What is Steqeyma?
Steqeyma is a prescription treatment that works by calming an overactive immune system. The immune system is the part of the body that fights infections, but in some people, it becomes too active and attacks healthy tissues.
Steqeyma helps block two proteins called interleukin 12 and interleukin 23. These proteins cause inflammation, which means swelling, redness, pain, and damage in the body.
By reducing this inflammation, Steqeyma helps improve long-term conditions like skin problems and bowel diseases. Steqeyma is given using a Steqeyma pen through an injection under the skin or into a vein.
Indications and Benefits of Steqeyma
Steqeyma is prescribed for people aged 6 years and older with moderate to severe plaque psoriasis, which is a skin condition that causes thick, red, scaly patches.
It is also used for psoriatic arthritis, a condition where joint pain and swelling happen along with skin symptoms.
For adults, Steqeyma is approved to treat Crohn’s disease and ulcerative colitis, which are long-term bowel conditions that cause stomach pain, diarrhea, and inflammation inside the digestive system.
Steqeyma helps reduce immune system activity, which lowers inflammation and improves symptoms.
Doctors choose this treatment for people who need stronger control of their condition through systemic therapy, meaning treatment that works throughout the whole body.
What Are the Benefits of Steqeyma?
- Helps reduce red, thick, and scaly skin patches caused by plaque psoriasis.
- Lowers joint pain, swelling, and stiffness linked to psoriatic arthritis.
- Calms bowel inflammation in Crohn’s disease, which can ease diarrhea and stomach pain.
- Improves ulcerative colitis symptoms such as bloody stools and frequent bathroom visits.
- Blocks immune system proteins that cause long-term inflammation in the body.
- Helps prevent flare-ups when symptoms suddenly become worse.
- Supports better daily comfort by reducing pain, itching, and skin irritation.
- May improve quality of life by helping people move, eat, and sleep more comfortably.
- Comes in an easy-to-use Steqeyma pen for home injections.
- Offers flexible Steqeyma route of administration, including under the skin or through a vein.
- Includes clear Steqeyma instructions for use provided by healthcare professionals.
- Has simple Steqeyma administration schedules that do not require daily dosing.
- Can be used as a long-term option for people who need stronger symptom control.
- Covers multiple Steqeyma uses for skin, joint, and bowel conditions.
- Has important Steqeyma contraindications, such as allergies to its ingredients or active infections.
- May reduce the need for hospital visits by keeping symptoms under control.
- Supports skin healing by lowering inflammation levels.
- Helps protect joints from long term damage caused by swelling.
- Allows many people to return to normal daily activities.
Fact Table
| Fact Category | Fact Details |
| Generic Name | ustekinumab stba |
| Steqeyma Class | Interleukin inhibitors |
| Primary Use | Treats plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis |
| Additional Benefit | Helps reduce inflammation, pain, swelling, and skin symptoms |
| Available Form | Injection and intravenous infusion |
| Method of Administration | Given under the skin or through a vein in the arm |
| Frequency | Every 8 to 12 weeks,s depending on the condition and body weight |
| Storage Instructions | Store in the refrigerator. Do not freeze. Protect from light |
| Pregnancy and Breastfeeding | Safety during pregnancy is unknown. Can pass into breast milk. Doctor’s advice is needed |
| Drug Interactions | Live vaccines, the BCG vaccine, and some immune system treatments |
| Manufacturer | Celltrion USA, Inc. |
How It Works
Steqeyma works by calming an overactive immune system that causes inflammation in the body.
In some conditions, like plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis, the immune system sends too many signals that lead to redness, swelling, pain, and tissue damage.
Steqeyma blocks two proteins called interleukin 12 and interleukin 23. These proteins act like messengers that tell the body to create inflammation.
By stopping these signals, Steqeyma helps reduce skin flare-ups, joint pain, and bowel irritation. This allows the body to heal and function more normally over time.
Dosage
Steqeyma dosage depends on the condition being treated, the age of the patient, and body weight.
For skin and joint conditions like plaque psoriasis and psoriatic arthritis, Steqeyma is given as an injection under the skin.
For bowel conditions like Crohn’s disease and ulcerative colitis, the first dose is given through a vein in the arm, followed by regular injections under the skin.
A healthcare provider decides the correct amount based on weight and health needs.
Most people receive Steqeyma every 8 to 12 weeks, which helps control inflammation over time. Always follow Steqeyma’s instructions for use and attend all follow-up visits for safe and effective Steqeyma administration.
What Dosage Strengths Does Steqeyma Come In?
- 45 mg in a single-dose prefilled syringe
- 90 mg in a single-dose prefilled syringe
- 130 mg in a vial for intravenous infusion
Dosage Chart
| Condition | Age Group | Body Weight | Starting Dose | Follow-Up Dose | Maintenance Schedule | Method |
| Plaque psoriasis | Adults | 100 kg or less | 45 mg | 45 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Plaque psoriasis | Adults | Over 100 kg | 90 mg | 90 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Plaque psoriasis | Children 6 to 17 | 60 to 100 kg | 45 mg | 45 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Plaque psoriasis | Children 6 to 17 | Over 100 kg | 90 mg | 90 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Psoriatic arthritis | Adults | Any weight | 45 mg | 45 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Psoriatic arthritis with severe psoriasis | Adults | Over 100 kg | 90 mg | 90 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Psoriatic arthritis | Children 6 to 17 | 60 kg or more | 45 mg | 45 mg after 4 weeks | Every 12 weeks | Injection under the skin |
| Crohns disease | Adults | 55 kg or less | 260 mg | 90 mg after 8 weeks | Every 8 weeks | First through the vein, then under the skin |
| Crohns disease | Adults | 56 to 85 kg | 390 mg | 90 mg after 8 weeks | Every 8 weeks | First through the vein, then under the skin |
| Crohns disease | Adults | Over 85 kg | 520 mg | 90 mg after 8 weeks | Every 8 weeks | First through the vein, then under the skin |
| Ulcerative colitis | Adults | 55 kg or less | 260 mg | 90 mg after 8 weeks | Every 8 weeks | First through the vein, then under the skin |
| Ulcerative colitis | Adults | 56 to 85 kg | 390 mg | 90 mg after 8 weeks | Every 8 weeks | First through the vein, then under the skin |
| Ulcerative colitis | Adults | Over 85 kg | 520 mg | 90 mg after 8 weeks | Every 8 weeks | First through the vein, then under the skin |
Usage Guide
Steqeyma should always be used exactly as your healthcare provider instructs. The dose, schedule, and method depend on the condition being treated and your body weight.
For Crohn’s disease and ulcerative colitis, the first dose is given through a vein in the arm at a healthcare facility.
This process usually takes at least one hour. After this, future doses are given as injections under the skin every eight weeks.
For plaque psoriasis and psoriatic arthritis, both adults and children aged six years and older receive Steqeyma only as injections under the skin.
Some people may be trained to give the injection at home, but this should only happen after proper instruction from a doctor or nurse. Regular checkups are important to make sure the treatment is working safely.
How do you administer Steqeyma?
- A healthcare provider gives the first dose through a vein for people with Crohn’s disease or ulcerative colitis.
- The infusion usually takes about one hour in a medical facility.
- Future doses for bowel conditions are given as injections under the skin every eight weeks.
- People with plaque psoriasis or psoriatic arthritis receive only under-the-skin injections.
- Children aged six years and older usually receive their injections from a healthcare provider.
- Some adults or caregivers may be trained to give injections at home after proper instruction.
- The injection can be given in the upper arms, thighs, stomach area, or buttocks.
- The injection site should not be red, bruised, hard, or painful.
- A different injection area should be used each time to protect the skin.
- The dose and schedule are decided by a healthcare provider based on body weight and health needs.
- If more than the prescribed amount is given, a doctor should be contacted right away.
- All follow-up appointments should be kept to monitor safety and progress.
Side Effects
Steqeyma can cause both mild and serious side effects. Some people may only experience minor symptoms, while others may have stronger reactions that need medical care.
It is important to know what signs to watch for and to contact a healthcare provider if any unusual symptoms appear.
Serious side effects are rare but can be life-threatening if not treated quickly.
Common Side Effects
- Stuffy or runny nose
- Sore throat
- Upper respiratory infections
- Fever
- Headache
- Tiredness
- Itching
- Nausea
- Vomiting
- Redness at the injection site
- Vaginal yeast infections
- Urinary tract infections
- Sinus infection
- Bronchitis
- Diarrhea
Severe Side Effects
- Serious allergic reactions
- Feeling faint
- Swelling of the face, eyelids, tongue, or throat
- Chest tightness
- Skin rash
- Shortness of breath
- Persistent cough that does not go away
- Serious infections, including tuberculosis or diseases caused by bacteria, viruses, or fungi
- Lung inflammation that may require hospital treatment
- Signs of cancer, such as new skin growths
- Severe headache
- Confusion or changes in mental status
- Vision problems
- Seizures
Missed Dose
If a dose of Steqeyma is missed, contact your healthcare provider as soon as possible for guidance.
Do not try to make up for a missed dose by taking more than prescribed. Your doctor will advise the safest way to continue your treatment and adjust the schedule if needed.
Following your dosing plan closely helps keep your condition under control and reduces the risk of flare-ups.
Overdose
In clinical trials, high doses of Steqeyma given through a vein were generally safe, but taking more than prescribed can still cause unwanted effects.
If an overdose occurs, a healthcare provider should monitor for any symptoms and provide supportive care as needed.
It may also be helpful to contact a poison control center or a medical toxicologist for additional advice. Prompt medical attention is important to ensure safety.
Storage Information
Steqeyma should be stored in the refrigerator between thirty six degrees Fahrenheit and forty six degrees Fahrenheit, which is two degrees Celsius to eight degrees Celsius, in its original carton to protect it from light.
Keep the vials standing upright and do not freeze or shake them.
If necessary, Steqeyma can be stored at room temperature up to eighty-six degrees Fahrenheit, which is thirty degrees Celsius, for a maximum of fifteen days.
Still, it cannot be returned to the refrigerator once removed.
Always record the date when it is first taken out of the fridge and discard any unused vials or syringes after fifteen days at room temperature or after the expiration date. Keep Steqeyma out of the reach of children.
Warnings
Steqeyma may increase the risk of infections, cancer, and serious allergic reactions. Patients should be closely monitored before and during treatment.
Tell your healthcare provider about any history of infections, tuberculosis, or cancer before starting Steqeyma. Using Steqeyma safely involves proper screening, regular follow-ups, and avoiding live vaccines while on treatment.
- Steqeyma can increase the risk of serious infections, including bacterial, viral, and fungal infections.
- Avoid using Steqeyma if you have an active infection until it is fully treated.
- Patients with chronic or repeated infections should discuss risks and benefits with their doctor before starting Steqeyma.
- People with a genetic deficiency in certain immune proteins may be more vulnerable to severe infections while using Steqeyma.
- Your doctor will check for tuberculosis before starting Steqeyma and may begin treatment for latent tuberculosis if needed.
- Steqeyma may increase the risk of certain types of cancer, including skin cancers, especially in patients with a history of prolonged immunosuppressive therapy or previous skin treatments.
- Severe allergic reactions, including swelling of the face, tongue, or throat, hives, and breathing difficulties, may occur. Seek immediate medical attention if these happen.
- Rare brain conditions, such as posterior reversible encephalopathy syndrome, can occur and may cause headaches, seizures, confusion, or vision problems.
- Avoid live vaccines during treatment with Steqeyma and for one year after stopping treatment. Household members receiving live vaccines should exercise caution.
- Lung inflammation and noninfectious pneumonia have been reported, causing cough, shortness of breath, or respiratory failure in rare cases.
Boxed Warning and Precautions for Steqeyma
| Steqeyma carries important precautions due to its effect on the immune system. It can lower the body’s ability to fight infections and may increase the risk of cancer and serious allergic reactions. Before starting Steqeyma, patients should be screened for infections, tuberculosis, and cancer. Regular monitoring by a healthcare provider is necessary to ensure safe use. Avoid live vaccines and report any unusual symptoms immediately, including fever, persistent cough, skin changes, or neurological symptoms. Proper precautions help reduce risks and ensure Steqeyma is used safely and effectively. |
Contraindications
Steqeyma should not be used in patients who are allergic to ustekinumab, which is the active ingredient in Steqeyma, or to any of the inactive ingredients in the injection.
A hypersensitivity reaction means the body reacts strongly to a substance, which can cause symptoms such as swelling of the face, lips, tongue, or throat, difficulty breathing, chest tightness, or skin rash.
Using Steqeyma in these patients could lead to a severe allergic reaction and may be life-threatening.
Inform your healthcare provider if you have had allergic reactions to similar treatments before starting Steqeyma.
Interactions
- Immunosuppressive agents
- Phototherapy
- Methotrexate (MTX)
- 6-Mercaptopurine (6-MP)
- Azathioprine (AZA)
- Corticosteroids
- CYP450 substrates
- Allergen immunotherapy
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