pharma Giant and take control of your health with reliable, affordable access to medication.

How to Order Sprycel Online?

1. Search for Sprycel, select the strength, and click “Buy.” Add any other medications, then go to checkout.
2. Enter your shipping, payment, and contact details. If you are new, create an account. Returning customers can log in. Apply the coupon for Sprycel, PGSAVE10, for 10% off your first purchase. Submit your order and check your email for confirmation.
3. After checkout, upload your prescription, email it to info@pharmagiant.com, or fax it to 1-888-562-8159. If a prescription is required and not received, our team will contact you to assist you.

Frequently Asked Questions

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.