Stivarga (regorafenib)

What is Stivarga?

Stivarga (regorafenib) is used as a prescription medication for specific types of advanced or metastatic cancers.

This medication is generally used in adults and must be prescribed and monitored by a healthcare professional.

Stivarga is approved for the treatment of the following conditions:

• Metastatic colorectal cancer (CRC): This is cancer that started in the colon or rectum and has spread to other parts of the body. Stivarga is used when the patient has already been treated with chemotherapy drugs such as fluoropyrimidine, oxaliplatin, and irinotecan and has also received anti-VEGF therapy. For patients with a specific gene type (RAS wild-type), Stivarga is used after receiving anti-EGFR therapy.
• Gastrointestinal stromal tumors (GIST): These are rare cancers that start in the digestive tract, most commonly in the stomach or small intestine. Stivarga is used in patients whose tumors cannot be removed by surgery or have spread and who have already been treated with Imatinib and Sunitinib, two other cancer medications.
• Hepatocellular carcinoma (HCC): This is the most common type of liver cancer. Stivarga is used in patients who have already been treated with sorafenib, another targeted cancer therapy. It may help slow the progression of the disease in cases where other treatments are no longer effective.

Before starting Stivarga, talk to your doctor about your health conditions. Let your doctor know if you have liver disease, heart problems, high blood pressure, or a history of bleeding issues.

Women who are pregnant or planning to get pregnant should not use Stivarga, as it can harm the baby. Use effective birth control during treatment and for two months after your last dose. Avoid breastfeeding during this time as well.

Be sure to give your doctor a full list of all prescriptions, over-the-counter medications, and supplements you are taking.

How Does Stivarga Work?

Stivarga is a medication that targets several proteins that help cancer cells grow, spread, and form new blood vessels. Its active ingredient is regorafenib, a multikinase inhibitor.

This means it blocks the activity of multiple enzymes called kinases, which play a role in cancer development. These enzymes control how cells grow, divide, and repair themselves. In cancer, these processes become abnormal, leading to uncontrolled tumor growth.

Stivarga blocks specific kinases such as VEGFR, KIT, RET, RAF, and PDGFR. These proteins allow cancer cells to create new blood vessels through angiogenesis.

By stopping angiogenesis, Stivarga cuts off the blood supply that tumors need to grow. It also blocks proteins that help cancer cells spread to other body parts, known as metastasis.

Stivarga blocks multiple pathways that help slow down or stop cancer progression. This makes it a useful treatment option for people with certain advanced cancers when other treatments no longer work.

Dosing Information and Usage

Stivarga dosing must be carefully followed to get the best results from this treatment. Stivarga is available as a film-coated tablet and is taken orally once daily.

Always take the dose of Stivarga exactly as directed by your healthcare provider. If any side effects occur, your doctor may need to adjust your dose.

Dosage Form and Strengths of Stivarga

Stivarga is available as a 40 mg tablet. It is taken orally once daily as part of a cycle-based regimen.

Patients take four tablets (160 mg total) daily for 21 consecutive days, followed by a 7-day break. Based on individual tolerance or side effects, Stivarga dose adjustments may be required.

How to Use Stivarga?

Follow your doctor’s instructions carefully, and do not change your dose of Stivarga without medical advice.

• Take Stivarga once daily for 21 days, then stop for 7 days. This makes up one complete treatment cycle.
• The usual recommended dose of Stivarga is 160 mg daily, which equals four 40 mg tablets.
• Take Stivarga with a low-fat meal containing less than 600 calories and less than 30% fat.
• Swallow the tablets whole with water. Do not crush, split, or chew the tablets.
• Take your dose of Stivarga at the same time every day.
• If you forget to take a dose, take it as soon as you remember that day. Do not take two doses on the same day.
• If you take too much Stivarga, seek emergency medical help right away.

If you experience side effects, your doctor may adjust your dose of Stivarga. Dose reductions are usually made in 40 mg steps. The lowest recommended dose is 80 mg per day.

If serious side effects occur and do not improve, your doctor may decide to stop the medication permanently.

Stivarga Side Effects

Stivarga can cause a range of side effects that affect different parts of the body. Some of the most common Stivarga side effects include tiredness, pain in the stomach area, diarrhea, and voice changes.

However, more serious Stivarga adverse effects, such as severe bleeding, high blood pressure, and infections that affect the lungs, urinary tract, or skin, may also occur.

In some cases, Stivarga can cause heart problems, liver damage, or a tear in the stomach or intestinal wall. Knowing the common and severe side effects is important for recognizing them early and getting help if needed.

Common Side Effects

• Pain in the stomach area or other parts of the body
• Feeling tired, weak, or low on energy
• Diarrhea (frequent or loose bowel movements)
• Loss of appetite
• Mild infections like colds or urinary tract infections
• Hoarseness or changes in voice
• Fever
• Mouth sores or irritation in the throat and digestive tract (mucositis)
• Weight loss
• Higher levels in liver function tests

Severe Side Effects

• Serious infections (lung, urinary tract, or body-wide fungal infections)
• Bleeding that may include vomiting blood, dark stools, or frequent nosebleeds
• Bowel perforation (a tear in the stomach or intestine), with symptoms like sudden stomach pain and swelling
• Hand-foot skin reaction (redness, pain, blisters, or swelling on hands and feet)
• High blood pressure that may cause headaches or vision changes
• Decreased blood flow to the heart or heart attack (chest pain, dizziness, shortness of breath)
• Reversible Posterior Leukoencephalopathy Syndrome (RPLS), a brain condition with headaches, confusion, and seizures
• Delayed wound healing after surgery
• Liver problems, shown by high liver enzymes or yellowing of the skin and eyes

Tell your healthcare provider immediately if you notice any unusual symptoms during treatment. Knowing about Stivarga’s adverse effects can help you stay safe while taking this medication.

Warnings and Precautions for Stivarga

Knowing the warnings and precautions before using it is important so patients can be monitored closely and avoid serious harm.

These safety concerns are based on how the medication works and what was seen in clinical trials.

Here are the following warnings and precautions of Stivarga:

• Stivarga can seriously damage the liver, especially in the first two months of treatment. Your doctor will check your liver regularly using blood tests before and during treatment.
• Stivarga increases the chance of getting infections. These can be mild or serious and can even cause death. Common infections include urinary tract infections, colds, fungi, and pneumonia.
• Stivarga can cause brain, lung, stomach, or urinary tract bleeding. Severe or life-threatening bleeding may require stopping the medication permanently. If you take blood thinners like warfarin, your blood will be checked more often.
• Stivarga may cause holes (perforations) or abnormal openings (fistulas) in the stomach or intestines. These problems can be severe and deadly, so Stivarga must be stopped completely.
• Stivarga can cause skin problems. Many people get rashes or a condition called hand-foot skin reaction, which causes redness, swelling, and pain on the palms or soles of the feet. Skin problems usually start early in treatment. Depending on how severe they get, treatment may need to be paused or stopped.
• Stivarga can raise blood pressure quickly, often in the first few weeks of treatment. Blood pressure must be checked frequently.
• Stivarga can reduce blood flow to the heart, which can lead to chest pain or even a heart attack. If this happens, Stivarga should be stopped until the heart is stable.
• Stivarga may cause a rare brain condition called reversible posterior leukoencephalopathy syndrome (RPLS). Signs include seizures, severe headaches, vision problems, confusion, or behavior changes. If this happens, treatment must be stopped right away.
• If you have surgery, stop taking Stivarga at least two weeks before and do not retake it until your wound has healed well.
• Stivarga can harm unborn babies. It can cause congenital disabilities or loss of pregnancy in animals. Women who are pregnant or planning to become pregnant should not take Stivarga. Men and women must use birth control during treatment and for two months after the last dose. If you are pregnant or become pregnant while on Stivarga, tell your doctor right away.

Stivarga Drug Interactions

Before you take Stivarga, always know how it might interact with other medications, foods, or supplements. These Stivarga interactions can change how the medication works in your body or increase the risk of side effects.

• Avoid strong CYP3A4 inducers: These medications can lower the level of Stivarga in your body and make it less effective.
  • Rifampin
  • Phenytoin
  • Carbamazepine
  • Phenobarbital
  • St. John’s Wort (a herbal supplement for depression)
• Avoid strong CYP3A4 inhibitors: These can raise the level of Stivarga in your body and increase side effects.
  • Clarithromycin
  • Grapefruit or grapefruit juice
  • Itraconazole
  • Ketoconazole
  • Posaconazole
  • Telithromycin
  • Nefazodone
  • Voriconazole
• Watch for interactions with BCRP substrates: Stivarga can raise the levels of these medications in your blood and increase the risk of side effects.
  • Methotrexate
  • Atorvastatin
  • Fluvastatin

• Alcohol

Stivarga Alternatives

If Stivarga is not right for you or if you are looking for other options, talk to your doctor. The best alternative depends on your type of cancer, your overall health, and how your body responds to treatment.

Your doctor can help you choose the best medication for your condition and treatment goals.

• Keytruda (pembrolizumab)
• Opdivo (nivolumab)
• Nexavar (sorafenib)
• Imfinzi (durvalumab)
• Xeloda (capecitabine)
• Adrucil (fluorouracil)
• Avastin (bevacizumab)
• Eloxatin (oxaliplatin)
• Leucovorin

These medications are used to treat similar types of cancer, such as colorectal cancer, gastrointestinal stromal tumors, and liver cancer.

Order Stivarga Online and Save with Pharma Giant

Accessing life-saving medication like Stivarga should not come with the stress of high costs.

Many patients find it challenging to afford the cost of Stivarga, which can prevent them from getting the treatment they need.

By working with a trusted network of pharmacies, Pharma Giant provides the lowest prices possible for Stivarga, including competitive Stivarga costs in Canada.

Our easy-to-use platform ensures you know exactly how much you will pay upfront, with no hidden fees. Plus, you can purchase up to a 3-month supply of your medication at a reduced price, making long-term treatment easier on your budget.

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Ordering from a Pharma Giant means you can trust the process and rest assured that you are receiving the medication you need at an affordable price.

How to Order Stivarga Online?

1. Search for Stivarga using the search bar. Choose the strength and click “Buy.” Add any other medications and proceed to checkout.
2. Fill in your details and create an account or log in. Use PGSAVE10 to get 10% off your first order.
3. After submitting, you will get a confirmation email. Send your prescription to info@pharmagiant.com or fax it to 1-888-562-8159.

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Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.